Publications by authors named "Ralph S Baric"

314Publications

Comparison of Subgenomic and Total RNA in SARS-CoV-2 Challenged Rhesus Macaques.

Authors:
Gabriel Dagotto Noe B Mercado David R Martinez Yixuan J Hou Joseph P Nkolola Robert H Carnahan James E Crowe Ralph S Baric Dan H Barouch

J Virol 2021 Jan 20. Epub 2021 Jan 20.

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA

View Article and Find Full Text PDF
January 2021

Publisher Correction: A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures.

Authors:
Kenneth H Dinnon Sarah R Leist Alexandra Schäfer Caitlin E Edwards David R Martinez Stephanie A Montgomery Ande West Boyd L Yount Yixuan J Hou Lily E Adams Kendra L Gully Ariane J Brown Emily Huang Matthew D Bryant Ingrid C Choong Jeffrey S Glenn Lisa E Gralinski Timothy P Sheahan Ralph S Baric

Nature 2021 Jan 19. Epub 2021 Jan 19.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

View Article and Find Full Text PDF
January 2021

Publisher Correction: Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques.

Authors:
Noe B Mercado Roland Zahn Frank Wegmann Carolin Loos Abishek Chandrashekar Jingyou Yu Jinyan Liu Lauren Peter Katherine McMahan Lisa H Tostanoski Xuan He David R Martinez Lucy Rutten Rinke Bos Danielle van Manen Jort Vellinga Jerome Custers Johannes P Langedijk Ted Kwaks Mark J G Bakkers David Zuijdgeest Sietske K Rosendahl Huber Caroline Atyeo Stephanie Fischinger John S Burke Jared Feldman Blake M Hauser Timothy M Caradonna Esther A Bondzie Gabriel Dagotto Makda S Gebre Emily Hoffman Catherine Jacob-Dolan Marinela Kirilova Zhenfeng Li Zijin Lin Shant H Mahrokhian Lori F Maxfield Felix Nampanya Ramya Nityanandam Joseph P Nkolola Shivani Patel John D Ventura Kaylee Verrington Huahua Wan Laurent Pessaint Alex Van Ry Kelvin Blade Amanda Strasbaugh Mehtap Cabus Renita Brown Anthony Cook Serge Zouantchangadou Elyse Teow Hanne Andersen Mark G Lewis Yongfei Cai Bing Chen Aaron G Schmidt R Keith Reeves Ralph S Baric Douglas A Lauffenburger Galit Alter Paul Stoffels Mathai Mammen Johan Van Hoof Hanneke Schuitemaker Dan H Barouch

Nature 2021 Jan 19. Epub 2021 Jan 19.

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
January 2021

Norovirus-Specific CD8 T Cell Responses in Human Blood and Tissues.

Authors:
Ajinkya Pattekar Lena S Mayer Chi Wai Lau Chengyang Liu Olesya Palko Meenakshi Bewtra H P A P Consortium Lisa C Lindesmith Paul D Brewer-Jensen Ralph S Baric Michael R Betts Ali Naji E John Wherry Vesselin T Tomov

Cell Mol Gastroenterol Hepatol 2021 Jan 11. Epub 2021 Jan 11.

Department of Medicine, Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address:

View Article and Find Full Text PDF
January 2021

Dengue Vaccines: The Promise and Pitfalls of Antibody-Mediated Protection.

Authors:
David R Martinez Stefan W Metz Ralph S Baric

Cell Host Microbe 2021 01;29(1):13-22

Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, The University of North Carolina School of Medicine, Chapel Hill, NC, USA. Electronic address:

View Article and Find Full Text PDF
January 2021

The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates.

Authors:
Dapeng Li Robert J Edwards Kartik Manne David R Martinez Alexandra Schäfer S Munir Alam Kevin Wiehe Xiaozhi Lu Robert Parks Laura L Sutherland Thomas H Oguin Charlene McDanal Lautaro G Perez Katayoun Mansouri Sophie M C Gobeil Katarzyna Janowska Victoria Stalls Megan Kopp Fangping Cai Esther Lee Andrew Foulger Giovanna E Hernandez Aja Sanzone Kedamawit Tilahun Chuancang Jiang Longping V Tse Kevin W Bock Mahnaz Minai Bianca M Nagata Kenneth Cronin Victoria Gee-Lai Margaret Deyton Maggie Barr Tarra Von Holle Andrew N Macintyre Erica Stover Jared Feldman Blake M Hauser Timothy M Caradonna Trevor D Scobey M Anthony Moody Derek W Cain C Todd DeMarco Thomas N Denny Christopher W Woods Elizabeth W Petzold Aaron G Schmidt I-Ting Teng Tongqing Zhou Peter D Kwong John R Mascola Barney S Graham Ian N Moore Robert Seder Hanne Andersen Mark G Lewis David C Montefiori Gregory D Sempowski Ralph S Baric Priyamvada Acharya Barton F Haynes Kevin O Saunders

bioRxiv 2021 Jan 2. Epub 2021 Jan 2.

View Article and Find Full Text PDF
January 2021

Novel modulators of p53-signaling encoded by unknown genes of emerging viruses.

Authors:
Dina Alzhanova Kathleen Corcoran Aubrey G Bailey Kristin Long Sharon Taft-Benz Rachel L Graham Grant S Broussard Mark Heise Gabriele Neumann Peter Halfmann Yoshihiro Kawaoka Ralph S Baric Blossom Damania Dirk P Dittmer

PLoS Pathog 2021 01 7;17(1):e1009033. Epub 2021 Jan 7.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

View Article and Find Full Text PDF
January 2021

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes in COVID-19 convalescent plasma.

Authors:
William N Voss Yixuan J Hou Nicole V Johnson Jin Eyun Kim George Delidakis Andrew P Horton Foteini Bartzoka Chelsea J Paresi Yuri Tanno Shawn A Abbasi Whitney Pickens Katia George Daniel R Boutz Dalton M Towers Jonathan R McDaniel Daniel Billick Jule Goike Lori Rowe Dhwani Batra Jan Pohl Justin Lee Shivaprakash Gangappa Suryaprakash Sambhara Michelle Gadush Nianshuang Wang Maria D Person Brent L Iverson Jimmy D Gollihar John Dye Andrew Herbert Ralph S Baric Jason S McLellan George Georgiou Jason J Lavinder Gregory C Ippolito

bioRxiv 2020 Dec 21. Epub 2020 Dec 21.

View Article and Find Full Text PDF
December 2020

Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions.

Authors:
Andrea R Shiakolas Kevin J Kramer Daniel Wrapp Simone I Richardson Alexandra Schäfer Steven Wall Nianshuang Wang Katarzyna Janowska Kelsey A Pilewski Rohit Venkat Rob Parks Nelia P Manamela Nagarajan Raju Emilee Friedman Fechter Clinton M Holt Naveenchandra Suryadevara Rita E Chen David R Martinez Rachel S Nargi Rachel E Sutton Julie E Ledgerwood Barney S Graham Michael S Diamond Barton F Haynes Priyamvada Acharya Robert H Carnahan James E Crowe Ralph S Baric Lynn Morris Jason S McLellan Ivelin S Georgiev

bioRxiv 2020 Dec 20. Epub 2020 Dec 20.

View Article and Find Full Text PDF
December 2020

Preadaptation of pandemic GII.4 noroviruses in unsampled virus reservoirs years before emergence.

Authors:
Christopher Ruis Lisa C Lindesmith Michael L Mallory Paul D Brewer-Jensen Josephine M Bryant Veronica Costantini Christopher Monit Jan Vinjé Ralph S Baric Richard A Goldstein Judith Breuer

Virus Evol 2020 Jul 21;6(2):veaa067. Epub 2020 Nov 21.

Division of Infection and Immunity, University College London, London WC1E 6BT, UK.

View Article and Find Full Text PDF
July 2020

A Newcastle Disease Virus (NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective Inactivated SARS-CoV-2 Vaccine.

Authors:
Weina Sun Stephen McCroskery Wen-Chun Liu Sarah R Leist Yonghong Liu Randy A Albrecht Stefan Slamanig Justine Oliva Fatima Amanat Alexandra Schäfer Kenneth H Dinnon Bruce L Innis Adolfo García-Sastre Florian Krammer Ralph S Baric Peter Palese

Vaccines (Basel) 2020 Dec 17;8(4). Epub 2020 Dec 17.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

View Article and Find Full Text PDF
December 2020

Evaluation of SARS-CoV-2 neutralization assays for antibody monitoring in natural infection and vaccine trials.

Authors:
Anton M Sholukh Andrew Fiore-Gartland Emily S Ford Yixuan Hou Longping Victor Tse Florian A Lempp Hanna Kaiser Russell Saint Germain Emily Bossard Jia Jin Kee Kurt Diem Andrew B Stuart Peter B Rupert Chance Brock Matthew Buerger Margaret K Doll April Kaur Randhawa Leonidas Stamatatos Roland K Strong Colleen McLaughlin Keith R Jerome Ralph S Baric David Montefiori Lawrence Corey

medRxiv 2020 Dec 8. Epub 2020 Dec 8.

View Article and Find Full Text PDF
December 2020

Emergence of a Highly Fit SARS-CoV-2 Variant.

Authors:
Ralph S Baric

N Engl J Med 2020 12 16;383(27):2684-2686. Epub 2020 Dec 16.

From the Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill.

View Article and Find Full Text PDF
December 2020

Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes.

Authors:
Raffaello Verardi Lisa C Lindesmith Yaroslav Tsybovsky Jason Gorman Gwo-Yu Chuang Caitlin E Edwards Paul D Brewer-Jensen Michael L Mallory Li Ou Arne Schön Wei Shi Ena S Tully George Georgiou Ralph S Baric Peter D Kwong

NPJ Vaccines 2020 Dec 14;5(1):110. Epub 2020 Dec 14.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20892, MD, USA.

View Article and Find Full Text PDF
December 2020

Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine and Pyronaridine: In vitro Activity Against SARS-CoV-2 and Potential Mechanisms.

Authors:
Ana C Puhl Ethan James Fritch Thomas R Lane Longping V Tse Boyd L Yount Carol Queiroz Sacramento Tatyana Almeida Tavella Fabio Trindade Maranhão Costa Stuart Weston James Logue Matthew Frieman Lakshmanane Premkumar Kenneth H Pearce Brett L Hurst Carolina Horta Andrade James A Levi Nicole J Johnson Samantha C Kisthardt Frank Scholle Thiago Moreno L Souza Nathaniel John Moorman Ralph S Baric Peter Madrid Sean Ekins

bioRxiv 2020 Dec 2. Epub 2020 Dec 2.

View Article and Find Full Text PDF
December 2020

Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid.

Authors:
Christiane Iserman Christine A Roden Mark A Boerneke Rachel S G Sealfon Grace A McLaughlin Irwin Jungreis Ethan J Fritch Yixuan J Hou Joanne Ekena Chase A Weidmann Chandra L Theesfeld Manolis Kellis Olga G Troyanskaya Ralph S Baric Timothy P Sheahan Kevin M Weeks Amy S Gladfelter

Mol Cell 2020 12 27;80(6):1078-1091.e6. Epub 2020 Nov 27.

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

View Article and Find Full Text PDF
December 2020

A highly immunogenic and effective measles virus-based Th1-biased COVID-19 vaccine.

Authors:
Cindy Hörner Christoph Schürmann Arne Auste Aileen Ebenig Samada Muraleedharan Kenneth H Dinnon Tatjana Scholz Maike Herrmann Barbara S Schnierle Ralph S Baric Michael D Mühlebach

Proc Natl Acad Sci U S A 2020 12 30;117(51):32657-32666. Epub 2020 Nov 30.

Product Testing of Immunological Medicinal Products for Veterinary Use, Division of Veterinary Medicine, Paul-Ehrlich-Institut, D-63225 Langen, Germany;

View Article and Find Full Text PDF
December 2020

Progenitor identification and SARS-CoV-2 infection in human distal lung organoids.

Authors:
Ameen A Salahudeen Shannon S Choi Arjun Rustagi Junjie Zhu Vincent van Unen Sean M de la O Ryan A Flynn Mar Margalef-Català António J M Santos Jihang Ju Arpit Batish Tatsuya Usui Grace X Y Zheng Caitlin E Edwards Lisa E Wagar Vincent Luca Benedict Anchang Monica Nagendran Khanh Nguyen Daniel J Hart Jessica M Terry Phillip Belgrader Solongo B Ziraldo Tarjei S Mikkelsen Pehr B Harbury Jeffrey S Glenn K Christopher Garcia Mark M Davis Ralph S Baric Chiara Sabatti Manuel R Amieva Catherine A Blish Tushar J Desai Calvin J Kuo

Nature 2020 12 25;588(7839):670-675. Epub 2020 Nov 25.

Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

View Article and Find Full Text PDF
December 2020

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19.

Authors:
C Garrett Rappazzo Longping V Tse Chengzi I Kaku Daniel Wrapp Mrunal Sakharkar Deli Huang Laura M Deveau Thomas J Yockachonis Andrew S Herbert Michael B Battles Cecilia M O'Brien Michael E Brown James C Geoghegan Jonathan Belk Linghang Peng Linlin Yang Trevor D Scobey Dennis R Burton David Nemazee John M Dye James E Voss Bronwyn M Gunn Jason S McLellan Ralph S Baric Lisa E Gralinski Laura M Walker

bioRxiv 2020 Nov 17. Epub 2020 Nov 17.

View Article and Find Full Text PDF
November 2020

Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as a live virus vaccine candidate.

Authors:
Weina Sun Sarah R Leist Stephen McCroskery Yonghong Liu Stefan Slamanig Justine Oliva Fatima Amanat Alexandra Schäfer Kenneth H Dinnon Adolfo García-Sastre Florian Krammer Ralph S Baric Peter Palese

EBioMedicine 2020 Dec 21;62:103132. Epub 2020 Nov 21.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States. Electronic address:

View Article and Find Full Text PDF
December 2020