Ralph J DeBerardinis

Ralph J DeBerardinis

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Ralph J DeBerardinis

Publications by authors named "Ralph J DeBerardinis"

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Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation.

Cell Commun Signal 2019 Oct 17;17(1):129. Epub 2019 Oct 17.

Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1186/s12964-019-0444-1DOI Listing
October 2019

Mechanisms and Implications of Metabolic Heterogeneity in Cancer.

Cell Metab 2019 Sep;30(3):434-446

Howard Hughes Medical Institute and Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730674PMC
September 2019

Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.

Mol Cell 2019 Sep 24. Epub 2019 Sep 24.

Children's Medical Center Research Institute at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.08.028DOI Listing
September 2019

AIF: an acquired metabolic liability in lung cancer.

Cell Res 2019 Aug;29(8):607-608

Hamon Center for Therapeutic Oncology Research, Dallas, TX, USA.

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http://dx.doi.org/10.1038/s41422-019-0197-9DOI Listing
August 2019

Systematic Analysis of Gene Expression in Lung Adenocarcinoma and Squamous Cell Carcinoma with a Case Study of and .

Cancers (Basel) 2019 Jun 25;11(6). Epub 2019 Jun 25.

Quantitative Biomedical Research Center, Department of Population and Data Sciences, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA.

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http://dx.doi.org/10.3390/cancers11060886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627508PMC
June 2019

Autophagy Regulation of Metabolism Is Required for CD8 T Cell Anti-tumor Immunity.

Cell Rep 2019 Apr;27(2):502-513.e5

Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.037DOI Listing
April 2019

Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans.

Cell Rep 2019 Apr;27(5):1376-1386.e6

Children's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Eugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.04.005DOI Listing
April 2019

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo.

Cell Metab 2018 11 23;28(5):793-800.e2. Epub 2018 Aug 23.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; Annette G. Strauss Center for Neuro-Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221993PMC
November 2018

Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism.

Cell Rep 2018 11;25(8):2223-2233.e6

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.10.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338450PMC
November 2018

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers.

Cell Metab 2018 09 28;28(3):369-382.e5. Epub 2018 Jun 28.

Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pediatrics and Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125205PMC
September 2018

Applications of metabolomics to study cancer metabolism.

Biochim Biophys Acta Rev Cancer 2018 08 25;1870(1):2-14. Epub 2018 Apr 25.

Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd. Dallas, TX 75390-8502, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0304419X183005
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http://dx.doi.org/10.1016/j.bbcan.2018.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193562PMC
August 2018

Lipoic acid metabolism and mitochondrial redox regulation.

J Biol Chem 2018 05 30;293(20):7522-7530. Epub 2017 Nov 30.

From the Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390

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http://dx.doi.org/10.1074/jbc.TM117.000259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961061PMC
May 2018

Metabolic regulation of transcription through compartmentalized NAD biosynthesis.

Science 2018 05;360(6389)

Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aan5780
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http://dx.doi.org/10.1126/science.aan5780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465534PMC
May 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Lkb1 deficiency confers glutamine dependency in polycystic kidney disease.

Nat Commun 2018 02 26;9(1):814. Epub 2018 Feb 26.

Departments of Molecular Biology and Internal Medicine, UT Southwestern Medical Center, Dallas, TX, 75390, USA.

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http://www.nature.com/articles/s41467-018-03036-y
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http://dx.doi.org/10.1038/s41467-018-03036-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827653PMC
February 2018

Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications.

Pigment Cell Melanoma Res 2018 01 2;31(1):11-30. Epub 2017 Nov 2.

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1111/pcmr.12661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742019PMC
January 2018

Oxidation of [U- C]glucose in the human brain at 7T under steady state conditions.

Magn Reson Med 2017 Dec 23;78(6):2065-2071. Epub 2017 Jan 23.

Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://doi.wiley.com/10.1002/mrm.26603
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http://dx.doi.org/10.1002/mrm.26603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522773PMC
December 2017

Genomic regression analysis of coordinated expression.

Nat Commun 2017 12 19;8(1):2187. Epub 2017 Dec 19.

Quantitative Biomedical Research Center at UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.

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http://www.nature.com/articles/s41467-017-02181-0
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http://dx.doi.org/10.1038/s41467-017-02181-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736603PMC
December 2017

The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts.

Sci Adv 2017 11 1;3(11):eaao5268. Epub 2017 Nov 1.

Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aao
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http://dx.doi.org/10.1126/sciadv.aao5268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665593PMC
November 2017

Lactate Metabolism in Human Lung Tumors.

Cell 2017 Oct;171(2):358-371.e9

Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA; Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684706PMC
October 2017

Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein.

Metab Eng 2017 09 14;43(Pt B):198-207. Epub 2016 Nov 14.

Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymben.2016.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429990PMC
September 2017

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis.

Nature 2017 09 21;549(7673):476-481. Epub 2017 Aug 21.

Children's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1038/nature23876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910063PMC
September 2017

Engineering approaches to study cancer metabolism.

Metab Eng 2017 09;43(Pt B):93

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http://dx.doi.org/10.1016/j.ymben.2017.09.002DOI Listing
September 2017

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.

Nat Cell Biol 2017 Jun 15;19(6):626-638. Epub 2017 May 15.

Children's Medical Center Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1038/ncb3527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771482PMC
June 2017

Understanding the Intersections between Metabolism and Cancer Biology.

Cell 2017 02;168(4):657-669

Children's Medical Center Research Institute, Department of Pediatrics, and Eugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, TX 75390. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.12.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329766PMC
February 2017

Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism.

Proc Natl Acad Sci U S A 2017 01 9;114(4):746-751. Epub 2017 Jan 9.

Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390;

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http://dx.doi.org/10.1073/pnas.1611113114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278463PMC
January 2017

Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.

Mol Cell 2016 12 17;64(5):859-874. Epub 2016 Nov 17.

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135630PMC
December 2016

Meta-analysis of clinical metabolic profiling studies in cancer: challenges and opportunities.

EMBO Mol Med 2016 10 4;8(10):1134-1142. Epub 2016 Oct 4.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, Leuven, Belgium

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http://dx.doi.org/10.15252/emmm.201606798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048364PMC
October 2016

Blocking fatty acid synthesis reduces lung tumor growth in mice.

Nat Med 2016 10;22(10):1077-1078

Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1038/nm.4195DOI Listing
October 2016

Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features.

Proc Natl Acad Sci U S A 2016 09 6;113(38):E5598-607. Epub 2016 Sep 6.

Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912; Institute for Brain Science, Brown University, Providence, RI 02912; Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital and Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, East Providence, RI 02915;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035873PMC
http://dx.doi.org/10.1073/pnas.1609221113DOI Listing
September 2016

Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine.

Sci Rep 2016 09 8;6:32606. Epub 2016 Sep 8.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V5Z 1L3 Canada.

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http://dx.doi.org/10.1038/srep32606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015067PMC
September 2016

Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.

Cell Rep 2016 08 28;16(6):1614-1628. Epub 2016 Jul 28.

Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981512PMC
August 2016

Hepatic gluconeogenesis influences (13)C enrichment in lactate in human brain tumors during metabolism of [1,2-(13)C]acetate.

Neurochem Int 2016 07 26;97:133-6. Epub 2016 Mar 26.

Simmons Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390, USA; Annette G. Strauss Center for Neuro-Oncology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.neuint.2016.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951105PMC
July 2016

Hyperpolarized (13)C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused Organs.

Methods Enzymol 2015 14;561:73-106. Epub 2015 Jun 14.

Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00766879150026
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http://dx.doi.org/10.1016/bs.mie.2015.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729302PMC
June 2016

Proliferating Cells Conserve Nitrogen to Support Growth.

Cell Metab 2016 06;23(6):957-958

Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-8502, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.05.008DOI Listing
June 2016

Fundamentals of cancer metabolism.

Sci Adv 2016 05 27;2(5):e1600200. Epub 2016 May 27.

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1126/sciadv.1600200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928883PMC
May 2016

Liposuction: Extracellular Fat Removal Promotes Proliferation.

Cell Chem Biol 2016 04;23(4):431-2

Children's Medical Center Research Institute at the University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.04.003DOI Listing
April 2016

Cutting Edge: Critical Role of Glycolysis in Human Plasmacytoid Dendritic Cell Antiviral Responses.

J Immunol 2016 Mar 29;196(5):2004-9. Epub 2016 Jan 29.

Division of Infectious Disease, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390; Division of Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; and

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http://dx.doi.org/10.4049/jimmunol.1501557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761472PMC
March 2016

Metabolic Heterogeneity in Human Lung Tumors.

Cell 2016 Feb 4;164(4):681-94. Epub 2016 Feb 4.

Children's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Eugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.12.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752889PMC
February 2016

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Authors:
Keith I Block Charlotte Gyllenhaal Leroy Lowe Amedeo Amedei A R M Ruhul Amin Amr Amin Katia Aquilano Jack Arbiser Alexandra Arreola Alla Arzumanyan S Salman Ashraf Asfar S Azmi Fabian Benencia Dipita Bhakta Alan Bilsland Anupam Bishayee Stacy W Blain Penny B Block Chandra S Boosani Thomas E Carey Amancio Carnero Marianeve Carotenuto Stephanie C Casey Mrinmay Chakrabarti Rupesh Chaturvedi Georgia Zhuo Chen Helen Chen Sophie Chen Yi Charlie Chen Beom K Choi Maria Rosa Ciriolo Helen M Coley Andrew R Collins Marisa Connell Sarah Crawford Colleen S Curran Charlotta Dabrosin Giovanna Damia Santanu Dasgupta Ralph J DeBerardinis William K Decker Punita Dhawan Anna Mae E Diehl Jin-Tang Dong Q Ping Dou Janice E Drew Eyad Elkord Bassel El-Rayes Mark A Feitelson Dean W Felsher Lynnette R Ferguson Carmela Fimognari Gary L Firestone Christian Frezza Hiromasa Fujii Mark M Fuster Daniele Generali Alexandros G Georgakilas Frank Gieseler Michael Gilbertson Michelle F Green Brendan Grue Gunjan Guha Dorota Halicka William G Helferich Petr Heneberg Patricia Hentosh Matthew D Hirschey Lorne J Hofseth Randall F Holcombe Kanya Honoki Hsue-Yin Hsu Gloria S Huang Lasse D Jensen Wen G Jiang Lee W Jones Phillip A Karpowicz W Nicol Keith Sid P Kerkar Gazala N Khan Mahin Khatami Young H Ko Omer Kucuk Rob J Kulathinal Nagi B Kumar Byoung S Kwon Anne Le Michael A Lea Ho-Young Lee Terry Lichtor Liang-Tzung Lin Jason W Locasale Bal L Lokeshwar Valter D Longo Costas A Lyssiotis Karen L MacKenzie Meenakshi Malhotra Maria Marino Maria L Martinez-Chantar Ander Matheu Christopher Maxwell Eoin McDonnell Alan K Meeker Mahya Mehrmohamadi Kapil Mehta Gregory A Michelotti Ramzi M Mohammad Sulma I Mohammed D James Morre Vinayak Muralidhar Irfana Muqbil Michael P Murphy Ganji Purnachandra Nagaraju Rita Nahta Elena Niccolai Somaira Nowsheen Carolina Panis Francesco Pantano Virginia R Parslow Graham Pawelec Peter L Pedersen Brad Poore Deepak Poudyal Satya Prakash Mark Prince Lizzia Raffaghello Jeffrey C Rathmell W Kimryn Rathmell Swapan K Ray Jörg Reichrath Sarallah Rezazadeh Domenico Ribatti Luigi Ricciardiello R Brooks Robey Francis Rodier H P Vasantha Rupasinghe Gian Luigi Russo Elizabeth P Ryan Abbas K Samadi Isidro Sanchez-Garcia Andrew J Sanders Daniele Santini Malancha Sarkar Tetsuro Sasada Neeraj K Saxena Rodney E Shackelford H M C Shantha Kumara Dipali Sharma Dong M Shin David Sidransky Markus David Siegelin Emanuela Signori Neetu Singh Sharanya Sivanand Daniel Sliva Carl Smythe Carmela Spagnuolo Diana M Stafforini John Stagg Pochi R Subbarayan Tabetha Sundin Wamidh H Talib Sarah K Thompson Phuoc T Tran Hendrik Ungefroren Matthew G Vander Heiden Vasundara Venkateswaran Dass S Vinay Panagiotis J Vlachostergios Zongwei Wang Kathryn E Wellen Richard L Whelan Eddy S Yang Huanjie Yang Xujuan Yang Paul Yaswen Clement Yedjou Xin Yin Jiyue Zhu Massimo Zollo

Semin Cancer Biol 2015 Dec;35 Suppl:S276-S304

Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II, Via Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1016/j.semcancer.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819002PMC
December 2015

Oxidative stress inhibits distant metastasis by human melanoma cells.

Nature 2015 Nov 14;527(7577):186-91. Epub 2015 Oct 14.

Children's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1038/nature15726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644103PMC
November 2015

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth.

Mol Cell 2015 Nov 17;60(4):571-83. Epub 2015 Oct 17.

Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA; Department of Pathology, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656111PMC
November 2015

A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles.

Nat Commun 2015 Oct 5;6:8524. Epub 2015 Oct 5.

Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1038/ncomms9524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600749PMC
October 2015

From "N of 1" to N of more.

Cold Spring Harb Mol Case Stud 2015 Oct;1(1):a000521

Washington University School of Medicine, St. Louis, Missouri 63108, USA.

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http://dx.doi.org/10.1101/mcs.a000521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850895PMC
October 2015

Metabolic dysregulation in monogenic disorders and cancer - finding method in madness.

Nat Rev Cancer 2015 Jul 18;15(7):440-8. Epub 2015 Jun 18.

Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Room NL12.138B, Dallas, Texas 75390-8502, USA.

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http://dx.doi.org/10.1038/nrc3949DOI Listing
July 2015

Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells.

Cancer Metab 2015 29;3. Epub 2015 Jun 29.

Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-8502 USA ; Departments of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390-8502 USA ; McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390-8502 USA.

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http://dx.doi.org/10.1186/s40170-015-0134-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487196PMC
July 2015

D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2.

Nat Commun 2015 Jul 16;6:7768. Epub 2015 Jul 16.

1] Division of Hematology and Medical Oncology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA [2] Greehey Children's Cancer Research Institute, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78229, USA [3] Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA [4] South Texas Veterans Health Care System, Audie Murphy VA Hospital, San Antonio, Texas 78229, USA.

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http://dx.doi.org/10.1038/ncomms8768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515030PMC
July 2015

Hypoxic metabolism in human hematopoietic stem cells.

Cell Biosci 2015 17;5:39. Epub 2015 Jul 17.

Hongqiao International Institute of Medicine, Shanghai Tongren Hospital / Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 China.

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http://dx.doi.org/10.1186/s13578-015-0020-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517642PMC
July 2015

Metabolic pathways promoting cancer cell survival and growth.

Nat Cell Biol 2015 Apr 16;17(4):351-9. Epub 2015 Mar 16.

1] Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-8502, USA [2] Department of Pediatrics University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-8502, USA [3] McDermott Center for Human Growth and Development University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-8502, USA.

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http://dx.doi.org/10.1038/ncb3124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939711PMC
April 2015

Metabolism: Growth in the fat lane.

Nature 2015 Apr 1;520(7546):165-6. Epub 2015 Apr 1.

Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas 75390-8502, USA.

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http://dx.doi.org/10.1038/nature14375DOI Listing
April 2015

Real-time detection of hepatic gluconeogenic and glycogenolytic states using hyperpolarized [2-13C]dihydroxyacetone.

J Biol Chem 2014 Dec 28;289(52):35859-67. Epub 2014 Oct 28.

From the Advanced Imaging Research Center, Radiology, University of Texas - Southwestern Medical Center, Dallas, Texas 75390 and

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http://dx.doi.org/10.1074/jbc.M114.613265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276855PMC
December 2014

MCT4 defines a glycolytic subtype of pancreatic cancer with poor prognosis and unique metabolic dependencies.

Cell Rep 2014 Dec 11;9(6):2233-49. Epub 2014 Dec 11.

Department of Pathology, UT Southwestern, Dallas, TX 75390, USA; Simmons Cancer Center, UT Southwestern, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.11.025DOI Listing
December 2014

Acetate is a bioenergetic substrate for human glioblastoma and brain metastases.

Cell 2014 Dec;159(7):1603-14

Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390, USA; Annette G. Strauss Center for Neuro-Oncology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.11.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374602PMC
December 2014

A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth.

Mol Cell 2014 Nov 21;56(3):400-13. Epub 2014 Oct 21.

Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112-5650, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.09.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268416PMC
November 2014

Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.

Mol Cell 2014 Nov 21;56(3):414-24. Epub 2014 Oct 21.

Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-8502, USA; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390-8502, USA; McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390-8502, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268166PMC
November 2014