Ralph A Defronzo

Ralph A Defronzo

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Ralph A Defronzo

Ralph A Defronzo

Publications by authors named "Ralph A Defronzo"

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A neural signature of metabolic syndrome.

Hum Brain Mapp 2019 Aug 7;40(12):3575-3588. Epub 2019 May 7.

Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.24617
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http://dx.doi.org/10.1002/hbm.24617DOI Listing
August 2019

Mild Physiologic Hyperglycemia Induces Hepatic Insulin Resistance in Healthy Normal Glucose-Tolerant Participants.

J Clin Endocrinol Metab 2019 Jul;104(7):2842-2850

Department of Medicine, Diabetes Division, University of Texas Health Science, San Antonio, Texas.

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http://dx.doi.org/10.1210/jc.2018-02304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543508PMC
July 2019

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.

Authors:
Jason Flannick Josep M Mercader Christian Fuchsberger Miriam S Udler Anubha Mahajan Jennifer Wessel Tanya M Teslovich Lizz Caulkins Ryan Koesterer Francisco Barajas-Olmos Thomas W Blackwell Eric Boerwinkle Jennifer A Brody Federico Centeno-Cruz Ling Chen Siying Chen Cecilia Contreras-Cubas Emilio Córdova Adolfo Correa Maria Cortes Ralph A DeFronzo Lawrence Dolan Kimberly L Drews Amanda Elliott James S Floyd Stacey Gabriel Maria Eugenia Garay-Sevilla Humberto García-Ortiz Myron Gross Sohee Han Nancy L Heard-Costa Anne U Jackson Marit E Jørgensen Hyun Min Kang Megan Kelsey Bong-Jo Kim Heikki A Koistinen Johanna Kuusisto Joseph B Leader Allan Linneberg Ching-Ti Liu Jianjun Liu Valeriya Lyssenko Alisa K Manning Anthony Marcketta Juan Manuel Malacara-Hernandez Angélica Martínez-Hernández Karen Matsuo Elizabeth Mayer-Davis Elvia Mendoza-Caamal Karen L Mohlke Alanna C Morrison Anne Ndungu Maggie C Y Ng Colm O'Dushlaine Anthony J Payne Catherine Pihoker Wendy S Post Michael Preuss Bruce M Psaty Ramachandran S Vasan N William Rayner Alexander P Reiner Cristina Revilla-Monsalve Neil R Robertson Nicola Santoro Claudia Schurmann Wing Yee So Xavier Soberón Heather M Stringham Tim M Strom Claudia H T Tam Farook Thameem Brian Tomlinson Jason M Torres Russell P Tracy Rob M van Dam Marijana Vujkovic Shuai Wang Ryan P Welch Daniel R Witte Tien-Yin Wong Gil Atzmon Nir Barzilai John Blangero Lori L Bonnycastle Donald W Bowden John C Chambers Edmund Chan Ching-Yu Cheng Yoon Shin Cho Francis S Collins Paul S de Vries Ravindranath Duggirala Benjamin Glaser Clicerio Gonzalez Ma Elena Gonzalez Leif Groop Jaspal Singh Kooner Soo Heon Kwak Markku Laakso Donna M Lehman Peter Nilsson Timothy D Spector E Shyong Tai Tiinamaija Tuomi Jaakko Tuomilehto James G Wilson Carlos A Aguilar-Salinas Erwin Bottinger Brian Burke David J Carey Juliana C N Chan Josée Dupuis Philippe Frossard Susan R Heckbert Mi Yeong Hwang Young Jin Kim H Lester Kirchner Jong-Young Lee Juyoung Lee Ruth J F Loos Ronald C W Ma Andrew D Morris Christopher J O'Donnell Colin N A Palmer James Pankow Kyong Soo Park Asif Rasheed Danish Saleheen Xueling Sim Kerrin S Small Yik Ying Teo Christopher Haiman Craig L Hanis Brian E Henderson Lorena Orozco Teresa Tusié-Luna Frederick E Dewey Aris Baras Christian Gieger Thomas Meitinger Konstantin Strauch Leslie Lange Niels Grarup Torben Hansen Oluf Pedersen Philip Zeitler Dana Dabelea Goncalo Abecasis Graeme I Bell Nancy J Cox Mark Seielstad Rob Sladek James B Meigs Steve S Rich Jerome I Rotter David Altshuler Noël P Burtt Laura J Scott Andrew P Morris Jose C Florez Mark I McCarthy Michael Boehnke

Nature 2019 06 22;570(7759):71-76. Epub 2019 May 22.

Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.

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http://www.nature.com/articles/s41586-019-1231-2
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http://dx.doi.org/10.1038/s41586-019-1231-2DOI Listing
June 2019

Pioglitazone: inexpensive; very effective at reducing HbA ; no evidence of bladder cancer risk; plenty of evidence of cardiovascular benefit.

Diabet Med 2019 Jun 18. Epub 2019 Jun 18.

University of Texas Health Science Center, San Antonio, Texas, USA.

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http://dx.doi.org/10.1111/dme.14053DOI Listing
June 2019

Insulin Resistance and Atherosclerosis: Implications for Insulin Sensitizing Agents.

Endocr Rev 2019 May 3. Epub 2019 May 3.

Diabetes Division, University of Texas Health Science Center and Texas Diabetes Institute, San Antonio, Texas.

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http://dx.doi.org/10.1210/er.2018-00141DOI Listing
May 2019

Pioglitazone: The forgotten, cost-effective cardioprotective drug for type 2 diabetes.

Diab Vasc Dis Res 2019 Mar 1;16(2):133-143. Epub 2019 Feb 1.

3 Cleveland Clinic Foundation, Cleveland, OH, USA.

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http://dx.doi.org/10.1177/1479164118825376DOI Listing
March 2019

Insulin Resistance the Link between T2DM and CVD: Basic Mechanisms and Clinical Implications.

Curr Vasc Pharmacol 2019 ;17(2):153-163

Cardio-Metabolic Institute, Hamad Medical Corporation, Doha, Qatar.

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http://dx.doi.org/10.2174/1570161115666171010115119DOI Listing
January 2019

The Impact of Vitamin D Deficiency on Retinopathy and Hearing Loss among Type 2 Diabetic Patients.

Biomed Res Int 2018 9;2018:2714590. Epub 2018 Jul 9.

Division of Diabetes, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.

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http://dx.doi.org/10.1155/2018/2714590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077590PMC
January 2019

Glucose-Mediated Glucose Disposal at Baseline Insulin Is Impaired in IFG.

J Clin Endocrinol Metab 2019 Jan;104(1):163-171

Diabetes Division, University of Texas Health Science Center at San Antonio, San Antonio, Texas.

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http://dx.doi.org/10.1210/jc.2017-01866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286408PMC
January 2019

Effect of Chronic Hyperglycemia on Glucose Metabolism in Subjects With Normal Glucose Tolerance.

Diabetes 2018 12 13;67(12):2507-2517. Epub 2018 Sep 13.

Division of Diabetes, University of Texas Health Science Center and Texas Diabetes Institute, San Antonio, TX

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http://dx.doi.org/10.2337/db18-0439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245228PMC
December 2018

Successful treatment of prediabetes in clinical practice using physiological assessment (STOP DIABETES).

Lancet Diabetes Endocrinol 2018 10 14;6(10):781-789. Epub 2018 Sep 14.

Providence Little Company of Mary Cardiometabolic Center, Torrance, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22138587183023
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http://dx.doi.org/10.1016/S2213-8587(18)30234-1DOI Listing
October 2018

Older Subjects With β-Cell Dysfunction Have an Accentuated Incretin Release.

J Clin Endocrinol Metab 2018 07;103(7):2613-2619

Diabetes Division, University of Texas Health Science Center, San Antonio, Texas.

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http://dx.doi.org/10.1210/jc.2018-00260DOI Listing
July 2018

Safety and Tolerability of Combinations of Empagliflozin and Linagliptin in Patients with Type 2 Diabetes: Pooled Data from Two Randomized Controlled Trials.

Adv Ther 2018 Jul 15;35(7):1009-1022. Epub 2018 Jun 15.

Boehringer Ingelheim International GmbH, Ingelheim, Germany.

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http://dx.doi.org/10.1007/s12325-018-0724-yDOI Listing
July 2018

Endogenous Glucose Production and Hormonal Changes in Response to Canagliflozin and Liraglutide Combination Therapy.

Diabetes 2018 06 30;67(6):1182-1189. Epub 2018 Mar 30.

Division of Diabetes, Department of Medicine, University of Texas Health Science Center and Texas Diabetes Institute, University Health System, San Antonio, TX.

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http://dx.doi.org/10.2337/db17-1278DOI Listing
June 2018

Empagliflozin Treatment Is Associated With Improved β-Cell Function in Type 2 Diabetes Mellitus.

J Clin Endocrinol Metab 2018 04;103(4):1402-1407

Texas Diabetes Institute and Diabetes Division, University of Texas Health Science Center at San Antonio, San Antonio, Texas.

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http://dx.doi.org/10.1210/jc.2017-01838DOI Listing
April 2018

Impaired left ventricular diastolic function in T2DM patients is closely related to glycemic control.

Endocrinol Diabetes Metab 2018 Apr 6;1(2):e00014. Epub 2018 Apr 6.

Diabetes Division Department of Medicine Texas Diabetes Institute University of Texas Health Science Center at San Antonio San Antonio TX USA.

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http://dx.doi.org/10.1002/edm2.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354805PMC
April 2018

A novel experimental model for human mixed acinar-ductal pancreatic cancer.

Carcinogenesis 2018 02;39(2):180-190

Diabetes Division, University of Texas Health Science Center at San Antonio, USA.

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http://dx.doi.org/10.1093/carcin/bgx119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862347PMC
February 2018

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.

Authors:
Jason Flannick Christian Fuchsberger Anubha Mahajan Tanya M Teslovich Vineeta Agarwala Kyle J Gaulton Lizz Caulkins Ryan Koesterer Clement Ma Loukas Moutsianas Davis J McCarthy Manuel A Rivas John R B Perry Xueling Sim Thomas W Blackwell Neil R Robertson N William Rayner Pablo Cingolani Adam E Locke Juan Fernandez Tajes Heather M Highland Josee Dupuis Peter S Chines Cecilia M Lindgren Christopher Hartl Anne U Jackson Han Chen Jeroen R Huyghe Martijn van de Bunt Richard D Pearson Ashish Kumar Martina Müller-Nurasyid Niels Grarup Heather M Stringham Eric R Gamazon Jaehoon Lee Yuhui Chen Robert A Scott Jennifer E Below Peng Chen Jinyan Huang Min Jin Go Michael L Stitzel Dorota Pasko Stephen C J Parker Tibor V Varga Todd Green Nicola L Beer Aaron G Day-Williams Teresa Ferreira Tasha Fingerlin Momoko Horikoshi Cheng Hu Iksoo Huh Mohammad Kamran Ikram Bong-Jo Kim Yongkang Kim Young Jin Kim Min-Seok Kwon Juyoung Lee Selyeong Lee Keng-Han Lin Taylor J Maxwell Yoshihiko Nagai Xu Wang Ryan P Welch Joon Yoon Weihua Zhang Nir Barzilai Benjamin F Voight Bok-Ghee Han Christopher P Jenkinson Teemu Kuulasmaa Johanna Kuusisto Alisa Manning Maggie C Y Ng Nicholette D Palmer Beverley Balkau Alena Stančáková Hanna E Abboud Heiner Boeing Vilmantas Giedraitis Dorairaj Prabhakaran Omri Gottesman James Scott Jason Carey Phoenix Kwan George Grant Joshua D Smith Benjamin M Neale Shaun Purcell Adam S Butterworth Joanna M M Howson Heung Man Lee Yingchang Lu Soo-Heon Kwak Wei Zhao John Danesh Vincent K L Lam Kyong Soo Park Danish Saleheen Wing Yee So Claudia H T Tam Uzma Afzal David Aguilar Rector Arya Tin Aung Edmund Chan Carmen Navarro Ching-Yu Cheng Domenico Palli Adolfo Correa Joanne E Curran Dennis Rybin Vidya S Farook Sharon P Fowler Barry I Freedman Michael Griswold Daniel Esten Hale Pamela J Hicks Chiea-Chuen Khor Satish Kumar Benjamin Lehne Dorothée Thuillier Wei Yen Lim Jianjun Liu Marie Loh Solomon K Musani Sobha Puppala William R Scott Loïc Yengo Sian-Tsung Tan Herman A Taylor Farook Thameem Gregory Wilson Tien Yin Wong Pål Rasmus Njølstad Jonathan C Levy Massimo Mangino Lori L Bonnycastle Thomas Schwarzmayr João Fadista Gabriela L Surdulescu Christian Herder Christopher J Groves Thomas Wieland Jette Bork-Jensen Ivan Brandslund Cramer Christensen Heikki A Koistinen Alex S F Doney Leena Kinnunen Tõnu Esko Andrew J Farmer Liisa Hakaste Dylan Hodgkiss Jasmina Kravic Valeri Lyssenko Mette Hollensted Marit E Jørgensen Torben Jørgensen Claes Ladenvall Johanne Marie Justesen Annemari Käräjämäki Jennifer Kriebel Wolfgang Rathmann Lars Lannfelt Torsten Lauritzen Narisu Narisu Allan Linneberg Olle Melander Lili Milani Matt Neville Marju Orho-Melander Lu Qi Qibin Qi Michael Roden Olov Rolandsson Amy Swift Anders H Rosengren Kathleen Stirrups Andrew R Wood Evelin Mihailov Christine Blancher Mauricio O Carneiro Jared Maguire Ryan Poplin Khalid Shakir Timothy Fennell Mark DePristo Martin Hrabé de Angelis Panos Deloukas Anette P Gjesing Goo Jun Peter Nilsson Jacquelyn Murphy Robert Onofrio Barbara Thorand Torben Hansen Christa Meisinger Frank B Hu Bo Isomaa Fredrik Karpe Liming Liang Annette Peters Cornelia Huth Stephen P O'Rahilly Colin N A Palmer Oluf Pedersen Rainer Rauramaa Jaakko Tuomilehto Veikko Salomaa Richard M Watanabe Ann-Christine Syvänen Richard N Bergman Dwaipayan Bharadwaj Erwin P Bottinger Yoon Shin Cho Giriraj R Chandak Juliana C N Chan Kee Seng Chia Mark J Daly Shah B Ebrahim Claudia Langenberg Paul Elliott Kathleen A Jablonski Donna M Lehman Weiping Jia Ronald C W Ma Toni I Pollin Manjinder Sandhu Nikhil Tandon Philippe Froguel Inês Barroso Yik Ying Teo Eleftheria Zeggini Ruth J F Loos Kerrin S Small Janina S Ried Ralph A DeFronzo Harald Grallert Benjamin Glaser Andres Metspalu Nicholas J Wareham Mark Walker Eric Banks Christian Gieger Erik Ingelsson Hae Kyung Im Thomas Illig Paul W Franks Gemma Buck Joseph Trakalo David Buck Inga Prokopenko Reedik Mägi Lars Lind Yossi Farjoun Katharine R Owen Anna L Gloyn Konstantin Strauch Tiinamaija Tuomi Jaspal Singh Kooner Jong-Young Lee Taesung Park Peter Donnelly Andrew D Morris Andrew T Hattersley Donald W Bowden Francis S Collins Gil Atzmon John C Chambers Timothy D Spector Markku Laakso Tim M Strom Graeme I Bell John Blangero Ravindranath Duggirala E Shyong Tai Gilean McVean Craig L Hanis James G Wilson Mark Seielstad Timothy M Frayling James B Meigs Nancy J Cox Rob Sladek Eric S Lander Stacey Gabriel Karen L Mohlke Thomas Meitinger Leif Groop Goncalo Abecasis Laura J Scott Andrew P Morris Hyun Min Kang David Altshuler Noël P Burtt Jose C Florez Michael Boehnke Mark I McCarthy

Sci Data 2018 01 23;5:180002. Epub 2018 Jan 23.

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http://dx.doi.org/10.1038/sdata.2018.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779067PMC
January 2018

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.

Authors:
Jason Flannick Christian Fuchsberger Anubha Mahajan Tanya M Teslovich Vineeta Agarwala Kyle J Gaulton Lizz Caulkins Ryan Koesterer Clement Ma Loukas Moutsianas Davis J McCarthy Manuel A Rivas John R B Perry Xueling Sim Thomas W Blackwell Neil R Robertson N William Rayner Pablo Cingolani Adam E Locke Juan Fernandez Tajes Heather M Highland Josee Dupuis Peter S Chines Cecilia M Lindgren Christopher Hartl Anne U Jackson Han Chen Jeroen R Huyghe Martijn van de Bunt Richard D Pearson Ashish Kumar Martina Müller-Nurasyid Niels Grarup Heather M Stringham Eric R Gamazon Jaehoon Lee Yuhui Chen Robert A Scott Jennifer E Below Peng Chen Jinyan Huang Min Jin Go Michael L Stitzel Dorota Pasko Stephen C J Parker Tibor V Varga Todd Green Nicola L Beer Aaron G Day-Williams Teresa Ferreira Tasha Fingerlin Momoko Horikoshi Cheng Hu Iksoo Huh Mohammad Kamran Ikram Bong-Jo Kim Yongkang Kim Young Jin Kim Min-Seok Kwon Juyoung Lee Selyeong Lee Keng-Han Lin Taylor J Maxwell Yoshihiko Nagai Xu Wang Ryan P Welch Joon Yoon Weihua Zhang Nir Barzilai Benjamin F Voight Bok-Ghee Han Christopher P Jenkinson Teemu Kuulasmaa Johanna Kuusisto Alisa Manning Maggie C Y Ng Nicholette D Palmer Beverley Balkau Alena Stančáková Hanna E Abboud Heiner Boeing Vilmantas Giedraitis Dorairaj Prabhakaran Omri Gottesman James Scott Jason Carey Phoenix Kwan George Grant Joshua D Smith Benjamin M Neale Shaun Purcell Adam S Butterworth Joanna M M Howson Heung Man Lee Yingchang Lu Soo-Heon Kwak Wei Zhao John Danesh Vincent K L Lam Kyong Soo Park Danish Saleheen Wing Yee So Claudia H T Tam Uzma Afzal David Aguilar Rector Arya Tin Aung Edmund Chan Carmen Navarro Ching-Yu Cheng Domenico Palli Adolfo Correa Joanne E Curran Dennis Rybin Vidya S Farook Sharon P Fowler Barry I Freedman Michael Griswold Daniel Esten Hale Pamela J Hicks Chiea-Chuen Khor Satish Kumar Benjamin Lehne Dorothée Thuillier Wei Yen Lim Jianjun Liu Marie Loh Solomon K Musani Sobha Puppala William R Scott Loïc Yengo Sian-Tsung Tan Herman A Taylor Farook Thameem Gregory Wilson Tien Yin Wong Pål Rasmus Njølstad Jonathan C Levy Massimo Mangino Lori L Bonnycastle Thomas Schwarzmayr João Fadista Gabriela L Surdulescu Christian Herder Christopher J Groves Thomas Wieland Jette Bork-Jensen Ivan Brandslund Cramer Christensen Heikki A Koistinen Alex S F Doney Leena Kinnunen Tõnu Esko Andrew J Farmer Liisa Hakaste Dylan Hodgkiss Jasmina Kravic Valeri Lyssenko Mette Hollensted Marit E Jørgensen Torben Jørgensen Claes Ladenvall Johanne Marie Justesen Annemari Käräjämäki Jennifer Kriebel Wolfgang Rathmann Lars Lannfelt Torsten Lauritzen Narisu Narisu Allan Linneberg Olle Melander Lili Milani Matt Neville Marju Orho-Melander Lu Qi Qibin Qi Michael Roden Olov Rolandsson Amy Swift Anders H Rosengren Kathleen Stirrups Andrew R Wood Evelin Mihailov Christine Blancher Mauricio O Carneiro Jared Maguire Ryan Poplin Khalid Shakir Timothy Fennell Mark DePristo Martin Hrabé de Angelis Panos Deloukas Anette P Gjesing Goo Jun Peter Nilsson Jacquelyn Murphy Robert Onofrio Barbara Thorand Torben Hansen Christa Meisinger Frank B Hu Bo Isomaa Fredrik Karpe Liming Liang Annette Peters Cornelia Huth Stephen P O'Rahilly Colin N A Palmer Oluf Pedersen Rainer Rauramaa Jaakko Tuomilehto Veikko Salomaa Richard M Watanabe Ann-Christine Syvänen Richard N Bergman Dwaipayan Bharadwaj Erwin P Bottinger Yoon Shin Cho Giriraj R Chandak Juliana Cn Chan Kee Seng Chia Mark J Daly Shah B Ebrahim Claudia Langenberg Paul Elliott Kathleen A Jablonski Donna M Lehman Weiping Jia Ronald C W Ma Toni I Pollin Manjinder Sandhu Nikhil Tandon Philippe Froguel Inês Barroso Yik Ying Teo Eleftheria Zeggini Ruth J F Loos Kerrin S Small Janina S Ried Ralph A DeFronzo Harald Grallert Benjamin Glaser Andres Metspalu Nicholas J Wareham Mark Walker Eric Banks Christian Gieger Erik Ingelsson Hae Kyung Im Thomas Illig Paul W Franks Gemma Buck Joseph Trakalo David Buck Inga Prokopenko Reedik Mägi Lars Lind Yossi Farjoun Katharine R Owen Anna L Gloyn Konstantin Strauch Tiinamaija Tuomi Jaspal Singh Kooner Jong-Young Lee Taesung Park Peter Donnelly Andrew D Morris Andrew T Hattersley Donald W Bowden Francis S Collins Gil Atzmon John C Chambers Timothy D Spector Markku Laakso Tim M Strom Graeme I Bell John Blangero Ravindranath Duggirala E Shyong Tai Gilean McVean Craig L Hanis James G Wilson Mark Seielstad Timothy M Frayling James B Meigs Nancy J Cox Rob Sladek Eric S Lander Stacey Gabriel Karen L Mohlke Thomas Meitinger Leif Groop Goncalo Abecasis Laura J Scott Andrew P Morris Hyun Min Kang David Altshuler Noël P Burtt Jose C Florez Michael Boehnke Mark I McCarthy

Sci Data 2017 12 19;4:170179. Epub 2017 Dec 19.

Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/sdata.2017.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735917PMC
December 2017

A Loss-of-Function Splice Acceptor Variant in Is Protective for Type 2 Diabetes.

Diabetes 2017 11 24;66(11):2903-2914. Epub 2017 Aug 24.

Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA

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http://dx.doi.org/10.2337/db17-0187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652606PMC
November 2017

Combination therapy with GLP-1 receptor agonist and SGLT2 inhibitor.

Authors:
Ralph A DeFronzo

Diabetes Obes Metab 2017 10 7;19(10):1353-1362. Epub 2017 Jun 7.

Diabetes Division, University of Texas Health Science Center, San Antonio, Texas.

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http://doi.wiley.com/10.1111/dom.12982
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http://dx.doi.org/10.1111/dom.12982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643008PMC
October 2017

Sodium-glucose co-transporter (SGLT) and glucose transporter (GLUT) expression in the kidney of type 2 diabetic subjects.

Diabetes Obes Metab 2017 09 13;19(9):1322-1326. Epub 2017 Jul 13.

Shanghai Diabetes Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China.

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http://doi.wiley.com/10.1111/dom.13003
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http://dx.doi.org/10.1111/dom.13003DOI Listing
September 2017

Is It Time to Change the Type 2 Diabetes Treatment Paradigm? Yes! GLP-1 RAs Should Replace Metformin in the Type 2 Diabetes Algorithm.

Diabetes Care 2017 08;40(8):1121-1127

Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX.

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http://dx.doi.org/10.2337/dc16-2368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521981PMC
August 2017

Efficacy of Exenatide Plus Pioglitazone Vs Basal/Bolus Insulin in T2DM Patients With Very High HbA1c.

J Clin Endocrinol Metab 2017 07;102(7):2162-2170

Diabetes Research, Academic Health System, Hamad General Hospital, Doha, Qatar.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2016-3423DOI Listing
July 2017

Decreased basal hepatic glucose uptake in impaired fasting glucose.

Diabetologia 2017 07 22;60(7):1325-1332. Epub 2017 Mar 22.

Diabetes Division, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA.

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http://dx.doi.org/10.1007/s00125-017-4252-0DOI Listing
July 2017

A Low-Frequency Inactivating Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.

Authors:
Alisa Manning Heather M Highland Jessica Gasser Xueling Sim Taru Tukiainen Pierre Fontanillas Niels Grarup Manuel A Rivas Anubha Mahajan Adam E Locke Pablo Cingolani Tune H Pers Ana Viñuela Andrew A Brown Ying Wu Jason Flannick Christian Fuchsberger Eric R Gamazon Kyle J Gaulton Hae Kyung Im Tanya M Teslovich Thomas W Blackwell Jette Bork-Jensen Noël P Burtt Yuhui Chen Todd Green Christopher Hartl Hyun Min Kang Ashish Kumar Claes Ladenvall Clement Ma Loukas Moutsianas Richard D Pearson John R B Perry N William Rayner Neil R Robertson Laura J Scott Martijn van de Bunt Johan G Eriksson Antti Jula Seppo Koskinen Terho Lehtimäki Aarno Palotie Olli T Raitakari Suzanne B R Jacobs Jennifer Wessel Audrey Y Chu Robert A Scott Mark O Goodarzi Christine Blancher Gemma Buck David Buck Peter S Chines Stacey Gabriel Anette P Gjesing Christopher J Groves Mette Hollensted Jeroen R Huyghe Anne U Jackson Goo Jun Johanne Marie Justesen Massimo Mangino Jacquelyn Murphy Matt Neville Robert Onofrio Kerrin S Small Heather M Stringham Joseph Trakalo Eric Banks Jason Carey Mauricio O Carneiro Mark DePristo Yossi Farjoun Timothy Fennell Jacqueline I Goldstein George Grant Martin Hrabé de Angelis Jared Maguire Benjamin M Neale Ryan Poplin Shaun Purcell Thomas Schwarzmayr Khalid Shakir Joshua D Smith Tim M Strom Thomas Wieland Jaana Lindstrom Ivan Brandslund Cramer Christensen Gabriela L Surdulescu Timo A Lakka Alex S F Doney Peter Nilsson Nicholas J Wareham Claudia Langenberg Tibor V Varga Paul W Franks Olov Rolandsson Anders H Rosengren Vidya S Farook Farook Thameem Sobha Puppala Satish Kumar Donna M Lehman Christopher P Jenkinson Joanne E Curran Daniel Esten Hale Sharon P Fowler Rector Arya Ralph A DeFronzo Hanna E Abboud Ann-Christine Syvänen Pamela J Hicks Nicholette D Palmer Maggie C Y Ng Donald W Bowden Barry I Freedman Tõnu Esko Reedik Mägi Lili Milani Evelin Mihailov Andres Metspalu Narisu Narisu Leena Kinnunen Lori L Bonnycastle Amy Swift Dorota Pasko Andrew R Wood João Fadista Toni I Pollin Nir Barzilai Gil Atzmon Benjamin Glaser Barbara Thorand Konstantin Strauch Annette Peters Michael Roden Martina Müller-Nurasyid Liming Liang Jennifer Kriebel Thomas Illig Harald Grallert Christian Gieger Christa Meisinger Lars Lannfelt Solomon K Musani Michael Griswold Herman A Taylor Gregory Wilson Adolfo Correa Heikki Oksa William R Scott Uzma Afzal Sian-Tsung Tan Marie Loh John C Chambers Jobanpreet Sehmi Jaspal Singh Kooner Benjamin Lehne Yoon Shin Cho Jong-Young Lee Bok-Ghee Han Annemari Käräjämäki Qibin Qi Lu Qi Jinyan Huang Frank B Hu Olle Melander Marju Orho-Melander Jennifer E Below David Aguilar Tien Yin Wong Jianjun Liu Chiea-Chuen Khor Kee Seng Chia Wei Yen Lim Ching-Yu Cheng Edmund Chan E Shyong Tai Tin Aung Allan Linneberg Bo Isomaa Thomas Meitinger Tiinamaija Tuomi Liisa Hakaste Jasmina Kravic Marit E Jørgensen Torsten Lauritzen Panos Deloukas Kathleen E Stirrups Katharine R Owen Andrew J Farmer Timothy M Frayling Stephen P O'Rahilly Mark Walker Jonathan C Levy Dylan Hodgkiss Andrew T Hattersley Teemu Kuulasmaa Alena Stančáková Inês Barroso Dwaipayan Bharadwaj Juliana Chan Giriraj R Chandak Mark J Daly Peter J Donnelly Shah B Ebrahim Paul Elliott Tasha Fingerlin Philippe Froguel Cheng Hu Weiping Jia Ronald C W Ma Gilean McVean Taesung Park Dorairaj Prabhakaran Manjinder Sandhu James Scott Rob Sladek Nikhil Tandon Yik Ying Teo Eleftheria Zeggini Richard M Watanabe Heikki A Koistinen Y Antero Kesaniemi Matti Uusitupa Timothy D Spector Veikko Salomaa Rainer Rauramaa Colin N A Palmer Inga Prokopenko Andrew D Morris Richard N Bergman Francis S Collins Lars Lind Erik Ingelsson Jaakko Tuomilehto Fredrik Karpe Leif Groop Torben Jørgensen Torben Hansen Oluf Pedersen Johanna Kuusisto Gonçalo Abecasis Graeme I Bell John Blangero Nancy J Cox Ravindranath Duggirala Mark Seielstad James G Wilson Josee Dupuis Samuli Ripatti Craig L Hanis Jose C Florez Karen L Mohlke James B Meigs Markku Laakso Andrew P Morris Michael Boehnke David Altshuler Mark I McCarthy Anna L Gloyn Cecilia M Lindgren

Diabetes 2017 07 24;66(7):2019-2032. Epub 2017 Mar 24.

Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.

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http://dx.doi.org/10.2337/db16-1329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482074PMC
July 2017

Empagliflozin and Kinetics of Renal Glucose Transport in Healthy Individuals and Individuals With Type 2 Diabetes.

Diabetes 2017 07 20;66(7):1999-2006. Epub 2017 Apr 20.

Texas Diabetes Institute and The University of Texas Health Science Center at San Antonio, San Antonio, TX.

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July 2017

Cardiovascular Disease and Type 2 Diabetes: Has the Dawn of a New Era Arrived?

Diabetes Care 2017 07;40(7):813-820

Sandwell and West Birmingham Hospitals National Health Service Trust, Birmingham, U.K.

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http://dx.doi.org/10.2337/dc16-2736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481984PMC
July 2017

Determinants of the increase in ketone concentration during SGLT2 inhibition in NGT, IFG and T2DM patients.

Diabetes Obes Metab 2017 06 27;19(6):809-813. Epub 2017 Mar 27.

Diabetes Division, University of Texas Health Science Center, San Antonio, Texas.

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June 2017

Role of Adipose Tissue Insulin Resistance in the Natural History of Type 2 Diabetes: Results From the San Antonio Metabolism Study.

Diabetes 2017 04 4;66(4):815-822. Epub 2017 Jan 4.

University of Texas Health Science Center at San Antonio, San Antonio, TX.

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http://dx.doi.org/10.2337/db16-1167DOI Listing
April 2017

Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes.

Trends Endocrinol Metab 2017 02 27;28(2):88-103. Epub 2016 Oct 27.

NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.tem.2016.10.001DOI Listing
February 2017

Pioglitazone inhibits mitochondrial pyruvate metabolism and glucose production in hepatocytes.

FEBS J 2017 02 18;284(3):451-465. Epub 2017 Jan 18.

Diabetes Division, University of Texas Health Science Center, San Antonio, TX, USA.

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http://dx.doi.org/10.1111/febs.13992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763915PMC
February 2017

Islet amyloid polypeptide response to maximal hyperglycemia and arginine is altered in impaired glucose tolerance and type 2 diabetes mellitus.

Acta Diabetol 2017 Jan 13;54(1):53-61. Epub 2016 Sep 13.

Diabetes Division, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, 78229, TX, USA.

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http://dx.doi.org/10.1007/s00592-016-0904-7DOI Listing
January 2017

Renal, metabolic and cardiovascular considerations of SGLT2 inhibition.

Nat Rev Nephrol 2017 Jan 12;13(1):11-26. Epub 2016 Dec 12.

Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA.

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http://dx.doi.org/10.1038/nrneph.2016.170DOI Listing
January 2017

Pioglitazone is equally effective for diabetes prevention in older versus younger adults with impaired glucose tolerance.

Age (Dordr) 2016 Dec 1;38(5-6):485-493. Epub 2016 Sep 1.

Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78223, USA.

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http://dx.doi.org/10.1007/s11357-016-9946-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266219PMC
December 2016

Dapagliflozin Enhances Fat Oxidation and Ketone Production in Patients With Type 2 Diabetes.

Diabetes Care 2016 Nov 25;39(11):2036-2041. Epub 2016 Aug 25.

Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX

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http://dx.doi.org/10.2337/dc15-2688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079607PMC
November 2016

The EMPA-REG study: What has it told us? A diabetologist's perspective.

Authors:
Ralph A DeFronzo

J Diabetes Complications 2016 Jan-Feb;30(1):1-2. Epub 2015 Oct 21.

Chief, Diabetes Division, University of Texas Health Science Center, San Antonio, TX, 78229 USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888368PMC
October 2016

Prediabetes and risk of diabetes and associated complications: impaired fasting glucose versus impaired glucose tolerance: does it matter?

Curr Opin Clin Nutr Metab Care 2016 Sep;19(5):394-399

aDivision of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA bDepartment of Medicine, Diabetes and Obesity Clinical Research Center, Hamad General Hospital, Doha, Qatar.

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September 2016

Beta Cell Formation in vivo Through Cellular Networking, Integration and Processing (CNIP) in Wild Type Adult Mice.

Curr Pharm Biotechnol 2016 ;17(4):376-88

Diabetes Division University of Texas Health Science Center 7703 Floyd Curl Drive San Antonio, Texas, 78231.

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August 2016

The genetic architecture of type 2 diabetes.

Authors:
Christian Fuchsberger Jason Flannick Tanya M Teslovich Anubha Mahajan Vineeta Agarwala Kyle J Gaulton Clement Ma Pierre Fontanillas Loukas Moutsianas Davis J McCarthy Manuel A Rivas John R B Perry Xueling Sim Thomas W Blackwell Neil R Robertson N William Rayner Pablo Cingolani Adam E Locke Juan Fernandez Tajes Heather M Highland Josee Dupuis Peter S Chines Cecilia M Lindgren Christopher Hartl Anne U Jackson Han Chen Jeroen R Huyghe Martijn van de Bunt Richard D Pearson Ashish Kumar Martina Müller-Nurasyid Niels Grarup Heather M Stringham Eric R Gamazon Jaehoon Lee Yuhui Chen Robert A Scott Jennifer E Below Peng Chen Jinyan Huang Min Jin Go Michael L Stitzel Dorota Pasko Stephen C J Parker Tibor V Varga Todd Green Nicola L Beer Aaron G Day-Williams Teresa Ferreira Tasha Fingerlin Momoko Horikoshi Cheng Hu Iksoo Huh Mohammad Kamran Ikram Bong-Jo Kim Yongkang Kim Young Jin Kim Min-Seok Kwon Juyoung Lee Selyeong Lee Keng-Han Lin Taylor J Maxwell Yoshihiko Nagai Xu Wang Ryan P Welch Joon Yoon Weihua Zhang Nir Barzilai Benjamin F Voight Bok-Ghee Han Christopher P Jenkinson Teemu Kuulasmaa Johanna Kuusisto Alisa Manning Maggie C Y Ng Nicholette D Palmer Beverley Balkau Alena Stančáková Hanna E Abboud Heiner Boeing Vilmantas Giedraitis Dorairaj Prabhakaran Omri Gottesman James Scott Jason Carey Phoenix Kwan George Grant Joshua D Smith Benjamin M Neale Shaun Purcell Adam S Butterworth Joanna M M Howson Heung Man Lee Yingchang Lu Soo-Heon Kwak Wei Zhao John Danesh Vincent K L Lam Kyong Soo Park Danish Saleheen Wing Yee So Claudia H T Tam Uzma Afzal David Aguilar Rector Arya Tin Aung Edmund Chan Carmen Navarro Ching-Yu Cheng Domenico Palli Adolfo Correa Joanne E Curran Denis Rybin Vidya S Farook Sharon P Fowler Barry I Freedman Michael Griswold Daniel Esten Hale Pamela J Hicks Chiea-Chuen Khor Satish Kumar Benjamin Lehne Dorothée Thuillier Wei Yen Lim Jianjun Liu Yvonne T van der Schouw Marie Loh Solomon K Musani Sobha Puppala William R Scott Loïc Yengo Sian-Tsung Tan Herman A Taylor Farook Thameem Gregory Wilson Tien Yin Wong Pål Rasmus Njølstad Jonathan C Levy Massimo Mangino Lori L Bonnycastle Thomas Schwarzmayr João Fadista Gabriela L Surdulescu Christian Herder Christopher J Groves Thomas Wieland Jette Bork-Jensen Ivan Brandslund Cramer Christensen Heikki A Koistinen Alex S F Doney Leena Kinnunen Tõnu Esko Andrew J Farmer Liisa Hakaste Dylan Hodgkiss Jasmina Kravic Valeriya Lyssenko Mette Hollensted Marit E Jørgensen Torben Jørgensen Claes Ladenvall Johanne Marie Justesen Annemari Käräjämäki Jennifer Kriebel Wolfgang Rathmann Lars Lannfelt Torsten Lauritzen Narisu Narisu Allan Linneberg Olle Melander Lili Milani Matt Neville Marju Orho-Melander Lu Qi Qibin Qi Michael Roden Olov Rolandsson Amy Swift Anders H Rosengren Kathleen Stirrups Andrew R Wood Evelin Mihailov Christine Blancher Mauricio O Carneiro Jared Maguire Ryan Poplin Khalid Shakir Timothy Fennell Mark DePristo Martin Hrabé de Angelis Panos Deloukas Anette P Gjesing Goo Jun Peter Nilsson Jacquelyn Murphy Robert Onofrio Barbara Thorand Torben Hansen Christa Meisinger Frank B Hu Bo Isomaa Fredrik Karpe Liming Liang Annette Peters Cornelia Huth Stephen P O'Rahilly Colin N A Palmer Oluf Pedersen Rainer Rauramaa Jaakko Tuomilehto Veikko Salomaa Richard M Watanabe Ann-Christine Syvänen Richard N Bergman Dwaipayan Bharadwaj Erwin P Bottinger Yoon Shin Cho Giriraj R Chandak Juliana C N Chan Kee Seng Chia Mark J Daly Shah B Ebrahim Claudia Langenberg Paul Elliott Kathleen A Jablonski Donna M Lehman Weiping Jia Ronald C W Ma Toni I Pollin Manjinder Sandhu Nikhil Tandon Philippe Froguel Inês Barroso Yik Ying Teo Eleftheria Zeggini Ruth J F Loos Kerrin S Small Janina S Ried Ralph A DeFronzo Harald Grallert Benjamin Glaser Andres Metspalu Nicholas J Wareham Mark Walker Eric Banks Christian Gieger Erik Ingelsson Hae Kyung Im Thomas Illig Paul W Franks Gemma Buck Joseph Trakalo David Buck Inga Prokopenko Reedik Mägi Lars Lind Yossi Farjoun Katharine R Owen Anna L Gloyn Konstantin Strauch Tiinamaija Tuomi Jaspal Singh Kooner Jong-Young Lee Taesung Park Peter Donnelly Andrew D Morris Andrew T Hattersley Donald W Bowden Francis S Collins Gil Atzmon John C Chambers Timothy D Spector Markku Laakso Tim M Strom Graeme I Bell John Blangero Ravindranath Duggirala E Shyong Tai Gilean McVean Craig L Hanis James G Wilson Mark Seielstad Timothy M Frayling James B Meigs Nancy J Cox Rob Sladek Eric S Lander Stacey Gabriel Noël P Burtt Karen L Mohlke Thomas Meitinger Leif Groop Goncalo Abecasis Jose C Florez Laura J Scott Andrew P Morris Hyun Min Kang Michael Boehnke David Altshuler Mark I McCarthy

Nature 2016 08 11;536(7614):41-47. Epub 2016 Jul 11.

Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034897PMC
August 2016

Positioning SGLT2 Inhibitors/Incretin-Based Therapies in the Treatment Algorithm.

Diabetes Care 2016 Aug;39 Suppl 2:S154-64

Diabetes Division, The University of Texas Health Science Center at San Antonio, San Antonio, TX.

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August 2016

Empagliflozin and linagliptin combination therapy for treatment of patients with type 2 diabetes mellitus.

Expert Opin Pharmacother 2015 19;16(18):2819-33. Epub 2015 Nov 19.

a Department of Medicine, Diabetes Division , University of Texas Health Science Center and Texas Diabetes Institute , San Antonio , TX 78229 , USA.

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June 2016

Transcriptomics in type 2 diabetes: Bridging the gap between genotype and phenotype.

Genom Data 2016 Jun 17;8:25-36. Epub 2015 Dec 17.

Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, TX, USA; South Texas Veterans Health Care System, San Antonio, TX, USA.

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http://dx.doi.org/10.1016/j.gdata.2015.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832048PMC
June 2016

Diabetes Incidence and Glucose Tolerance after Termination of Pioglitazone Therapy: Results from ACT NOW.

J Clin Endocrinol Metab 2016 05 16;101(5):2056-62. Epub 2016 Mar 16.

Texas Diabetes Institute and University of Texas Health Science Center (D.T., N.M., R.A.D.), South Texas Veterans Health Care System, San Antonio, Texas 78229; Phoenix VA Health Care System (D.C.S., P.D.R.), Phoenix, Arizona 85012; College of Nursing & Health Innovation (D.C.S.), Arizona State University, Phoenix, Arizona 85281; SUNY Health Science Center at Brooklyn (M.A.B.), Brooklyn, New York 11203; Pennington Biomedical Research Center (G.A.B.), Louisiana State University, Baton Rouge, Louisiana 70803; University of Southern California Keck School of Medicine (T.A.B.), Los Angeles, California; Inova Fairfax Hospital (S.C.C.), Falls Church, Virginia 22042; VA San Diego Healthcare System and University of California, San Diego (R.R.H., S.M.), San Diego, California 92093; Division of Endocrinology, Diabetes and Metabolism (A.E.K., F.B.S.), University of Tennessee-Memphis, Memphis, Tennessee; and Medstar Research Institute (R.E.R.), Hyattsville, Maryland 20782.

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http://dx.doi.org/10.1210/jc.2015-4202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287507PMC
May 2016

Effect of Dapagliflozin With and Without Acipimox on Insulin Sensitivity and Insulin Secretion in T2DM Males.

J Clin Endocrinol Metab 2016 Mar 14;101(3):1249-56. Epub 2016 Jan 14.

Division of Diabetes (A.Me., M.A.-G., C.S.-H., J.X., G.D., D.T., R.A.D.), University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; and Institute of Biomedical Engineering (A.Ma.), National Research Council, 35127 Padova, Italy.

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http://dx.doi.org/10.1210/jc.2015-2597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803159PMC
March 2016

Renal sodium-glucose cotransporter inhibition in the management of type 2 diabetes mellitus.

Am J Physiol Renal Physiol 2015 Dec 9;309(11):F889-900. Epub 2015 Sep 9.

Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, Texas

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http://dx.doi.org/10.1152/ajprenal.00267.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669360PMC
December 2015

Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes.

Eur Heart J 2015 Sep 10;36(34):2288-96. Epub 2015 Jun 10.

Diabetes Division, University of Texas Health Science Center, San Antonio, TX, USA.

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http://dx.doi.org/10.1093/eurheartj/ehv239DOI Listing
September 2015

Treatment of prediabetes.

World J Diabetes 2015 Sep;6(12):1207-22

Mustafa Kanat, Division of Diabetes, Department of Internal Medicine, Istanbul Medipol University, 34214 Istanbul, Turkey.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598604PMC
September 2015

Type 2 diabetes mellitus.

Nat Rev Dis Primers 2015 07 23;1:15019. Epub 2015 Jul 23.

Department of Human Metabolism and Nutrition, Braun School of Public Health, Hebrew University, Jerusalem, Israel.

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http://dx.doi.org/10.1038/nrdp.2015.19DOI Listing
July 2015

A novel insulin resistance index to monitor changes in insulin sensitivity and glucose tolerance: the ACT NOW study.

J Clin Endocrinol Metab 2015 May 20;100(5):1855-62. Epub 2015 Jan 20.

Texas Diabetes Institute (D.T., N.M., R.A.D.), University of Texas Health Science Center, San Antonio, Texas 78207; South Texas Veterans Health Care System (D.T., N.M., R.A.D.), Audie L. Murphy Division, San Antonio, Texas 78228; Metabolon, Inc (J.E.C., W.G., K.-P.A., T.G.), Durham, North Carolina 27713; Phoenix VA Health Care System (D.C.S., P.D.R.), Phoenix, Arizona 85012; College of Nursing and Health Care Innovation (D.C.S.), Arizona State University, Phoenix, Arizona 85004; SUNY Health Science Center at Brooklyn (M.A.B.), Brooklyn, New York 11203; Pennington Biomedical Research Center/Louisiana State University (G.A.B.), Baton Rouge, Louisiana 70808; University of Southern California Keck School of Medicine (T.A.B.), Los Angeles, California 90033; VA San Diego Healthcare System and University of California at San Diego (R.R.H., S.M.), San Diego, California 92161; Division of Endocrinology, Diabetes and Metabolism (A.E.K., F.B.S.), University of Tennessee, Memphis, Tennessee 38163; Inova Fairfax Hospital (S.C.C.), Falls Church, Virginia 22042; Medstar Research Institute (R.E.R.), Hyattsville, Maryland 20782; and Department of Clinical and Experimental Medicine (E.F.), CNR Institute of Clinical Physiology, 56126 Pisa, Italy.

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http://dx.doi.org/10.1210/jc.2014-3824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422894PMC
May 2015

Dapagliflozin lowers plasma glucose concentration and improves β-cell function.

J Clin Endocrinol Metab 2015 05 24;100(5):1927-32. Epub 2015 Feb 24.

Division of Diabetes (A.Me., C.S., G.D., A.C.-V., D.T., S.U.M., M.A.-G., R.A.D.), University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; and Consiglio Nazionale delle Ricerche Institute of Biomedical Engineering (A.Ma.), 35127 Padova, Italy.

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http://dx.doi.org/10.1210/jc.2014-3472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422889PMC
May 2015

Nox2 mediates skeletal muscle insulin resistance induced by a high fat diet.

J Biol Chem 2015 May 30;290(21):13427-39. Epub 2015 Mar 30.

From the Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229-3900,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505590PMC
May 2015

Practical implementation of incretin-based therapy in hospitalized patients with type 2 diabetes.

Postgrad Med 2015 Mar 30;127(2):251-7. Epub 2014 Dec 30.

Affiliate, Main Line Health System, Clinical Associate Professor of Medicine Emeritus, University of Pennsylvania , Philadelphia, PA , USA.

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http://dx.doi.org/10.1080/00325481.2015.996504DOI Listing
March 2015

Peripheral insulin resistance and impaired insulin signaling contribute to abnormal glucose metabolism in preterm baboons.

Endocrinology 2015 Mar 5;156(3):813-23. Epub 2015 Jan 5.

Department of Pediatrics (C.L.B., L.L.M.-V., S.R.S., D.C.M., M.M.L., D.G.A., M.C.J.), Division of Neonatology, University of Texas Health Science Center at San Antonio, Department of Medicine (A.G., H.L., R.A.D., N.M.), Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; Texas Diabetes Institute (H.L., R.A.D., N.M.), San Antonio, Texas 78207; San Antonio Geriatric, Research and Education Center and Barshop Institute for Longevity and Aging Studies (N.M.), San Antonio, Texas 78245, and Institute of Clinical Physiology, CNR, Pisa, Italy (A.G.).

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http://dx.doi.org/10.1210/en.2014-1757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330304PMC
March 2015

Combination of empagliflozin and linagliptin as second-line therapy in subjects with type 2 diabetes inadequately controlled on metformin.

Diabetes Care 2015 Mar 12;38(3):384-93. Epub 2015 Jan 12.

Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany.

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March 2015

Initial combination of empagliflozin and linagliptin in subjects with type 2 diabetes.

Diabetes Care 2015 Mar 29;38(3):394-402. Epub 2015 Jan 29.

Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany.

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March 2015

Chronic continuous exenatide infusion does not cause pancreatic inflammation and ductal hyperplasia in non-human primates.

Am J Pathol 2015 Jan 6;185(1):139-50. Epub 2014 Nov 6.

Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas; Faculdade de Ciencias Medicas (FCM), Departamento de Clinica Medica, Obesity and Comorbidities Research Center (O.C.R.C.), Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278248PMC
January 2015

The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells.

Nucleic Acids Res 2014 Dec 20;42(22):13646-61. Epub 2014 Nov 20.

Institute of Biomedicine, University of Eastern Finland, Kuopio 70211, Finland

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267646PMC
December 2014

Adjusting glucose-stimulated insulin secretion for adipose insulin resistance: an index of β-cell function in obese adults.

Diabetes Care 2014 Nov 19;37(11):2940-6. Epub 2014 Aug 19.

Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH Metabolic Translational Research Center, Endocrine and Metabolism Institute, Cleveland Clinic, Cleveland, OH

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207203PMC
November 2014

The disposition index does not reflect β-cell function in IGT subjects treated with pioglitazone.

J Clin Endocrinol Metab 2014 Oct 17;99(10):3774-81. Epub 2014 Jun 17.

Texas Diabetes Institute and University of Texas Health Science Center at San Antonio (R.A.D., D.T., M.A.-G., N.M., A.G.), South Texas Veterans Health Care System Audie Murphy Division (R.A.D., D.T.), San Antonio, Texas 78229; and Cardiometabolic Risk Unit, Institute of Clinical Physiology (A.G.), 56124 Pisa, Italy.

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October 2014

What are the pharmacotherapy options for treating prediabetes?

Expert Opin Pharmacother 2014 Oct 19;15(14):2003-18. Epub 2014 Aug 19.

University of Texas Health Science Center at San Antonio, Division of Diabetes , 7703 Floyd Curve Dr, San Antonio, TX, 78229 , USA +1 210 567 6691 ; +1 210 567 6554 ;

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October 2014

Strong association between insulin-mediated glucose uptake and the 2-hour, not the fasting plasma glucose concentration, in the normal glucose tolerance range.

J Clin Endocrinol Metab 2014 Sep 5;99(9):3444-9. Epub 2014 May 5.

Diabetes Division (D.W., L.N., R.A., M.F., A.H.-D., D.T., R.A.D., C.P.J., M.A.-G.), University of Texas Health Science Center at San Antonio, Texas 78229; and Division of Diabetes (M.K.), Istanbul Medipol University, 34810 Istanbul, Turkey.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154101PMC
September 2014

APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.

Cell Rep 2014 May 10;7(4):1227-38. Epub 2014 May 10.

Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA; The Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380268PMC
May 2014

The use of non-insulin anti-diabetic agents to improve glycemia without hypoglycemia in the hospital setting: focus on incretins.

Curr Diab Rep 2014 Mar;14(3):466

Main Line Health System, University of Pennsylvania, Philadelphia, PA, USA,

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March 2014