Publications by authors named "Ralf Weiskirchen"

100Publications

Intrahepatic T17/T Cells in Homeostasis and Disease-It's All About the Balance.

Front Pharmacol 2020 2;11:588436. Epub 2020 Oct 2.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), University Hospital, RWTH Aachen, Aachen, Germany.

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http://dx.doi.org/10.3389/fphar.2020.588436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566778PMC
October 2020

Commentary on "Reregulation of hepatic stellate cell contraction and cirrhotic portal hypertension by Wnt/β-catenin signaling via interaction with Gli1".

Authors:
Ralf Weiskirchen

Br J Pharmacol 2020 Oct 21. Epub 2020 Oct 21.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, D-52074, Aachen, Germany.

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http://dx.doi.org/10.1111/bph.15282DOI Listing
October 2020

Milk Exosomes Prevent Intestinal Inflammation in a Genetic Mouse Model of Ulcerative Colitis: A Pilot Experiment.

Inflamm Intest Dis 2020 Aug 20;5(3):117-123. Epub 2020 May 20.

Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany.

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http://dx.doi.org/10.1159/000507626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506232PMC
August 2020

Severity of Coronavirus Disease 2019 (COVID-19): Does Surfactant Matter?

Authors:
Ralf Weiskirchen

Front Microbiol 2020 26;11:1905. Epub 2020 Aug 26.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen, Germany.

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http://dx.doi.org/10.3389/fmicb.2020.01905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479844PMC
August 2020

Severity assessment in mice subjected to carbon tetrachloride.

Sci Rep 2020 09 25;10(1):15790. Epub 2020 Sep 25.

Institute for Laboratory Animal Science and Experimental Surgery, Faculty of Medicine, RWTH, Aachen International University, Aachen, Germany.

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http://dx.doi.org/10.1038/s41598-020-72801-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519684PMC
September 2020

Inflammatory Responses of Astrocytes Are Independent from Lipocalin 2.

J Mol Neurosci 2020 Sep 21. Epub 2020 Sep 21.

Institute of Neuroanatomy, RWTH University Hospital Aachen, Aachen, Germany.

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http://dx.doi.org/10.1007/s12031-020-01712-7DOI Listing
September 2020

Accurate Measurement of Copper Overload in an Experimental Model of Wilson Disease by Laser Ablation Inductively Coupled Plasma Mass Spectrometry.

Biomedicines 2020 Sep 16;8(9). Epub 2020 Sep 16.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, D-52074 Aachen, Germany.

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http://dx.doi.org/10.3390/biomedicines8090356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555421PMC
September 2020

Roles of CCR2 and CCR5 for Hepatic Macrophage Polarization in Mice With Liver Parenchymal Cell-Specific NEMO Deletion.

Cell Mol Gastroenterol Hepatol 2020 Sep 4. Epub 2020 Sep 4.

Department of Medicine III, RWTH Aachen University, Aachen, Germany; Department of Hepatology and Gastroenterology, Charité University Medicine Berlin, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2020.08.012DOI Listing
September 2020

Advances in the clinical use of collagen as biomarker of liver fibrosis.

Expert Rev Mol Diagn 2020 Sep 24;20(9):947-969. Epub 2020 Sep 24.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen , Aachen, Germany.

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http://dx.doi.org/10.1080/14737159.2020.1814746DOI Listing
September 2020

What Does the "AKT" Stand for in the Name "AKT Kinase"? Some Historical Comments.

Front Oncol 2020 11;10:1329. Epub 2020 Aug 11.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen, Germany.

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http://dx.doi.org/10.3389/fonc.2020.01329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431881PMC
August 2020

Editorial: Macrophages in Liver Disease.

Front Immunol 2020 4;11:1754. Epub 2020 Aug 4.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen, Germany.

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http://dx.doi.org/10.3389/fimmu.2020.01754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417358PMC
August 2020

Differential regulation of Lipocalin 2 (LCN2) in doxorubicin-resistant 4T1 triple negative breast cancer cells.

Cell Signal 2020 Oct 3;74:109731. Epub 2020 Aug 3.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, D-52074 Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2020.109731DOI Listing
October 2020

Chronic Carbon Tetrachloride Applications Induced Hepatocyte Apoptosis in Lipocalin 2 Null Mice Through Endoplasmic Reticulum Stress and Unfolded Protein Response.

Int J Mol Sci 2020 Jul 23;21(15). Epub 2020 Jul 23.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH Aachen University Hospital, D-52074 Aachen, Germany.

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http://dx.doi.org/10.3390/ijms21155230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432394PMC
July 2020

TNF-α controls Lipocalin-2 expression in PC-3 prostate cancer cells.

Cytokine 2020 Nov 24;135:155214. Epub 2020 Jul 24.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2020.155214DOI Listing
November 2020

Targeting Activated Hepatic Stellate Cells Using Collagen-Binding Chitosan Nanoparticles for siRNA Delivery to Fibrotic Livers.

Pharmaceutics 2020 Jun 25;12(6). Epub 2020 Jun 25.

Department of Pharmaceutical Technology, Faculty of Pharmacy & Biotechnology, The German University in Cairo (GUC), 11835 Cairo, Egypt.

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http://dx.doi.org/10.3390/pharmaceutics12060590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356502PMC
June 2020

The hepatic lipidome: From basic science to clinical translation.

Adv Drug Deliv Rev 2020 Jun 30. Epub 2020 Jun 30.

Translational Liver Research, Department of Medical Cell BioPhysics, Faculty of Science and Technology, Technical Medical Center, University of Twente, Enschede 7500 AE, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2020.06.027DOI Listing
June 2020

Deletion of Perilipin 5 Protects Against Hepatic Injury in Nonalcoholic Fatty Liver Disease via Missing Inflammasome Activation.

Cells 2020 05 28;9(6). Epub 2020 May 28.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, 52074 Aachen, Germany.

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http://dx.doi.org/10.3390/cells9061346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348929PMC
May 2020

Special Issue on "Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis".

Authors:
Ralf Weiskirchen

Cells 2020 04 29;9(5). Epub 2020 Apr 29.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, D-52074 Aachen, Germany.

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http://dx.doi.org/10.3390/cells9051105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291324PMC
April 2020

Disorders of the glucose metabolism correlate with the phenotype and the severity in women with polycystic ovary syndrome.

Clin Endocrinol (Oxf) 2020 Jul 29;93(1):44-51. Epub 2020 Apr 29.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen, Germany.

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http://dx.doi.org/10.1111/cen.14181DOI Listing
July 2020

Age-specific reference values improve the diagnostic performance of AMH in polycystic ovary syndrome.

Clin Chem Lab Med 2020 Jul;58(8):1291-1301

Laboratory Diagnostic Center, University Hospital RWTH Aachen, Pauwelsstr. 30, 52074 Aachen, Germany.

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http://dx.doi.org/10.1515/cclm-2019-1059DOI Listing
July 2020

The nucleic acid binding protein YB-1-controlled expression of CXCL-1 modulates kidney damage in liver fibrosis.

Kidney Int 2020 04 9;97(4):741-752. Epub 2019 Nov 9.

Department of Nephrology and Clinical Immunology, University Hospital RWTH-Aachen, Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2019.10.024DOI Listing
April 2020

Four-And-A-Half LIM-Domain Protein 2 (FHL2) Deficiency Aggravates Cholestatic Liver Injury.

Cells 2020 01 19;9(1). Epub 2020 Jan 19.

Institute of Biochemistry, Emil-Fischer-Zentrum, Friedrich-Alexander University Erlangen-Nürnberg, Fahrstr. 17, D-91054 Erlangen, Germany.

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http://dx.doi.org/10.3390/cells9010248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016690PMC
January 2020

All You Can Feed: Some Comments on Production of Mouse Diets Used in Biomedical Research with Special Emphasis on Non-Alcoholic Fatty Liver Disease Research.

Nutrients 2020 Jan 7;12(1). Epub 2020 Jan 7.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, D-52074 Aachen, Germany.

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http://dx.doi.org/10.3390/nu12010163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019265PMC
January 2020

Identification of Ppar-modulated miRNA hubs that target the fibrotic tumor microenvironment.

Proc Natl Acad Sci U S A 2020 01 23;117(1):454-463. Epub 2019 Dec 23.

Department for Molecular Biology, Interfaculty Institute of Cell Biology, Eberhard Karls University Tübingen, 72076 Tübingen, Germany;

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http://dx.doi.org/10.1073/pnas.1909145117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955372PMC
January 2020

Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases.

Front Immunol 2019 3;10:2852. Epub 2019 Dec 3.

Department of Biomaterials Science and Technology, Faculty of Science and Technology, Technical Medical Center, University of Twente, Enschede, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2019.02852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901832PMC
November 2020

Mast Cells in Liver Fibrogenesis.

Cells 2019 11 13;8(11). Epub 2019 Nov 13.

Institute of Biochemistry and Molecular Immunology, Medical Faculty, RWTH Aachen University, D-52074 Aachen, Germany.

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http://dx.doi.org/10.3390/cells8111429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912398PMC
November 2019

Investigation of soluble anti-Müllerian hormone receptor type 2 as a biomarker for diagnosis of female fertility disorders.

Reprod Biomed Online 2019 Dec 27;39(6):1017-1025. Epub 2019 Aug 27.

Laboratory Diagnostic Center, University Hospital RWTH Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.rbmo.2019.08.007DOI Listing
December 2019

The Bile Acid-Phospholipid Conjugate Ursodeoxycholyl-Lysophosphatidylethanolamide (UDCA-LPE) Disintegrates the Lipid Backbone of Raft Plasma Membrane Domains by the Removal of the Membrane Phospholipase A2.

Int J Mol Sci 2019 Nov 11;20(22). Epub 2019 Nov 11.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, 52074 Aachen, Germany.

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http://dx.doi.org/10.3390/ijms20225631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888454PMC
November 2019

Commentary: Montelukast Prevents Mice Against Acetaminophen-Induced Liver Injury.

Authors:
Ralf Weiskirchen

Front Pharmacol 2019 25;10:1289. Epub 2019 Oct 25.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen, Germany.

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http://dx.doi.org/10.3389/fphar.2019.01289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824288PMC
October 2019

Mechanisms Underlying Cell Therapy in Liver Fibrosis: An Overview.

Cells 2019 10 29;8(11). Epub 2019 Oct 29.

Laboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20550-170, Brazil.

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http://dx.doi.org/10.3390/cells8111339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912561PMC
October 2019

Magnetic-Assisted Treatment of Liver Fibrosis.

Cells 2019 10 19;8(10). Epub 2019 Oct 19.

Department of Medicine III, Medical Faculty, RWTH Aachen, D-52074 Aachen, Germany.

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http://dx.doi.org/10.3390/cells8101279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830324PMC
October 2019

Reference change values of M-protein, free light chain and immunoglobulins in monoclonal gammopathy.

Clin Biochem 2019 Dec 14;74:42-46. Epub 2019 Sep 14.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, D-52074 Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2019.09.004DOI Listing
December 2019

Endoglin Trafficking/Exosomal Targeting in Liver Cells Depends on -Glycosylation.

Cells 2019 08 28;8(9). Epub 2019 Aug 28.

RWTH University Hospital Aachen, Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, D-52074 Aachen, Germany.

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http://dx.doi.org/10.3390/cells8090997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769735PMC
August 2019

High Prevalence of Sticky Platelet Syndrome in Patients with Infertility and Pregnancy Loss.

J Clin Med 2019 Aug 28;8(9). Epub 2019 Aug 28.

Department of Gynecological Endocrinology and Reproductive Medicine, RWTH-University Hospital Aachen, D-52074 Aachen, Germany.

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http://dx.doi.org/10.3390/jcm8091328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780264PMC
August 2019

Phosphatidylcholine Passes by Paracellular Transport to the Apical Side of the Polarized Biliary Tumor Cell Line Mz-ChA-1.

Int J Mol Sci 2019 Aug 19;20(16). Epub 2019 Aug 19.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, D-52074 Aachen, Germany.

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http://dx.doi.org/10.3390/ijms20164034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720464PMC
August 2019

Current Status in Testing for Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH).

Cells 2019 08 7;8(8). Epub 2019 Aug 7.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital, 52074 Aachen, Germany.

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http://dx.doi.org/10.3390/cells8080845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721710PMC
August 2019

Decreased CTRP3 Plasma Concentrations Are Associated with Sepsis and Predict Mortality in Critically Ill Patients.

Diagnostics (Basel) 2019 Jun 21;9(2). Epub 2019 Jun 21.

Department of Medicine III, RWTH-University Hospital Aachen, D-52074 Aachen, Germany.

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http://dx.doi.org/10.3390/diagnostics9020063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628070PMC
June 2019

The interesting case-orphan diseases-double trouble.

Ann Transl Med 2019 Apr;7(Suppl 2):S74

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen, Germany.

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http://dx.doi.org/10.21037/atm.2019.04.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531648PMC
April 2019

Determination of copper poisoning in Wilson's disease using laser ablation inductively coupled plasma mass spectrometry.

Ann Transl Med 2019 Apr;7(Suppl 2):S72

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen, Germany.

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http://dx.doi.org/10.21037/atm.2018.10.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531650PMC
April 2019

Clinical features of Wilson disease.

Ann Transl Med 2019 Apr;7(Suppl 2):S61

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH-University Hospital, Aachen, Germany.

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http://dx.doi.org/10.21037/atm.2019.01.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531660PMC
April 2019

Editorial for focused issue "Wilson Disease: From Genetics to Management of Disease".

Ann Transl Med 2019 Apr;7(Suppl 2):S55

Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.21037/atm.2018.12.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531652PMC
April 2019

Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblasts in Liver Fibrosis.

Cells 2019 05 24;8(5). Epub 2019 May 24.

Department of Hepatology/Gastroenterology, Charité University Medical Center, D-13353 Berlin, Germany.

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http://dx.doi.org/10.3390/cells8050503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562512PMC
May 2019

Bone Morphogenetic Protein-8B Expression is Induced in Steatotic Hepatocytes and Promotes Hepatic Steatosis and Inflammation In Vitro.

Cells 2019 05 15;8(5). Epub 2019 May 15.

Institute of Biochemistry (Emil-Fischer Zentrum), Friedrich-Alexander University Erlangen-Nürnberg, Fahrstr. 17, D-91054 Erlangen, Germany.

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http://dx.doi.org/10.3390/cells8050457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562647PMC
May 2019

Perilipin 5 and Lipocalin 2 Expression in Hepatocellular Carcinoma.

Cancers (Basel) 2019 Mar 19;11(3). Epub 2019 Mar 19.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, 52074 Aachen, Germany.

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http://dx.doi.org/10.3390/cancers11030385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468921PMC
March 2019

Hypoxia Induces Astrocyte-Derived Lipocalin-2 in Ischemic Stroke.

Int J Mol Sci 2019 Mar 13;20(6). Epub 2019 Mar 13.

Institute of Neuroanatomy, RWTH Aachen University, 52074 Aachen, Germany.

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https://www.mdpi.com/1422-0067/20/6/1271
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http://dx.doi.org/10.3390/ijms20061271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471434PMC
March 2019

Has GnRH a direct role in AMH regulation?

Clin Endocrinol (Oxf) 2019 06 16;90(6):827-833. Epub 2019 Apr 16.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, Aachen, Germany.

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http://doi.wiley.com/10.1111/cen.13967
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http://dx.doi.org/10.1111/cen.13967DOI Listing
June 2019

Structure of mammalian plasma fetuin-B and its mechanism of selective metallopeptidase inhibition.

IUCrJ 2019 Mar 28;6(Pt 2):317-330. Epub 2019 Feb 28.

Proteolysis Laboratory, Department of Structural Biology, Molecular Biology Institute of Barcelona, CSIC, Barcelona Science Park, Helix Building, c/o Baldiri Reixac 15-21, E-08028 Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1107/S2052252519001568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400186PMC
March 2019

Software solutions for evaluation and visualization of laser ablation inductively coupled plasma mass spectrometry imaging (LA-ICP-MSI) data: a short overview.

J Cheminform 2019 Feb 18;11(1):16. Epub 2019 Feb 18.

Department of Biochemistry and Biotechnology, Center for Research and Advanced Studies (CINVESTAV) Irapuato, Km. 9.6 Libramiento Norte Carr. Irapuato-León, 36824, Irapuato, Gto., Mexico.

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http://dx.doi.org/10.1186/s13321-019-0338-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690067PMC
February 2019

Liver parenchymal cells lacking Lipocalin 2 (LCN2) are prone to endoplasmic reticulum stress and unfolded protein response.

Cell Signal 2019 03 4;55:90-99. Epub 2019 Jan 4.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH Aachen University Hospital, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08986568193000
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http://dx.doi.org/10.1016/j.cellsig.2019.01.001DOI Listing
March 2019

Relevance of Autophagy in Parenchymal and Non-Parenchymal Liver Cells for Health and Disease.

Cells 2019 01 1;8(1). Epub 2019 Jan 1.

Department of Medicine III, University Hospital RWTH Aachen, D-52074 Aachen, Germany.

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http://www.mdpi.com/2073-4409/8/1/16
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http://dx.doi.org/10.3390/cells8010016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357193PMC
January 2019

Vitamin B interpretation: Erroneous higher levels in non-anemic populations.

Nutrition 2019 04 5;60:25-29. Epub 2018 Sep 5.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH-University Hospital, Aachen, Germany.

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http://dx.doi.org/10.1016/j.nut.2018.09.002DOI Listing
April 2019

Quantification of liver iron overload disease with laser ablation inductively coupled plasma mass spectrometry.

BMC Med Imaging 2018 12 4;18(1):51. Epub 2018 Dec 4.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Pauwelsstr 30, D-52074, Aachen, Germany.

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http://dx.doi.org/10.1186/s12880-018-0291-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278171PMC
December 2018

Prevention of hepatic stellate cell activation using JQ1- and atorvastatin-loaded chitosan nanoparticles as a promising approach in therapy of liver fibrosis.

Eur J Pharm Biopharm 2019 Jan 22;134:96-106. Epub 2018 Nov 22.

Department of Pharmaceutical Technology, Faculty of Pharmacy & Biotechnology, The German University in Cairo (GUC), Cairo, Egypt.

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http://dx.doi.org/10.1016/j.ejpb.2018.11.018DOI Listing
January 2019

Technical and diagnostic performance of a new fully automated immunoassay for the determination of intact fibroblast growth factor 23 (FGF23).

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):584-590. Epub 2018 Oct 31.

b Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), University Hospital RWTH Aachen , Aachen , Germany.

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1526411DOI Listing
April 2019

An update on the recent advances in antifibrotic therapy.

Expert Rev Gastroenterol Hepatol 2018 Nov 3;12(11):1143-1152. Epub 2018 Oct 3.

b Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry , RWTH University Hospital Aachen , Aachen , Germany.

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https://www.tandfonline.com/doi/full/10.1080/17474124.2018.1
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http://dx.doi.org/10.1080/17474124.2018.1530110DOI Listing
November 2018

Cross-method comparison of serum androstenedione measurement with respect to the validation of a new fully automated chemiluminescence immunoassay.

Clin Biochem 2018 Dec 24;62:32-38. Epub 2018 Sep 24.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), University Hospital RWTH, Aachen, Germany.

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http://dx.doi.org/10.1016/j.clinbiochem.2018.09.009DOI Listing
December 2018

Visfatin Serum Levels Predict Mortality in Critically Ill Patients.

Dis Markers 2018 26;2018:7315356. Epub 2018 Aug 26.

Department of Medicine III, RWTH-University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.

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http://dx.doi.org/10.1155/2018/7315356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129328PMC
January 2019

Mining the Age-Dependent Reference Intervals of B Vitamins from Routine Laboratory Test Results.

Lab Med 2019 Jan;50(1):54-63

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, Germany.

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http://dx.doi.org/10.1093/labmed/lmy045DOI Listing
January 2019

Portal myofibroblasts are sensitive to CCN-mediated endoplasmic reticulum stress-related apoptosis with potential to attenuate biliary fibrogenesis.

Cell Signal 2018 11 22;51:72-85. Epub 2018 Jul 22.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH Aachen University Hospital, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08986568183015
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http://dx.doi.org/10.1016/j.cellsig.2018.07.005DOI Listing
November 2018

Recent advances in understanding liver fibrosis: bridging basic science and individualized treatment concepts.

F1000Res 2018 27;7. Epub 2018 Jun 27.

Department of Medicine III, RWTH University Hospital Aachen, D-52074 Aachen, Pauwelsstraße 30, Germany.

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http://dx.doi.org/10.12688/f1000research.14841.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024236PMC
June 2018

Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications.

Mol Aspects Med 2019 02 30;65:2-15. Epub 2018 Jun 30.

Dept. of Medicine III, University Hospital Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2018.06.003DOI Listing
February 2019

High mobility group box 1 as a biomarker in critically ill patients.

J Clin Lab Anal 2018 Oct 3;32(8):e22584. Epub 2018 Jun 3.

Department of Medicine III, RWTH-University Hospital Aachen, Aachen, Germany.

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http://doi.wiley.com/10.1002/jcla.22584
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http://dx.doi.org/10.1002/jcla.22584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816880PMC
October 2018

Brain copper storage after genetic long-term correction in a mouse model of Wilson disease.

Neurol Genet 2018 Jun 18;4(3):e243. Epub 2018 May 18.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (R.U., R.W.), RWTH University Hospital Aachen, Aachen, Germany; Gene Therapy and Regulation of Gene Expression Program (D.M., O.M., C.G., R.H.-A., G.G.-A.), CIMA, Foundation for Applied Medical Research, University of Navarra; Instituto de Investigacion Sanitaria de Navarra (IDISNA) (D.M., O.M., C.G., R.H-.A., G.G.-A.); and Vivet-Therapeutics (G.G.-A.), Pamplona, Spain.

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http://dx.doi.org/10.1212/NXG.0000000000000243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961192PMC
June 2018

-Glycosylation of Lipocalin 2 Is Not Required for Secretion or Exosome Targeting.

Front Pharmacol 2018 25;9:426. Epub 2018 Apr 25.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen, Germany.

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http://dx.doi.org/10.3389/fphar.2018.00426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932398PMC
April 2018

Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!

Front Pharmacol 2018 12;9:98. Epub 2018 Feb 12.

Institute of Molecular Pathobiochemistry, Experimental Gene, and Clinical Chemistry, RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.3389/fphar.2018.00098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816342PMC
February 2018

Visualization of the therapeutic efficacy of a gene correction approach in Wilson's disease by laser-ablation inductively coupled mass spectrometry.

J Hepatol 2018 05 6;68(5):1088-1090. Epub 2018 Jan 6.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, D-52074 Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.12.022DOI Listing
May 2018

Lipocalin-2 in Fructose-Induced Fatty Liver Disease.

Front Physiol 2017 28;8:964. Epub 2017 Nov 28.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen, Germany.

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http://dx.doi.org/10.3389/fphys.2017.00964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712346PMC
November 2017

Combining GP73 with liver stiffness measurements: A proof-of-concept for non-invasive fibrosis assessment in antiviral-naïve HBV patients.

Liver Int 2017 11;37(11):1605-1607

Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.

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http://dx.doi.org/10.1111/liv.13563DOI Listing
November 2017

Fructose: A Dietary Sugar in Crosstalk with Microbiota Contributing to the Development and Progression of Non-Alcoholic Liver Disease.

Front Immunol 2017 19;8:1159. Epub 2017 Sep 19.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen, Germany.

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http://dx.doi.org/10.3389/fimmu.2017.01159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609573PMC
September 2017

ITIH5 induces a shift in TGF-β superfamily signaling involving Endoglin and reduces risk for breast cancer metastasis and tumor death.

Mol Carcinog 2018 02 30;57(2):167-181. Epub 2017 Oct 30.

Institute of Pathology, Medical Faculty of the RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1002/mc.22742DOI Listing
February 2018