Publications by authors named "Ralf P Brandes"

100Publications

Deletion of NoxO1 limits atherosclerosis development in female mice.

Redox Biol 2020 Sep 4;37:101713. Epub 2020 Sep 4.

Institute for Cardiovascular Physiology, Goethe-University, Theodor-Stern Kai 7, 60590, Frankfurt Am Main, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhein Main, Theodor-Stern Kai 7, 60590, Frankfurt Am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2020.101713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502371PMC
September 2020

Thymosin beta-4x LINCs SPAAR to its non-coding function.

Cardiovasc Res 2020 Oct;116(12):1927-1928

Institute für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe-Universität, Theodor-Stern Kai 7, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1093/cvr/cvaa098DOI Listing
October 2020

Glucose-Stimulated Insulin Secretion Fundamentally Requires HO Signaling by NADPH Oxidase 4.

Diabetes 2020 Jul 3;69(7):1341-1354. Epub 2020 Apr 3.

Department of Mitochondrial Physiology, No. 75, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic

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http://dx.doi.org/10.2337/db19-1130DOI Listing
July 2020

Shear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation.

Redox Biol 2020 01 13;28:101379. Epub 2019 Nov 13.

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2019.101379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880097PMC
January 2020

Narciclasine inhibits angiogenic processes by activation of Rho kinase and by downregulation of the VEGF receptor 2.

J Mol Cell Cardiol 2019 10 2;135:97-108. Epub 2019 Aug 2.

Institute of Pharmaceutical Biology, Faculty of Biochemistry, Chemistry and Pharmacy, Goethe University, Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2019.08.001DOI Listing
October 2019

The histone demethylase PHF8 facilitates alternative splicing of the histocompatibility antigen HLA-G.

FEBS Lett 2019 03 27;593(5):487-498. Epub 2019 Feb 27.

Institute for Cardiovascular Physiology, Medical Faculty, Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1002/1873-3468.13337DOI Listing
March 2019

BIAM switch assay coupled to mass spectrometry identifies novel redox targets of NADPH oxidase 4.

Redox Biol 2019 02 29;21:101125. Epub 2019 Jan 29.

Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2019.101125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360804PMC
February 2019

Redox Regulation Beyond ROS: Why ROS Should Not Be Measured as Often.

Circ Res 2018 07;123(3):326-328

From the Institut für Kardiovaskuläre Physiologie, Goethe-Universität, Frankfurt, Germany (R.P.B., F.R., K.S.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061830PMC
July 2018

Stay in Shape With BH4: Loss of Endothelial Tetrahydrobiopterin Promotes Aortic Aneurysm Development in Mice.

Authors:
Ralf P Brandes

Hypertension 2018 07 29;72(1):61-62. Epub 2018 May 29.

From the Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe-Universität, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11295DOI Listing
July 2018

Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension.

Eur Respir J 2018 Feb 1. Epub 2018 Feb 1.

Excellence Cluster Cardiopulmonary System, University of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), Justus-Liebig-University, 35392 Giessen, Germany.

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http://dx.doi.org/10.1183/13993003.01024-2017DOI Listing
February 2018

Long noncoding RNA LISPR1 is required for S1P signaling and endothelial cell function.

J Mol Cell Cardiol 2018 03 3;116:57-68. Epub 2018 Feb 3.

Goethe-University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222828183002
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http://dx.doi.org/10.1016/j.yjmcc.2018.01.015DOI Listing
March 2018

Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Apr;1863(4):433-446

Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry I, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2018.01.009DOI Listing
April 2018

The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice.

Redox Biol 2018 05 22;15:12-21. Epub 2017 Nov 22.

Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany; German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723277PMC
May 2018

Detection of Hydrogen Peroxide with Fluorescent Dyes.

Antioxid Redox Signal 2018 08 13;29(6):585-602. Epub 2017 Dec 13.

Institute for Cardiovascular Physiology, Goethe-University , Frankfurt am Main, Germany .

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http://dx.doi.org/10.1089/ars.2017.7401DOI Listing
August 2018

Lung Ischaemia-Reperfusion Injury: The Role of Reactive Oxygen Species.

Adv Exp Med Biol 2017 ;967:195-225

Excellence Cluster Cardio-pulmonary System, University of Giessen Lung Center, German Center for Lung Research (DZL), Justus-Liebig-University Giessen, Aulweg 130, 35392, Giessen, Germany.

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http://dx.doi.org/10.1007/978-3-319-63245-2_12DOI Listing
April 2018

Both cardiomyocyte and endothelial cell Nox4 mediate protection against hemodynamic overload-induced remodelling.

Cardiovasc Res 2018 Mar;114(3):401-408

Cardiovascular Division, James Black Centre, King's College London British Heart Foundation Centre of Excellence, 125 Coldharbour Lane, London SE5 9NU, UK.

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http://dx.doi.org/10.1093/cvr/cvx204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018755PMC
March 2018

Redox Regulation and Noncoding RNAs.

Antioxid Redox Signal 2018 09 18;29(9):793-812. Epub 2017 Sep 18.

1 Institute for Cardiovascular Physiology, Goethe-University , Frankfurt, Germany .

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http://dx.doi.org/10.1089/ars.2017.7276DOI Listing
September 2018

Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing.

Circ Res 2017 Aug 15;121(4):424-438. Epub 2017 Jun 15.

From the Excellence Cluster Cardiopulmonary System, University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany (N.S., O.P., S.S., F.K., M.M., M.G., A.E., S.K., F.J., C.V., A.S., N.A., K.G., M.H., W.S., F.G., H.A.G., R.T.S., N.W.); Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI (M.H., C.S., S.A., L.I.G.); Institut für Kardiovaskuläre Physiologie, Goethe-Universität, German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt am Main, Germany (R.P.B.); and Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany (W.S.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.310482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544581PMC
August 2017

Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies.

Circulation 2017 Jul 27;136(4):388-403. Epub 2017 Apr 27.

From Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany (Y.D., E.P.C.v.d.V., C.N., V.E., M.D., M.M., Y.J., K.B., R.T.A.M., C.R., O.S., E.T., C.W.); Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Germany (H.N., L.P., W.T.); Institute for Cardiovascular Physiology, Vascular Research Centre, Goethe University, Frankfurt am Main, Germany (K.S., R.P.B.); Division of Nephrology and Immunology, RWTH Aachen University Hospital, Germany (B.M.K., P.B.); Cardiovascular Research Institute Maastricht (CARIM), Department of Biochemistry, Maastricht University, the Netherlands (R.T.A.M., R.v.G., T.M.H., C.W.); Academic Medical Center, Department of Pathology and Department of Medical Biochemistry, Amsterdam University, the Netherlands (P.J.H.K., A.v.D.W., E.T.); Department of Vascular and Endovascular Surgery, LMU Munich, Germany (G.G.); DZHK (German Centre for Cardiovascular Research), partner site Frankfurt am Main, Germany (R.P.B.); DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Germany (O.S., C.W.); Department of Physiology and Pharmacology, Karolinksa Institutet, Stockholm, Sweden (O.S.); Max-Plank-Institute for Molecular Biomedicine, Münster, Germany (D.V.); Institute for Laboratory Medicine, LMU Munich, Germany (D.T., L.M.H.); and Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (D.J.R., D.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.027646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777319PMC
July 2017

Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.

Circulation 2017 Jul 28;136(1):65-79. Epub 2017 Mar 28.

From Institute for Cardiovascular Physiology (M.S.L., C.F., I.J., M.J.M., J.E., F.M., R.P.B.), Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine (F.M.R., J.H., I.W.), Institute of Vascular Signalling (J.H.), Institute of Cardiovascular Regeneration (P.H. Y.P., S.U., K.S., R.A.B., S.D.), Department of Neurosurgery (T.M.F.), Pharmazentrum Frankfurt, Institute of General Pharmacology and Toxicology (K.D.), Goethe University, Germany; ECCPS Bioinformatics and Sequencing Facility (J.P., S.G., C.K., M.L.) and Department of Lung Development and Remodeling (C.V., S.S.P.), Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany; Institute of Neurology (K.H.P., M.M., K.D.); Department of Vascular and Endovascular Surgery, Klinikum Rechts der Isar, Technical University Munich, Germany (L.M.); Luxembourg Centre of Neuropathology (M.M.); Laboratoire National de Santé, Dudelange, Luxembourg (M.M.); Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette (M.M.); NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health (M.M.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Department of Internal Medicine, Member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany (R.T.S., N.W., S.S.P.); Department of Medicine, Duke University and Durham VA Medical Center, NC (F.J.M.); and German Center of Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt, Germany (M.S.L., C.F., I.J., J.H., J.E., P.H., F.M., Y.P., K.H.P., K.S., I.W., R.A.B., S.D., R.P.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.026991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491227PMC
July 2017

Organizers and activators: Cytosolic Nox proteins impacting on vascular function.

Free Radic Biol Med 2017 08 21;109:22-32. Epub 2017 Mar 21.

Institut für Kardiovaskuläre Physiologie, Goethe-Universität Frankfurt, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.03.017DOI Listing
August 2017

Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants.

Int J Mol Sci 2017 Mar 9;18(3). Epub 2017 Mar 9.

Pharmazentrum Frankfurt, Institut für Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe Universität, Theodor-Stern-Kai 7, Frankfurt am Main 60590, Germany.

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http://dx.doi.org/10.3390/ijms18030595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372611PMC
March 2017

Epigenetic control of microsomal prostaglandin E synthase-1 by HDAC-mediated recruitment of p300.

J Lipid Res 2017 02 2;58(2):386-392. Epub 2016 Dec 2.

Institute for Cardiovascular Physiology, Medical Faculty, Goethe-University Frankfurt, Frankfurt, Germany.

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http://dx.doi.org/10.1194/jlr.M072280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282954PMC
February 2017

CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity.

Redox Biol 2016 10 24;9:287-295. Epub 2016 Aug 24.

Institut für Kardiovaskuläre Physiologie, Goethe-Universität, 60590 Frankfurt am Main, Germany; German Center for Cardiovascular Research (DZHK), Partner site RheinMain, 60590 Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2016.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021817PMC
October 2016

A Buttery Taste to Vascular Biology: Endothelial Cells Generate and Release γ-Aminobutyric Acid.

Authors:
Ralf P Brandes

Circ Res 2016 08;119(5):577-9

From the Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe-Universität, Theodor-Stern Kai 7, 60590 Frankfurt, Germany.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.116.30944
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http://dx.doi.org/10.1161/CIRCRESAHA.116.309444DOI Listing
August 2016

The NADPH Oxidase Nox2 Mediates Vitamin D-Induced Vascular Regeneration in Male Mice.

Endocrinology 2016 Oct 11;157(10):4032-4040. Epub 2016 Jul 11.

Institute for Cardiovascular Physiology (M.S.L., A.B., M.S.K.W., V.H., R.P.B., K.S.), Goethe-University, Frankfurt, 60590 Germany; Cancer Research Institute BMC SAS (A.B.), Bratislava, 845 05 Slovakia; and Justus-Liebig Universität Giessen (N.W.), Giessen, 35392 Germany.

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http://dx.doi.org/10.1210/en.2016-1257DOI Listing
October 2016

The Cytosolic NADPH Oxidase Subunit NoxO1 Promotes an Endothelial Stalk Cell Phenotype.

Arterioscler Thromb Vasc Biol 2016 08 9;36(8):1558-65. Epub 2016 Jun 9.

From the Institute for Cardiovascular Physiology (R.P.B., S.H., C.S., I.J., B.R., F.R., O.L., F.M., J.E., K.S.), Pharmazentrum Frankfurt (J.E.), Institute for Biochemistry II (A.N.), and Neurological Institute (Edinger Institute) (C.P., M.M.), Goethe University, Frankfurt, Germany; Department of Physiology, Medical Faculty, TU Dresden, Dresden, Germany (I.K.); Justus-Liebig Universität Giessen, Giessen, Germany (N.W.); and German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt, Germany (R.P.B., C.S., I.J., F.R., O.L., F.M., K.S.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307132DOI Listing
August 2016

The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein.

J Biol Chem 2016 Mar 9;291(13):7045-59. Epub 2016 Feb 9.

From the Institut für Kardiovaskuläre Physiologie, Goethe-Universität, Frankfurt am Main, 60590 Germany, the German Center for Cardiovascular Research (DZHK), Partner site RheinMain, 60590 Frankfurt am Main, Germany

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http://www.jbc.org/content/early/2016/02/09/jbc.M115.710772.
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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.710772
Publisher Site
http://dx.doi.org/10.1074/jbc.M115.710772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807287PMC
March 2016

Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis.

Matrix Biol 2016 Jan 12;49:61-81. Epub 2015 Dec 12.

Pharmazentrum Frankfurt, Institut für Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2015.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953411PMC
January 2016

NOX4-dependent Hydrogen peroxide promotes shear stress-induced SHP2 sulfenylation and eNOS activation.

Free Radic Biol Med 2015 Dec 30;89:419-30. Epub 2015 Sep 30.

Centro de Biología Molecular "Severo Ochoa" CSIC-UAM, Campus Universidad Autónoma, E-28049 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.08.014DOI Listing
December 2015

The NADPH oxidase Nox4 has anti-atherosclerotic functions.

Eur Heart J 2015 Dec 17;36(48):3447-56. Epub 2015 Sep 17.

Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt, Germany

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http://eurheartj.oxfordjournals.org/content/ehj/early/2015/0
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http://eurheartj.oxfordjournals.org/lookup/doi/10.1093/eurhe
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http://dx.doi.org/10.1093/eurheartj/ehv460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751217PMC
December 2015

Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice.

Nat Commun 2015 Aug 10;6:7920. Epub 2015 Aug 10.

King's College London, Cardiovascular Division, The British Heart Foundation Centre of Excellence, The Rayne Institute, Saint Thomas' Hospital, London SE1 7EH, UK.

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http://dx.doi.org/10.1038/ncomms8920DOI Listing
August 2015

Molecular mechanisms of hypoxia-inducible factor-induced pulmonary arterial smooth muscle cell alterations in pulmonary hypertension.

J Physiol 2016 Mar 30;594(5):1167-77. Epub 2015 Sep 30.

Universities of Giessen and Marburg Lung Centre (UGMLC), member of the German Centre for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary System (ECCPS), 35392, Giessen, Germany.

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http://dx.doi.org/10.1113/JP270689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771790PMC
March 2016

Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling.

Arterioscler Thromb Vasc Biol 2015 Sep 23;35(9):1954-62. Epub 2015 Jul 23.

From the Institute for Cardiovascular Physiology, Goethe University, Frankfurt, Germany (C.K., K.P., R.P.B., C.F., U.R.M.); Walter-Brendel Center of Experimental Medicine, Ludwig-Maximilians University, Munich, Germany (A.R.M.K., M.S.); Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, and Sir Peter MacCallum Department of Oncology, Department of Pathology, Department of Molecular Biology and Biochemistry, The University of Melbourne, Parkville, Victoria, Australia (P.O.H.); and DZHK (German Centre for Cardiovascular Research), partner sites Rhine-Main and Munich, Germany (C.K., A.R.M.K., K.P., M.S., R.P.B., C.F., U.R.M.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305678DOI Listing
September 2015

Response to Pagano et al.

Antioxid Redox Signal 2015 Nov 14;23(15):1247-9. Epub 2015 Jul 14.

1 Institute for Cardiovascular Physiology, Goethe-University Frankfurt , Frankfurt, Germany .

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http://dx.doi.org/10.1089/ars.2015.6396DOI Listing
November 2015

Micro-CT Technique Is Well Suited for Documentation of Remodeling Processes in Murine Carotid Arteries.

PLoS One 2015 18;10(6):e0130374. Epub 2015 Jun 18.

Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe-Universität, Theodor-Stern-Kai 7, Frankfurt am Main, Germany; German Center for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130374PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472757PMC
April 2016

Response to letter regarding article, "Vitamin D promotes vascular regeneration".

Circulation 2015 06;131(22):e515-6

Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, GermanyGerman Center for Cardiovascular Research, Partner Site RheinMain, Frankfurt, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.014781DOI Listing
June 2015

Epigenetic Regulation of Angiogenesis by JARID1B-Induced Repression of HOXA5.

Arterioscler Thromb Vasc Biol 2015 Jul 28;35(7):1645-52. Epub 2015 May 28.

From the Institute for Cardiovascular Physiology, Medical Faculty (C.F., L.G., J.H., I.J., M.S.W., M.S.L., R.P.B.), Institutes of Vascular Signalling (J.H., I.F.) and Cardiovascular Regeneration (Y.P., S.U.), Centre for Molecular Medicine, and Institute of Pharmaceutical Chemistry/ZAFES (D.S.), Goethe-University Frankfurt, Frankfurt am Main, Germany; Biotech Research and Innovation Centre (BRIC) (M.A., S.U.S., K.H.), Centre for Epigenetics (M.A., S.U.S., K.H.), University of Copenhagen, Copenhagen, Denmark; and German Center for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany (C.F., L.G., J.H., I.J., M.S.W., Y.P., S.U., I.F., M.S.L., R.P.B.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305561DOI Listing
July 2015

The interaction between delayed rectifier channel alpha-subunits does not involve hetero-tetramer formation.

Naunyn Schmiedebergs Arch Pharmacol 2015 Sep 20;388(9):973-81. Epub 2015 Mar 20.

Division of Cardiology, Goethe-University, Theodor Stern Kai 7, 60590, Frankfurt, Germany.

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http://link.springer.com/10.1007/s00210-015-1108-3
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http://dx.doi.org/10.1007/s00210-015-1108-3DOI Listing
September 2015

Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8(+) T cell function by limiting GSH and Cys availability.

Free Radic Biol Med 2015 Jun 14;83:77-88. Epub 2015 Feb 14.

Institute of Biochemistry I-Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.02.004DOI Listing
June 2015

Hypoxia-dependent reactive oxygen species signaling in the pulmonary circulation: focus on ion channels.

Antioxid Redox Signal 2015 Feb;22(6):537-52

1 Excellence Cluster Cardiopulmonary System (ECCPS), Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL) , Giessen, Germany .

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http://dx.doi.org/10.1089/ars.2014.6234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322788PMC
February 2015

Nicotinamide adenine dinucleotide phosphate oxidase-4-dependent upregulation of nuclear factor erythroid-derived 2-like 2 protects the heart during chronic pressure overload.

Hypertension 2015 Mar 22;65(3):547-53. Epub 2014 Dec 22.

From the Department of Cardiology, Cardiovascular Division, King's College London British Heart Foundation Centre, London, United Kingdom (I.S., X.Z., M.Z., T.V.A.M., A.C.B., A.M.S.); and Vascular Research Centre, Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany (R.P.B., K.S.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04208DOI Listing
March 2015

NOXious phosphorylation: Smooth muscle reactive oxygen species production is facilitated by direct activation of the NADPH oxidase Nox1.

Circ Res 2014 Nov;115(11):898-900

From the Institute for Cardiovascular Physiology, Faculty of Medicine, Goethe-University, Frankfurt, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.114.305280DOI Listing
November 2014

Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells.

Basic Res Cardiol 2014 10;109(6):439. Epub 2014 Sep 10.

Institute for Cardiovascular Physiology, Medical Faculty, Goethe-University Frankfurt, Theodor Stern Kai 7, 60690, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s00395-014-0439-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330457PMC
May 2015

Nox family NADPH oxidases: Molecular mechanisms of activation.

Free Radic Biol Med 2014 Nov 23;76:208-26. Epub 2014 Aug 23.

Institut für Kardiovaskuläre Physiologie, Goethe-Universität Frankfurt, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.07.046DOI Listing
November 2014

Endothelial dysfunction and hypertension.

Authors:
Ralf P Brandes

Hypertension 2014 Nov 25;64(5):924-8. Epub 2014 Aug 25.

From the Fachbereich Medizin der Goethe-Universität, Institut für Kardiovaskuläre Physiologie, Frankfurt am Main, Germany.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.114.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03575DOI Listing
November 2014

Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity.

Pain 2014 Oct 17;155(10):2161-70. Epub 2014 Aug 17.

Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University Medical School, Frankfurt am Main, Germany; Institute of Pharmacology and Toxicology, ZBAF, Witten/Herdecke University, Witten, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pain.2014.08.013DOI Listing
October 2014

Laminar shear stress regulates mitochondrial dynamics, bioenergetics responses and PRX3 activation in endothelial cells.

Biochim Biophys Acta 2014 Nov 17;1843(11):2403-13. Epub 2014 Jul 17.

Centro de Biología Molecular 'Severo Ochoa' CSIC-UAM, Campus Universidad Autónoma, Nicolás Cabrera 1, E-28049 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2014.07.003DOI Listing
November 2014

Vitamin D promotes vascular regeneration.

Circulation 2014 Sep 11;130(12):976-86. Epub 2014 Jul 11.

From the Institute for Cardiovascular Physiology (M.S.K.W., M.S.L., C.K., J.V., C.S., K.S., R.P.B.), Institute of Biochemistry I (N.D., A.W., B.B.), Institute for Biostatistics and Mathematical Modeling (E.H.), Institute of Pharmaceutical Chemistry/Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit (D.S.), Goethe University, Frankfurt, Germany; German Center for Cardiovascular Research, Partner Site RheinMain, Frankfurt, Germany (M.S.L., C.K., C.S., E.H., S.O., K.S., R.P.B.); Cardiovascular Division, King's College London British Heart Foundation Center of Excellence, London, United Kingdom (A.M.S.); Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany (S.O.); Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium (G.C.); and Department of Endocrinology and Diabetes, Internal Medicine 1, University Hospital Frankfurt, Frankfurt, Germany (K.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.010650DOI Listing
September 2014

Phenotypic characterization of miR-92a-/- mice reveals an important function of miR-92a in skeletal development.

PLoS One 2014 30;9(6):e101153. Epub 2014 Jun 30.

Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, J. W. Goethe University Frankfurt, Frankfurt am Main, Germany; German Centre of Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt am Main, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101153PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076267PMC
February 2015

Sympathoactivation and rho-kinase-dependent baroreflex function in experimental renovascular hypertension with reduced kidney mass.

BMC Physiol 2014 Jun 19;14. Epub 2014 Jun 19.

Institute for Cardiovascular Physiology, Vascular Research Centre, Fachbereich Medizin, Goethe University, Frankfurt (Main), Germany.

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http://dx.doi.org/10.1186/1472-6793-14-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074138PMC
June 2014

SYNCRIP-dependent Nox2 mRNA destabilization impairs ROS formation in M2-polarized macrophages.

Antioxid Redox Signal 2014 Dec 29;21(18):2483-97. Epub 2014 Jul 29.

1 Faculty of Medicine, Institute of Biochemistry I-Pathobiochemistry, Goethe-University Frankfurt , Frankfurt, Germany .

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http://dx.doi.org/10.1089/ars.2013.5760DOI Listing
December 2014

Redox-mediated signal transduction by cardiovascular Nox NADPH oxidases.

J Mol Cell Cardiol 2014 Aug 19;73:70-9. Epub 2014 Feb 19.

Institut für Kardiovaskuläre Physiologie, Goethe-Universität Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.yjmcc.2014.02.006DOI Listing
August 2014

Inhalation of the BK(Ca)-opener NS1619 attenuates right ventricular pressure and improves oxygenation in the rat monocrotaline model of pulmonary hypertension.

PLoS One 2014 31;9(1):e86636. Epub 2014 Jan 31.

Department of Anesthesiology and Critical Care Medicine, University Hospital Mannheim, Faculty of Medicine, University of Heidelberg, Heidelberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086636PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909005PMC
October 2014

Endo-PDI is required for TNFα-induced angiogenesis.

Free Radic Biol Med 2013 Dec 5;65:1398-1407. Epub 2013 Oct 5.

Institut für Kardiovaskuläre Physiologie, Goethe-Universität, 60590 Frankfurt am Main, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08915849130063
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http://dx.doi.org/10.1016/j.freeradbiomed.2013.09.028DOI Listing
December 2013

L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects.

Hypertension 2013 Dec 30;62(6):1098-104. Epub 2013 Sep 30.

Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.01986DOI Listing
December 2013

Do not overcharge the system or it will explode!: how mitochondrial uncoupling protein 2 maintains endothelial function.

Authors:
Ralf P Brandes

Circ Res 2013 Sep;113(7):846-8

From the Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe-Universität, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.113.302127DOI Listing
September 2013

Targeting inflammation and oxidative stress in atrial fibrillation: role of 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibition with statins.

Antioxid Redox Signal 2014 Mar 19;20(8):1268-85. Epub 2013 Oct 19.

1 Department of Cardiovascular Medicine, University of Oxford , John Radcliffe Hospital, Oxford, United Kingdom .

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http://dx.doi.org/10.1089/ars.2013.5542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934546PMC
March 2014

Function of NADPH oxidase 1 in pulmonary arterial smooth muscle cells after monocrotaline-induced pulmonary vascular remodeling.

Antioxid Redox Signal 2013 Dec 20;19(18):2213-31. Epub 2013 Jul 20.

1 Excellencecluster Cardio-Pulmonary System (ECCPS), German Lung Center (DZL), Universities of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University Giessen , Giessen, Germany .

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http://dx.doi.org/10.1089/ars.2012.4904DOI Listing
December 2013

Nox family NADPH oxidases in mechano-transduction: mechanisms and consequences.

Antioxid Redox Signal 2014 Feb 5;20(6):887-98. Epub 2013 Jul 5.

1 Institut für Kardiovaskuläre Physiologie, Goethe-Universität Frankfurt , Frankfurt am Main, Germany .

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http://dx.doi.org/10.1089/ars.2013.5414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924808PMC
February 2014

Monoamine oxidases are mediators of endothelial dysfunction in the mouse aorta.

Hypertension 2013 Jul 13;62(1):140-6. Epub 2013 May 13.

Institut für Kardiovaskuläre Physiologie, Goethe-Universität, Frankfurt, Germany.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.01314DOI Listing
July 2013

Anti-atherosclerotic mechanisms of statin therapy.

Curr Opin Pharmacol 2013 Apr 9;13(2):260-4. Epub 2013 Feb 9.

Institut für Kardiovaskuläre Physiologie, Goethe-Universität, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.coph.2013.01.004DOI Listing
April 2013

The polarity protein Scrib is essential for directed endothelial cell migration.

Circ Res 2013 Mar 29;112(6):924-34. Epub 2013 Jan 29.

Institut für Kardiovaskuläre Physiologie, Goethe-Universität, Theodor-Stern-Kai 7, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.112.300592DOI Listing
March 2013

NADPH oxidase-4 maintains neuropathic pain after peripheral nerve injury.

J Neurosci 2012 Jul;32(30):10136-45

Pharmazentrum Frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe-Universität, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.6227-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703722PMC
July 2012

Role of Nox4 in murine models of kidney disease.

Free Radic Biol Med 2012 Aug 27;53(4):842-53. Epub 2012 Jun 27.

Institut für Kardiovaskuläre Physiologie, Goethe-Universität Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.freeradbiomed.2012.06.027DOI Listing
August 2012

Which NADPH oxidase isoform is relevant for ischemic stroke? The case for nox 2.

Antioxid Redox Signal 2013 Apr 20;18(12):1400-17. Epub 2012 Aug 20.

Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe-Universität , Frankfurt am Main, Germany .

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http://dx.doi.org/10.1089/ars.2012.4721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603497PMC
April 2013

NADPH oxidases as therapeutic targets in ischemic stroke.

Cell Mol Life Sci 2012 Jul 23;69(14):2345-63. Epub 2012 May 23.

Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe-Universität, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s00018-012-1011-8DOI Listing
July 2012