Ralf Kittler

Ralf Kittler

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Ralf Kittler

Ralf Kittler

Publications by authors named "Ralf Kittler"

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Targeting the turnover of oncoproteins as a new avenue for therapeutics development in castration-resistant prostate cancer.

Cancer Lett 2018 12 11;438:86-96. Epub 2018 Sep 11.

Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186492PMC
December 2018

PPARγ-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice.

Proc Natl Acad Sci U S A 2018 11 12;115(48):12102-12111. Epub 2018 Nov 12.

Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390;

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http://dx.doi.org/10.1073/pnas.1814522115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275522PMC
November 2018

FoxA transcription factor Fork head maintains the intestinal stem/progenitor cell identities in Drosophila.

Dev Biol 2018 01 3;433(2):324-343. Epub 2017 Nov 3.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00121606173032
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http://dx.doi.org/10.1016/j.ydbio.2017.09.002DOI Listing
January 2018

Identification of the Underlying Androgen Receptor Defect in the Dallas Reifenstein Family.

J Endocr Soc 2017 Jul 19;1(7):836-842. Epub 2017 May 19.

Division of Endocrinology and Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75390.

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http://dx.doi.org/10.1210/js.2017-00124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686667PMC
July 2017

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.

Cell Rep 2017 05;19(8):1669-1684

Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531293PMC
May 2017

Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma.

Cell Rep 2017 01;18(4):961-976

Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Annette G. Strauss Center for Neuro-Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.12.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321610PMC
January 2017

The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.

Oncotarget 2016 Oct;7(40):64921-64931

Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.11915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323126PMC
October 2016

HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing.

Mol Cell 2016 08 14;63(3):420-32. Epub 2016 Jul 14.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; International Institute for Integrated Sleep Medicine, University of Tsukuba, Tsukuba 305-8575, Japan; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975613PMC
August 2016

Harnessing the nuclear receptor PPARγ to inhibit the growth of lung adenocarcinoma by rewiring metabolic circuitries.

Mol Cell Oncol 2015 Apr-Jun;2(2):e980660. Epub 2015 Jan 20.

Eugene McDermott Center for Human Growth and Development; The University of Texas Southwestern Medical Center; Dallas, TX USA; Simmons Comprehensive Cancer Center; The University of Texas Southwestern Medical Center; Dallas, TX USA; Department of Pharmacology; The University of Texas Southwestern Medical Center; Dallas, TX USA; Green Center for Reproductive Biology Sciences; The University of Texas Southwestern Medical Center; Dallas, TX USA.

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http://dx.doi.org/10.4161/23723556.2014.980660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905022PMC
June 2016

Minireview: Familiar Faces in Unfamiliar Places: The Emerging Role of Nuclear Receptors in Lung Cancer.

Mol Endocrinol 2015 Dec 20;29(12):1675-83. Epub 2015 Oct 20.

Eugene McDermott Center for Human Growth and Development (P.Y., R.K.), Hamon Center for Therapeutic Oncology Research (P.Y., R.K.), Simmons Comprehensive Cancer Center (R.K.), Department of Pharmacology (R.K.), and Green Center for Reproductive Biology Sciences (R.K.), The University of Texas Southwestern Medical Center, Dallas, Texas 75390.

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http://dx.doi.org/10.1210/me.2015-1199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414662PMC
December 2015

Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin.

Cell Rep 2015 Oct 8;13(3):495-503. Epub 2015 Oct 8.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618234PMC
October 2015

An integrated functional genomic analysis identifies the antitumorigenic mechanism of action for PPARγ in lung cancer cells.

Genom Data 2015 Mar 5;3:80-6. Epub 2014 Dec 5.

Eugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA ; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA ; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA ; Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.gdata.2014.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535999PMC
March 2015

TCF4 Triplet Repeat Expansion and Nuclear RNA Foci in Fuchs' Endothelial Corneal Dystrophy.

Invest Ophthalmol Vis Sci 2015 Feb 26;56(3):2003-11. Epub 2015 Feb 26.

Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, United States.

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http://dx.doi.org/10.1167/iovs.14-16222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373545PMC
February 2015

Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels.

Cell Metab 2014 Oct 25;20(4):650-61. Epub 2014 Sep 25.

Eugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191999PMC
October 2014

Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.

Proc Natl Acad Sci U S A 2014 Mar 3;111(11):4251-6. Epub 2014 Mar 3.

Eugene McDermott Center for Human Growth and Development, Departments of Urology, Pathology, and Phamacology, Simmons Comprehensive Cancer Center, and Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390.

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http://dx.doi.org/10.1073/pnas.1322198111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964108PMC
March 2014

Lsd1 restricts the number of germline stem cells by regulating multiple targets in escort cells.

PLoS Genet 2014 Mar 13;10(3):e1004200. Epub 2014 Mar 13.

Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952827PMC
March 2014

A comprehensive nuclear receptor network for breast cancer cells.

Cell Rep 2013 Feb 31;3(2):538-51. Epub 2013 Jan 31.

Institute of Genomics and Systems Biology, Argonne National Laboratory, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.01.004DOI Listing
February 2013

Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer.

Proc Natl Acad Sci U S A 2012 Dec 3;109(51):21058-63. Epub 2012 Dec 3.

Touchstone Diabetes Center and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.1214400109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529089PMC
December 2012

Consequences of eukaryotic enhancer architecture for gene expression dynamics, development, and fitness.

PLoS Genet 2011 Nov 10;7(11):e1002364. Epub 2011 Nov 10.

Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America.

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http://dx.plos.org/10.1371/journal.pgen.1002364
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http://dx.doi.org/10.1371/journal.pgen.1002364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213169PMC
November 2011

Allele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations.

PLoS Genet 2010 Oct 28;6(10):e1001178. Epub 2010 Oct 28.

Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1001178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965758PMC
October 2010

Genomic antagonism between retinoic acid and estrogen signaling in breast cancer.

Cell 2009 Jun;137(7):1259-71

Institute for Genomics and Systems Biology and Department of Human Genetics, The University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.cell.2009.04.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374131PMC
June 2009

Systems biology of mammalian cell division.

Cell Cycle 2008 Jul 21;7(14):2123-8. Epub 2008 May 21.

Department of Human Genetics and Institute of Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.4161/cc.7.14.6322DOI Listing
July 2008

The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis.

Curr Biol 2008 Jan;18(2):136-41

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1016/j.cub.2007.12.055DOI Listing
January 2008

Genome-scale RNAi profiling of cell division in human tissue culture cells.

Nat Cell Biol 2007 Dec 11;9(12):1401-12. Epub 2007 Nov 11.

Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D-01307 Dresden, Germany.

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http://dx.doi.org/10.1038/ncb1659DOI Listing
December 2007

Enzymatically prepared RNAi libraries.

Nat Methods 2006 Sep;3(9):696-700

Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D-01307 Dresden, Germany.

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http://dx.doi.org/10.1038/nmeth912DOI Listing
September 2006

Evaluation of saliva as a source of human DNA for population and association studies.

Anal Biochem 2006 Jun 30;353(2):272-7. Epub 2006 Mar 30.

Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany.

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http://dx.doi.org/10.1016/j.ab.2006.03.021DOI Listing
June 2006

Production of endoribonuclease-prepared short interfering RNAs for gene silencing in mammalian cells.

Nat Methods 2005 Oct;2(10):779-84

Max-Planck-Institute for Molecular Cell Biology and Genetics, Dresden, Germany.

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http://dx.doi.org/10.1038/nmeth1005-779DOI Listing
October 2005

Functional genomic analysis of cell division by endoribonuclease-prepared siRNAs.

Cell Cycle 2005 Apr 19;4(4):564-7. Epub 2005 Apr 19.

Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

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April 2005

RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells.

Proc Natl Acad Sci U S A 2005 Feb 3;102(7):2396-401. Epub 2005 Feb 3.

Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0409861102
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http://dx.doi.org/10.1073/pnas.0409861102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548992PMC
February 2005

A comprehensive survey of human Y-chromosomal microsatellites.

Am J Hum Genet 2004 Jun;74(6):1183-97

Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

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http://dx.doi.org/10.1086/421531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182082PMC
June 2004

Tissue-specific RNA interference in post-implantation mouse embryos using directional electroporation and whole embryo culture.

Differentiation 2004 Mar;72(2-3):92-102

Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D-01307, Dresden, Germany.

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http://dx.doi.org/10.1111/j.1432-0436.2004.07202002.xDOI Listing
March 2004

Molecular evolution of Pediculus humanus and the origin of clothing.

Curr Biol 2003 Aug;13(16):1414-7

Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany.

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http://www.headlice.org/news/2003/louseorigins-stoneking.pdf
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http://dx.doi.org/10.1016/s0960-9822(03)00507-4DOI Listing
August 2003

RNA interference: gene silencing in the fast lane.

Semin Cancer Biol 2003 Aug;13(4):259-65

Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauer Strasse 108, D-01307 Dresden, Germany.

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August 2003

Apparent intrachromosomal exchange on the human Y chromosome explained by population history.

Eur J Hum Genet 2003 Apr;11(4):304-14

Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher platz 6, D-04103 Leipzig, Germany.

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http://dx.doi.org/10.1038/sj.ejhg.5200960DOI Listing
April 2003

A whole genome amplification method to generate long fragments from low quantities of genomic DNA.

Anal Biochem 2002 Jan;300(2):237-44

Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D-04103 Leipzig, Germany.

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http://dx.doi.org/10.1006/abio.2001.5460DOI Listing
January 2002