Publications by authors named "Ralf Ketter"

55Publications

miRNA-26a expression influences the therapy response to carmustine wafer implantation in patients with glioblastoma multiforme.

Acta Neurochir (Wien) 2019 11 2;161(11):2299-2309. Epub 2019 Sep 2.

Department of Neurosurgery, Faculty of Medicine, Saarland University, Geb. 90 Kirrbergerstr, 66424, Homburg/Saar, Germany.

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http://dx.doi.org/10.1007/s00701-019-04051-8DOI Listing
November 2019

The Influence of Distinct Regulatory miRNAs of the p15/p16/RB1/E2F Pathway on the Clinical Progression of Glioblastoma Multiforme.

World Neurosurg 2019 Dec 24;132:e900-e908. Epub 2019 Jul 24.

Department of Neurosurgery, University of Saarland, Faculty of Medicine, Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.wneu.2019.07.134DOI Listing
December 2019

Incidence, mortality and outcome of meningiomas: A population-based study from Germany.

Cancer Epidemiol 2019 10 17;62:101562. Epub 2019 Jul 17.

Department of Neurosurgery, Saarland University, D-66421 Homburg/Saar, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.canep.2019.07.001DOI Listing
October 2019

Deletions in the 17q chromosomal region and their influence on the clonal cytogenetic evolution of recurrent meningiomas.

Mol Cytogenet 2019 24;12:22. Epub 2019 May 24.

Department of Neurosurgery, Saarland University Hospital, Kirrberger Straße, 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.1186/s13039-019-0434-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534836PMC
May 2019

Fluorescence imaging of meningioma cells with somatostatin receptor ligands: an in vitro study.

Acta Neurochir (Wien) 2019 05 15;161(5):1017-1024. Epub 2019 Mar 15.

Klinik für Neurochirurgie, Universitätsklinikum des Saarlandes, 66421, Homburg, Saar, Germany.

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http://dx.doi.org/10.1007/s00701-019-03872-xDOI Listing
May 2019

MiRNA-181d Expression Significantly Affects Treatment Responses to Carmustine Wafer Implantation.

Neurosurgery 2019 07;85(1):147-155

Department of Neurosurgery, Faculty of Medicine, University of Saarland, Kirrbergerstraße, Homburg/ Saar, Germany.

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http://dx.doi.org/10.1093/neuros/nyy214DOI Listing
July 2019

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

Promoter methylation of , , , and and their impact on the clinical course of pilocytic astrocytomas.

Oncol Lett 2018 Feb 24;15(2):1600-1606. Epub 2017 Nov 24.

Department of Neurosurgery, University of Saarland, Faculty of Medicine, Homburg/Saar, D-66424 Homburg, Germany.

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http://www.spandidos-publications.com/10.3892/ol.2017.7490
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http://dx.doi.org/10.3892/ol.2017.7490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776924PMC
February 2018

Importance of biomarkers in glioblastomas patients receiving local BCNU wafer chemotherapy.

Mol Cytogenet 2017 4;10:16. Epub 2017 May 4.

Department of Neurosurgery, Saarland University, 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.1186/s13039-017-0317-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418867PMC
May 2017

Prognosis of meningiomas in the early 1970s and today.

Clin Neurol Neurosurg 2016 Oct 3;149:98-103. Epub 2016 Aug 3.

Klinik für Neurochirurgie, Universitätsklinikum des Saarlandes, 66421 Homburg, Saar, Germany.

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http://dx.doi.org/10.1016/j.clineuro.2016.08.007DOI Listing
October 2016

Tumor antigen-specific T cells for immune monitoring of dendritic cell-treated glioblastoma patients.

Cytotherapy 2016 09 14;18(9):1146-61. Epub 2016 Jul 14.

Institute of Clinical Hemostaseology and Transfusion Medicine, Saarland University Medical Center, Homburg, Germany.

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http://dx.doi.org/10.1016/j.jcyt.2016.05.014DOI Listing
September 2016

Long-term analysis of the NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with PCV or temozolomide.

Neuro Oncol 2016 11 1;18(11):1529-1537. Epub 2016 Jul 1.

Department of Neurology Clinic, University of Heidelberg, Heidelberg, Germany (W.W., A.W., M.P., B.W.); Clinical Cooperation Unit (CCU Neurooncology), German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany (W.W., B.W.); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (P.R., C.H., M.W.); Department of Neuropathology, Hannover Medical School, Hannover, Germany (C.H.); Department of Neurology, Regensburg University, Regensburg, Germany (P.H.); Department of Neurosurgery Clinic, Hannover Medical School, Hannover, Germany (M.N.); Department of Neurosurgery Clinic, Charité, Berlin, Germany (F.S., P.V.); Department of Neurosurgery, Heinrich Heine University, Düsseldorf, Germany (M.C.S.); Department of Neurology Clinic, Essen Medical Center, Essen, Germany (S.K.); Department of Neurosurgery Clinic, Saarland University, Homburg, Germany (R.K.); Department of Neurosurgery Clinic, University of Göttingen, Göttingen, Germany (F.S.); Department of Neurosurgery Clinic, University of Erlangen, Erlangen, Germany (I.E.); Department of Neurosurgery Clinic, University of Jena, Jena, Germany (R.K.); Department of Neurology Clinic, Cologne University, Cologne, Germany (N.G.); Department of Neurology Clinic, TU Munich, Munich, Germany (F.S.-G.); Department of Neuropathology, University of Heidelberg, Heidelberg, Germany (A.v.D.); CCU Neuropathology, (C.H., A.v.D.); CCU Brain Tumor Immunology, DKFZ, all Heidelberg, Germany (M.P.); Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany (G.R.); DKTK partner site Essen/Düsseldorf, Düsseldorf, Germany (G.R.), Department of General Neurology, Tübingen, Germany (W.W., A.W., F.S.-G., M.P., M.W.), Department of Radiation Oncology, Tübingen, Germany (M.B.), Department of Medical Biometry, University Hospital Tübingen, Tübingen, Germany (C.M.).

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http://dx.doi.org/10.1093/neuonc/now133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063521PMC
November 2016

Complete resection of contrast-enhancing tumor volume is associated with improved survival in recurrent glioblastoma-results from the DIRECTOR trial.

Neuro Oncol 2016 Apr 27;18(4):549-56. Epub 2016 Jan 27.

Department of Neurosurgery, Ludwig-Maximilians University Munich, Munich, Germany (B.S., J.C.T.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W., G.T., H.-G.W.); Department of Neurology, University Hospital Tübingen, Tübingen, Germany (G.T.); Department of Neurosurgery, University Hospital Frankfurt, Frankfurt am Main, Germany (C.S.); Department of Neurology, University Hospital Regensburg, Regensburg, Germany (P.H.); Department of Neurosurgery, University Hospital Düsseldorf, Düsseldorf, Germany (M.C.S.); Department of Neurology, University Hospital Bonn, Bonn, Germany (U.H.); Department of Neurosurgery, University Hospital Saarland, Homburg/Saar, Germany (R.K.); Department of Neurology, Knappschaftskrankenhaus Bochum, Bochum, Germany (U.S.); Department of Oncology, Vienna General Hospital, Vienna, Austria (C.M.); Institute of Neuropathology, University Hospital Düsseldorf, Düsseldorf, Germany (G.R.); Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany (W.W.).

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http://neuro-oncology.oxfordjournals.org/content/early/2016/
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http://neuro-oncology.oxfordjournals.org/lookup/doi/10.1093/
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http://dx.doi.org/10.1093/neuonc/nov326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799687PMC
April 2016

TERT Promoter Mutations and Risk of Recurrence in Meningioma.

J Natl Cancer Inst 2016 May 13;108(5). Epub 2015 Dec 13.

Affiliations of authors:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg , Heidelberg , Germany (FS, DS, CK, DR, JB, AK, DC, SS, AvD); Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg , Germany (FS, DS, CK, DR, AK, DC, AvD); Department of Pathology (AO), Department of Genomic Medicine (QW), Department of Radiation Oncology (QW, EPS), and Department of Bioinformatics and Computational Biology (QW), The University of Texas MD Anderson Cancer Center , Houston, TX ; Department of Radiation Oncology (SA, JD) and Department of Neurosurgery (MSc, TU, CHM), University Hospital Heidelberg , Heidelberg , Germany ; Department of Neuropathology, Charité Medical University , Berlin , Germany (AK); Department of Pathology, University Hospital Nürnberg , Nürnberg , Germany (AFO): Department of Neurosurgery, Medical Faculty of the Ruprecht-Karls-University of Heidelberg , Mannheim , Germany (SB); Department of Neuropathology, Institute of Pathology and Neuropathology, University Tübingen , Tübingen , Germany (JS); Department of Neuropathology, University of Bonn , Bonn , Germany (AB); Department of Neurosurgery (BB) and Institute of Neuropathology (WP), University Hospital Münster , Münster , Germany (BB); Department of Neurosurgery, University Hospital Bonn , Bonn , Germany (KG, MSi); Department of Neurosurgery, University Hospital Würzburg , Würzburg , Germany (AFK); Department of Neurosurgery, University Hospital Hamburg , Hamburg , Germany (KL); Department of Neuropathology, Otto von Guericke University Magdeburg , Magdeburg , Germany (CM); Institute of Pathology, Saarland University , Homburg, Saarland , Germany (YJK); Department of Neurosurgery, Saarland University , Homburg , Germany (RK); MacFeeters-Hamilton Brain Tumour Centre, Princess Margaret Cancer Center , Toronto, Ontario , Canada (KDA); Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg , Germany (TH).

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http://dx.doi.org/10.1093/jnci/djv377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849806PMC
May 2016

Establishment of a molecular cytogenetic analysis for native tumor tissue of meningiomas-suitable for clinical application.

Mol Cytogenet 2014 Feb 5;7(1):12. Epub 2014 Feb 5.

Department of Neurosurgery, Saarland University, Homburg/Saar D-66421, Germany.

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http://dx.doi.org/10.1186/1755-8166-7-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937053PMC
February 2014

Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation.

Neurology 2013 Oct 25;81(17):1515-22. Epub 2013 Sep 25.

From the Departments of Neuro-oncology (W.W., M.P., A.S., B.W., M. Weiler) and Neuropathology (A.v.D.), University of Heidelberg; German Cancer Consortium (DKTK) (W.W., B.W., M. Weiler), Clinical Cooperation Unit Neuro-oncology and Clinical Cooperation Unit Neuropathology (A.v.D.), German Cancer Research Center, Heidelberg; Department of Medical Biometry (C.M.), University of Tübingen; Institute for Medical Informatics, Statistics and Epidemiology (B.H., M.L.), University Leipzig; Departments of Neurosurgery (M.C.S.) and Neuropathology (G.R.), Heinrich-Heine-University and DKTK (G.R.), Düsseldorf; Department of Neurology (S.K.), University of Essen Medical School; Department of Neurosurgery (R.K.), Saarland University, Homburg, Germany; Department of Neurology (G.T., D.G., M. Weller), University Hospital Zurich, Switzerland; Department of Neurosurgery (M. Westphal), University Clinic Hamburg Eppendorf, Hamburg; Department of Neurosurgery (G.S.) and DKTK (G.S.), Technical University Dresden; and Department of Neurosurgery (M.S.), University of Bonn, Germany.

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http://dx.doi.org/10.1212/WNL.0b013e3182a95680DOI Listing
October 2013

Red blood cell transfusion in neurosurgery.

Acta Neurochir (Wien) 2012 Jul 15;154(7):1303-8. Epub 2012 May 15.

Department of Neurosurgery, Saarland University, 66421, Homburg, Saarland, Germany.

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http://dx.doi.org/10.1007/s00701-012-1373-6DOI Listing
July 2012

Toxicity after radiochemotherapy for glioblastoma using temozolomide--a retrospective evaluation.

Radiat Oncol 2011 Oct 21;6:141. Epub 2011 Oct 21.

Department of Radiotherapy, Saarland University Hospital, Kirrberger Strasse, D-66421 Homburg, Germany.

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http://dx.doi.org/10.1186/1748-717X-6-141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213071PMC
October 2011

Clonal cytogenetic progression within intratumorally heterogeneous meningiomas predicts tumor recurrence.

Int J Oncol 2011 Dec 12;39(6):1601-8. Epub 2011 Sep 12.

Department of Neurosurgery, Saarland University, D-66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.3892/ijo.2011.1199DOI Listing
December 2011

Prospective study of p-[123I]iodo-L-phenylalanine and SPECT for the evaluation of newly diagnosed cerebral lesions: specific confirmation of glioma.

Eur J Nucl Med Mol Imaging 2010 Dec 30;37(12):2344-53. Epub 2010 Jul 30.

Department of Nuclear Medicine, Saarland University Medical Center, 66421, Homburg/Saar, Germany.

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http://dx.doi.org/10.1007/s00259-010-1572-4DOI Listing
December 2010

Amplicons on chromosome 12q13-21 in glioblastoma recurrences.

Int J Cancer 2010 Jun;126(11):2594-602

Department of Human Genetics, Saarland University, 66421 Homburg/Saar, Germany.

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http://doi.wiley.com/10.1002/ijc.24971
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http://dx.doi.org/10.1002/ijc.24971DOI Listing
June 2010

p15 promoter methylation - a novel prognostic marker in glioblastoma patients.

Int J Oncol 2009 Jun;34(6):1743-8

Department of Neurosurgery, Saarland University, D-66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.3892/ijo_00000305DOI Listing
June 2009

Ultrasonic radio-frequency spectrum analysis differentiates normal and edematous brain tissue from meningioma intraoperatively.

J Neuroimaging 2008 Jan;18(1):73-80

Department of Neurosurgery, Saarland University Medical School, Homburg-Saar, Germany.

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http://dx.doi.org/10.1111/j.1552-6569.2007.00173.xDOI Listing
January 2008

Intra-individual comparison of p-[123I]-iodo-L-phenylalanine and L-3-[123I]-iodo-alpha-methyl-tyrosine for SPECT imaging of gliomas.

Eur J Nucl Med Mol Imaging 2008 Jan 11;35(1):24-31. Epub 2007 Sep 11.

Department of Nuclear Medicine, Saarland University Medical Center, 66421, Homburg, Germany.

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http://dx.doi.org/10.1007/s00259-007-0514-2DOI Listing
January 2008

Prognostic significance of the mitotic index using the mitosis marker anti-phosphohistone H3 in meningiomas.

Am J Clin Pathol 2007 Jul;128(1):118-25

Institute of Neuropathology, Saarland University, School of Medicine, Homburg/Saar, Germany.

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http://dx.doi.org/10.1309/HXUNAG34B3CEFDU8DOI Listing
July 2007

Hyperdiploidy defines a distinct cytogenetic entity of meningiomas.

J Neurooncol 2007 Jun 17;83(2):213-21. Epub 2007 Jan 17.

Neurosurgical Clinic, Saarland University, Homburg/Saar, Germany.

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http://dx.doi.org/10.1007/s11060-006-9318-7DOI Listing
June 2007

Histopathologic indicators of recurrence in meningiomas: correlation with clinical and genetic parameters.

Virchows Arch 2006 Nov 3;449(5):529-38. Epub 2006 Oct 3.

School of Medicine, Institute of Neuropathology, Saarland University, Bldg. 90.3, 66421 Homburg-Saar, Germany.

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http://dx.doi.org/10.1007/s00428-006-0285-3DOI Listing
November 2006

Intratumoral genetic heterogeneity in pilocytic astrocytomas revealed by CGH-analysis of microdissected tumor cells and FISH on tumor tissue sections.

Int J Oncol 2006 Feb;28(2):353-60

Department of Neurosurgery, Saarland University, D-66421 Homburg/Saar, Germany.

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February 2006

Validation of brain tumour imaging with p-[123I]iodo-L-phenylalanine and SPECT.

Eur J Nucl Med Mol Imaging 2005 Sep 18;32(9):1041-9. Epub 2005 May 18.

Department of Nuclear Medicine, Saarland University Medical Center, 66421 Homburg/Saar, Germany.

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http://link.springer.com/10.1007/s00259-005-1807-y
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http://dx.doi.org/10.1007/s00259-005-1807-yDOI Listing
September 2005

Interstitial loss and gain of sequences on chromosome 22 in meningiomas with normal karyotype.

Int J Oncol 2005 Feb;26(2):385-93

Department of Neurosurgery, Neuro-Oncology, Saarland University, D-66421 Homburg, Germany.

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February 2005

Evidence for gains at 15q and 20q in brain metastases of prostate cancer.

Cancer Genet Cytogenet 2004 Oct;154(2):119-23

Department of Urology and Pediatric Urology, University of the Saarland, 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.cancergencyto.2004.01.005DOI Listing
October 2004

Nasoethmoidal meningioma with cytogenetic features of tumor aggressiveness in a 16-year-old child.

Pediatr Neurosurg 2003 Oct;39(4):190-4

Department of Neurosurgery, Saarland University, Homburg/Saar, Germany.

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http://dx.doi.org/10.1159/000072470DOI Listing
October 2003

Monosomy 7p in meningiomas: a rare constituent of tumor progression.

Cancer Genet Cytogenet 2003 Jul;144(1):65-8

Institute of Human Genetics, Saarland University, Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/s0165-4608(02)00871-3DOI Listing
July 2003

Analysis of the antibody repertoire of astrocytoma patients against antigens expressed by gliomas.

Int J Cancer 2002 Mar;98(1):73-7

Department of Medicine, Saarland University Medical School, Homburg, Germany.

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http://dx.doi.org/10.1002/ijc.10170DOI Listing
March 2002