Ralf J Ludwig

Ralf J Ludwig

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Ralf J Ludwig

Ralf J Ludwig

Publications by authors named "Ralf J Ludwig"

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100Publications

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Induction of Hypergammaglobulinemia and Autoantibodies by Infection in MyD88-Deficient Mice.

Front Immunol 2018 20;9:1384. Epub 2018 Jun 20.

Department of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.

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June 2018

TNF-α -308G/A gene polymorphism in bullous pemphigoid and alopecia areata.

Hum Antibodies 2018 May 11. Epub 2018 May 11.

Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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May 2018

Regulatory T-cell deficiency leads to pathogenic bullous pemphigoid antigen 230 autoantibody and autoimmune bullous disease.

J Allergy Clin Immunol 2018 Apr 26. Epub 2018 Apr 26.

Department of Dermatology, Ruprecht-Karls University Heidelberg, Heidelberg, Germany. Electronic address:

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April 2018

Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice.

Front Immunol 2018 16;9:535. Epub 2018 Mar 16.

Institute of Genetics, Department of Biology, University of Erlangen-Nuremberg, Erlangen, Germany.

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March 2018

The Anti-C1s Antibody TNT003 Prevents Complement Activation in the Skin Induced by Bullous Pemphigoid Autoantibodies.

J Invest Dermatol 2018 Feb 9;138(2):458-461. Epub 2017 Sep 9.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany; Department of Dermatology University of Lübeck, Lübeck, Germany.

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February 2018

IgE-Selective Immunoadsorption for Severe Atopic Dermatitis.

Front Med (Lausanne) 2018 12;5:27. Epub 2018 Feb 12.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

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February 2018

Targeting IgE Antibodies by Immunoadsorption in Atopic Dermatitis.

Front Immunol 2018 19;9:254. Epub 2018 Feb 19.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

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February 2018

Signalling and targeted therapy of inflammatory cells in epidermolysis bullosa acquisita.

Authors:
Ralf J Ludwig

Exp Dermatol 2017 Dec 9;26(12):1179-1186. Epub 2017 May 9.

Lübeck Institute of Experimental Dermatology and Department of Dermatology, University of Lübeck, Lübeck, Germany.

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December 2017

Analysis of serum markers of cellular immune activation in patients with bullous pemphigoid.

Exp Dermatol 2017 Dec 15;26(12):1248-1252. Epub 2017 Aug 15.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

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December 2017

New insights into pemphigoid diseases.

Exp Dermatol 2017 Dec;26(12):1151-1153

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

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December 2017

CCL3/MIP1α represents a biomarker but not a mandatory cytokine for disease development in experimental epidermolysis bullosa acquisita.

J Dermatol Sci 2017 Nov 30;88(2):248-250. Epub 2017 Jun 30.

Department of Dermatology, University of Lübeck, Lübeck, Germany; Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

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November 2017

Increased TREM-1 expression in inflamed skin has no functional impact on the pathogenesis of cutaneous disorders.

J Dermatol Sci 2017 Oct 30;88(1):152-155. Epub 2017 May 30.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Germany; Institute of Anatomy, University of Lübeck, Germany; Lübeck Institute of Experimental Dermatology, University of Lübeck, Germany.

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October 2017

In vivo enzymatic modulation of IgG antibodies prevents immune complex-dependent skin injury.

Exp Dermatol 2017 08 15;26(8):691-696. Epub 2016 Dec 15.

Department of Biology, Institute of Genetics, University of Erlangen-Nuremberg, Erlangen, Germany.

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August 2017

Nadroparin carries a potentially high risk of inducing cutaneous delayed-type hypersensitivity responses.

Contact Dermatitis 2017 Jul 14;77(1):35-41. Epub 2017 Mar 14.

Department of Dermatology and Lübeck Institute of Experimental Dermatology, University of Lübeck, 23538, Lübeck, Germany.

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July 2017

Matrix meets inflammation and DNA repair: Meeting report of the third ADF Round Table.

Exp Dermatol 2017 05;26(5):464-466

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

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May 2017

The genetic difference between C57Bl/6J and C57Bl/6N mice significantly impacts Aldara™-induced psoriasiform dermatitis.

Exp Dermatol 2017 04 20;26(4):349-351. Epub 2016 Dec 20.

Department of Dermatology, Allergy, and Venereology, University of Lübeck, Lübeck, Germany.

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April 2017

Clinical features and diagnosis of epidermolysis bullosa acquisita.

Expert Rev Clin Immunol 2017 Feb 8;13(2):157-169. Epub 2016 Sep 8.

a Department of Dermatology , University of Lübeck , Lübeck , Germany.

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February 2017

Topically Applied Hsp90 Blocker 17AAG Inhibits Autoantibody-Mediated Blister-Inducing Cutaneous Inflammation.

J Invest Dermatol 2017 02 19;137(2):341-349. Epub 2016 Sep 19.

Department of Dermatology, University of Lübeck, Lübeck, Germany. Electronic address:

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February 2017

T cells mediate autoantibody-induced cutaneous inflammation and blistering in epidermolysis bullosa acquisita.

Sci Rep 2016 12 5;6:38357. Epub 2016 Dec 5.

Lübeck Institute of Experimental Dermatology (LIED), University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany.

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December 2016

PDE4 Inhibition as Potential Treatment of Epidermolysis Bullosa Acquisita.

J Invest Dermatol 2016 11 5;136(11):2211-2220. Epub 2016 Jul 5.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany; Department of Dermatology, University of Lübeck, Lübeck, Germany.

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November 2016

In Vivo Expansion of Endogenous Regulatory T Cell Populations Induces Long-Term Suppression of Contact Hypersensitivity.

J Immunol 2016 09 20;197(5):1567-76. Epub 2016 Jul 20.

Institute for Systemic Inflammation Research, University of Lübeck, 23538 Lübeck, Germany;

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September 2016

Discovering potential drug-targets for personalized treatment of autoimmune disorders - what we learn from epidermolysis bullosa acquisita.

Expert Opin Ther Targets 2016 Aug 19;20(8):985-98. Epub 2016 Feb 19.

a Lübeck Institute of Experimental Dermatology (LIED) , University of Lübeck , Lübeck , Germany.

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August 2016

Cytoskeletal Regulation of Inflammation and Its Impact on Skin Blistering Disease Epidermolysis Bullosa Acquisita.

Int J Mol Sci 2016 Jul 13;17(7). Epub 2016 Jul 13.

Future Industries Institute, Regenerative Medicine, University of South Australia, Mawson Lakes 5095, Adelaide, Australia.

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July 2016

Animal models to investigate pathomechanisms and evaluate novel treatments for autoimmune bullous dermatoses.

Curr Pharm Des 2015 ;21(18):2422-39

Lubeck Institute of Experimental Dermatology, University of Lubeck, Ratzeburger Allee 160, D- 23538 Lubeck, Germany.

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May 2016

Myeloid-related proteins-8 and -14 are expressed but dispensable in the pathogenesis of experimental epidermolysis bullosa acquisita and bullous pemphigoid.

J Dermatol Sci 2016 Mar 2;81(3):165-72. Epub 2015 Dec 2.

Priority Area Asthma & Allergy, Research Center Borstel, 23845 Borstel, Germany; Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Germany. Electronic address:

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March 2016

Epidermolysis Bullosa Acquisita: From Pathophysiology to Novel Therapeutic Options.

J Invest Dermatol 2016 Jan;136(1):24-33

Department of Dermatology, University of Lübeck, Lübeck, Germany; Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

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January 2016

Dimethylfumarate Impairs Neutrophil Functions.

J Invest Dermatol 2016 Jan;136(1):117-26

Department of Dermatology, University of Lübeck, Lübeck, Germany. Electronic address:

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January 2016

Tolerance of Fondaparinux in Immediate-type Hypersensitivity to Heparins.

Am J Med 2015 Nov 11;128(11):e21-2. Epub 2015 Jul 11.

Department of Dermatology, University of Lübeck, Germany; Lübeck Institute of Experimental Dermatology, University of Lübeck, Germany. Electronic address:

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November 2015

Dimethylfumarate Impairs Neutrophil Functions.

J Invest Dermatol 2015 Oct 5. Epub 2015 Oct 5.

Department of Dermatology, University of Lübeck, Germany.

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October 2015

Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita.

J Immunol 2015 Sep 22;195(5):1945-54. Epub 2015 Jul 22.

Department of Dermatology, University of Lübeck, D-23538 Lübeck, Germany; Lübeck Institute of Experimental Dermatology, University of Lübeck, D-23538 Lübeck, Germany;

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September 2015

Conditional depletion of mast cells has no impact on the severity of experimental epidermolysis bullosa acquisita.

Eur J Immunol 2015 May 12;45(5):1462-70. Epub 2015 Mar 12.

Priority Area Asthma and Allergy, Members of the German Center for Lung Research, Research Center Borstel, Borstel, Germany.

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May 2015

Recombinant soluble CD32 suppresses disease progression in experimental epidermolysis bullosa acquisita.

J Invest Dermatol 2015 Mar 20;135(3):916-919. Epub 2014 Oct 20.

Department of Dermatology, University of Lübeck, Lübeck, Germany; Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany. Electronic address:

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March 2015

Effects of intravenous immunoglobulins on mice with experimental epidermolysis bullosa acquisita.

J Invest Dermatol 2015 Mar 20;135(3):768-775. Epub 2014 Oct 20.

Department of Dermatology, University of Lübeck, Lübeck, Germany. Electronic address:

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March 2015

ptRNApred: computational identification and classification of post-transcriptional RNA.

Nucleic Acids Res 2014 Dec 10;42(22):e167. Epub 2014 Oct 10.

Department of Dermatology, University of Lübeck, 23538 Lübeck, Germany

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December 2014

From bedside to bench--reverse translational medicine. Scientific lessons from revertant mosaicism in 'knockout' humans.

Exp Dermatol 2014 Aug 21;23(8):549-50. Epub 2014 Jul 21.

Lübeck Institute for Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany.

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August 2014

Broad requirement for terminal sialic acid residues and FcγRIIB for the preventive and therapeutic activity of intravenous immunoglobulins in vivo.

Eur J Immunol 2014 May 7;44(5):1444-53. Epub 2014 Mar 7.

Department of Biology, Institute of Genetics, University of Erlangen-Nürnberg, Erlangen, Germany.

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May 2014

Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering.

J Pathol 2014 Apr 5;232(5):541-52. Epub 2014 Feb 5.

Centre for Regenerative Medicine, Mawson Institute, University of South Australia, Adelaide, Australia; Women's and Children's Health Research Institute, Adelaide, Australia.

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April 2014

The immune system of mouse vibrissae follicles: cellular composition and indications of immune privilege.

Exp Dermatol 2013 Sep;22(9):593-8

Department of Dermatology, University of Lübeck, Lübeck, Germany.

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September 2013

Emerging treatments for pemphigoid diseases.

Trends Mol Med 2013 Aug 4;19(8):501-12. Epub 2013 Jul 4.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

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August 2013

Clinical presentation, pathogenesis, diagnosis, and treatment of epidermolysis bullosa acquisita.

Authors:
Ralf J Ludwig

ISRN Dermatol 2013 15;2013:812029. Epub 2013 Jul 15.

Department of Dermatology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.

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August 2013

High incidence of heparin-induced allergic delayed-type hypersensitivity reactions in pregnancy.

J Allergy Clin Immunol 2013 Jul 30;132(1):131-9. Epub 2013 May 30.

Department of Internal Medicine, Division of Vascular Medicine and Hemostaseology, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany.

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July 2013

Metabolite analysis distinguishes between mice with epidermolysis bullosa acquisita and healthy mice.

Orphanet J Rare Dis 2013 Jun 26;8:93. Epub 2013 Jun 26.

Excellence Cluster Inflammation at Interfaces, Schleswig-Holstein, Germany.

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June 2013

Topically applied flightless I neutralizing antibodies improve healing of blistered skin in a murine model of epidermolysis bullosa acquisita.

J Invest Dermatol 2013 Apr 6;133(4):1008-16. Epub 2012 Dec 6.

Women's and Children's Health Research Institute, North Adelaide, South Australia, Australia.

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April 2013

Pathogenicity of autoantibodies in anti-p200 pemphigoid.

PLoS One 2012 24;7(7):e41769. Epub 2012 Jul 24.

Department of Dermatology, University of Luebeck, Luebeck, Germany.

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February 2013

Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction.

J Autoimmun 2013 Feb 11;40:74-85. Epub 2012 Sep 11.

Excellence Cluster Inflammation at Interfaces, Schleswig-Holstein, Germany; Department of Dermatology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.

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February 2013

Enzymatic autoantibody glycan hydrolysis alleviates autoimmunity against type VII collagen.

J Autoimmun 2012 Dec 30;39(4):304-14. Epub 2012 May 30.

Department of Dermatology, University of Lübeck, Ratzeburger Allee 160, Lübeck D-23538, Germany.

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December 2012

Heparin-induced skin lesions.

Lancet 2012 Nov 28;380(9856):1867-79. Epub 2012 May 28.

Division of Vascular Medicine and Haemostaseology, Department of Internal Medicine, Hospital of the Johann Wolfgang Goethe University, Frankfurt am Main, Germany.

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November 2012

Identification of quantitative trait loci in experimental epidermolysis bullosa acquisita.

J Invest Dermatol 2012 May 2;132(5):1409-15. Epub 2012 Feb 2.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

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May 2012

Model systems duplicating epidermolysis bullosa acquisita: a methodological review.

Authors:
Ralf J Ludwig

Autoimmunity 2012 Feb 19;45(1):102-10. Epub 2011 Sep 19.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

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February 2012

Mapping of B cell epitopes on desmoglein 3 in pemphigus vulgaris patients by the use of overlapping peptides.

J Dermatol Sci 2012 Feb 30;65(2):102-9. Epub 2011 Dec 30.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

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February 2012

Application, tolerance and safety of fondaparinux therapy in a German hospital: a prospective single-centre experience.

Thromb Res 2012 Jan 7;129(1):17-21. Epub 2011 Jul 7.

Department of Internal Medicine, Division of Vascular Medicine and Haemostaseology, J.W. Goethe University Hospital Frankfurt am Main, Germany.

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January 2012

The risk for cross-reactions after a cutaneous delayed-type hypersensitivity reaction to heparin preparations is independent of their molecular weight: a systematic review.

Contact Dermatitis 2011 Oct 1;65(4):187-94. Epub 2011 Jun 1.

Department of Dermatology, Venereology and Allergology, Hospital of the Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

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October 2011

Rituximab for treatment-refractory pemphigus and pemphigoid: a case series of 17 patients.

J Am Acad Dermatol 2011 Sep;65(3):552-558

Department of Dermatology, University of Lübeck, Lübeck, Germany; Comprehensive Center for Inflammatory Medicine, University of Lübeck, Lübeck, Germany.

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September 2011

Pathogenesis of epidermolysis bullosa acquisita.

Dermatol Clin 2011 Jul;29(3):493-501, xi

Department of Dermatology, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany.

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July 2011

Low allergenic potential with fondaparinux: results of a prospective investigation.

Mayo Clin Proc 2010 Oct 15;85(10):913-9. Epub 2010 Sep 15.

Department of Internal Medicine, J. W. Goethe University Hospital, Theodor-Stern-Kai 7, Bldg. 13A, 60590 Frankfurt am Main, Germany.

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October 2010