Ralf H Adams

Ralf H Adams

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Ralf H Adams

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Apelin Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury.

Cell Stem Cell 2019 Dec 21;25(6):768-783.e6. Epub 2019 Nov 21.

Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine, Röntgenstrasse 20, 48149 Münster, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900750PMC
December 2019

Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy.

Nat Commun 2019 11 20;10(1):5243. Epub 2019 Nov 20.

Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster, Faculty of Medicine, D-48149, Münster, Germany.

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http://dx.doi.org/10.1038/s41467-019-13220-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868140PMC
November 2019

Endothelial Cell-Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact Vasculature.

Arterioscler Thromb Vasc Biol 2018 11;38(11):2691-2705

From the Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder (C.Z., M.B.L., V.J., Z.C., H.J.J.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.311689
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http://dx.doi.org/10.1161/ATVBAHA.118.311689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221394PMC
November 2018

NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy.

Nat Commun 2018 08 27;9(1):3463. Epub 2018 Aug 27.

Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT, 06511, USA.

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http://www.nature.com/articles/s41467-018-05926-7
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http://dx.doi.org/10.1038/s41467-018-05926-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110853PMC
August 2018

Biology of Bone: The Vasculature of the Skeletal System.

Cold Spring Harb Perspect Med 2018 07 2;8(7). Epub 2018 Jul 2.

Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine, D-48149 Münster, Germany.

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http://dx.doi.org/10.1101/cshperspect.a031559DOI Listing
July 2018

Endothelial C-Type Natriuretic Peptide Acts on Pericytes to Regulate Microcirculatory Flow and Blood Pressure.

Circulation 2018 07;138(5):494-508

Institute of Physiology, University of Würzburg and Comprehensive Heart Failure Center, University Hospital Würzburg, Germany (K. Špiranec, W.C., S.C., F.W., T.N., F.K., P.E.-N., K. Schuh, M.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.033383DOI Listing
July 2018

Pulmonary pericytes regulate lung morphogenesis.

Nat Commun 2018 06 22;9(1):2448. Epub 2018 Jun 22.

Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine, D-48149, Münster, Germany.

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http://dx.doi.org/10.1038/s41467-018-04913-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015030PMC
June 2018

Spatiotemporal endothelial cell - pericyte association in tumors as shown by high resolution 4D intravital imaging.

Sci Rep 2018 06 25;8(1):9596. Epub 2018 Jun 25.

Laboratory Experimental Surgical Oncology, Department of Surgery, Erasmus MC, 3015CE, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41598-018-27943-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018425PMC
June 2018

Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.

Nature 2018 05 9;557(7705):439-445. Epub 2018 May 9.

Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.1038/s41586-018-0110-6DOI Listing
May 2018

Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers.

Arterioscler Thromb Vasc Biol 2018 04 15;38(4):854-869. Epub 2018 Feb 15.

From the Department of Pathology, Oslo University Hospital Rikshospitalet (L.l.C.P., R.J.E., S.K., T.E.S.-N., A.R., M.S., J.W., M.K., E.B., O.S., H.S., G.H., E.S., J.H.), Department of Pathology, Institute for Clinical Medical Sciences (H.S., G.H.) and Department of Molecular Medicine, Institute for Basal Medical Sciences (A.S., P.C.), University of Oslo, Norway; Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, University of Münster, Germany (R.D.-H., M.E., R.B., R.H.A.); Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford, United Kingdom (K.S.M.); and Department of Discovery Oncology, Genentech, Inc, South San Francisco, CA (C.W.S.).

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http://dx.doi.org/10.1161/ATVBAHA.117.310388DOI Listing
April 2018

Endothelial Tie1-mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis.

J Clin Invest 2018 02 22;128(2):834-845. Epub 2018 Jan 22.

Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), Heidelberg, Germany.

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http://dx.doi.org/10.1172/JCI94674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785248PMC
February 2018

Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis.

Nat Commun 2017 12 20;8(1):2210. Epub 2017 Dec 20.

Institute of Anatomy and Vascular Biology, Westfälische Wilhelms University of Münster, Faculty of Medicine, D-48149, Münster, Germany.

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http://dx.doi.org/10.1038/s41467-017-02373-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738342PMC
December 2017

Prox1-GFP/Flt1-DsRed transgenic mice: an animal model for simultaneous live imaging of angiogenesis and lymphangiogenesis.

Angiogenesis 2017 Nov 9;20(4):581-598. Epub 2017 Aug 9.

Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA.

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http://dx.doi.org/10.1007/s10456-017-9572-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782821PMC
November 2017

Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1.

Nat Commun 2017 11 17;8(1):1574. Epub 2017 Nov 17.

Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine, D-48149, Münster, Germany.

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http://dx.doi.org/10.1038/s41467-017-01738-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691060PMC
November 2017

Transcriptional regulation of endothelial cell behavior during sprouting angiogenesis.

Nat Commun 2017 09 28;8(1):726. Epub 2017 Sep 28.

Department of Tissue Morphogenesis, Max-Planck-Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149, Münster, Germany.

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http://dx.doi.org/10.1038/s41467-017-00738-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620061PMC
September 2017

Dll4 and Notch signalling couples sprouting angiogenesis and artery formation.

Nat Cell Biol 2017 Aug 17;19(8):915-927. Epub 2017 Jul 17.

Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine, Röntgenstrasse 20, D-48149 Münster, Germany.

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http://www.nature.com/doifinder/10.1038/ncb3555
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http://dx.doi.org/10.1038/ncb3555DOI Listing
August 2017

Plastic roles of pericytes in the blood-retinal barrier.

Nat Commun 2017 05 16;8:15296. Epub 2017 May 16.

Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.

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http://dx.doi.org/10.1038/ncomms15296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440855PMC
May 2017

Cell-matrix signals specify bone endothelial cells during developmental osteogenesis.

Nat Cell Biol 2017 03 20;19(3):189-201. Epub 2017 Feb 20.

Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine, D-48149 Münster, Germany.

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http://dx.doi.org/10.1038/ncb3476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580829PMC
March 2017

Flow Dynamics and HSPC Homing in Bone Marrow Microvessels.

Cell Rep 2017 02;18(7):1804-1816

Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany; Faculty of Medicine, University of Münster, 48149 Münster, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.01.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318670PMC
February 2017

Blood flow controls bone vascular function and osteogenesis.

Nat Commun 2016 12 6;7:13601. Epub 2016 Dec 6.

Faculty of Medicine, Department of Tissue Morphogenesis, Max-Planck-Institute for Molecular Biomedicine and University of Münster, D-48149 Münster, Germany.

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http://dx.doi.org/10.1038/ncomms13601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150650PMC
December 2016

Akt1 promotes stimuli-induced endothelial-barrier protection through FoxO-mediated tight-junction protein turnover.

Cell Mol Life Sci 2016 10 25;73(20):3917-33. Epub 2016 Apr 25.

Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA, USA.

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http://dx.doi.org/10.1007/s00018-016-2232-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023469PMC
October 2016

Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals.

Annu Rev Cell Dev Biol 2016 10 17;32:649-675. Epub 2016 Aug 17.

Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, D-48169 Münster, Germany; email:

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http://dx.doi.org/10.1146/annurev-cellbio-111315-124936DOI Listing
October 2016

Blood vessel formation and function in bone.

Development 2016 08;143(15):2706-15

Max-Planck-Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine, Münster D-48149, Germany

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http://dx.doi.org/10.1242/dev.136861DOI Listing
August 2016

Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells.

Nat Commun 2016 08 12;7:12422. Epub 2016 Aug 12.

Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, Faculty of Medicine, University of Münster, D-48149 Münster, Germany.

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http://dx.doi.org/10.1038/ncomms12422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990645PMC
August 2016

Age-dependent modulation of vascular niches for haematopoietic stem cells.

Nature 2016 Apr 13;532(7599):380-4. Epub 2016 Apr 13.

Max-Planck-Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine, D-48149 Münster, Germany.

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http://dx.doi.org/10.1038/nature17638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035541PMC
April 2016

Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis.

Dev Biol 2016 Mar 10;411(2):183-194. Epub 2016 Feb 10.

Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, United States; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2016.02.005DOI Listing
March 2016

Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium.

Nat Commun 2016 Mar 14;7:10960. Epub 2016 Mar 14.

Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/ncomms10960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793084PMC
March 2016

KLF4 is a key determinant in the development and progression of cerebral cavernous malformations.

EMBO Mol Med 2016 Jan;8(1):6-24

IFOM the FIRC Institute of Molecular Oncology, Milan, Italy Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Department of Oncology and Oncohematology, University of Milan, Milan, Italy

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http://dx.doi.org/10.15252/emmm.201505433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718159PMC
January 2016

Inducible glomerular erythropoietin production in the adult kidney.

Kidney Int 2015 Dec 23;88(6):1345-1355. Epub 2015 Sep 23.

Institute of Physiology, University of Regensburg, Regensburg, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S00852538156106
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http://dx.doi.org/10.1038/ki.2015.274DOI Listing
December 2015

Sample preparation for high-resolution 3D confocal imaging of mouse skeletal tissue.

Nat Protoc 2015 Dec 29;10(12):1904-14. Epub 2015 Oct 29.

Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany.

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http://dx.doi.org/10.1038/nprot.2015.125DOI Listing
December 2015

MoD Special Issue on interactions at the neurovascular interface.

Authors:
Ralf H Adams

Mech Dev 2015 Nov 31;138 Pt 1. Epub 2015 Jul 31.

Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster, Faculty of Medicine, Münster, Germany.

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http://dx.doi.org/10.1016/j.mod.2015.07.012DOI Listing
November 2015

Ephrin-Bs Drive Junctional Downregulation and Actin Stress Fiber Disassembly to Enable Wound Re-epithelialization.

Cell Rep 2015 Nov 5;13(7):1380-1395. Epub 2015 Nov 5.

Schools of Biochemistry and Physiology & Pharmacology, University of Bristol, Bristol BS8 1TD, UK; School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.09.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660216PMC
November 2015

Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension.

Sci Transl Med 2015 Oct;7(308):308ra159

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 George Street, Room 773J, New Haven, CT 06511, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa9712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629985PMC
October 2015

Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions.

Oncotarget 2015 Sep;6(27):24404-23

Centro Interdisciplinar de Investigação em Sanidade Animal (CIISA), University of Lisbon, Lisbon, Portugal.

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http://dx.doi.org/10.18632/oncotarget.4380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695194PMC
September 2015

The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells.

Cell Rep 2015 Sep 3;12(11):1761-73. Epub 2015 Sep 3.

Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), 69120 Heidelberg, Germany; Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.08.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309948PMC
September 2015

Regulation of signaling interactions and receptor endocytosis in growing blood vessels.

Cell Adh Migr 2014 ;8(4):366-77

a Department of Tissue Morphogenesis; Max Planck Institute for Molecular Biomedicine; and Faculty of Medicine , University of Münster ; Münster , Germany.

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http://dx.doi.org/10.4161/19336918.2014.970010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594521PMC
August 2015

Junctional adhesion molecule B interferes with angiogenic VEGF/VEGFR2 signaling.

FASEB J 2015 Aug 24;29(8):3411-25. Epub 2015 Apr 24.

*Department of Pathology and Immunology, Medical Faculty, University Medical Center, University of Geneva, Geneva, Switzerland; Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Basel, Switzerland; Unité Mixte de Recherche 1068, Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France; Institut Paoli-Calmettes, Marseille, France; Marseille Université, Marseille, France; Unité Mixte de Recherche 7258, Centre National de la Recherche Scientifique, Marseille, France; Department of Tissue Morphogenesis, Max-Planck-Institute for Molecular Biomedicine, Münster, Münster, Germany; and Faculty of Medicine, University of Münster, Münster, Germany

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http://dx.doi.org/10.1096/fj.15-270223DOI Listing
August 2015

Regulation of vascular endothelial growth factor receptor function in angiogenesis by numb and numb-like.

Arterioscler Thromb Vasc Biol 2015 Aug 11;35(8):1815-25. Epub 2015 Jun 11.

From the Max-Planck-Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine, Münster, Germany (M.v.L., M.N., K. Kato, J.M.K., R.H.A.); and Department of Cell Pharmacology, Nagoya University, Graduate School of Medicine, Nagoya, Japan (K. Kato, K. Kaibuchi).

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http://dx.doi.org/10.1161/ATVBAHA.115.305473DOI Listing
August 2015

Endothelial depletion of murine SRF/MRTF provokes intracerebral hemorrhagic stroke.

Proc Natl Acad Sci U S A 2015 Aug 28;112(32):9914-9. Epub 2015 Jul 28.

Department of Molecular Biology, Interfaculty Institute of Cell Biology, University of Tuebingen, 72076 Tuebingen, Germany;

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http://dx.doi.org/10.1073/pnas.1509047112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538672PMC
August 2015

Perilipin+ embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion.

Development 2015 Aug;142(15):2623-32

Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea

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http://dev.biologists.org/lookup/doi/10.1242/dev.125336
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http://dx.doi.org/10.1242/dev.125336DOI Listing
August 2015

Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice.

Proc Natl Acad Sci U S A 2015 Jul 24;112(27):8421-6. Epub 2015 Jun 24.

Fondazione Italiana per la Ricerca sul Cancro (FIRC) Institute of Molecular Oncology Fondazione, 20139 Milan, Italy; Mario Negri Institute for Pharmacological Research, 20156 Milan, Italy

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http://dx.doi.org/10.1073/pnas.1501352112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500248PMC
July 2015

Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2.

Nat Commun 2015 Jun 1;6:7274. Epub 2015 Jun 1.

Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University, 81377 Munich, Germany.

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http://dx.doi.org/10.1038/ncomms8274DOI Listing
June 2015

Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1.

Arterioscler Thromb Vasc Biol 2015 May 12;35(5):1134-46. Epub 2015 Mar 12.

From the Centro Interdisciplinar de Investigação em Sanidade Animal (CIISA), University of Lisbon, Lisbon, Portugal (A.-R.P., A.T., A.-C.F., C.C., J.G., A.T.T., A.D.); Instituto Gulbenkian de Ciência, Oeiras, Portugal (A.T., A.T.T., A.D.); Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Muenster, Faculty of Medicine, Muenster, Germany (R.D.-H., R.H.A.); and Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan (H.Y.).

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http://dx.doi.org/10.1161/ATVBAHA.114.304741DOI Listing
May 2015

APJ Regulates Parallel Alignment of Arteries and Veins in the Skin.

Dev Cell 2015 May 23;33(3):247-59. Epub 2015 Apr 23.

Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, K's Gobancho, 7 Gobancho, Chiyoda-ku, Tokyo 102-0076, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.02.024DOI Listing
May 2015

RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.

Nat Commun 2015 Apr 10;6:6725. Epub 2015 Apr 10.

Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncomms7725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394241PMC
April 2015

Regulation of tissue morphogenesis by endothelial cell-derived signals.

Trends Cell Biol 2015 Mar 17;25(3):148-57. Epub 2014 Dec 17.

Max-Planck-Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster, Faculty of Medicine, D-48149 Münster, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2014.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943524PMC
March 2015

Integrin β1 controls VE-cadherin localization and blood vessel stability.

Nat Commun 2015 Mar 10;6:6429. Epub 2015 Mar 10.

1] Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D-48149 Münster, Germany [2] Faculty of Medicine, University of Münster, Röntgenstrasse 20, D-48149 Münster, Germany.

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http://dx.doi.org/10.1038/ncomms7429DOI Listing
March 2015

cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.

Cell Rep 2015 Mar 12;10(10):1708-1721. Epub 2015 Mar 12.

The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.026DOI Listing
March 2015

Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels.

Proc Natl Acad Sci U S A 2014 Dec 2;111(50):18007-12. Epub 2014 Dec 2.

Laboratory for Accelerated Vascular Research, Department of Surgery, Division of Vascular Surgery, University of California, San Francisco, CA 94143;

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http://dx.doi.org/10.1073/pnas.1415316111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273347PMC
December 2014

Direct cell-cell contact with the vascular niche maintains quiescent neural stem cells.

Nat Cell Biol 2014 Nov 5;16(11):1045-56. Epub 2014 Oct 5.

Cell Interactions and Cancer Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road London W12 0NN, UK.

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http://dx.doi.org/10.1038/ncb3045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298702PMC
November 2014

Osteoclast progenitors promote bone vascularization and osteogenesis.

Nat Med 2014 Nov;20(11):1238-40

Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and in the Faculty of Medicine, University of Münster, Münster, Germany.

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http://dx.doi.org/10.1038/nm.3747DOI Listing
November 2014

Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability.

Circ Res 2014 Aug 23;115(6):581-90. Epub 2014 Jul 23.

From the Max Planck Institute for Molecular Biomedicine, Münster, Germany (S.F.R., M.S., D.J., H.L., S.B., D.V., D.B., H.C.A.D., S.A., R.B., R.H.A.); University of Münster, Münster, Germany (R.H.A.); Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain (S.F.R., R.B.); and Neurochirurgische Klinik, Charite Universitätsmedizin, Berlin, Germany (M.N.-K., P.V.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.304718DOI Listing
August 2014

Deficiency of endothelial CXCR4 reduces reendothelialization and enhances neointimal hyperplasia after vascular injury in atherosclerosis-prone mice.

Arterioscler Thromb Vasc Biol 2014 Jun 10;34(6):1209-20. Epub 2014 Apr 10.

From the Institute for Molecular Cardiovascular Research (H.N., B.Z., P.V.T., W.T., X.L., L.P., S.A., S.S., E.S., E.A.L.) and Institute of Biochemistry and Molecular Cell Biology (C.S., J.B.), University Hospital Aachen, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University, Aachen, Germany; Institute for Cardiovascular Prevention (A.S., Y.D., C.W.) and August-Lenz-Stiftung, Institute for Cardiovascular Research (J.B.), Ludwig-Maximilians-University Munich, Munich, Germany; Max Planck Institute for Molecular Biomedicine, University of Münster, Münster, Germany (R.H.A.); Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands (C.W.); and German Centre for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung), partner site Munich Heart Alliance, Munich, Germany (C.W.).

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http://dx.doi.org/10.1161/ATVBAHA.113.302878DOI Listing
June 2014

MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.

Nat Commun 2014 Jun 9;5:3970. Epub 2014 Jun 9.

1] Medizinische Klinik und Poliklinik I, Klinikum Grosshadern, 81377 Munich, Germany [2] DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, 80802 München, Germany [3] Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians University, 81377 München, Germany.

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http://dx.doi.org/10.1038/ncomms4970DOI Listing
June 2014

Hemogenic endothelium generates mesoangioblasts that contribute to several mesodermal lineages in vivo.

Development 2014 May;141(9):1821-34

Department of Health Sciences, University of Milano-Bicocca, Monza 20900, Italy.

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http://dx.doi.org/10.1242/dev.103242DOI Listing
May 2014

AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion.

Nat Commun 2014 May 7;5:3743. Epub 2014 May 7.

1] Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska University Hospital, 171 76 Stockholm, Sweden [2].

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http://dx.doi.org/10.1038/ncomms4743DOI Listing
May 2014

Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells.

Stem Cells 2014 Apr;32(4):1043-54

Centre de Recherche en Cancérologie de Marseille, Inserm, UMR1068, Marseille, France; Institut Paoli-Calmettes, Marseille, France; Aix-Marseille Université, Marseille, France; CNRS, UMR7258, Marseille, France.

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http://dx.doi.org/10.1002/stem.1624DOI Listing
April 2014

Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis.

Development 2014 Apr;141(8):1757-66

Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), Heidelberg 69221, Germany.

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http://dx.doi.org/10.1242/dev.104422DOI Listing
April 2014

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone.

Nature 2014 Mar 12;507(7492):323-328. Epub 2014 Mar 12.

Max-Planck-Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine, D-48149 Münster, Germany.

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http://dx.doi.org/10.1038/nature13145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943525PMC
March 2014

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone.

Nature 2014 Mar 12;507(7492):376-380. Epub 2014 Mar 12.

Max-Planck-Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine, Münster, German.

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http://dx.doi.org/10.1038/nature13146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943529PMC
March 2014

Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid.

J Exp Med 2014 Feb 20;211(2):281-95. Epub 2014 Jan 20.

Institute for Vascular Signaling, Centre for Molecular Medicine, Johann Wolfgang Goethe University and DZHK (German Centre for Cardiovascular Research) partner site Rhine-Main, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.1084/jem.20131494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920554PMC
February 2014

Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption.

Cancer Cell 2014 Jan;25(1):102-17

National Research Laboratory of Vascular Biology and Stem Cells, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea; Graduate School of Medical Science and Engineering, KAIST, Daejeon 305-701, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2013.12.010DOI Listing
January 2014

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.

Nat Med 2013 Dec 10;19(12):1617-24. Epub 2013 Nov 10.

1] Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, California, USA. [2] Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/nm.3282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855865PMC
December 2013

Ephrin-B2 controls PDGFRβ internalization and signaling.

Genes Dev 2013 Dec;27(23):2576-89

Department of Tissue Morphogenesis, Max-Planck-Institute for Molecular Biomedicine, D-48149 Münster, Germany;

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http://dx.doi.org/10.1101/gad.224089.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861671PMC
December 2013