Publications by authors named "Ralf Buettner"

33Publications

Glucocorticoid receptor expression in multiple myeloma patients is a predictor of survival.

Leuk Lymphoma 2020 Sep 13:1-5. Epub 2020 Sep 13.

City Hope National Medical Center, Duarte, CA, USA.

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http://dx.doi.org/10.1080/10428194.2020.1811860DOI Listing
September 2020

Leflunomide Synergizes with Gemcitabine in Growth Inhibition of PC Cells and Impairs c-Myc Signaling through PIM Kinase Targeting.

Mol Ther Oncolytics 2019 Sep 17;14:149-158. Epub 2019 May 17.

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1016/j.omto.2019.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562366PMC
September 2019

Increasing Antitumor Activity of JAK Inhibitor by Simultaneous Blocking Multiple Survival Signaling Pathways in Human Ovarian Cancer.

Transl Oncol 2019 Aug 26;12(8):1015-1025. Epub 2019 May 26.

Department of Surgery, Beckman Research Institute, City of Hope Comprehensive Cancer Center, 1500 East Duarte Rd., Duarte, CA 91010. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2019.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542771PMC
August 2019

Allosteric Communication across STAT3 Domains Associated with STAT3 Function and Disease-Causing Mutation.

J Mol Biol 2016 Feb 14;428(3):579-589. Epub 2016 Jan 14.

Department of Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767637PMC
February 2016

Synergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancer.

Mol Cancer 2015 May 1;14:100. Epub 2015 May 1.

Department of Surgery, Beckman Research Institute, City of Hope Comprehensive Cancer Center, 1500 East Duarte Rd., Duarte, CA, 91010, USA.

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http://molecular-cancer.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12943-015-0366-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437681PMC
May 2015

Revisiting STAT3 signalling in cancer: new and unexpected biological functions.

Nat Rev Cancer 2014 Nov;14(11):736-46

Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, Florida 34987, USA.

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http://dx.doi.org/10.1038/nrc3818DOI Listing
November 2014

Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling.

Cancer Res 2014 Feb 31;74(4):1227-37. Epub 2013 Oct 31.

Authors' Affiliations: Departments of Molecular Medicine, Cancer Immunotherapy and Tumor Immunology, and Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and Institute for Biochemistry and Molecular Biology, Universitätsklinikum RWTH Aachen, Aachen, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539262PMC
February 2014

3-O-methylthespesilactam, a new small-molecule anticancer pan-JAK inhibitor against A2058 human melanoma cells.

Biochem Pharmacol 2013 Nov 7;86(10):1411-8. Epub 2013 Sep 7.

Marine Drugs Research Center, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, PR China.

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http://dx.doi.org/10.1016/j.bcp.2013.08.065DOI Listing
November 2013

Critical role of STAT3 in IL-6-mediated drug resistance in human neuroblastoma.

Cancer Res 2013 Jul 30;73(13):3852-64. Epub 2013 Apr 30.

Division of Hematology-Oncology, Department of Pediatrics, Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-2353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740971PMC
July 2013

Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis.

Cancer Biol Ther 2012 May 1;13(7):534-41. Epub 2012 May 1.

Molecular Medicine, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.

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http://dx.doi.org/10.4161/cbt.19603DOI Listing
May 2012

Molecular dynamics simulations of the conformational changes in signal transducers and activators of transcription, Stat1 and Stat3.

J Mol Graph Model 2009 Nov 6;28(4):347-56. Epub 2009 Sep 6.

Department of Immunology, Beckman Research Institute, City of Hope, Duarte, CA 91010, United States.

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http://dx.doi.org/10.1016/j.jmgm.2009.08.013DOI Listing
November 2009

Inhibition of Src family kinases with dasatinib blocks migration and invasion of human melanoma cells.

Mol Cancer Res 2008 Nov;6(11):1766-74

Molecular Medicine, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-08
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http://dx.doi.org/10.1158/1541-7786.MCR-08-0169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768340PMC
November 2008

SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells.

Mol Cancer Ther 2008 May;7(5):1185-94

Molecular Medicine, Beckman Research Institute, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794837PMC
May 2008

Activated signal transducers and activators of transcription 3 signaling induces CD46 expression and protects human cancer cells from complement-dependent cytotoxicity.

Mol Cancer Res 2007 Aug;5(8):823-32

Molecular Medicine, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-06-0352DOI Listing
August 2007

Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells.

Cancer Res 2005 Oct;65(20):9185-9

Molecular Oncology and Biostatistics Programs, H. Lee Moffitt Cancer Center and Research Institute, Department of Pathology, University of South Florida College of Medicine, Tampa, Florida.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1731DOI Listing
October 2005

Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells.

Proc Natl Acad Sci U S A 2005 Apr 18;102(17):5998-6003. Epub 2005 Apr 18.

Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

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http://dx.doi.org/10.1073/pnas.0409467102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087919PMC
April 2005

Stat3 regulates genes common to both wound healing and cancer.

Oncogene 2005 May;24(21):3397-408

Thoracic Oncology/Experimental Therapeutics, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

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http://dx.doi.org/10.1038/sj.onc.1208469DOI Listing
May 2005

Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells.

Cancer Res 2002 Nov;62(22):6659-66

Department of Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida 33612, USA.

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November 2002

Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.

Clin Cancer Res 2002 Apr;8(4):945-54

Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, College of Medicine, Tampa, Florida 33612, USA.

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April 2002