Publications by authors named "Rakesh Nagarajan"

56Publications

Proficiency Testing of Standardized Samples Shows High Interlaboratory Agreement for Clinical Next Generation Sequencing-Based Hematologic Malignancy Assays With Survey Material-Specific Differences in Variant Frequencies.

Arch Pathol Lab Med 2020 Jan 27. Epub 2020 Jan 27.

From the Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (Drs Keegan, Lindeman, and Kim); the Departments of Pathology and Microbiology, University of Nebraska Medical Center, Omaha (Dr Bridge); Biostatistics (Mr Long) and Proficiency Testing (Ms Vasalos), ollege of American Pathologists, Northfield, Illinois; the UNC Lineberger Comprehensive Cancer Center (Dr Merker) and the Department of Pathology and Laboratory Medicine (Dr Montgomery), University of North Carolina, Chapel Hill; the Office of the Director, The Joint Pathology Center, Silver Spring, Maryland (Dr Moncur); the Department of Pathology, PierianDx, St Louis, Missouri (Dr Nagarajan); the Department of Pathology and Laboratory Medicine, Strong Memorial Hospital, University of Rochester Medical Center, Rochester, New York (Dr Rothberg); the Department of Hematopathology, MD Anderson Cancer Center, Houston, Texas (Dr Routbort); and the Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland (Dr Xian).

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January 2020

Proficiency Testing of Standardized Samples Shows Very High Interlaboratory Agreement for Clinical Next-Generation Sequencing-Based Oncology Assays.

Arch Pathol Lab Med 2019 04 30;143(4):463-471. Epub 2018 Oct 30.

From the Departments of Pathology and Laboratory Medicine & Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill (Dr Merker); the Departments of Pathology (Drs Devereaux and Montgomery, and Mr Smail) and Genetics (Dr Montgomery), Stanford University School of Medicine, and the Biomedical Informatics Program (Mr Smail), Stanford University, Stanford, California; the Department of Pathology, Massachusetts General Hospital (Dr Iafrate), and the Department of Pathology, Brigham and Women's Hospital (Drs Kim and Lindeman), Harvard University, Boston; the Departments of Pathology and Clinical Laboratory Genetics, The University Health Network and the University of Toronto, Toronto, Ontario, Canada (Dr Kamel-Reid); the Department of Pathology, Walter Reed National Military Medical Center, Bethesda, Maryland (Dr Moncur); PierianDx, St Louis, Missouri (Dr Nagarajan); the Department of Global Medical Affairs, Roche, Tucson, Arizona (Dr Portier); the Departments of Hematopathology (Dr Routbort) and Pathology, Genomic Medicine, and Translational Molecular Pathology (Dr Lazar), he University of Texas MD Anderson Cancer Center, Houston (Dr Routbort); the Department of Pathology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia (Dr Surrey); and Proficiency Testing, College of American Pathologists, Northfield, Illinois (Ms Vasalos).

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April 2019

Next-Generation Sequencing Informatics: Challenges and Strategies for Implementation in a Clinical Environment.

Arch Pathol Lab Med 2016 Sep 22;140(9):958-75. Epub 2016 Feb 22.

From the Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Drs Roy, LaFramboise, Nikiforov, Nikiforova, and Pantanowitz); the Department of Pathology, MD Anderson Cancer Center, Houston, Texas (Dr Routbort); the Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri (Drs Pfeifer and Nagarajan); PierianDx, St Louis, Missouri (Dr Nagarajan); and the Department of Pathology and Laboratory Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia (Dr Carter).

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September 2016

Identification of Medically Actionable Secondary Findings in the 1000 Genomes.

PLoS One 2015 2;10(9):e0135193. Epub 2015 Sep 2.

Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America.

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May 2016

caTissue Suite to OpenSpecimen: Developing an extensible, open source, web-based biobanking management system.

J Biomed Inform 2015 Oct 29;57:456-64. Epub 2015 Aug 29.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.

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October 2015

College of American Pathologists' laboratory standards for next-generation sequencing clinical tests.

Arch Pathol Lab Med 2015 Apr 25;139(4):481-93. Epub 2014 Aug 25.

From Molecular Medicine (Dr Aziz), Laboratory Improvement Programs (Dr Zhao and Ms Palicki), and Laboratory Accreditation and Regulatory Affairs (Ms Driscoll), College of American Pathologists, Northfield, Illinois; the Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts (Dr Bry); the Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (Dr Funke); the Department of Clinical Sciences, University of Central Florida College of Medicine, Orlando (Dr Gibson); the Divisions of Medical Genetics and Molecular Diagnostics, Department of Pathology & Laboratory Medicine, Pediatrics, and Human Genetics, UCLA School of Medicine, UCLA Institute for Society and Genetics, Molecular Diagnostic Laboratories and Clinical Genomics Center, UCLA Medical Center, Los Angeles, California (Dr Grody); the Department of Human Genetics, Emory University School of Medicine, Decatur, Georgia (Dr Hegde); Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio (Dr Hoeltge); the Department of Pathology, University of Vermont College of Medicine, Burlington (Dr Leonard); the Departments of Pathology (Drs Merker and Schrijver) and Pediatrics (Dr Schrijver), Stanford University School of Medicine, Stanford, California; the Department of Pathology & Immunology, Washington University School of Medicine, St Louis, Missouri (Dr Nagarajan); the Department of Laboratory Medicine & Pathology, Mayo Clinic in Arizona, Phoenix (Dr Robetorye); the Departments of Pathology & Laboratory Medicine and Genetics, University of North Carolina at Chapel Hill, Chapel Hill (Dr Weck); and ARUP Laboratories Institute for Clinical and Experimental Pathology, and Department of Pathology, University of Utah School of Medicine, Salt Lake City (Dr Voelkerding). Dr Aziz is now with Phoenix Children's Hospital, Phoenix, Arizona.

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April 2015

An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury.

BMC Genomics 2013 Feb 6;14:84. Epub 2013 Feb 6.

Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave, St, Louis, MO 63110, USA.

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February 2013

Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice.

PLoS One 2012 8;7(10):e46529. Epub 2012 Oct 8.

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

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June 2013

Three ontologies to define phenotype measurement data.

Front Genet 2012 28;3:87. Epub 2012 May 28.

Human and Molecular Genetics Center, Medical College of Wisconsin Milwaukee, WI, USA.

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June 2012

Real-time assessment of community health needs and concerns.

Sci Transl Med 2012 Feb;4(119):119mr2

Department of Epidemiology, University of Florida, Gainesville, FL 32606, USA.

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February 2012

MicroRNAs modulate Schwann cell response to nerve injury by reinforcing transcriptional silencing of dedifferentiation-related genes.

J Neurosci 2011 Nov;31(48):17358-69

Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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November 2011

Identification of transcriptional regulatory networks specific to pilocytic astrocytoma.

BMC Med Genomics 2011 Jul 11;4:57. Epub 2011 Jul 11.

Department of Pathology and Immunology, Washington University School of Medicine, 660, S, Euclid Ave, St, Louis, MO 63110, USA.

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July 2011

Regulation of the PMP22 gene through an intronic enhancer.

J Neurosci 2011 Mar;31(11):4242-50

Program in Cellular and Molecular Biology, University of Wisconsin, Madison, Wisconsin 53705, USA.

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March 2011

Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.

Blood 2011 Feb 29;117(8):2460-8. Epub 2010 Dec 29.

Section of Stem Cell Biology, Division of Oncology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.

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February 2011

Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes.

J Neurochem 2010 Dec 4;115(6):1409-20. Epub 2010 Nov 4.

Program in Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.

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December 2010

The Washington University Institute for Clinical and Translational Sciences.

Clin Transl Sci 2009 Oct;2(5):322-4

Washington University School of Medicine, St. Louis, MO, USA.

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October 2009

High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples.

J Clin Invest 2009 Jun 18;119(6):1714-26. Epub 2009 May 18.

Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University Medical School, St. Louis, Missouri 63110, USA.

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June 2009

Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation.

J Neurosci 2009 Feb;29(8):2312-21

Department of Neurology, and Hope Center for Neurological Diseases, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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February 2009

Natural language processing to identify adverse drug events.

AMIA Annu Symp Proc 2008 Nov 6:961. Epub 2008 Nov 6.

BJC HealthCare, Center for Healthcare Quality & Effectiveness; Washington University School of Medicine, St. Louis, MO, USA.

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November 2008

Analysis of peripheral nerve expression profiles identifies a novel myelin glycoprotein, MP11.

J Neurosci 2008 Jul;28(30):7563-73

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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July 2008

Interactions of Sox10 and Egr2 in myelin gene regulation.

Neuron Glia Biol 2007 Nov;3(4):377-87

Program in Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, WI 53706, USA.

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November 2007

A luminal breast cancer genome atlas: progress and barriers.

J Steroid Biochem Mol Biol 2007 Aug-Sep;106(1-5):125-9. Epub 2007 May 24.

Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63119, USA.

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November 2007

PAP: a comprehensive workbench for mammalian transcriptional regulatory sequence analysis.

Nucleic Acids Res 2007 Jul 21;35(Web Server issue):W238-44. Epub 2007 May 21.

Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA.

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July 2007

A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles.

Genome Res 2006 Mar 31;16(3):405-13. Epub 2006 Jan 31.

Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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March 2006

Nab proteins are essential for peripheral nervous system myelination.

Nat Neurosci 2005 Jul;8(7):932-40

Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, Saint Louis, Missouri 63110, USA.

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July 2005

Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination.

Proc Natl Acad Sci U S A 2005 Feb 3;102(7):2596-601. Epub 2005 Feb 3.

Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, St. Louis, MO 63110, USA.

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February 2005

Expression profiling of murine acute promyelocytic leukemia cells reveals multiple model-dependent progression signatures.

Mol Cell Biol 2004 Dec;24(24):10882-93

Division of Oncology, Section of Stem Cell Biology, Campus Box 8007, 660 South Euclid Ave., St. Louis, MO 63110-1093, USA.

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December 2004

Mechanisms of transcriptional regulation by Rb-E2F segregate by biological pathway.

Oncogene 2003 Oct;22(46):7209-17

Departments of Medicine and Cell Biology, Washington University School of Medicine, 4940 Parkview Place, St Louis, MO 63110, USA.

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October 2003

FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer.

J Biol Chem 2002 Dec 25;277(49):47928-37. Epub 2002 Sep 25.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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December 2002

Deciphering peripheral nerve myelination by using Schwann cell expression profiling.

Proc Natl Acad Sci U S A 2002 Jun;99(13):8998-9003

Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, St. Louis, MO 63110, USA.

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June 2002

Comparative gene expression profile analysis of neurofibromatosis 1-associated and sporadic pilocytic astrocytomas.

Cancer Res 2002 Apr;62(7):2085-91

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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April 2002