Rakesh K Jain

Rakesh K Jain

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Rakesh K Jain

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Inducible Nitric Oxide Synthase and CD11bGr1 Cells Impair Lymphatic Contraction of Tumor-Draining Lymphatic Vessels.

Lymphat Res Biol 2019 Jun 24;17(3):294-300. Epub 2018 Oct 24.

1 Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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https://www.liebertpub.com/doi/10.1089/lrb.2018.0013
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http://dx.doi.org/10.1089/lrb.2018.0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589499PMC
June 2019

Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy.

Proc Natl Acad Sci U S A 2019 May 30;116(22):10674-10680. Epub 2019 Apr 30.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1819889116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561160PMC
May 2019

Role of Apelin in Glioblastoma Vascularization and Invasion after Anti-VEGF Therapy: What Is the Impact on the Immune System?

Cancer Res 2019 May;79(9):2104-2106

Edwin L. Steele Laboratories for Tumor Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-0749DOI Listing
May 2019

Mapping Physical Tumor Microenvironment and Drug Delivery.

Clin Cancer Res 2019 Apr 10;25(7):2024-2026. Epub 2019 Jan 10.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-3724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445672PMC
April 2019

Taxonomy of the order Bunyavirales: second update 2018.

Arch Virol 2019 Mar;164(3):927-941

Integrated Research Facility at Fort Detrick (IRF-Frederick), Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), B-8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA.

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http://link.springer.com/10.1007/s00705-018-04127-3
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http://dx.doi.org/10.1007/s00705-018-04127-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581445PMC
March 2019

Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies.

Proc Natl Acad Sci U S A 2019 02 30;116(7):2662-2671. Epub 2019 Jan 30.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1818322116
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http://dx.doi.org/10.1073/pnas.1818322116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377457PMC
February 2019

Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges.

Annu Rev Physiol 2019 Feb;81:505-534

Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA; email:

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http://dx.doi.org/10.1146/annurev-physiol-020518-114700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571025PMC
February 2019

Dual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancer.

NPJ Breast Cancer 2019 15;5. Epub 2019 Jan 15.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA.

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http://dx.doi.org/10.1038/s41523-018-0100-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333771PMC
January 2019

Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer.

Proc Natl Acad Sci U S A 2019 Jan 30. Epub 2019 Jan 30.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1815515116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410779PMC
January 2019

Reprogramming the Tumor Microenvironment to Improve Immunotherapy: Emerging Strategies and Combination Therapies.

Am Soc Clin Oncol Educ Book 2019 Jan 17;39:165-174. Epub 2019 May 17.

1 Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/EDBK_237987DOI Listing
January 2019

Publisher Correction: Engineering and physical sciences in oncology: challenges and opportunities.

Nat Rev Cancer 2018 11;18(11):720

Department of Chemical Engineering, David H. Koch Institute for Integrated Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts, 02139, USA.

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http://www.nature.com/articles/s41568-018-0072-x
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http://dx.doi.org/10.1038/s41568-018-0072-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357229PMC
November 2018

Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption.

Proc Natl Acad Sci U S A 2018 09 27;115(37):E8717-E8726. Epub 2018 Aug 27.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1807105115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140479PMC
September 2018

Renin-Angiotensin System Inhibitors to Mitigate Cancer Treatment-Related Adverse Events.

Clin Cancer Res 2018 Aug 2;24(16):3803-3812. Epub 2018 Apr 2.

Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-0236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095804PMC
August 2018

Taxonomy of the family Arenaviridae and the order Bunyavirales: update 2018.

Authors:
Piet Maes Sergey V Alkhovsky Yīmíng Bào Martin Beer Monica Birkhead Thomas Briese Michael J Buchmeier Charles H Calisher Rémi N Charrel Il Ryong Choi Christopher S Clegg Juan Carlos de la Torre Eric Delwart Joseph L DeRisi Patrick L Di Bello Francesco Di Serio Michele Digiaro Valerian V Dolja Christian Drosten Tobiasz Z Druciarek Jiang Du Hideki Ebihara Toufic Elbeaino Rose C Gergerich Amethyst N Gillis Jean-Paul J Gonzalez Anne-Lise Haenni Jussi Hepojoki Udo Hetzel Thiện Hồ Ní Hóng Rakesh K Jain Petrus Jansen van Vuren Qi Jin Miranda Gilda Jonson Sandra Junglen Karen E Keller Alan Kemp Anja Kipar Nikola O Kondov Eugene V Koonin Richard Kormelink Yegor Korzyukov Mart Krupovic Amy J Lambert Alma G Laney Matthew LeBreton Igor S Lukashevich Marco Marklewitz Wanda Markotter Giovanni P Martelli Robert R Martin Nicole Mielke-Ehret Hans-Peter Mühlbach Beatriz Navarro Terry Fei Fan Ng Márcio Roberto Teixeira Nunes Gustavo Palacios Janusz T Pawęska Clarence J Peters Alexander Plyusnin Sheli R Radoshitzky Víctor Romanowski Pertteli Salmenperä Maria S Salvato Hélène Sanfaçon Takahide Sasaya Connie Schmaljohn Bradley S Schneider Yukio Shirako Stuart Siddell Tarja A Sironen Mark D Stenglein Nadia Storm Harikishan Sudini Robert B Tesh Ioannis E Tzanetakis Mangala Uppala Olli Vapalahti Nikos Vasilakis Peter J Walker Guópíng Wáng Lìpíng Wáng Yànxiăng Wáng Tàiyún Wèi Michael R Wiley Yuri I Wolf Nathan D Wolfe Zhìqiáng Wú Wénxìng Xú Li Yang Zuòkūn Yāng Shyi-Dong Yeh Yǒng-Zhèn Zhāng Yàzhōu Zhèng Xueping Zhou Chénxī Zhū Florian Zirkel Jens H Kuhn

Arch Virol 2018 Aug 21;163(8):2295-2310. Epub 2018 Apr 21.

Division of Clinical Research (DCR), Integrated Research Facility at Fort Detrick (IRF-Frederick), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), B-8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA.

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http://dx.doi.org/10.1007/s00705-018-3843-5DOI Listing
August 2018

Consensus guidelines for the use and interpretation of angiogenesis assays.

Angiogenesis 2018 Aug;21(3):425-532

Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10456-018-9613-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237663PMC
August 2018

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.

Nat Rev Clin Oncol 2018 05 6;15(5):325-340. Epub 2018 Mar 6.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/nrclinonc.2018.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921900PMC
May 2018

Quantifying solid stress and elastic energy from excised or in situ tumors.

Nat Protoc 2018 05 19;13(5):1091-1105. Epub 2018 Apr 19.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2018.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546092PMC
May 2018

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.

Cancer Cell 2018 05 19;33(5):874-889.e7. Epub 2018 Apr 19.

Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, CA 94143, USA; Department of Pediatrics, University of Cambridge and Wellcome Trust-MRC Stem Cell Institute, Hills Road, Cambridge CB2 0AN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211172PMC
May 2018

Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity.

J Immunol 2018 04 2;200(8):3000-3007. Epub 2018 Mar 2.

Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women's Hospital, Ann Romney Center for Neurologic Diseases, Boston, MA 02115;

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http://dx.doi.org/10.4049/jimmunol.1700407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893394PMC
April 2018

A Physical View of Cancer.

Trends Cancer 2018 04 16;4(4):257. Epub 2018 Mar 16.

Editor, Trends in Cancer. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24058033183005
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http://dx.doi.org/10.1016/j.trecan.2018.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296379PMC
April 2018

Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy.

Trends Cancer 2018 04 17;4(4):258-259. Epub 2018 Mar 17.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2018.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161778PMC
April 2018

Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside.

Trends Cancer 2018 04 13;4(4):292-319. Epub 2018 Mar 13.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2018.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930008PMC
April 2018

Anti-VEGF treatment improves neurological function in tumors of the nervous system.

Exp Neurol 2018 01 11;299(Pt B):326-333. Epub 2017 Sep 11.

Edwin Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2017.09.008DOI Listing
January 2018

MicroRNA-378 enhances radiation response in ectopic and orthotopic implantation models of glioblastoma.

J Neurooncol 2018 Jan 28;136(1):63-71. Epub 2017 Oct 28.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s11060-017-2646-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922763PMC
January 2018

Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers.

Oncotarget 2017 Dec 26;8(65):108292-108302. Epub 2017 Nov 26.

Department of Radiation Oncology, Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.18632/oncotarget.22660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752445PMC
December 2017

A cerebellar window for intravital imaging of normal and disease states in mice.

Nat Protoc 2017 Nov 5;12(11):2251-2262. Epub 2017 Oct 5.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2017.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918134PMC
November 2017

Engineering and physical sciences in oncology: challenges and opportunities.

Nat Rev Cancer 2017 11 13;17(11):659-675. Epub 2017 Oct 13.

Department of Chemical Engineering, David H. Koch Institute for Integrated Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nrc.2017.83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683724PMC
November 2017

Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy.

Sci Transl Med 2017 Oct;9(410)

Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/scitranslmed.aan5616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928511PMC
October 2017

Effect of angiotensin system inhibitors on survival in newly diagnosed glioma patients and recurrent glioblastoma patients receiving chemotherapy and/or bevacizumab.

J Neurooncol 2017 Sep 19;134(2):325-330. Epub 2017 Jun 19.

Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s11060-017-2528-3DOI Listing
September 2017

Antibody-based therapies for the treatment of brain metastases from HER2-positive breast cancer: time to rethink the importance of the BBB?

Breast Cancer Res Treat 2017 09 22;165(2):467-468. Epub 2017 Jun 22.

Edwin L. Steele Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s10549-017-4351-0DOI Listing
September 2017

Emerging strategies for delivering antiangiogenic therapies to primary and metastatic brain tumors.

Adv Drug Deliv Rev 2017 09 22;119:159-174. Epub 2017 Jun 22.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital (MGH), Harvard Medical School (HMS), Boston, MA, 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2017.06.011DOI Listing
September 2017

YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis.

Dev Cell 2017 09 31;42(5):462-478.e7. Epub 2017 Aug 31.

Biochemistry Center (BZH), University of Heidelberg, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.08.002DOI Listing
September 2017

Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.

J Clin Invest 2017 Aug 10;127(8):3039-3051. Epub 2017 Jul 10.

Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI93182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531423PMC
August 2017

Origins of lymphatic and distant metastases in human colorectal cancer.

Science 2017 Jul;357(6346):55-60

Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/science.aai8515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536201PMC
July 2017

CD4 T Cell Activation and Vascular Normalization: Two Sides of the Same Coin?

Immunity 2017 05;46(5):773-775

Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.04.015DOI Listing
May 2017

New Directions in Anti-Angiogenic Therapy for Glioblastoma.

Neurotherapeutics 2017 04;14(2):321-332

Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1007/s13311-016-0510-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398985PMC
April 2017

Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma.

J Neurooncol 2017 02 16;131(3):603-610. Epub 2016 Nov 16.

Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital Cancer Center, Yawkey 9E, 55 Fruit Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s11060-016-2332-5DOI Listing
February 2017

Role of vascular normalization in benefit from metronomic chemotherapy.

Proc Natl Acad Sci U S A 2017 02 7;114(8):1994-1999. Epub 2017 Feb 7.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114

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http://dx.doi.org/10.1073/pnas.1700340114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338413PMC
February 2017

Stress granule-associated protein G3BP2 regulates breast tumor initiation.

Proc Natl Acad Sci U S A 2017 01 17;114(5):1033-1038. Epub 2017 Jan 17.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1525387114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293063PMC
January 2017

Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.

Cold Spring Harb Perspect Med 2016 Dec 1;6(12). Epub 2016 Dec 1.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114.

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http://dx.doi.org/10.1101/cshperspect.a027094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131751PMC
December 2016

Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds.

Sci Rep 2016 12 1;6:37949. Epub 2016 Dec 1.

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/srep37949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131361PMC
December 2016

Improving treatment of liver metastases by targeting nonangiogenic mechanisms.

Nat Med 2016 11;22(11):1209-1210

Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.4228DOI Listing
November 2016

Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma.

Transl Oncol 2016 Oct;9(5):431-437

Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA; Division of Body Imaging, Department of Diagnostic Radiology, Oregon Health Sciences University, Portland, OR. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2016.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067928PMC
October 2016

Closing the gap: astrocytes and brain metastasis.

Cell Res 2016 09 12;26(9):973-4. Epub 2016 Aug 12.

Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034114PMC
http://dx.doi.org/10.1038/cr.2016.96DOI Listing
September 2016

Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages.

PLoS One 2015 7;10(12):e0141392. Epub 2015 Dec 7.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141392PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671732PMC
June 2016

Targeting the Tumor Microenvironment to Enhance Pediatric Brain Cancer Treatment.

Cancer J 2015 Jul-Aug;21(4):307-13

From Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/PPO.0000000000000125DOI Listing
May 2016

Efficacy and Biomarker Study of Bevacizumab for Hearing Loss Resulting From Neurofibromatosis Type 2-Associated Vestibular Schwannomas.

J Clin Oncol 2016 05 14;34(14):1669-75. Epub 2016 Mar 14.

Jaishri O. Blakeley, Xiaobu Ye, Amanda L. Bergner, Laura M. Fayad, Shivani Ahlawat, and Michael A. Jacobs, Johns Hopkins University, Baltimore; Christopher Zalewski, National Institute on Deafness and Other Communication Disorders; Eva Dombi and Brigitte C. Widemann, National Cancer Institute, Bethesda, MD; Dan G. Duda, Alona Muzikansky, Vanessa L. Merker, Elizabeth R. Gerstner, Rakesh K. Jain, and Scott R. Plotkin, Massachusetts General Hospital; and Chris F. Halpin, Massachusetts Eye and Ear Infirmary, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2015.64.3817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872317PMC
May 2016

Mathematical Model of Oxygen Transport in Tuberculosis Granulomas.

Ann Biomed Eng 2016 Apr 8;44(4):863-72. Epub 2015 Aug 8.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Cox 7, 100 Blossom Street, Boston, MA, 02114, USA.

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http://link.springer.com/10.1007/s10439-015-1415-3
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http://dx.doi.org/10.1007/s10439-015-1415-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795989PMC
April 2016

Obesity and Cancer: An Angiogenic and Inflammatory Link.

Microcirculation 2016 Apr;23(3):191-206

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1111/micc.12270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818678PMC
April 2016

Lessons From 30 Years of Teaching About the Microenvironment of Tumors.

Cancer J 2015 May-Jun;21(3):137

From Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/PPO.0000000000000119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792516PMC
February 2016

Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment.

J Natl Cancer Inst 2016 Feb 7;108(2). Epub 2015 Nov 7.

: Edwin L. Steele Laboratories, Department of Radiation Oncology (VA, GBF, DPK, MB, RCS, GS, JK, TV, JDM, KN, DB, XQ, DGD, PH, DF, RKJ), Department of Pathology (MKS, EB), and Department of Medicine, Cancer Center (JAE), Massachusetts General Hospital and Harvard Medical School, Boston MA.

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http://dx.doi.org/10.1093/jnci/djv313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862418PMC
February 2016

Mast Cells Contribute to Radiation-Induced Vascular Hyperpermeability.

Radiat Res 2016 Feb 15;185(2):182-9. Epub 2016 Jan 15.

a  Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;

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http://dx.doi.org/10.1667/RR14190.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761451PMC
February 2016

Mouse embryonic fibroblasts exhibit extensive developmental and phenotypic diversity.

Proc Natl Acad Sci U S A 2016 Jan 22;113(1):122-7. Epub 2015 Dec 22.

Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114; Department of Genetics, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1522401112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711836PMC
January 2016

Design considerations for nanotherapeutics in oncology.

Nanomedicine 2015 Nov 15;11(8):1893-907. Epub 2015 Aug 15.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2015.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628869PMC
November 2015

Vascular diseases await translation of blood vessels engineered from stem cells.

Sci Transl Med 2015 Oct;7(309):309rv6

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa1805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799660PMC
October 2015

Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases.

J Natl Cancer Inst 2015 Sep 10;107(9). Epub 2015 Jun 10.

Edwin L. Steele Laboratories, Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA (HSJ, DJ, SL, DAW, CC, DGD, RKJ, TPP); Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea (HSJ); Department of Radiation Oncology, Duke University Medical Center, Durham, NC (CGW).Current affiliation: Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada (SL).

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http://dx.doi.org/10.1093/jnci/djv155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651102PMC
September 2015

Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors.

J Am Chem Soc 2015 Aug 29;137(31):9832-42. Epub 2015 Jul 29.

†Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.

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http://dx.doi.org/10.1021/jacs.5b04765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750386PMC
August 2015

An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis.

Nat Protoc 2015 Aug 23;10(8):1264-74. Epub 2015 Jul 23.

Department of Radiation Oncology, Steele Laboratories for Tumor Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2015.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800979PMC
August 2015

Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients.

Proc Natl Acad Sci U S A 2015 Jul 16;112(27):E3454. Epub 2015 Jun 16.

Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1507225112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500270PMC
July 2015