Rajiv R Ratan

Rajiv R Ratan

UNVERIFIED PROFILE

Are you Rajiv R Ratan?   Register this Author

Register author
Rajiv R Ratan

Rajiv R Ratan

Publications by authors named "Rajiv R Ratan"

Are you Rajiv R Ratan?   Register this Author

100Publications

1642Reads

19Profile Views

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke.

Cell 2019 May 2;177(5):1262-1279.e25. Epub 2019 May 2.

Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2019.03.032DOI Listing
May 2019

Arginase overexpression in neurons and its effect on traumatic brain injury.

Mol Genet Metab 2018 09 25;125(1-2):112-117. Epub 2018 Jul 25.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgme.2018.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175653PMC
September 2018

The interferon response as a common final pathway for many preconditioning stimuli: unexpected crosstalk between hypoxic adaptation and antiviral defense.

Cond Med 2018 Apr 15;1(4):143-150. Epub 2018 Jun 15.

Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute; White Plains, NY, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126377PMC
April 2018

Building on NeuroNEXT: Next generation clinics to cure chronic neurological disability.

Authors:
Rajiv R Ratan

Ann Neurol 2017 12 8;82(6):859-862. Epub 2017 Dec 8.

Burke Medical Research Institute at Weill Cornell Medicine, White Plains, NY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739997PMC
December 2017

Rehabilitation following hemorrhagic stroke: building the case for stroke-subtype specific recovery therapies.

F1000Res 2017 23;6:2044. Epub 2017 Nov 23.

Burke Medical Research Institute, White Plains, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12688/f1000research.11913.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701438PMC
November 2017

Hypoxic Adaptation in the Nervous System: Promise for Novel Therapeutics for Acute and Chronic Neurodegeneration.

Adv Exp Med Biol 2016;903:221-43

Burke-Cornell Medical Research Institute, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4899-7678-9_16DOI Listing
June 2017

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis.

Stroke 2017 04 1;48(4):1033-1043. Epub 2017 Mar 1.

From the Burke Medical Research Institute, White Plains, New York (M.Z., S.S.K., Y.C., R.R.R.); Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York (M.Z., S.S.K., Y.C., T.A.M., R.R.R.); Host Defense Discovery Performance Unit, Infectious Diseases Therapy Area Unit (P.J.G.) and Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area (J.B., J.F.), GlaxoSmithKline, Collegeville, PA; Laboratory of Neuroendocrinology, The Rockefeller University, New York (T.A.M.); and Department of Internal Medicine, Section of Endocrinology, Yale University, New Haven, CT (E.A.J.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.116.015609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613764PMC
April 2017

Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson's Disease.

Aging Dis 2016 Dec 1;7(6):745-762. Epub 2016 Dec 1.

1Burke Medical Research Institute, Weill Medical College of Cornell University, White Plains, NY 10605, USA; 5Department of Chemical Enzymology, Moscow State University, Moscow 119992, Russia; 8Department of Chemistry and Physical Sciences, Dyson College, Pace University, Pleasantville, NY 10570, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14336/AD.2016.0505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201116PMC
December 2016

Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly.

J Huntingtons Dis 2016 10;5(3):217-237

Burke Medical Research Institute, White Plains, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JHD-160205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310831PMC
October 2016

Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?

Neurosci Lett 2016 06 8;625:56-63. Epub 2016 Feb 8.

Sperling Center for Hemorrhagic Stroke Recovery, Burke Medical Research Institute, 785 Mamaroneck Ave, White Plains, NY 10605, USA; Brain and Mind Research Institute, Weill Medical College of Cornell University, 1300 York Ave. Box 65, New York, NY 10065, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2016.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903954PMC
June 2016

Nature and nurture meet at the epigenome to modulate disorders of the nervous system.

Neurosci Lett 2016 06;625:1-3

Burke Medical Research Institute, 785 Mamaroneck Ave., White Plains, NY 10605, United States; The Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2016.05.052DOI Listing
June 2016

Metabolism and epigenetics in the nervous system: Creating cellular fitness and resistance to neuronal death in neurological conditions via modulation of oxygen-, iron-, and 2-oxoglutarate-dependent dioxygenases.

Brain Res 2015 Dec 29;1628(Pt B):273-287. Epub 2015 Jul 29.

Burke Medical Research Institute, White Plains, NY, USA; Feil Family Brain and Mind Research Institute, Department of Neurology, Weill Medical College of Cornell University, New York, NY, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainres.2015.07.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681673PMC
December 2015

Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic Stroke.

J Neurosci 2015 Nov;35(45):15113-26

Burke-Cornell Medical Research Institute, White Plains, New York 10605, Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York 10021,

View Article

Download full-text PDF

Source
http://www.jneurosci.org/content/35/45/15113.full.pdf
Web Search
http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2890-15.2
Publisher Site
http://dx.doi.org/10.1523/JNEUROSCI.2890-15.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642242PMC
November 2015

Spatial, temporal, and quantitative manipulation of intracellular hydrogen peroxide in cultured cells.

Methods Enzymol 2014 ;547:251-73

Department of Neurology and Neuroscience, The Burke Medical Research Institute, Weill Medical College of Cornell University, White Plains, New York, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/B978-0-12-801415-8.00014-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311899PMC
August 2015

The interplay between microRNAs and histone deacetylases in neurological diseases.

Neurochem Int 2014 Nov 27;77:33-9. Epub 2014 Mar 27.

Burke-Cornell Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA; Department of Neurology and Neuroscience, Weill Medical College, Cornell University, 525 E. 68th Street, New York, NY 10065, USA. Electronic address:

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321688PMC
http://dx.doi.org/10.1016/j.neuint.2014.03.012DOI Listing
November 2014

cAMP-responsive element-binding protein (CREB) and cAMP co-regulate activator protein 1 (AP1)-dependent regeneration-associated gene expression and neurite growth.

J Biol Chem 2014 Nov 8;289(47):32914-25. Epub 2014 Oct 8.

From the Burke-Cornell Medical Research Institute, White Plains, New York 10605 and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M114.582460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239638PMC
November 2014

Recent advances in hydrogen peroxide imaging for biological applications.

Cell Biosci 2014 27;4(1):64. Epub 2014 Oct 27.

Burke Medical Research Institute, Weill Medical College of Cornell University, White Plains, NY 10605 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/2045-3701-4-64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232666PMC
November 2014

Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition.

J Neurosci 2014 Oct;34(43):14328-37

Burke Medical Research Institute, White Plains, New York 10605, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.1010-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205555PMC
October 2014

Transcriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasis.

Drug Discov Today 2014 Jul 21;19(7):956-62. Epub 2014 Mar 21.

Burke Medical Research Institute, White Plains, NY 10065, USA; Brain and Mind Research Institute, Weill Medical College, Cornell University, White Plains, NY 10605, USA; Department of Neurology, Weill Medical College, Cornell University, White Plains, NY 10605, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drudis.2014.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082751PMC
July 2014

A selective phenelzine analogue inhibitor of histone demethylase LSD1.

ACS Chem Biol 2014 Jun 7;9(6):1284-93. Epub 2014 Apr 7.

Department of Pharmacology, ∥Center for Epigenetics and Department of Medicine, ⊥Department of Ophthalmology, and ¶The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine , Baltimore, Maryland 21205, United States.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/cb500018s
Publisher Site
http://dx.doi.org/10.1021/cb500018sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076021PMC
June 2014

An adaptive role for BDNF Val66Met polymorphism in motor recovery in chronic stroke.

J Neurosci 2014 Feb;34(7):2493-502

Weill Cornell Medical College at Burke Medical Research Institute, White Plains, New York 10605, and Weill Cornell Medical College, New York, New York 10021.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.4140-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921423PMC
February 2014

Two-photon fluorescence imaging of intracellular hydrogen peroxide with chemoselective fluorescent probes.

J Biomed Opt 2013 Oct;18(10):106002

University of Maryland, Fischell Department of Bioengineering, College Park, Maryland 20742bWeill Medical College of Cornell University, Burke Medical Research Institute, White Plains, New York 10605.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1117/1.JBO.18.10.106002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787808PMC
October 2013

The epigenetics of stroke recovery and rehabilitation: from polycomb to histone deacetylases.

Neurotherapeutics 2013 Oct;10(4):808-16

Center for Stroke Recovery, Burke-Cornell Medical Research Institute, 785 Mamaroneck Avenue White Plains, New York, 10605, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13311-013-0224-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805866PMC
October 2013

Looking above but not beyond the genome for therapeutics in neurology and psychiatry: epigenetic proteins and RNAs find a new focus.

Neurotherapeutics 2013 Oct;10(4):551-5

Burke Medical Research Institute, Weill Medical College of Cornell University, 785 Mamaroneck Avenue, White Plains, New York, 10605, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13311-013-0225-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805863PMC
October 2013

Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke.

Free Radic Biol Med 2013 Sep 31;62:26-36. Epub 2013 Jan 31.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA; Burke Medical Research Institute, White Plains, NY 10605, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2013.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327984PMC
September 2013

Derivation of multivariate syndromic outcome metrics for consistent testing across multiple models of cervical spinal cord injury in rats.

PLoS One 2013 27;8(3):e59712. Epub 2013 Mar 27.

Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059712PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609747PMC
September 2013

In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation.

J Neurosci Res 2013 Aug 4;91(8):1066-75. Epub 2013 Mar 4.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jnr.23204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321689PMC
August 2013

Transglutaminase is a therapeutic target for oxidative stress, excitotoxicity and stroke: a new epigenetic kid on the CNS block.

J Cereb Blood Flow Metab 2013 Jun 10;33(6):809-18. Epub 2013 Apr 10.

Burke-Cornell Medical Research Institute, White Plains, New York 10605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/jcbfm.2013.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677119PMC
June 2013

15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPARγ.

J Neurochem 2013 Feb 3;124(4):536-47. Epub 2013 Jan 3.

The Burke Medical Research Institute, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, White Plains, NY 10605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jnc.12107DOI Listing
February 2013

Epigenetics and the environment: in search of the "toleroasome" vital to execution of ischemic preconditioning.

Transl Stroke Res 2013 Feb 8;4(1):56-62. Epub 2013 Jan 8.

Amherst College, Amherst, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12975-012-0235-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040454PMC
February 2013

A screen for inducers of p21(waf1/cip1) identifies HIF prolyl hydroxylase inhibitors as neuroprotective agents with antitumor properties.

Neurobiol Dis 2013 Jan 27;49:13-21. Epub 2012 Aug 27.

Burke-Cornell Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA; Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10065, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2012.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706502PMC
January 2013

Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke.

Ann Neurol 2013 Jan 28;73(1):129-35. Epub 2012 Nov 28.

Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.23734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563836PMC
January 2013

Higher Blood Glucose within the Normal Range Is Associated with More Severe Strokes.

Stroke Res Treat 2012 28;2012:659610. Epub 2012 Mar 28.

Burke/Cornell Medical Research Institute, White Plains, NY 10605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2012/659610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329666PMC
August 2012

Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics?

J Cereb Blood Flow Metab 2012 Jul 14;32(7):1347-61. Epub 2012 Mar 14.

Center for Stroke Recovery, Burke Medical Research Institute, White Plains, NY, USA.

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1038/jcbfm.2012.28
Publisher Site
http://dx.doi.org/10.1038/jcbfm.2012.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390817PMC
July 2012

miR-886-3p levels are elevated in Friedreich ataxia.

J Neurosci 2012 Jul;32(27):9369-73

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10065, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0059-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471167PMC
July 2012

Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration.

Pharmaceuticals (Basel) 2011 Aug;4(8):1183-1195

Burke-Cornell Medical Research Institute, 785 Mamaroneck Ave, White Plains, New York, NY 10605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ph4081183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349345PMC
August 2011

Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice.

Acta Neuropathol 2011 Apr 16;121(4):487-98. Epub 2010 Dec 16.

Department of Neurology and Pathology, Boston University School of Medicine, Boston, MA 02118, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-010-0788-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151672PMC
April 2011

Beyond neuroprotection to brain repair: exploring the next frontier in clinical neuroscience to expand the therapeutic window for stroke.

Authors:
Rajiv R Ratan

Transl Stroke Res 2010 Jun 18;1(2):71-3. Epub 2010 May 18.

Burke-Cornell Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12975-010-0024-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881323PMC
June 2010

Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation.

Chem Biol 2010 Apr;17(4):380-91

Burke Medical Research Institute, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 785 Mamaroneck Ave, White Plains, NY 10605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2010.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327942PMC
April 2010

Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream.

Biochem Biophys Res Commun 2010 Mar 17;393(4):673-7. Epub 2010 Feb 17.

Burke Medical Research Institute, 785 Mamaroneck Ave, White Plains, NY 10605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2010.02.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848448PMC
March 2010

Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.

Biochim Biophys Acta 2010 Jan 26;1802(1):122-34. Epub 2009 Aug 26.

Department of Neurology and Neuroscience, Weill Cornell Medical College of Cornell University at Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2009.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790547PMC
January 2010

A nonradioactive dot blot assay for transglutaminase activity.

Anal Biochem 2009 Jul 21;390(1):91-3. Epub 2009 Mar 21.

Burke Medical Research Institute, White Plains, NY 10605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2009.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845163PMC
July 2009

Novel multi-modal strategies to promote brain and spinal cord injury recovery.

Stroke 2009 Mar 8;40(3 Suppl):S130-2. Epub 2008 Dec 8.

Winifred Masterson Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.108.534933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655641PMC
March 2009

Mitochondria and oxidative stress in neurodegenerative disorders. Preface.

Ann N Y Acad Sci 2008 Dec;1147:xi-xii

Weill Cornell Medical College, Burke Medical Research Institute, White Plains, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1196/annals.1427.039DOI Listing
December 2008

Advances in stroke regenerative medicine 2007.

Stroke 2008 Feb 10;39(2):273-5. Epub 2008 Jan 10.

King's College London School of Medicine, Bessemer Road, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.107.511972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586139PMC
February 2008

Prolyl 4-hydroxylase activity-responsive transcription factors: from hydroxylation to gene expression and neuroprotection.

Front Biosci 2008 Jan 1;13:2875-87. Epub 2008 Jan 1.

Burke Medical Research Institute, White Plains, New York 10605, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570096PMC
http://dx.doi.org/10.2741/2892DOI Listing
January 2008

CD81, a cell cycle regulator, is a novel target for histone deacetylase inhibition in glioma cells.

Neurobiol Dis 2007 Jun 28;26(3):671-80. Epub 2007 Mar 28.

The Winifred Masterson Burke/Cornell Medical Research Institute, 785 Mamaroneck Ave., White Plains, NY 10605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2007.03.008DOI Listing
June 2007

Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress.

Neurochem Res 2007 Apr-May;32(4-5):931-46. Epub 2007 Mar 7.

Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11064-006-9268-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576999PMC
May 2007

The metabolic coupling of arginine metabolism to nitric oxide generation by astrocytes.

Antioxid Redox Signal 2006 May-Jun;8(5-6):919-28

Burke/Cornell Medical Research Institute, White Plains, New York 10605, USA.

View Article

Download full-text PDF

Source
http://www.liebertpub.com/doi/10.1089/ars.2006.8.919
Publisher Site
http://dx.doi.org/10.1089/ars.2006.8.919DOI Listing
March 2007

Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response.

FASEB J 2006 Nov 28;20(13):2375-7. Epub 2006 Sep 28.

Geriatric Research Education and Clinical Center, Bedford Veteran's Affairs Medical Center, 200 Springs Rd., Bedford, MA 01730, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.06-5957fjeDOI Listing
November 2006

Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: prolyl hydroxylases tune the biological normoxic set point.

Free Radic Biol Med 2006 Jun 9;40(12):2147-54. Epub 2006 Mar 9.

Laboratory of Molecular Medicine, Davis Heart & Lung Research Institute, Department of Surgery, The Ohio State University Medical Center, Columbus, 43210, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2006.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489266PMC
June 2006

The histone deacetylase inhibitor sodium butyrate protects against cisplatin-induced hearing loss in guinea pigs.

Laryngoscope 2006 Feb;116(2):292-6

Department of Otolaryngology, Children's Hospital, and the Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.mlg.0000197630.85208.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570099PMC
February 2006

Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons.

Proc Natl Acad Sci U S A 2005 Sep 16;102(39):13915-20. Epub 2005 Sep 16.

Geriatric Research Education and Clinical Center, Veteran's Affairs Medical Center, Bedford, MA 01730, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.0502878102
Publisher Site
http://dx.doi.org/10.1073/pnas.0502878102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236533PMC
September 2005

Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line.

J Biol Chem 2005 Feb 22;280(5):3996-4003. Epub 2004 Nov 22.

Department of Neurology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M409223200DOI Listing
February 2005

Proteasome inhibition protects HT22 neuronal cells from oxidative glutamate toxicity.

J Neurochem 2005 Feb;92(4):824-30

Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1471-4159.2004.02915.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570092PMC
February 2005

Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents.

Curr Drug Targets CNS Neurol Disord 2005 Feb;4(1):41-50

Burke Medical Research Institute, White Plains, NY 10605, USA.

View Article

Download full-text PDF

Source
February 2005

Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease.

J Biol Chem 2005 Jan 19;280(1):556-63. Epub 2004 Oct 19.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York 10021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M410210200DOI Listing
January 2005

Translation of ischemic preconditioning to the patient: prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy.

Stroke 2004 Nov 7;35(11 Suppl 1):2687-9. Epub 2004 Oct 7.

Department of Neurology and Neuroscience, Burke/Cornell Medical Research Institute, Weill Medical College of Cornell, White Plains, NY 10605, USA.

View Article

Download full-text PDF

Source
http://stroke.ahajournals.org/cgi/doi/10.1161/01.STR.0000143
Publisher Site
http://dx.doi.org/10.1161/01.STR.0000143216.85349.9eDOI Listing
November 2004

Novel roles for arginase in cell survival, regeneration, and translation in the central nervous system.

J Nutr 2004 10;134(10 Suppl):2812S-2817S; discussion 2818S-2819S

Department of Neurology, Harvard Medical School and the Beth Israel Deaconess Medical Center, Boston MA 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jn/134.10.2812SDOI Listing
October 2004