Publications by authors named "Rajiv Dhir"

100Publications

Abnormal expression of Rab27B in prostatic epithelial cells of benign prostatic hyperplasia alters intercellular communication.

Int J Biochem Cell Biol 2020 Dec 4;131:105898. Epub 2020 Dec 4.

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, United States. Electronic address:

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December 2020

Tight junction protein claudin-1 is downregulated by TGF-β1 via MEK signaling in benign prostatic epithelial cells.

Prostate 2020 10 21;80(14):1203-1215. Epub 2020 Jul 21.

Department of Urology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

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October 2020

Lessons learned from clinical trial queries on small biopsy collections: importance of rapid on-site evaluation.

J Am Soc Cytopathol 2020 Sep - Oct;9(5):461-468. Epub 2020 May 6.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address:

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May 2020

An institutional experience evaluating hTERT immunostaining in 100 consecutive ThinPrep urine specimens.

J Am Soc Cytopathol 2020 Apr 6. Epub 2020 Apr 6.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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April 2020

SIRPB1 promotes prostate cancer cell proliferation via Akt activation.

Prostate 2020 03 6;80(4):352-364. Epub 2020 Jan 6.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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March 2020

Ultrasonic-assisted extraction and digestion of proteins from solid biopsies followed by peptide sequential extraction hyphenated to MALDI-based profiling holds the promise of distinguishing renal oncocytoma from chromophobe renal cell carcinoma.

Talanta 2020 Jan 27;206:120180. Epub 2019 Jul 27.

LAQV, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516, Caparica, Portugal; PROTEOMASS Scientific Society, Madan Park, Rua dos Inventores, 2825-152, Caparica, Portugal. Electronic address:

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January 2020

Conditional Deletion of Eaf1 Induces Murine Prostatic Intraepithelial Neoplasia in Mice.

Neoplasia 2019 08 21;21(8):752-764. Epub 2019 Jun 21.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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August 2019

Development of a Robust Ultrasonic-Based Sample Treatment To Unravel the Proteome of OCT-Embedded Solid Tumor Biopsies.

J Proteome Res 2019 07 19;18(7):2979-2986. Epub 2019 Jun 19.

BIOSCOPE Research Group, LAQV, REQUIMTE, Department of Chemistry, Faculdade de Ciências e Tecnologia , Universidade NOVA de Lisboa , 2829-516 Caparica , Portugal.

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July 2019

The Biospecimen Preanalytical Variables Program: A Multiassay Comparison of Effects of Delay to Fixation and Fixation Duration on Nucleic Acid Quality.

Arch Pathol Lab Med 2019 09 20;143(9):1106-1118. Epub 2019 Feb 20.

From Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland (Drs Carithers, Guan, Odeh, Sachs, Branton, and Moore); Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland (Drs Agarwal, Barcus, Lih, Williams, Sobin, Roche, and Mr Soria); Preferred Solutions Group, Preferred Scientific Group, Washington, District of Columbia (Dr Engel); Kelly Government Solutions, Kelly Services, Rockville, Maryland (Dr Greytak and Mr Fombonne); the Department of Pathology, University of New Mexico, Albuquerque (Dr Bocklage); the Department of Pathology and Laboratory Medicine, Boston Medical Center, Boston, Massachusetts (Dr Andry and Ms Duffy); the Department of Pathology and Laboratory Medicine, Emory University, Winship Cancer Institute, Atlanta, Georgia (Dr Sica); the Department of Pathology, University of Pittsburg, Pittsburgh, Pennsylvania (Dr Dhir); and Van Andel Research Institute, Pathology and Biorepository Core, VARI Core Technologies and Services, Grand Rapids, Michigan (Dr Jewell).

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September 2019

A prolonged response to platinum-based therapy in a patient with metastatic urothelial carcinoma harboring a single rearranged and truncated NF2 gene.

Genes Chromosomes Cancer 2018 08 30;57(8):430-433. Epub 2018 Mar 30.

Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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August 2018

Epidermoid cyst of the renal pelvis masquerading as malignancy.

Indian J Pathol Microbiol 2017 Oct-Dec;60(4):571-573

Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH, USA.

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July 2018

Utility of the laminin immunohistochemical stain in distinguishing invasive from noninvasive urothelial carcinoma.

J Cancer Res Ther 2017 Oct-Dec;13(6):947-950

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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July 2018

Methods to Improve Sustainability of a Large Academic Biorepository.

Biopreserv Biobank 2017 Feb 18;15(1):31-36. Epub 2016 Nov 18.

2 Department of Pathology, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.

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February 2017

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.

Authors:
W Marston Linehan Paul T Spellman Christopher J Ricketts Chad J Creighton Suzanne S Fei Caleb Davis David A Wheeler Bradley A Murray Laura Schmidt Cathy D Vocke Myron Peto Abu Amar M Al Mamun Eve Shinbrot Anurag Sethi Samira Brooks W Kimryn Rathmell Angela N Brooks Katherine A Hoadley A Gordon Robertson Denise Brooks Reanne Bowlby Sara Sadeghi Hui Shen Daniel J Weisenberger Moiz Bootwalla Stephen B Baylin Peter W Laird Andrew D Cherniack Gordon Saksena Scott Haake Jun Li Han Liang Yiling Lu Gordon B Mills Rehan Akbani Mark D M Leiserson Benjamin J Raphael Pavana Anur Donald Bottaro Laurence Albiges Nandita Barnabas Toni K Choueiri Bogdan Czerniak Andrew K Godwin A Ari Hakimi Thai H Ho James Hsieh Michael Ittmann William Y Kim Bhavani Krishnan Maria J Merino Kenna R Mills Shaw Victor E Reuter Ed Reznik Carl S Shelley Brian Shuch Sabina Signoretti Ramaprasad Srinivasan Pheroze Tamboli George Thomas Satish Tickoo Kenneth Burnett Daniel Crain Johanna Gardner Kevin Lau David Mallery Scott Morris Joseph D Paulauskis Robert J Penny Candace Shelton W Troy Shelton Mark Sherman Eric Thompson Peggy Yena Melissa T Avedon Jay Bowen Julie M Gastier-Foster Mark Gerken Kristen M Leraas Tara M Lichtenberg Nilsa C Ramirez Tracie Santos Lisa Wise Erik Zmuda John A Demchok Ina Felau Carolyn M Hutter Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean C Zenklusen Jiashan Zhang Brenda Ayala Julien Baboud Sudha Chudamani Jia Liu Laxmi Lolla Rashi Naresh Todd Pihl Qiang Sun Yunhu Wan Ye Wu Adrian Ally Miruna Balasundaram Saianand Balu Rameen Beroukhim Tom Bodenheimer Christian Buhay Yaron S N Butterfield Rebecca Carlsen Scott L Carter Hsu Chao Eric Chuah Amanda Clarke Kyle R Covington Mahmoud Dahdouli Ninad Dewal Noreen Dhalla Harsha V Doddapaneni Jennifer A Drummond Stacey B Gabriel Richard A Gibbs Ranabir Guin Walker Hale Alicia Hawes D Neil Hayes Robert A Holt Alan P Hoyle Stuart R Jefferys Steven J M Jones Corbin D Jones Divya Kalra Christie Kovar Lora Lewis Jie Li Yussanne Ma Marco A Marra Michael Mayo Shaowu Meng Matthew Meyerson Piotr A Mieczkowski Richard A Moore Donna Morton Lisle E Mose Andrew J Mungall Donna Muzny Joel S Parker Charles M Perou Jeffrey Roach Jacqueline E Schein Steven E Schumacher Yan Shi Janae V Simons Payal Sipahimalani Tara Skelly Matthew G Soloway Carrie Sougnez Angela Tam Donghui Tan Nina Thiessen Umadevi Veluvolu Min Wang Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Jane Zhou Jason Bedford Fengju Chen Yao Fu Mark Gerstein David Haussler Katayoon Kasaian Phillip Lai Shiyun Ling Amie Radenbaugh David Van Den Berg John N Weinstein Jingchun Zhu Monique Albert Iakovina Alexopoulou Jeremiah J Andersen J Todd Auman John Bartlett Sheldon Bastacky Julie Bergsten Michael L Blute Lori Boice Roni J Bollag Jeff Boyd Erik Castle Ying-Bei Chen John C Cheville Erin Curley Benjamin Davies April DeVolk Rajiv Dhir Laura Dike John Eckman Jay Engel Jodi Harr Ronald Hrebinko Mei Huang Lori Huelsenbeck-Dill Mary Iacocca Bruce Jacobs Michael Lobis Jodi K Maranchie Scott McMeekin Jerome Myers Joel Nelson Jeremy Parfitt Anil Parwani Nicholas Petrelli Brenda Rabeno Somak Roy Andrew L Salner Joel Slaton Melissa Stanton R Houston Thompson Leigh Thorne Kelinda Tucker Paul M Weinberger Cynthia Winemiller Leigh Anne Zach Rosemary Zuna

N Engl J Med 2016 Jan 4;374(2):135-45. Epub 2015 Nov 4.

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January 2016

Splicing Factor Prp8 Interacts With NES(AR) and Regulates Androgen Receptor in Prostate Cancer Cells.

Mol Endocrinol 2015 Dec 15;29(12):1731-42. Epub 2015 Sep 15.

Departments of Urology (D.W., M.M.N., K.Z.M., P.S., Y.J., K.O., J.A.D., Z.W.), Pharmacology and Chemical Biology (Z.W.), and Pathology (R.D., Z.W.) and University of Pittsburgh Cancer Institute (R.D., Z.W.), University of Pittsburgh, Pittsburgh, Pennsylvania 15232; and Department of Urology (Y.J.), The First People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200080, China.

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December 2015

Data Representation, Coding, and Communication Standards.

Surg Pathol Clin 2015 Jun;8(2):109-21

Department of Pathology, University of Pittsburgh Medical Center Shadyside Hospital, 5230 Centre Avenue, Room WG 02.6, Pittsburgh, PA 15232, USA.

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June 2015

Renal medullary carcinoma: case report of an aggressive malignancy with near-complete response to dose-dense methotrexate, vinblastine, Doxorubicin, and Cisplatin chemotherapy.

Case Rep Oncol Med 2014 19;2014:615895. Epub 2014 Aug 19.

Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA.

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September 2014

Argument for prostate cancer screening in populations of African-Caribbean origin.

BJU Int 2015 Oct 11;116(4):507-8. Epub 2015 Jun 11.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

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October 2015

Amylase α-1A (AMY1A): a novel immunohistochemical marker to differentiate chromophobe renal cell carcinoma from benign oncocytoma.

Am J Surg Pathol 2013 Dec;37(12):1824-30

*Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA †Department of Pathology, East Carolina University, Greenville, NC.

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December 2013

Frozen section diagnosis: is there discordance between what pathologists say and what surgeons hear?

Am J Clin Pathol 2013 Sep;140(3):363-9

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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September 2013

Genetic variation in ESR2 and estrogen receptor-beta expression in lung tumors.

Cancer Epidemiol 2013 Aug 23;37(4):518-22. Epub 2013 Apr 23.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.

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August 2013

Using the epigenetic field defect to detect prostate cancer in biopsy negative patients.

J Urol 2013 Jun 15;189(6):2335-41. Epub 2012 Nov 15.

University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

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June 2013

Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion.

Mol Cancer 2012 Jan 11;11. Epub 2012 Jan 11.

Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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January 2012

Relative quantitation of proteins in expressed prostatic secretion with a stable isotope labeled secretome standard.

J Proteome Res 2012 Feb 1;11(2):1089-99. Epub 2011 Dec 1.

Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States.

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February 2012

Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastases.

Cancer Microenviron 2012 Apr 3;5(1):19-28. Epub 2011 Sep 3.

Department of Pathology, Pittsburgh VAMC and University of Pittsburgh, Pittsburgh, PA, 15213, USA.

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April 2012

Identification of Hydroxysteroid (17β) dehydrogenase type 12 (HSD17B12) as a CD8+ T-cell-defined human tumor antigen of human carcinomas.

Cancer Immunol Immunother 2011 Jul 16;60(7):919-29. Epub 2011 Mar 16.

Division of Basic Research, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

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July 2011

Increased cancer cell proliferation in prostate cancer patients with high levels of serum folate.

Prostate 2011 Sep 9;71(12):1287-93. Epub 2011 Feb 9.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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September 2011

Differential proteomic analysis of renal cell carcinoma tissue interstitial fluid.

J Proteome Res 2011 Mar 12;10(3):1333-42. Epub 2011 Jan 12.

Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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March 2011

Hypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancer.

Clin Cancer Res 2010 Nov 9;16(22):5390-401. Epub 2010 Nov 9.

Department of Urology, University of Pittsburgh, 5200 Centre Avenue, Pittsburgh, PA 15232, USA.

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November 2010

Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasion.

Cancer Res 2010 Jun 25;70(11):4327-34. Epub 2010 May 25.

Departments of Urology and Pathology, University of Pittsburgh School of Medicine, Shadyside Medical Center, Prostate Cancer Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA.

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June 2010

Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance.

Cancer Res 2010 Mar 16;70(5):1885-95. Epub 2010 Feb 16.

Department of Surgery/Urology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA.

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March 2010

Magnetic activated cell sorting allows isolation of spermatogonia from adult primate testes and reveals distinct GFRa1-positive subpopulations in men.

J Med Primatol 2010 Apr 15;39(2):83-91. Epub 2009 Dec 15.

Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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April 2010

Utility of a dual immunostain cocktail comprising of p53 and CK20 to aid in the diagnosis of non-neoplastic and neoplastic bladder biopsies.

Diagn Pathol 2009 Oct 14;4:35. Epub 2009 Oct 14.

Department of Pathology, Shadyside Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

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October 2009

Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue.

Cancer Res 2009 Sep;69(17):6831-8

Department of Human Genetics, University of Pittsburgh School of Public Health, PA, USA.

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September 2009

Suppressive roles of calreticulin in prostate cancer growth and metastasis.

Am J Pathol 2009 Aug 16;175(2):882-90. Epub 2009 Jul 16.

Department of Urology, University of Pittsburgh, 5200 Centre Ave., Shadyside Medical Center, Suite G40, Pittsburgh, PA 15232, USA.

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August 2009

Immunohistochemical profile of paratesticular serous papillary adenocarcinoma and tunica vaginalis facilitates distinction from malignant mesothelioma.

Int J Surg Pathol 2011 Oct 3;19(5):692-8. Epub 2009 Jun 3.

Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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October 2011

Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis.

Am J Respir Crit Care Med 2009 Jul 10;180(2):167-75. Epub 2009 Apr 10.

Division of Pulmonary, Allergy and Critical Care Medicine, Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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July 2009

Polymeric immunoglobulin receptor-negative tumors represent a more aggressive type of adenocarcinomas of distal esophagus and gastroesophageal junction.

Arch Pathol Lab Med 2008 Aug;132(8):1295-301

Department of Pathology, McGill University, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.

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August 2008

A multidisciplinary approach to honest broker services for tissue banks and clinical data: a pragmatic and practical model.

Cancer 2008 Oct;113(7):1705-15

Department of Pathology, University of Pittsburgh, UPMC Shadyside-Presbyterian Hospital, Pittsburgh, Pennsylvania 15232, USA.

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October 2008

Prostate cancer biobanking.

Authors:
Rajiv Dhir

Curr Opin Urol 2008 May;18(3):309-14

Health Sciences Tissue Bank, University of Pittsburgh UPMC Shadyside-Presbyterian Hospital, Pittsburgh, Pennsylvania 15232, USA.

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May 2008

Tissue microarrays: an overview.

Authors:
Rajiv Dhir

Methods Mol Biol 2008 ;441:91-103

Department of Pathology, UPMC Shadyside-Presbyterian Hospital, Pittsburgh, PA, USA.

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May 2008

p16ink4 immunoreactivity is a reliable marker for urothelial carcinoma in situ.

Hum Pathol 2008 Apr 30;39(4):527-35. Epub 2008 Jan 30.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA.

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April 2008

Prevalence of incidental prostate cancer in the general population: a study of healthy organ donors.

J Urol 2008 Mar 22;179(3):892-5; discussion 895. Epub 2008 Jan 22.

Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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March 2008

Diagnostic utility of p501s (prostein) in comparison to prostate specific antigen (PSA) for the detection of metastatic prostatic adenocarcinoma.

Diagn Pathol 2007 Oct 27;2:41. Epub 2007 Oct 27.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

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October 2007

Stromal-epithelial cell interactions and androgen receptor-coregulator recruitment is altered in the tissue microenvironment of prostate cancer.

Cancer Res 2007 Jan;67(2):511-9

Department of Urologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14213, and Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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January 2007

Polymorphisms of catechol-O-methyltransferase in men with renal cell cancer.

Cancer Epidemiol Biomarkers Prev 2007 Jan;16(1):92-7

Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA.

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January 2007

Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with Bax and Bak induction.

Clin Cancer Res 2006 Nov;12(22):6836-43

Department of Pharmacology and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA.

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November 2006

Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma.

Am J Pathol 2006 Nov;169(5):1812-20

Department of Pathology, University of Pittsburgh, University of Pittsburgh Medical Center Presbyterian, C920.1, 200 Lothrop St., Pittsburgh, PA 15213, USA.

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November 2006

Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells.

Pulm Pharmacol Ther 2007 18;20(6):629-41. Epub 2006 Aug 18.

Department of Pharmacology, University of Pittsburgh, E1340 Biomedical Science Tower, Pittsburgh, PA 15213, USA.

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January 2008

Orthotopic expression of human 15-lipoxygenase (LO)-1 in the dorsolateral prostate of normal wild-type C57BL/6 mouse causes PIN-like lesions.

Prostaglandins Other Lipid Mediat 2006 Oct 25;81(1-2):1-13. Epub 2006 Jul 25.

Department of Urology, University of Pittsburgh and Cancer Institute, PA 15232, USA.

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October 2006

Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential.

Carcinogenesis 2006 Nov 13;27(11):2223-34. Epub 2006 Jun 13.

Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine Pittsburgh, PA, USA.

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November 2006

Hepatic gene expression response to acute indomethacin exposure.

Mol Diagn Ther 2006 ;10(3):187-96

Department of Pathology, University of Pittsburgh School of Medicine, Shadyside Hospital, Pittsburgh, Pennsylvania 15232, USA.

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October 2006

An informatics model for tissue banks--lessons learned from the Cooperative Prostate Cancer Tissue Resource.

BMC Cancer 2006 May 5;6:120. Epub 2006 May 5.

Department of Pathology, Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh, Pittsburgh, PA, USA.

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May 2006

The yin and yang of 15-lipoxygenase-1 and delta-desaturases: dietary omega-6 linoleic acid metabolic pathway in prostate.

J Carcinog 2006 Mar 27;5. Epub 2006 Mar 27.

Department of Urology and University of Pittsburgh Cancer Institute, 5200 Center Ave, SHMC-Suite G-37, Pittsburgh, PA 15232, USA.

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March 2006

Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma.

Hum Pathol 2006 Apr 7;37(4):401-9. Epub 2006 Feb 7.

Department of Urology, University of Pittsburgh, PA 15232, USA.

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April 2006

Protein kinase Cdelta signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cells.

Biochem Biophys Res Commun 2006 May 20;343(3):848-56. Epub 2006 Mar 20.

Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh VAMC, Pittsburgh, PA 15261, USA.

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May 2006

Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak.

Mol Cancer Ther 2005 Nov;4(11):1747-54

Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, 2.32A Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Pittsburgh, Pennsylvania 15213, USA.

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November 2005