Rajesh Ramachandran

Rajesh Ramachandran

UNVERIFIED PROFILE

Are you Rajesh Ramachandran?   Register this Author

Register author
Rajesh Ramachandran

Rajesh Ramachandran

Publications by authors named "Rajesh Ramachandran"

Are you Rajesh Ramachandran?   Register this Author

49Publications

382Reads

33Profile Views

Biphasic Role of Tgf-β Signaling during Müller Glia Reprogramming and Retinal Regeneration in Zebrafish.

iScience 2020 Feb 7;23(2):100817. Epub 2020 Jan 7.

Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, Knowledge City, SAS Nagar, Sector 81, Manauli PO, Mohali, Punjab 140306, India. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2019.100817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994856PMC
February 2020

Exploring the links between lipid geometry and mitochondrial fission: Emerging concepts.

Mitochondrion 2019 11 25;49:305-313. Epub 2019 Jul 25.

Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States of America. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mito.2019.07.010DOI Listing
November 2019

Clinical Utility of Cytokine Biomarker Analysis of Pancreatic Cyst Fluid Obtained by Endoscopic Ultrasound Fine Needle Aspiration: A Pilot Study.

Pancreas 2019 09;48(8):e60-e61

Division of Gastroenterology and Hepatology Department of Medicine SUNY Downstate Medical Center Brooklyn, NY Saint Barnabas Medical Center Livingston, NJ Division of Gastroenterology and Hepatology Department of Medicine SUNY Downstate Medical Center Brooklyn, NY Division of Gastroenterology and Hepatology Department of Medicine SUNY Downstate Medical Center Brooklyn, NY Department of General Surgery Yale University School of Medicine New Haven, CT Division of Gastroenterology and Hepatology Department of Medicine SUNY Downstate Medical Center Brooklyn, NY Gastro One Germantown, TN Department of Surgery SUNY Downstate Medical Center Brooklyn, NY Division of Gastroenterology and Hepatology Department of Medicine SUNY Downstate Medical Center Brooklyn, NY Division of Digestive and Liver Diseases Columbia University Medical Center New York, NY Center for Interventional Endoscopy Mount Sinai Hospital Long Island Oceanside, NY Division of Gastroenterology and Hepatology Department of Medicine SUNY Downstate Medical Center Brooklyn, NY

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MPA.0000000000001365DOI Listing
September 2019

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization.

Immunity 2019 07 13;51(1):43-49.e4. Epub 2019 May 13.

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 USA; Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, OH 44106 USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2019.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640092PMC
July 2019

The glutathione degrading enzyme, Chac1, is required for calcium signaling in developing zebrafish: redox as an upstream activator of calcium.

Biochem J 2019 Jul 2;476(13):1857-1873. Epub 2019 Jul 2.

Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, S.A.S. Nagar, Punjab 140306, India

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BCJ20190077DOI Listing
July 2019

ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.

Nat Commun 2019 03 26;10(1):1371. Epub 2019 Mar 26.

Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-09291-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435701PMC
March 2019

Dual regulation of by Myc is necessary during zebrafish retina regeneration.

J Cell Biol 2019 02 3;218(2):489-507. Epub 2019 Jan 3.

Indian Institute of Science Education and Research, Mohali, Knowledge City, Sector 81, SAS Nagar, Manauli, Mohali, Punjab, India

View Article

Download full-text PDF

Source
http://www.jcb.org/lookup/doi/10.1083/jcb.201802113
Publisher Site
http://dx.doi.org/10.1083/jcb.201802113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363449PMC
February 2019

Geometric instability catalyzes mitochondrial fission.

Mol Biol Cell 2019 01 31;30(1):160-168. Epub 2018 Oct 31.

Department of Mechanical Engineering, University of Houston, Houston, TX 77204.

View Article

Download full-text PDF

Source
https://www.researchgate.net/publication/262020327_A_dimeric
Web Search
https://www.molbiolcell.org/doi/10.1091/mbc.E18-01-0018
Publisher Site
http://dx.doi.org/10.1091/mbc.E18-01-0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337907PMC
January 2019

Histone Deacetylase-Mediated Müller Glia Reprogramming through Her4.1-Lin28a Axis Is Essential for Retina Regeneration in Zebrafish.

iScience 2018 Sep 16;7:68-84. Epub 2018 Aug 16.

Indian Institute of Science Education and Research, Mohali, Knowledge City, Room 3F10, Academic Block-1, Sector 81, SAS Nagar, Manauli PO, Mohali, Punjab 140306, India. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2018.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135741PMC
September 2018

let-7 MicroRNA-Mediated Regulation of Shh Signaling and the Gene Regulatory Network Is Essential for Retina Regeneration.

Cell Rep 2018 05;23(5):1409-1423

Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, Knowledge City, SAS Nagar, Sector 81, Manauli PO, 140306 Mohali, Punjab, India. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946716PMC
May 2018

Mitochondrial dynamics: The dynamin superfamily and execution by collusion.

Semin Cell Dev Biol 2018 04 25;76:201-212. Epub 2017 Jul 25.

Department of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, 44106-4970, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2017.07.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785577PMC
April 2018

The dynamin superfamily.

Curr Biol 2018 04;28(8):R411-R416

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2017.12.013DOI Listing
April 2018

Postconditioning with metformin attenuates apoptotic events in cardiomyoblasts associated with ischemic reperfusion injury.

Cardiovasc Ther 2017 Dec 20;35(6). Epub 2017 Oct 20.

Department of Biochemistry, Kerala University, Thiruvananthapuram, Kerala, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1755-5922.12279DOI Listing
December 2017

Insight into Oral Biofilm: Primary, Secondary and Residual Caries and Phyto-Challenged Solutions.

Open Dent J 2017 30;11:312-333. Epub 2017 Jun 30.

Department of Materials Science & Engineering, Center for Nanoscale Materials and Biointegration (CNMB), University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874210601711010312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543615PMC
June 2017

Coincident Phosphatidic Acid Interaction Restrains Drp1 in Mitochondrial Division.

Mol Cell 2016 09;63(6):1034-43

Department of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2016.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028122PMC
September 2016

Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission.

J Cell Sci 2016 06 12;129(11):2170-81. Epub 2016 Apr 12.

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne 3800, Australia

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.185165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919635PMC
June 2016

Distinct Splice Variants of Dynamin-related Protein 1 Differentially Utilize Mitochondrial Fission Factor as an Effector of Cooperative GTPase Activity.

J Biol Chem 2016 Jan 17;291(1):493-507. Epub 2015 Nov 17.

From the Department of Physiology and Biophysics, Cleveland Center for Membrane and Structural Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M115.680181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697187PMC
January 2016

Dynamin-related Protein 1 Oligomerization in Solution Impairs Functional Interactions with Membrane-anchored Mitochondrial Fission Factor.

J Biol Chem 2016 Jan 17;291(1):478-92. Epub 2015 Nov 17.

From the Department of Pharmacology, the Center for Mitochondrial Diseases, the Cleveland Center for Membrane and Structural Biology, and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M115.680025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697186PMC
January 2016

Cardiolipin's propensity for phase transition and its reorganization by dynamin-related protein 1 form a basis for mitochondrial membrane fission.

Mol Biol Cell 2015 Sep 8;26(17):3104-16. Epub 2015 Jul 8.

Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106 Cleveland Center for Membrane and Structural Biology, Case Western Reserve University School of Medicine, Cleveland, OH 44106

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.E15-06-0330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551322PMC
September 2015

The mechanoenzymatic core of dynamin-related protein 1 comprises the minimal machinery required for membrane constriction.

J Biol Chem 2015 May 13;290(18):11692-703. Epub 2015 Mar 13.

From the Department of Pharmacology, Center for Mitochondrial Diseases, and Cleveland Center for Membrane and Structural Biology, and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M114.610881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416870PMC
May 2015

Leptin and IL-6 family cytokines synergize to stimulate Müller glia reprogramming and retina regeneration.

Cell Rep 2014 Oct 25;9(1):272-284. Epub 2014 Sep 25.

Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2014.08.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194149PMC
October 2014

Antiproliferative effects of Plumbago rosea and its purified constituent plumbagin on SK-MEL 28 melanoma cell lines.

Pharmacognosy Res 2014 Oct;6(4):312-9

Department of Biotechnology, Bharathidasan Institute of Technology Campus, Anna University, Tiruchirappalli, Tamil Nadu, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/0974-8490.138280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166820PMC
October 2014

A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission.

Mol Biol Cell 2014 Jun 30;25(12):1905-15. Epub 2014 Apr 30.

Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.E14-02-0728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055269PMC
June 2014

Syndapin 3 modulates fusion pore expansion in mouse neuroendocrine chromaffin cells.

Am J Physiol Cell Physiol 2014 May 5;306(9):C831-43. Epub 2014 Feb 5.

Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpcell.00291.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010804PMC
May 2014

Alternate pleckstrin homology domain orientations regulate dynamin-catalyzed membrane fission.

Mol Biol Cell 2014 Mar 29;25(6):879-90. Epub 2014 Jan 29.

Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.E13-09-0548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952856PMC
March 2014

Application of Cre-loxP recombination for lineage tracing of adult zebrafish retinal stem cells.

Methods Mol Biol 2012 ;884:129-40

Department of Biological Chemistry, Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-61779-848-1_8DOI Listing
October 2012

Insm1a-mediated gene repression is essential for the formation and differentiation of Müller glia-derived progenitors in the injured retina.

Nat Cell Biol 2012 Oct 23;14(10):1013-23. Epub 2012 Sep 23.

Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb2586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463712PMC
October 2012

HB-EGF is necessary and sufficient for Müller glia dedifferentiation and retina regeneration.

Dev Cell 2012 Feb;22(2):334-47

Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2011.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285435PMC
February 2012

Ascl1a/Dkk/beta-catenin signaling pathway is necessary and glycogen synthase kinase-3beta inhibition is sufficient for zebrafish retina regeneration.

Proc Natl Acad Sci U S A 2011 Sep 12;108(38):15858-63. Epub 2011 Sep 12.

Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.1107220108
Publisher Site
http://dx.doi.org/10.1073/pnas.1107220108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179085PMC
September 2011

Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation.

Proc Natl Acad Sci U S A 2011 Jun 13;108(26):E234-42. Epub 2011 Jun 13.

Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1102710108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127893PMC
June 2011

Vesicle scission: dynamin.

Semin Cell Dev Biol 2011 Feb 15;22(1):10-7. Epub 2010 Sep 15.

Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2010.09.001DOI Listing
February 2011

Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway.

Nat Cell Biol 2010 Nov 10;12(11):1101-7. Epub 2010 Oct 10.

Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb2115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972404PMC
November 2010

Conditional gene expression and lineage tracing of tuba1a expressing cells during zebrafish development and retina regeneration.

J Comp Neurol 2010 Oct;518(20):4196-212

Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cne.22448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948409PMC
October 2010

Dissecting dynamin's role in clathrin-mediated endocytosis.

Biochem Soc Trans 2009 Oct;37(Pt 5):1022-6

Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST0371022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879887PMC
October 2009

Highly-restricted, cell-specific expression of the simian CMV-IE promoter in transgenic zebrafish with age and after heat shock.

Gene Expr Patterns 2009 Jan 6;9(1):54-64. Epub 2008 Aug 6.

Molecular and Behavioral Neuroscience Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109-2200, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gep.2008.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650475PMC
January 2009

Real-time detection reveals that effectors couple dynamin's GTP-dependent conformational changes to the membrane.

EMBO J 2008 Jan 13;27(1):27-37. Epub 2007 Dec 13.

Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.emboj.7601961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206142PMC
January 2008

The dynamin middle domain is critical for tetramerization and higher-order self-assembly.

EMBO J 2007 Jan 14;26(2):559-66. Epub 2006 Dec 14.

Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.emboj.7601491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783472PMC
January 2007

Physical and functional connection between auxilin and dynamin during endocytosis.

EMBO J 2006 Sep 31;25(18):4163-74. Epub 2006 Aug 31.

Renal Unit, Nephrology Division, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.emboj.7601298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570436PMC
September 2006

Robust colorimetric assays for dynamin's basal and stimulated GTPase activities.

Methods Enzymol 2005 ;404:490-503

The Scripps Research Institute, Department of Cell Biology, La Jolla, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0076-6879(05)04043-7DOI Listing
March 2006

The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation.

Proc Natl Acad Sci U S A 2005 May 6;102(20):7139-44. Epub 2005 May 6.

Department of Biochemistry, Texas A&M University, College Station, TX 77843-1114, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0500556102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1129106PMC
May 2005

Guillain-Barre syndrome in children and adolescents--a retrospective analysis.

J Indian Med Assoc 2004 Sep;102(9):480-2, 484, 486

Medical College, Calicut.

View Article

Download full-text PDF

Source
September 2004

Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit beta-strand alignment.

Nat Struct Mol Biol 2004 Aug 4;11(8):697-705. Epub 2004 Jul 4.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb793DOI Listing
August 2004

Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin.

Nat Struct Biol 2002 Nov;9(11):823-7

Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/doifinder/10.1038/nsb855
Publisher Site
http://dx.doi.org/10.1038/nsb855DOI Listing
November 2002