Publications by authors named "Rajendra Karki"

54Publications

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.

Cell 2020 04 15;181(3):674-687.e13. Epub 2020 Apr 15.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.03.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425208PMC
April 2020

IRF8 Regulates Gram-Negative Bacteria-Mediated NLRP3 Inflammasome Activation and Cell Death.

J Immunol 2020 May 23;204(9):2514-2522. Epub 2020 Mar 23.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105; and

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http://dx.doi.org/10.4049/jimmunol.1901508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291389PMC
May 2020

Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation.

Cell Mol Immunol 2020 Mar 19. Epub 2020 Mar 19.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1038/s41423-020-0398-7DOI Listing
March 2020

Role of AIM2 inflammasome in inflammatory diseases, cancer and infection.

Eur J Immunol 2019 11 14;49(11):1998-2011. Epub 2019 Aug 14.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1002/eji.201848070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015662PMC
November 2019

The NLRC4 inflammasome requires IRF8-dependent production of NAIPs.

Cell Stress 2018 May 22;2(6):144-146. Epub 2018 May 22.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.15698/cst2018.06.141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551684PMC
May 2018

Diverging inflammasome signals in tumorigenesis and potential targeting.

Nat Rev Cancer 2019 04;19(4):197-214

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://www.nature.com/articles/s41568-019-0123-y
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http://dx.doi.org/10.1038/s41568-019-0123-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953422PMC
April 2019

Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against .

J Immunol 2018 12 7;201(12):3662-3668. Epub 2018 Nov 7.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105; and

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http://dx.doi.org/10.4049/jimmunol.1800788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317867PMC
December 2018

Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice.

Cell Death Differ 2019 03 23;26(4):741-750. Epub 2018 Jul 23.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1038/s41418-018-0159-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460383PMC
March 2019

Phytochemical profile and pharmacological activity of Aegle marmelos Linn.

J Integr Med 2018 05 21;16(3):153-163. Epub 2018 Apr 21.

Department of Oriental Medicine Resources, Mokpo National University, Muan-gun, Jeonnam 534-729, South Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S20954964183004
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http://dx.doi.org/10.1016/j.joim.2018.04.007DOI Listing
May 2018

IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.

Cell 2018 05 22;173(4):920-933.e13. Epub 2018 Mar 22.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.02.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935577PMC
May 2018

ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming.

Am J Pathol 2018 04 31;188(4):1021-1030. Epub 2018 Jan 31.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436110PMC
April 2018

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.

Gastroenterology 2018 03 2;154(4):948-964.e8. Epub 2017 Dec 2.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.11.276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847456PMC
March 2018

NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer.

Cell Cycle 2017 Jul 9;16(13):1243-1251. Epub 2017 Jun 9.

a Department of Immunology , St. Jude Children's Research Hospital , Memphis , TN , USA.

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http://dx.doi.org/10.1080/15384101.2017.1317414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531621PMC
July 2017

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases.

Immunol Rev 2017 05;277(1):61-75

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1111/imr.12534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416822PMC
May 2017

Differential roles of caspase-1 and caspase-11 in infection and inflammation.

Sci Rep 2017 03 27;7:45126. Epub 2017 Mar 27.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1038/srep45126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366862PMC
March 2017

Inflammasomes and Cancer.

Cancer Immunol Res 2017 02 16;5(2):94-99. Epub 2017 Jan 16.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1158/2326-6066.CIR-16-0269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593081PMC
February 2017

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development.

Phytother Res 2017 Jan 26;31(1):3-26. Epub 2016 Sep 26.

Department of Oriental Medicine Resources, College of Natural Sciences, Mokpo National University, 61, Muan-gun, Jeonnam, 534-729, Korea.

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http://dx.doi.org/10.1002/ptr.5732DOI Listing
January 2017

Phytochemical profile and biological activity of Juglans regia.

J Integr Med 2016 Sep;14(5):359-73

Department of Oriental Medicine Resource, Mokpo National University, Muan-gun 534-729, South Korea.

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http://dx.doi.org/10.1016/S2095-4964(16)60274-1DOI Listing
September 2016

DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota.

Pathog Dis 2016 Jun 6;74(4):ftw028. Epub 2016 Apr 6.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA

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http://dx.doi.org/10.1093/femspd/ftw028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985483PMC
June 2016

Cepharanthine inhibits in vitro VSMC proliferation and migration and vascular inflammatory responses mediated by RAW264.7.

Toxicol In Vitro 2016 Aug 25;34:16-25. Epub 2016 Mar 25.

Department of Oriental Medicine Resources, Mokpo National University, Muan-gun, Jeonnam 534-729, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2016.03.010DOI Listing
August 2016

Alkaloid rich fraction from Nelumbo nucifera targets VSMC proliferation and migration to suppress restenosis in balloon-injured rat carotid artery.

Atherosclerosis 2016 May 21;248:179-89. Epub 2016 Mar 21.

Department of Oriental Medicine Resources, Mokpo National University, Muan-gun, Jeonnam 534-729, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.03.020DOI Listing
May 2016

AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity.

Eur J Immunol 2016 Feb 28;46(2):269-80. Epub 2015 Dec 28.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1002/eji.201545839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758349PMC
February 2016

Toll-like receptor 4 signaling: A common pathway for interactions between prooxidants and extracellular disulfide high mobility group box 1 (HMGB1) protein-coupled activation.

Biochem Pharmacol 2015 Nov 12;98(1):132-43. Epub 2015 Sep 12.

Division of Pharmacology and Toxicology, School of Pharmacy, University of Missour-Kansas City, 2464 Charlotte Street, HSB # 2247, Kansas City, MO 64108-2718, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00062952150056
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http://dx.doi.org/10.1016/j.bcp.2015.08.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600681PMC
November 2015

Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection.

Cell Host Microbe 2015 Mar 19;17(3):357-368. Epub 2015 Feb 19.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2015.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359672PMC
March 2015

Activation of c-Src: a hub for exogenous pro-oxidant-mediated activation of Toll-like receptor 4 signaling.

Free Radic Biol Med 2014 Jun 15;71:256-269. Epub 2014 Mar 15.

Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri at Kansas City, Kansas City, MO 64108, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037369PMC
June 2014

Magnolol inhibits migration of vascular smooth muscle cells via cytoskeletal remodeling pathway to attenuate neointima formation.

Exp Cell Res 2013 Dec 29;319(20):3238-50. Epub 2013 Jul 29.

Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri-Kansas City, USA; Department of Oriental Medicine Resources, Mokpo National University, South Korea.

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http://dx.doi.org/10.1016/j.yexcr.2013.07.016DOI Listing
December 2013

Extract of buckwheat sprouts scavenges oxidation and inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated macrophages (RAW264.7).

J Integr Med 2013 Jul;11(4):246-52

Department of Oriental Medicine Resources, Mokpo National University, Muan-gun, Jeollanam-do 534-729, South Korea; E-mail:

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http://dx.doi.org/10.3736/jintegrmed2013036DOI Listing
July 2013

Magnolol attenuates neointima formation by inducing cell cycle arrest via inhibition of ERK1/2 and NF-kappaB activation in vascular smooth muscle cells.

Biochim Biophys Acta 2013 Mar;1830(3):2619-28

Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri-Kansas City, USA.

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http://dx.doi.org/10.1016/j.bbagen.2012.12.015DOI Listing
March 2013

Nelumbo nucifera leaf extract inhibits neointimal hyperplasia through modulation of smooth muscle cell proliferation and migration.

Nutrition 2013 Jan 6;29(1):268-75. Epub 2012 Sep 6.

Department of Oriental Medicine Resources, Mokpo National University, 61 Muan-gun, Jeonnam 534-729, South Korea.

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http://dx.doi.org/10.1016/j.nut.2012.04.018DOI Listing
January 2013

Inhibitory Effect of Nelumbo nucifera (Gaertn.) on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice.

Evid Based Complement Alternat Med 2012 9;2012:153568. Epub 2012 Feb 9.

Department of Oriental Medicine Resources, College of Natural Science, Mokpo National University, 61 Muan-gun, Jeollanam-do 534-729, Republic of Korea.

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http://dx.doi.org/10.1155/2012/153568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291163PMC
August 2012

Magnoliae Cortex inhibits intimal thickening of carotid artery through modulation of proliferation and migration of vascular smooth muscle cells.

Food Chem Toxicol 2012 Mar 28;50(3-4):634-40. Epub 2011 Nov 28.

Department of Oriental Medicine Resources, Mokpo National University, South Korea.

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http://dx.doi.org/10.1016/j.fct.2011.11.043DOI Listing
March 2012

Chungtaejeon, a Korean fermented tea, scavenges oxidation and inhibits cytokine induced proliferation and migration of human aortic smooth muscle cells.

Plant Foods Hum Nutr 2011 Mar;66(1):27-33

Department of Oriental Medicine Resources, Mokpo National University, Mokpo, South Korea.

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http://link.springer.com/10.1007/s11130-011-0211-y
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http://dx.doi.org/10.1007/s11130-011-0211-yDOI Listing
March 2011