Rajaa A Mirghani

Rajaa A Mirghani

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Rajaa A Mirghani

Rajaa A Mirghani

Publications by authors named "Rajaa A Mirghani"

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14Publications

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Distribution of the major cytochrome P450 (CYP) 2C9 genetic variants in a Saudi population.

Basic Clin Pharmacol Toxicol 2011 Aug 28;109(2):111-4. Epub 2011 Mar 28.

King Saud Bin Abdulaziz University for Health Sciences, King Fahad Medical City, Riyadh, Saudi Arabia.

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http://dx.doi.org/10.1111/j.1742-7843.2011.00692.xDOI Listing
August 2011

Effects of Plasmodium falciparum infection on the pharmacokinetics of quinine and its metabolites in pregnant and non-pregnant Sudanese women.

Eur J Clin Pharmacol 2010 Dec 18;66(12):1229-34. Epub 2010 Aug 18.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-010-0877-3DOI Listing
December 2010

Pharmacogenetic studies of Paclitaxel in the treatment of ovarian cancer.

Basic Clin Pharmacol Toxicol 2009 Feb 16;104(2):130-7. Epub 2008 Dec 16.

Division of Drug Research, Faculty of Health Sciences, Linköping University, Linköping, Sweden.

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http://dx.doi.org/10.1111/j.1742-7843.2008.00351.xDOI Listing
February 2009

4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians.

Pharmacogenet Genomics 2008 Mar;18(3):201-8

Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, Sweden.

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http://dx.doi.org/10.1097/FPC.0b013e3282f50ee9DOI Listing
March 2008

Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers.

Eur J Clin Pharmacol 2007 Feb 3;63(2):173-9. Epub 2007 Jan 3.

Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Pharmacology at Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-006-0230-zDOI Listing
February 2007

CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population.

Pharmacogenet Genomics 2006 Sep;16(9):637-45

Department of Clinical Toxicology, Central Laboratories & Blood Bank, King Fahad Medical City, Riyadh 11525, Kingdom of Saudi Arabia.

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http://dx.doi.org/10.1097/01.fpc.0000230411.89973.1bDOI Listing
September 2006

Alprazolam as a probe for CYP3A using a single blood sample: pharmacokinetics of parent drug, and of alpha- and 4-hydroxy metabolites in healthy subjects.

Eur J Clin Pharmacol 2005 Apr 2;61(2):113-8. Epub 2005 Apr 2.

Division of Clinical Pharmacology C1:68, Karolinska University Hospital, Huddinge, 141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-004-0861-xDOI Listing
April 2005

Simultaneous quantification of alprazolam, 4- and alpha-hydroxyalprazolam in plasma samples using liquid chromatography mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2005 Jan;814(1):127-31

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, S-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jchromb.2004.10.012DOI Listing
January 2005

Metabolism and elimination of quinine in healthy volunteers.

Eur J Clin Pharmacol 2003 Sep 12;59(5-6):423-7. Epub 2003 Aug 12.

Department of Laboratory Medicine and Technology, C1-68 Huddinge University Hospital, 141 86 Stockholm, Sweden.

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http://link.springer.com/content/pdf/10.1007/s00228-003-0637
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http://link.springer.com/10.1007/s00228-003-0637-8
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http://dx.doi.org/10.1007/s00228-003-0637-8DOI Listing
September 2003

High-performance liquid chromatographic method for the determination of quinine and 3-hydroxyquinine in blood samples dried on filter paper.

J Chromatogr B Analyt Technol Biomed Life Sci 2003 Sep;795(1):151-6

Department of Laboratory Medicine, Karolinska Institutet at Huddinge University Hospital, Huddinge, Sweden.

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http://dx.doi.org/10.1016/s1570-0232(03)00554-3DOI Listing
September 2003

The Karolinska cocktail for phenotyping of five human cytochrome P450 enzymes.

Clin Pharmacol Ther 2003 Jun;73(6):517-28

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/S0009-9236(03)00050-XDOI Listing
June 2003

Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man.

Eur J Clin Pharmacol 2003 May 11;59(1):23-8. Epub 2003 Mar 11.

Division of Clinical Pharmacology, Department of Medical Laboratory Sciences and Technology, Karolinska Institutet and Hospital Pharmacy, C1-68 Huddinge University Hospital, 141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-003-0575-5DOI Listing
May 2003

Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro; 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway.

Drug Metab Dispos 2002 Dec;30(12):1368-71

Department of Medical Laboratory Sciences and Technology, Hospital Pharmacy at Huddinge University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1124/dmd.30.12.1368DOI Listing
December 2002