Publications by authors named "Raja Selvaraj"

116 Publications

Coumel's sign reversed: What is the mechanism?

Indian Pacing Electrophysiol J 2021 Nov 23. Epub 2021 Nov 23.

Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

A patient presented with documented narrow QRS tachycardia. During electrophysiological study, he has orthodromic reciprocating tachycardia with atrial activation consistent with left free wall accessory pathway. With induction of tachycardia, beats with LBBB morphology have shorter cycle length than those with narrow QRS. What is the mechanism?
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ipej.2021.11.007DOI Listing
November 2021

Magnetic activated charcoal/FeO nanocomposite for the adsorptive removal of 2,4-Dichlorophenoxyacetic acid (2,4-D) from aqueous solutions: Synthesis, characterization, optimization, kinetic and isotherm studies.

Chemosphere 2022 Jan 19;286(Pt 3):131938. Epub 2021 Aug 19.

Department of Chemical Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India. Electronic address:

Magnetic activated charcoal/FeO nanocomposite (AC/FeONC) was fabricated using Spondias dulcis leaf extract by a facile method and used for the adsorptive removal of 2,4-Dichlorophenoxyacetic acid (2,4-D) from aqueous solutions for the first time. The nanocomposite was characterized by methods such as FE-SEM, EDS, XRD, FTIR, TGA, VSM, and BET to identify and confirm the surface morphology, elemental composition, crystalline nature, functional groups, thermal stability, magnetic behavior, and surface area respectively. Box-Behnken Design (BBD) - an optimization method, which belongs to the Response surface methodology (RSM) and a modeling tool - Artificial Neural Network (ANN) were employed to design, optimize and predict the relationship between the input parameters (pH, initial concentration of 2,4-D, time and agitation speed) versus the output parameter (adsorption efficiency of 2,4-D). Adsorption efficiency of 98.12% was obtained at optimum conditions (pH: 2.05, initial concentration: 32 ppm, contact time: 100 min, agitation speed: 130 rpm, temperature: 30 °C, and dosage: 0.2 g/L). The predictive ability of the ANN was superior (R = 0.99) than the quadratic model, given by the RSM (R = 0.93). The equilibrium data were best-fitted to Langmuir isotherm (R = 0.9944) and the kinetics obeyed pseudo-second-order model (R = 0.9993) satisfactorily. Thermodynamic studies revealed the spontaneity and exothermic nature of adsorption. The maximum adsorption capacity, q was found to be 255.10 mg/g, substantially larger than the reported values for 2,4-D adsorption by other magnetic nanoadsorbents. Therefore, this nanoadsorbent may be utilized as an excellent alternative for the elimination of 2,4-D from the waterbodies.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2021.131938DOI Listing
January 2022

Modelling of fermentative bioethanol production from indigenous Ulva prolifera biomass by Saccharomyces cerevisiae NFCCI1248 using an integrated ANN-GA approach.

Sci Total Environ 2021 Oct 10;791:148429. Epub 2021 Jun 10.

Department of Chemical Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India. Electronic address:

Third generation biomass (marine macroalgae) has been projected as a promising alternative energy resource for bioethanol production due to its high carbon and no lignin composition. However, the major challenge in the technologies of production lies in the fermentative bioconversion process. Therefore, in the present study the predictive ability of an integrated artificial neural network with genetic algorithm (ANN-GA) in the modelling of bioethanol production was investigated for an indigenous marine macroalgal biomass (Ulva prolifera) by a novel yeast strain, Saccharomyces cerevisiae NFCCI1248 using six fermentative parameters, viz., substrate concentration, fermentation time, inoculum size, temperature, agitation speed and pH. The experimental model was developed using one-variable-at-a-time (OVAT) method to analyze the effects of the fermentative parameters on bioethanol production and the obtained regression equation was used as a fitness function for the ANN-GA modelling. The ANN-GA model predicted a maximum bioethanol production at 30 g/L substrate, 48 h fermentation time, 10% (v/v) inoculum, 30 °C temperature, 50 rpm agitation speed and pH 6. The maximum experimental bioethanol yield obtained after applying ANN-GA was 0.242 ± 0.002 g/g RS, which was in close proximity with the predicted value (0.239 g/g RS). Hence, the developed ANN-GA model can be applied as an efficient approach for predicting the fermentative bioethanol production from macroalgal biomass.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2021.148429DOI Listing
October 2021

Wide complex tachycardia: What is the mechanism?

J Cardiovasc Electrophysiol 2021 10 26;32(10):2746-2748. Epub 2021 Aug 26.

Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/jce.15216DOI Listing
October 2021

Recovery of value-added products from wastewater using Aqueous Two-Phase Systems - A review.

Sci Total Environ 2021 Jul 8;778:146293. Epub 2021 Mar 8.

Department of Chemical engineering, Manipal institute of technology (MIT), Manipal Academy of Higher Education (MAHE), Manipal 576104, Karnataka, India. Electronic address:

Aqueous two-phase system (ATPS) is long seen as a technique that promotes higher purity and yield in a single step. It is witnessing increased acceptance as a preferred choice for combined goals of concentration, separation and purification of a target product, be it industrially valuable or environmentally contaminating. Purification of biomolecules like enzymes, proteins, nucleic acids, viruses, etc. has been the forte of ATPS. Currently, the technique is used for concentrating the toxic fractions from diverse industrial let offs, from food, dairy, beverage, pharmaceuticals, agriculture, dyeing, tannery and metal-processing industries. Apart from being simple, efficient, rapid, flexible, economical, and biocompatible, the selectivity, purity and yield are on par and sometimes higher than the traditional downstream steps. From an industrial angle too, problems related to scale-up of ATPS are being actively addressed. Many novel approaches are being added by way of varying ATPS components to increase the yield and purity. Another case in point is the inclusion of optimization techniques for zeroing in on the precise setting of the operating parameters. With increasing impetus to the approach, we attempt to draw attention from academia and industries, alike, that are developing novel tweaks to the currently existing practices in ATPS. This review aims to assess and evaluate the different types of ATPS that have been used for the recovery of valuables and contaminants from industrial waste discharges.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2021.146293DOI Listing
July 2021

Response to the letter.

Authors:
Raja J Selvaraj

Indian Pacing Electrophysiol J 2021 Mar-Apr;21(2):140

Department of Cardiology, JIPMER, Puducherry, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ipej.2021.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952890PMC
March 2021

Paradoxical correction of bundle branch block-What is the mechanism?

J Cardiovasc Electrophysiol 2021 04 17;32(4):1199-1201. Epub 2021 Mar 17.

Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/jce.15001DOI Listing
April 2021

An epoch based methodology to denoise magnetocardiogram (MCG) signals and its application to measurements on subjects with implanted devices.

Biomed Phys Eng Express 2021 Mar 4. Epub 2021 Mar 4.

Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education, JIPMER, Dhanvantri Nagar, Puducherry, Pondicherry, Puducherry, 605006, INDIA.

Magnetocardiograms (MCG) provide clinically useful diagnostic information in a variety of cardiac dysfunctions. Low frequency baseline drifts and high frequency noise are inevitably present in routine MCG even for those measured inside magnetically shielded rooms. These interferences sometimes exceed subtle cardiac features in MCG recorded on subjects with implanted devices like cardiac pacemakers; this makes interpretation of cardiac magnetic fields difficult. The present study proposes a correlation-based beat-by-beat approach and principal component analysis to eliminate drifts and high frequency noise respectively; the approach is suitable for denoising both single and multi-channel MCG data. The methodology is critically evaluated on simulated noisy measurements using a 37 channel MCG system, when objects such as implantable permanent pacemaker and stainless-steel wire are sequentially kept externally on the chests of five healthy subjects. By characterizing the noise introduced by each of these objects, the deterioration in the quality of MCG and its subsequent restoration by using the proposed method is assessed. The performance of the proposed method is also compared with other conventional denoising techniques namely, bandpass filters, wavelets and ensemble empirical mode decomposition. The proposed method not only exhibits least distortion, but also preserves the beat-by-beat dynamics of cardiac time series. The method has also been illustrated on actual MCG measurements on two subjects with implanted pacemaker which highlight the ability of the proposed method for denoising MCG in general and during extremely noisy measurement situations. Keywords: Magnetocardiography (MCG), pacemaker, baseline correction, PCA.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1088/2057-1976/abec17DOI Listing
March 2021

Evaluation of seasonal variation and the optimization of reducing sugar extraction from Ulva prolifera biomass using thermochemical method.

Environ Sci Pollut Res Int 2021 Nov 5;28(42):58857-58871. Epub 2021 Feb 5.

Department of Chemical Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

Green macroalgae comprise significant amount of structural carbohydrates for their conversion to liquid biofuels. However, it generally relies on species characteristics and the variability in seasonal profile to determine its route for bioprocessing. Hence, this study was conducted to analyze the indigenous marine macroalgal strain (Ulva prolifera) with respect to periodic trend and reducing sugar extraction. Consequently, in our investigation, the monthly variation in sugar profile and bioethanol yield was assessed between the monsoon and post-monsoon seasons, of which relatively high reducing sugar and fermentative bioethanol yield of about 0.152 ± 0.009 g/gdw and 6.275 ± 0.161 g/L was obtained for the October-month isolate (MITM10). Thereafter, the biochemical profile of this collected biomass (MITM10) revealed carbohydrate 34.98 ± 3.30%, protein 12.45 ± 0.49%, and lipid 1.93 ± 0.07%, respectively, on dry weight basis. Of these, the total carbohydrate fraction yielded the maximum reducing sugar of 0.156 ± 0.005 g/gdw under optimal conditions (11.07% (w/v) dosage, 0.9 M HSO, 121°C for 50 min) for thermal-acid hydrolysis. Furthermore, the elimination of polysaccharides was confirmed using the characterization techniques scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR) spectroscopy. Therefore, the present thermochemical treatment method provides a species-specific novel strategy to breakdown the macroalgal cell wall polysaccharides that enhances sugar extraction for its utilization as an efficient bioenergy resource.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-021-12609-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541971PMC
November 2021

Paradoxical atrial capture during a wide complex tachycardia.

J Cardiovasc Electrophysiol 2021 04 18;32(4):1202-1204. Epub 2021 Feb 18.

Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/jce.14897DOI Listing
April 2021

Catheter ablation of scar based ventricular tachycardia - Procedural characteristics and outcomes.

Indian Heart J 2020 Nov-Dec;72(6):563-569. Epub 2020 Sep 19.

Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India. Electronic address:

Background: Ventricular tachycardia (VT) is a major cause of morbidity in patients with cardiomyopathy. Radiofrequency ablation has emerged as the mainstay of the management of recurrent sustained VT in these patients. We describe the clinical characteristics, procedural and medium term outcomes of patients undergoing ablation of scar VT in a tertiary care center in India.

Methods: This was a single-center descriptive cohort study. All patients who underwent ablation for scar related VT were included. Endpoints were immediate procedural success, procedural complications and recurrence during follow up.

Results: A total of 72 patients with scar VT underwent ablation with electroanatomic mapping. Previous myocardial infarction (MI) was the commonest etiology (69.4%) with arrhythmogenic right ventricular cardiomyopathy (ARVC) being the next common (19.4%). Acute procedural success was achieved in 69.4% patients, partial success in 9.7% and failure in 1 patient (1.4%). Outcome was labeled indeterminate in 19.4% who did not undergo post ablation VT induction. Procedural complications were seen in 4%. Follow up data was available in 95% of the patients with a mean follow up of 28.9 ± 22.8 months. At one year, freedom from VT was 83.8% and mortality was 13.2%. Overall mortality during follow up was 22.1% while VT recurrence was seen in 35.3%. Recurrence rate was higher in ARVC as compared to previous MI.

Conclusions: Ablation of scar VT has high acute success rates. Ablation is safe with low risk of major complications. Rates of recurrence are higher in patients with ARVC as compared to post MI VT.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ihj.2020.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772601PMC
June 2021

Sudden death and its predictors in myocardial infarction survivors in an Indian population.

Indian Pacing Electrophysiol J 2021 Mar-Apr;21(2):82-87. Epub 2020 Dec 19.

Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

Objective: This study was conducted to assess the incidence of sudden cardiac death (SCD) in post myocardial infarction patients and to determine the predictive value of various risk markers in identifying cardiac mortality and SCD.

Methods: Left ventricular function, arrhythmias on Holter and microvolt T wave alternans (MTWA) were assessed in patients with prior myocardial infarction and ejection fraction ≤ 40%. The primary outcome was a composite of cardiac death and resuscitated cardiac arrest during follow up. Secondary outcomes included total mortality and SCD.

Results: Fifty-eight patients were included in the study. Eight patients (15.5%) died during a mean follow-up of 22.3 ± 6.6 months. Seven of them (12.1%) had SCD. Among the various risk markers studied, left ventricular ejection fraction (LVEF) ≤ 30% (Hazard ratio 5.6, 95% CI 1.39 to 23) and non-sustained ventricular tachycardia (NSVT) in holter (5.7, 95% CI 1.14 to 29) were significantly associated with the primary outcome in multivariate analysis. Other measures, including QRS width, heart rate variability, heart rate turbulence and MTWA showed no association.

Conclusions: Among patients with prior myocardial infarction and reduced left ventricular function, the rate of cardiac death was substantial, with most of these being sudden cardiac death. Both LVEF ≤30% and NSVT were associated with cardiac death whereas only LVEF predicted SCD. Other parameters did not appear useful for prediction of events in these patients. These findings have implications for decision making for the use of implantable cardioverter defibrillators for primary prevention in these patients.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ipej.2020.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952752PMC
December 2020

Atrial fibrillation and preexcitation - A licence to kill.

Indian Pacing Electrophysiol J 2020 Jan - Feb;20(1):1-2. Epub 2020 Jan 9.

Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India. Electronic address:

Atrial fibrillation becomes a potentially lethal arrhythmia in the presence of preexcitation because the rapid ventricular activation can result in ventricular fibrillation. Fortunately, radiofrequency ablation is an effective treatment for these patients. Specific points of interest regarding this association are the mechanism of increased incidence of atrial fibrillation and the current management of patients presenting in atrial fibrillation. These are discussed in this editorial.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ipej.2020.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994397PMC
January 2020

Synthesis, characterization and photocatalytic dye degradation capability of Calliandra haematocephala-mediated zinc oxide nanoflowers.

J Photochem Photobiol B 2020 Jan 18;203:111760. Epub 2019 Dec 18.

Department of Biotechnology, Manipal Institute of Technology (MIT), Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India. Electronic address:

An environmentally sound approach towards the green synthesis of zinc oxide nanostructures has been achieved with an aqueous extract of Calliandra haematocephala leaves. The nanoparticles were characterized using various analytical techniques to substantiate the structural details. An absorption band at 358 nm corresponds to the formation of zinc oxide nanoparticles. Scanning electron microscopy revealed the nanoflower morphology of the nanoparticles. Energy dispersive spectral analysis portrayed the strong presence of zinc and oxygen, while X-ray diffraction showed the nanoparticles to conform to hexagonally-formed wurtzite structure. The crystallite size of the nanoflowers was estimated to be 19.45 nm. Vibrational frequencies, typical of zinc‑oxygen and other functional groups, were revealed using Fourier transform infrared spectroscopy. BET analysis revealed that the pores were of mesoporous nature with an estimated specific surface area of 9.18 m/g. The photocatalytic nature of the nanoparticles was established by the degradation of methylene blue (MB) dye, under solar radiation. Up to 88% degradation was achieved in a duration of 270 min. Kinetic data from the studies proved that the reaction was compliant with first-order model, with rate constant as 0.01 min. The study illustrated the synthesis of zinc oxide nanoparticles using a novel source, viz., the leaves of C. haematocephala.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jphotobiol.2019.111760DOI Listing
January 2020

A review on adsorptive removal of dyes from wastewater by hydroxyapatite nanocomposites.

Environ Sci Pollut Res Int 2021 Mar 23;28(10):11835-11849. Epub 2019 Dec 23.

Department of Chemical engineering, Manipal institute of technology (MIT), Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, 576104, India.

Dye removal from wastewater is of prominence due to its hostile effects on human health and the environment. The complex structure of the dye molecule is responsible for its difficulty in removal. Adsorption is found to be a promising technique to eliminate dye wastes due to its high removal capacity at low concentration. Among different adsorbents used, hydroxyapatite is a biocompatible adsorbent that is relatively efficient in both anionic and cationic dye removal. Recently, modification of hydroxyapatite by doping with other materials to increase its removal efficiency has gained much attention. This review summarizes compilation of recent literature on the removal of anionic and cationic dye by different hydroxyapatite nanocomposites, comparison of adsorption capacities of different hydroxyapatite nanocomposites, the possible adsorption mechanism of removal of dyes, the general isotherm, and kinetic and thermodynamic studies explaining the type of adsorption and the characteristics, advantages, and limitations of adsorbents.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-019-07319-9DOI Listing
March 2021

Human gingival derived neuronal cells in the optimized caffeic acid hydrogel for hemitransection spinal cord injury model.

J Cell Biochem 2020 03 23;121(3):2077-2088. Epub 2019 Oct 23.

Department of Periodontology and Implantology, Faculty of Dental Sciences and Centre for Regenerative Medicine and Stem Cell Research, Sri Ramachandra Medical College and Research Institute, Chennai, India.

Spinal cord injury induces scar formation causes axonal damage that leads to the degeneration of axonal function. Still, there is no robust conceptual design to regenerate the damaged axon after spinal injury. Therefore, the present study demonstrates that human gingival derived neuronal stem cells (GNSCs) transplants in the injectable caffeic acid bioconjugated hydrogel (CBGH) helps to bridge the cavity and promote the engraftment and repopulation of transplants in the injured spinal tissue. Our study reports that the bioluminescence imaging in vivo imaging system (IVIS) provides a satisfactory progression in CBGH-GNSCs transplants compare to lesion control and CBGH alone. Immune regulators interleukin-6 (IL-6), tumor necrosis factor-α, neutrophil elastase are decreased, IL-10 is increased. Likewise, immunostaining (TAU/TUJ-1, SOX-2/NeuN, MAP-2/PSD93, NSE, S100b, and GFAP) shown repopulated cells. Also, TRA-1-81 expression confirms the absence of immune rejection in the CBGH-GNSCs transplants. However, locomotor recovery test, gene (IL-6, CASPASE3, p14-ARF, VEGF, LCAM, BDNF, NT3, NGN2, TrKc, FGF2, Sox-2, TUJ-1, MAP-2, Nestin, and NeuN) and protein expression (TAU, TUJ-1, SOX-2 MAP-2, PSD93, NeuN, TRA-1-81, GFAP, TAU, and MBP) shows functional improvements in the CBGH-GNSCs group. Further, GABA and glutamine level demonstrates the new synaptic vesicle formation. Hence, the CBGH scaffold enhances GNSCs transplants to restore the injured spinal tissue.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.29452DOI Listing
March 2020

Photocatalytic degradation of Rhodamine B by zinc oxide nanoparticles synthesized using the leaf extract of Cyanometra ramiflora.

J Photochem Photobiol B 2019 Oct 10;199:111621. Epub 2019 Sep 10.

Department of Chemical Engineering, Manipal Institute of Technology (MIT), Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India. Electronic address:

In the current study, the green synthesis of zinc oxide nanoparticles (ZnONPs) using the leaf extract of Cyanometra ramiflora and zinc acetate precursor is presented. The phyto-components of the extract aided the reduction and the formation of nanoparticles. The purified ZnONPs were characterized by UV-Vis spectroscopy, SEM, EDS, XRD, BET, and FTIR techniques. A sharp absorption maximum at 360 nm in the UV-Vis data affirmed the formation of ZnONPs. SEM image revealed the nanoflower morphology and EDS showed strong signals for zinc and oxygen elements. XRD spectrum confirmed the hexagonal wurtzite crystalline structure of size 13.33 nm. A significant large surface area of 16.27 m/g with mesopores, was affirmed using BET analysis. FTIR substantiated the existence of the characteristic zinc and oxygen bonding vibrations at 557 cm, 511 cm and 433 cm. The photocatalytic activity of the ZnONPs was examined using the pollutant dye, Rhodamine B. A remarkable degradation efficiency of 98% within 200 min was achieved under sunlight irradiation and a degradation constant of 0.017 min was obtained. Therefore, ZnONPs synthesized using a cheap and abundant source - the leaf extract of C.ramiflora possibly will play a promising part in the degradation of toxic dyes present in the wastewater.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jphotobiol.2019.111621DOI Listing
October 2019

Magnetocardiography for identification of coronary ischemia in patients with chest pain and normal resting 12-lead electrocardiogram.

Ann Noninvasive Electrocardiol 2020 05 6;25(3):e12715. Epub 2019 Oct 6.

Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Background: Identification of coronary ischemia in patients presenting with chronic chest pain is difficult as resting ECG can be normal. Diagnosis of coronary ischemia requires evaluation during exercise or pharmacological stress. A noninvasive test to identify coronary ischemia at rest without the need for exercise is desirable. We studied the diagnostic accuracy of magnetocardiography (MCG) at rest to detect coronary ischemia in these patients.

Methods: Patients with chronic chest pain and suspected coronary ischemia with a normal ECG were included. Patients underwent treadmill test (TMT) and were divided into TMT positive and TMT negative groups. MCG was recorded in a magnetically shielded room. Iso-field contour maps generated at the T-wave peak were compared between the groups. From the magnetic field map (MFM), the magnetic field angle at T-wave peak was calculated and was also compared across the two groups.

Results: There were a total of 29 patients, 12 with positive TMT and 17 with negative TMT. An abnormal magnetic field angle was more common in the TMT positive group (72% vs. 6%). Abnormal contour maps in the form of nondipole patterns or abnormal orientation were seen in 81.8% (9/11) patients in TMT positive group and 6.8% (1/17) patients in the TMT negative group (p < .001).

Conclusion: Abnormal magnetic field angle and abnormal magnetic field maps in MCG recorded at rest are able to identify the presence of coronary ischemia in patients with chronic chest pain and a normal resting ECG.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/anec.12715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358824PMC
May 2020

Letter to the Editor regarding "Importance of over-reading ambulatory ECG-based microvolt T-wave alternans to eliminate three main sources of measurement error".

Authors:
Raja J Selvaraj

Ann Noninvasive Electrocardiol 2019 11 3;24(6):e12716. Epub 2019 Oct 3.

Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/anec.12716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931403PMC
November 2019

A paradoxical response to para-hisian pacing.

Pacing Clin Electrophysiol 2019 10 25;42(10):1396-1397. Epub 2019 Aug 25.

Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/pace.13778DOI Listing
October 2019

Upper loop re-entrant flutter.

Europace 2019 08;21(8):1192

Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantri Nagar, Puducherry, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/europace/euz173DOI Listing
August 2019

Device detected arrhythmias - Staying afloat in the data deluge.

Indian Pacing Electrophysiol J 2019 May - Jun;19(3):90-91. Epub 2019 Apr 20.

Jawaharlal Institute of Postgraduate Medical Education and Research, India. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ipej.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531779PMC
April 2019

Procedural and follow-up clinical outcomes after chronic total occlusion revascularization: Data from an Indian public hospital.

Indian Heart J 2019 Jan - Feb;71(1):65-73. Epub 2019 Jan 26.

Department of Cardiology, Jawaharlal Institute of Post Graduate Medical Education and Research(JIPMER), Puducherry, 605006, India.

Background: Chronic total occlusion (CTO) continues to be challenging lesion subset for percutaneous intervention. Last decade has seen tremendous increase in percutaneous coronary intervention (PCI) in this subset owing to improved understanding of the anatomy and enhanced skillset with availability of dedicated hardware. We sought to study the outcomes of CTO PCI in an Indian public hospital.

Methods: This was a single-center non-randomized descriptive follow-up study on CTO PCI. The end-points were procedural success, immediate, and late adverse cardiovascular events [major adverse cardiac event (MACE)] and change in angina and left ventricular function at follow-up.

Results: A total 389 CTO lesions were treated with a success rate of 87% (339/389). The mean Japanese chronic total occlusion (J-CTO) score was 1.78 ± 0.12 (mean ± standard deviation). Multivariate analysis of different angiographic components of J-CTO score identified tortuosity (p = 0.001), calcifications (p ≤ 0.001), and blunt stump (p = 0.007) as independent predictors of procedural failure. The periprocedural mortality was less than 1%, and the non-life threatening complications were about 4%. The MACE rate was significantly higher in the procedural failure group (60%) than in the procedural success group (5.3%, p < 0.001). An increase in left ventricular ejection fraction (LVEF) was noted following successful CTO PCI after complete revascularization.

Conclusions: The success rates for CTO PCI in this registry were about 87%. Immediate and long-term clinical outcomes were better with lower MACE (5%) after a successful procedure. A key outcome variable included an increase in LVEF among patients after a successful CTO PCI. The overall periprocedural complications were about 5.5%, but majority were non-life threatening.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ihj.2018.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477135PMC
September 2019

Body surface distribution of T wave alternans is modulated by heart rate and ventricular activation sequence in patients with cardiomyopathy.

PLoS One 2019 10;14(4):e0214729. Epub 2019 Apr 10.

Division of Cardiology, University Health Network, Toronto, Canada.

Background: T wave alternans (TWA) is an electrocardiographic marker of heightened sudden death risk from ventricular tachyarrhythmias in patients with cardiomyopathy. TWA is evaluated from the 12-lead electrocardiogram, Frank lead, or Holter lead recordings, however these clinical lead configurations will not record TWA from adjacent regions of the body torso.

Objective: We tested the hypothesis that changing heart rate or ventricular activation may alter the body surface distribution of TWA such that the clinical ECG leads fail to detect TWA in some patients; thereby producing a false-negative test.

Methods: In 28 cardiomyopathy patients (left ventricular ejection fraction 28±6%), 114 unipolar electrograms were recorded across the body torso during incremental atrial pacing, followed by atrioventricular pacing at 100, 110 and 120bpm. TWA was measured from each unipolar electrogram using the spectral method. A clinically positive TWA test was defined as TWA magnitude (Valt) ≥1.9 uV with k ≥3 at ≤110bpm.

Results: Maximum Valt (TWAmax) was greater from the body torso than clinical leads during atrial (p<0.005) and atrioventricular pacing (p<0.005). TWAmax was most prevalent in the right lower chest with atrial pacing 100 bpm and shifted to the left lower chest at 120 bpm. TWAmax was most prevalent in left lower chest with atrioventricular pacing at 100 bpm and shifted to the left upper chest at 120 bpm. Using the body torso as a gold standard, the false-negative rate for clinically positive TWA with clinical leads was 21% during atrial and 11% during atrioventricular pacing. Due to TWA signal migration outside the clinical leads, clinically positive TWA became false-negative when pacing mode was switched (atrial→atrioventricular pacing) in 21% of patients.

Conclusions: The body surface distribution of TWA is modulated by heart rate and the sequence of ventricular activation in patients with cardiomyopathy, which can give rise to modest false-negative TWA signal detection using standard clinical leads.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214729PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457562PMC
December 2019

Antibacterial and dye degradation potential of zero-valent silver nanoparticles synthesised using the leaf extract of .

IET Nanobiotechnol 2019 Feb;13(1):84-89

Department of Chemical Engineering, Manipal Institute of Technology (MIT), Manipal Academy of Higher Education, Manipal, Karnataka - 576104, India.

The present study reports a simple and low cost synthesis of zero-valent silver nanoparticles (ZVSNPs) from silver nitrate using the leaf extract of . The ZVSNPs showed a unique peak at 420 nm in UV-vis spectrum. The SEM image portrayed cuboidal shaped particles. The EDX spectrum designated the elemental silver peak at 3 keV. In XRD, a sharp peak at 32.47° denoted the existence of (1 0 1) lattice plane and the average crystallite size was calculated as 48.61 nm. The lattice parameter was determined as 0.39 nm. The FTIR spectra of the leaf extract and ZVSNPs showed shifts in the specific functional group bands which ascertained the involvement of phytoconstituents in the formation and capping of nanoparticles. The average hydrodynamic size was measured as 59.66 nm by DLS method. A low PDI, 0.187 witnessed the monodispersity. A negative zeta potential value of -15.7 mV indicated the negative surface charges of the nanoparticles. The bactericidal action of ZVSNPs was demonstrated against two pathogens and during which a dosage dependent zone of inhibition results was observed. Additionally, the catalytic potential of ZVSNPs was examined for the degradation of methylene blue dye in which an accelerated degradation of the dye was observed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1049/iet-nbt.2018.5058DOI Listing
February 2019

An unusual form of pre-excitation.

J Cardiovasc Electrophysiol 2019 Jun 13;30(6):976-977. Epub 2019 Feb 13.

Department of Cardiology, Indira Gandhi Government Hospital, Puducherry, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/jce.13871DOI Listing
June 2019

Hydatid cyst of the interventricular septum - A rare cause of heart block.

Indian Pacing Electrophysiol J 2019 Mar - Apr;19(2):79-80. Epub 2019 Jan 17.

Department of Cardiology, JIPMER, Puducherry, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ipej.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450826PMC
January 2019

Low power ablation for left coronary cusp ventricular tachycardia-Efficacy and long-term outcome.

Indian Heart J 2018 Dec 1;70 Suppl 3:S384-S388. Epub 2018 Sep 1.

Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India. Electronic address:

Background: The left coronary cusp is an uncommon but well-known site for the ablation of idiopathic ventricular tachycardia (VT). Proximity to the left coronary ostium makes ablation of this arrhythmia challenging. Different power settings have been described by various operators. Our objective was to describe the outcomes with low power ablation.

Methods: Once mapping confirmed origin from the left coronary cusp, ablation was performed if the best site was situated at least 5 mm from the left coronary ostium. Ablation was started at 15 W and, if successful, was stopped after 30 s. When required, higher powers were used up to 30 W.

Results: Ten patients with VT or premature ventricular beats mapped to the left coronary cusp were included in the study. No ablation was performed in one patient because of proximity to the left coronary ostium. Successful ablation was performed in eight of the other nine patients with a mean power of 18.1 ± 5.3 W and duration of 42.2 ± 13.5 s. There were no complications. All the eight patients remained free of recurrence at 16.8 ± 16.5 months of follow-up.

Conclusions: VT can be ablated from the left coronary cusp close to the left coronary ostium. Ablation with low power is effective in achieving immediate success which is also durable with time while avoiding complications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ihj.2018.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309714PMC
December 2018
-->