Rainer Spang

Rainer Spang

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Rainer Spang

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Automated macrophage counting in DLBCL tissue samples: a ROF filter based approach.

Biol Proced Online 2019 1;21:13. Epub 2019 Jul 1.

Department of Pathology, Hematopathology Section and Lymph Node Registry, University of Kiel/University Hospital Schleswig-Holstein, Arnold-Heller-Str. 3, Haus 14, Kiel, 24105 Germany.

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http://dx.doi.org/10.1186/s12575-019-0098-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600891PMC
July 2019

Random gene sets in predicting survival of patients with hepatocellular carcinoma.

J Mol Med (Berl) 2019 Jun 17;97(6):879-888. Epub 2019 Apr 17.

Division of Hepatology & Division of Clinical Bioinformatics, Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

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http://dx.doi.org/10.1007/s00109-019-01764-2DOI Listing
June 2019

Modelling cancer progression using Mutual Hazard Networks.

Bioinformatics 2019 Jun 28. Epub 2019 Jun 28.

Department of Statistical Bioinformatics, Institute of Functional Genomics, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btz513DOI Listing
June 2019

A Novel Metabolic Signature To Predict the Requirement of Dialysis or Renal Transplantation in Patients with Chronic Kidney Disease.

J Proteome Res 2019 Apr 12;18(4):1796-1805. Epub 2019 Mar 12.

Institute of Genetic Epidemiology, Department of Biometry, Epidemiology, and Medical Bioinformatics, Faculty of Medicine and Medical Center , University of Freiburg , Freiburg 79106 , Germany.

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http://dx.doi.org/10.1021/acs.jproteome.8b00983DOI Listing
April 2019

Identification of ADGRE5 as discriminating MYC target between Burkitt lymphoma and diffuse large B-cell lymphoma.

BMC Cancer 2019 Apr 5;19(1):322. Epub 2019 Apr 5.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, D-10117, Berlin, Germany.

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http://dx.doi.org/10.1186/s12885-019-5537-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451309PMC
April 2019

Round-robin test for the cell-of-origin classification of diffuse large B-cell lymphoma-a feasibility study using full slide staining.

Virchows Arch 2018 Sep 5;473(3):341-349. Epub 2018 May 5.

Department of Pathology, Hematopathology Section, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, D-24105, Kiel, Germany.

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http://dx.doi.org/10.1007/s00428-018-2367-4DOI Listing
September 2018

High-Dimensional Profiling for Computational Diagnosis.

Methods Mol Biol 2017 ;1526:205-229

Institute of Functional Genomics, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1007/978-1-4939-6613-4_12DOI Listing
January 2018

Spindle-Cell Variants of Primary Cutaneous Follicle Center B-Cell Lymphomas Are Germinal Center B-Cell Lymphomas by Gene Expression Profiling Using a Formalin-Fixed Paraffin-Embedded Specimen.

J Invest Dermatol 2017 11 3;137(11):2450-2453. Epub 2017 Jul 3.

Department of Pathology, Hematopathology Section and Lymph Node Registry, Christian-Albrechts-University of Kiel, University-Hospital Schleswig-Holstein (UKSH), Campus Kiel, Kiel, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X173177
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http://dx.doi.org/10.1016/j.jid.2017.06.016DOI Listing
November 2017

Cell-of-origin classification by gene expression and MYC-rearrangements in diffuse large B-cell lymphoma of children and adolescents.

Br J Haematol 2017 10 23;179(1):116-119. Epub 2017 Jun 23.

Department of Pathology, Haematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel/Christian-Albrecht University, Kiel, Germany.

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http://dx.doi.org/10.1111/bjh.14812DOI Listing
October 2017

Scale-Invariant Biomarker Discovery in Urine and Plasma Metabolite Fingerprints.

J Proteome Res 2017 10 7;16(10):3596-3605. Epub 2017 Sep 7.

Department of Physics, University of Regensburg , Universitätsstraße 31, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1021/acs.jproteome.7b00325DOI Listing
October 2017

Refining Pathways: A Model Comparison Approach.

PLoS One 2016 1;11(6):e0155999. Epub 2016 Jun 1.

Department of Statistical Bioinformatics, Institute of Functional Genomics, University of Regensburg, Regensburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155999PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889067PMC
July 2017

Synergy of interleukin 10 and toll-like receptor 9 signalling in B cell proliferation: Implications for lymphoma pathogenesis.

Int J Cancer 2017 Mar 17;140(5):1147-1158. Epub 2016 Oct 17.

Clinic of Haematology and Medical Oncology, University Medical Centre of the Georg-August University Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1002/ijc.30444DOI Listing
March 2017

External calibration with Drosophila whole-cell spike-ins delivers absolute mRNA fold changes from human RNA-Seq and qPCR data.

Biotechniques 2017 02 1;62(2):53-61. Epub 2017 Feb 1.

Statistical Bioinformatics, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.2144/000114514DOI Listing
February 2017

Adjusting microbiome profiles for differences in microbial load by spike-in bacteria.

Microbiome 2016 06 21;4(1):28. Epub 2016 Jun 21.

Chair of Statistical Bioinformatics, University of Regensburg, Am BioPark 9, 93053, Regensburg, Germany.

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http://dx.doi.org/10.1186/s40168-016-0175-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915049PMC
June 2016

Analyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models.

Bioinformatics 2016 03 17;32(6):893-900. Epub 2015 Nov 17.

Statistical Bioinformatics Department, Institute of Functional Genomics, University of Regensburg, 93053 Regensburg and.

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http://dx.doi.org/10.1093/bioinformatics/btv680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939970PMC
March 2016

A statistical approach to virtual cellular experiments: improved causal discovery using accumulation IDA (aIDA).

Bioinformatics 2015 Dec 6;31(23):3807-14. Epub 2015 Aug 6.

Department of Statistical Bioinformatics, University of Regensburg, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btv461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653390PMC
December 2015

Clinical and pathological features of Burkitt lymphoma showing expression of BCL2--an analysis including gene expression in formalin-fixed paraffin-embedded tissue.

Br J Haematol 2015 Nov 27;171(4):501-8. Epub 2015 Jul 27.

Department of Pathology, Haematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel/Christian-Albrecht University, Kiel, Germany.

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http://doi.wiley.com/10.1111/bjh.13624
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http://dx.doi.org/10.1111/bjh.13624DOI Listing
November 2015

Data Normalization of (1)H NMR Metabolite Fingerprinting Data Sets in the Presence of Unbalanced Metabolite Regulation.

J Proteome Res 2015 Aug 22;14(8):3217-28. Epub 2015 Jul 22.

Institute of Functional Genomics, University of Regensburg, Josef-Engert-Str. 9, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1021/acs.jproteome.5b00192DOI Listing
August 2015

YBX1 is a modulator of MIA/CD-RAP-dependent chondrogenesis.

PLoS One 2013 12;8(12):e82166. Epub 2013 Dec 12.

Institute of Pathology, University of Regensburg, Regensburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082166PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861381PMC
October 2014

siPools: highly complex but accurately defined siRNA pools eliminate off-target effects.

Nucleic Acids Res 2014 Jul 29;42(12):8049-61. Epub 2014 May 29.

Biochemistry Center Regensburg (BZR), Laboratory for RNA Biology, University of Regensburg, Universitätsstrasse 31, 93053 Regensburg, Germany

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gku480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081087PMC
July 2014

Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells.

Nat Commun 2013 ;4:2610

1] German Cancer Research Center (DKFZ), Div. Signalling and Functional Genomics, and Heidelberg University, Dept. Cell and Molecular Biology, Faculty of Medicine Mannheim, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany [2].

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http://dx.doi.org/10.1038/ncomms3610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826636PMC
June 2014

Increased expression of c-Jun in nonalcoholic fatty liver disease.

Lab Invest 2014 Apr 3;94(4):394-408. Epub 2014 Feb 3.

Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1038/labinvest.2014.3DOI Listing
April 2014

Exact likelihood computation in Boolean networks with probabilistic time delays, and its application in signal network reconstruction.

Bioinformatics 2014 Feb 30;30(3):414-9. Epub 2013 Nov 30.

Institute for Genetics, University of Cologne, 50674 Cologne, Max Planck Institute for Plant Breeding Research, 50829 Cologne, Gene Center, Department of Biochemistry, Ludwig-Maximilians University, 81379 Munich, Germany, Insitute for Functional Genomics, 93053 Regensburg, Germany, Department of Radiology, Center for Cancer Systems Biology, Stanford University, Stanford, CA 94305-5488, USA and ETH Zürich, Department of Biosystems Science and Engineering, Mattenstrasse 26 4058 Basel, Switzerland.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btt696DOI Listing
February 2014

Considering unknown unknowns: reconstruction of nonconfoundable causal relations in biological networks.

J Comput Biol 2013 Nov;20(11):920-32

Institute of Functional Genomics, Computational Diagnostics Group, University of Regensburg , Regensburg, Germany .

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http://dx.doi.org/10.1089/cmb.2013.0119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822397PMC
November 2013

Melanoma inhibitory activity promotes melanoma development through activation of YBX1.

Pigment Cell Melanoma Res 2013 Sep 14;26(5):685-96. Epub 2013 Jun 14.

Institute of Pathology, University of Regensburg Medical School, Regensburg, Germany.

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http://dx.doi.org/10.1111/pcmr.12119DOI Listing
September 2013

Molecular classification of mature aggressive B-cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens.

Blood 2013 Sep;122(11):1985-6

Department of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel/Christian-Albrecht University, Kiel, Germany.

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http://dx.doi.org/10.1182/blood-2013-06-508937DOI Listing
September 2013

Aberrant lymphocyte enhancer-binding factor 1 expression is characteristic for sporadic Burkitt's lymphoma.

Am J Pathol 2013 Apr 31;182(4):1092-8. Epub 2013 Jan 31.

Department of Hematology and Oncology, University Medical Centre of the Georg-August University of Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1016/j.ajpath.2012.12.013DOI Listing
April 2013

A least angle regression model for the prediction of canonical and non-canonical miRNA-mRNA interactions.

PLoS One 2012 17;7(7):e40634. Epub 2012 Jul 17.

Department of Statistical Bioinformatics, Institute for Functional Genomics, University of Regensburg, Regensburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040634PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398908PMC
March 2013

Performance evaluation of algorithms for the classification of metabolic 1H NMR fingerprints.

J Proteome Res 2012 Dec 12;11(12):6242-51. Epub 2012 Nov 12.

Institute of Functional Genomics, University of Regensburg, Josef-Engert-Strasse 9, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1021/pr3009034DOI Listing
December 2012

High Myc activity is an independent negative prognostic factor for diffuse large B cell lymphomas.

Int J Cancer 2012 Aug 23;131(4):E348-61. Epub 2011 Oct 23.

Department of Haematology and Oncology, University Medical Centre of the Georg-August University Göttingen, Germany.

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http://dx.doi.org/10.1002/ijc.26423DOI Listing
August 2012

T cells become licensed in the lung to enter the central nervous system.

Nature 2012 Aug;488(7413):675-9

Institute for Multiple Sclerosis Research, Department of Neuroimmunology, Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen, 37073 Göttingen, Germany.

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http://dx.doi.org/10.1038/nature11337DOI Listing
August 2012

State-of-the art data normalization methods improve NMR-based metabolomic analysis.

Metabolomics 2012 Jun 12;8(Suppl 1):146-160. Epub 2011 Aug 12.

Institute of Functional Genomics, University of Regensburg, Josef-Engert-Strasse 9, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1007/s11306-011-0350-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337420PMC
June 2012

Patient age at diagnosis is associated with the molecular characteristics of diffuse large B-cell lymphoma.

Blood 2012 Feb 11;119(8):1882-7. Epub 2012 Jan 11.

Department of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel/University of Kiel, Kiel, Germany.

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http://dx.doi.org/10.1182/blood-2011-10-388470DOI Listing
February 2012

Estimating classification probabilities in high-dimensional diagnostic studies.

Bioinformatics 2011 Sep 22;27(18):2563-70. Epub 2011 Jul 22.

Institute of Functional Genomics, University of Regensburg, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btr434DOI Listing
September 2011

Genomic data integration using guided clustering.

Bioinformatics 2011 Aug 17;27(16):2231-8. Epub 2011 Jun 17.

Institut für funktionelle Genomik, Universität Regensburg, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btr363DOI Listing
August 2011

Transcriptome asymmetry within mouse zygotes but not between early embryonic sister blastomeres.

EMBO J 2011 May 5;30(9):1841-51. Epub 2011 Apr 5.

Laboratory of Mammalian Molecular Embryology, RIKEN Center for Developmental Biology, Kobe, Japan.

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http://dx.doi.org/10.1038/emboj.2011.92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101998PMC
May 2011

ReseqChip: automated integration of multiple local context probe data from the MitoChip array in mitochondrial DNA sequence assembly.

BMC Bioinformatics 2009 Dec 22;10:440. Epub 2009 Dec 22.

Institute of Functional Genomics, University of Regensburg, Josef-Engert-Str, 9, D-93053 Regensburg, Germany.

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http://dx.doi.org/10.1186/1471-2105-10-440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087351PMC
December 2009

Modeling the temporal interplay of molecular signaling and gene expression by using dynamic nested effects models.

Proc Natl Acad Sci U S A 2009 Apr 27;106(16):6447-52. Epub 2009 Mar 27.

Institute of Functional Genomics, University of Regensburg, Josef-Engert-Strasse 9, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1073/pnas.0809822106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672479PMC
April 2009

Kinetic laws, phase-phase expansions, renormalization group, and INR calibration.

Proc Natl Acad Sci U S A 2009 Apr 6;106(16):6465-70. Epub 2009 Apr 6.

Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.

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http://dx.doi.org/10.1073/pnas.0809855106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672524PMC
April 2009

Analyzing gene perturbation screens with nested effects models in R and bioconductor.

Bioinformatics 2008 Nov 21;24(21):2549-50. Epub 2008 Aug 21.

German Cancer Research Center, INF 580, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btn446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732276PMC
November 2008

Computational diagnostics with gene expression profiles.

Methods Mol Biol 2008 ;453:281-96

Max Planck Institute for Molecular Genetics and Berlin Center for Genome-Based Bioinformatics, Berlin, Germany.

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http://dx.doi.org/10.1007/978-1-60327-429-6_15DOI Listing
October 2008

Detecting hierarchical structure in molecular characteristics of disease using transitive approximations of directed graphs.

Bioinformatics 2008 Apr 19;24(7):995-1001. Epub 2008 Feb 19.

Computational Diagnostics Group, Institute of Functional Genomics, University of Regensburg, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btn056DOI Listing
April 2008

CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells.

Am J Pathol 2008 Feb 10;172(2):510-20. Epub 2008 Jan 10.

Charité-University Medicine Berlin, Campus Benjamin Franklin, Institute of Pathology, D-12200 Berlin, Germany.

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http://dx.doi.org/10.2353/ajpath.2008.070858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2312360PMC
February 2008

Microarray based diagnosis profits from better documentation of gene expression signatures.

PLoS Comput Biol 2008 Feb;4(2):e22

Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://dx.doi.org/10.1371/journal.pcbi.0040022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242819PMC
February 2008

Ataxia telangiectasia-mutated gene is a possible biomarker for discrimination of infiltrative deep penetrating nevi and metastatic vertical growth phase melanoma.

Cancer Epidemiol Biomarkers Prev 2007 Nov;16(11):2486-90

Department of Dermatology, Regensburg University Medical Center, Franz-Josef Strauss-Allee 11, D-93053 Regensburg, Germany.

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http://dx.doi.org/10.1158/1055-9965.EPI-07-0224DOI Listing
November 2007

Annotation-based distance measures for patient subgroup discovery in clinical microarray studies.

Bioinformatics 2007 Sep 22;23(17):2256-64. Epub 2007 Jun 22.

Max Planck Institute for Molecular Genetics and Berlin Center for Genome Based Bioinformatics, Ihnestr. 73, D-14195 Berlin, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btm322DOI Listing
September 2007

Inferring cellular networks--a review.

BMC Bioinformatics 2007 Sep 27;8 Suppl 6:S5. Epub 2007 Sep 27.

Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany.

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http://dx.doi.org/10.1186/1471-2105-8-S6-S5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995541PMC
September 2007

Nested effects models for high-dimensional phenotyping screens.

Bioinformatics 2007 Jul;23(13):i305-12

Lewis-Sigler Institute for Integrative Genomics and Department of Computer Science, Princeton University, Princeton, NJ, 08544, USA.

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http://dx.doi.org/10.1093/bioinformatics/btm178DOI Listing
July 2007

Compensating for unknown confounders in microarray data analysis using filtered permutations.

J Comput Biol 2007 Jun;14(5):669-81

Max Planck Institute for Molecular Genetics, Computational Diagnostics Group, Berlin, Germany.

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http://dx.doi.org/10.1089/cmb.2007.R009DOI Listing
June 2007

Gene expression signatures for tumor progression, tumor subtype, and tumor thickness in laser-microdissected melanoma tissues.

Clin Cancer Res 2007 Feb;13(3):806-15

Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-06-1820DOI Listing
February 2007

A stochastic downhill search algorithm for estimating the local false discovery rate.

IEEE/ACM Trans Comput Biol Bioinform 2004 Jul-Sep;1(3):98-108

Max Planck Institute for Molecular Genetics, Computational Diagnostics, Berlin, Germany.

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http://dx.doi.org/10.1109/TCBB.2004.24DOI Listing
November 2006

OrderedList--a bioconductor package for detecting similarity in ordered gene lists.

Bioinformatics 2006 Sep 14;22(18):2315-6. Epub 2006 Jul 14.

Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics Ihnestrasse 63-73, D-14195 Berlin, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btl385DOI Listing
September 2006

Expression of late cell cycle genes and an increased proliferative capacity characterize very early relapse of childhood acute lymphoblastic leukemia.

Clin Cancer Res 2006 Aug;12(15):4553-61

Department of Pediatric Oncology/Hematology, HELIOS Klinikum Berlin, Robert-Roessle-Clinic, Laboratory for Functional Genomics, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-0235DOI Listing
August 2006

Selecting normalization genes for small diagnostic microarrays.

BMC Bioinformatics 2006 Aug 22;7:388. Epub 2006 Aug 22.

Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany.

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http://dx.doi.org/10.1186/1471-2105-7-388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560169PMC
August 2006

Automated in-silico detection of cell populations in flow cytometry readouts and its application to leukemia disease monitoring.

BMC Bioinformatics 2006 Jun 5;7:282. Epub 2006 Jun 5.

Max Planck Institute for Molecular Genetics & Berlin Center for Genome Based Bioinformatics, Ihnestrasse, 73, D-14195 Berlin, Germany.

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http://dx.doi.org/10.1186/1471-2105-7-282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1501051PMC
June 2006

Similarities of ordered gene lists.

J Bioinform Comput Biol 2006 Jun;4(3):693-708

Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Ihnestr. 73, 14195 Berlin, Germany.

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June 2006

Early diagnostic marker panel determination for microarray based clinical studies.

Stat Appl Genet Mol Biol 2005 26;4:Article9. Epub 2005 Apr 26.

Max Planck Institute for Molecular Genetics, Berlin.

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http://dx.doi.org/10.2202/1544-6115.1109DOI Listing
May 2006

Non-transcriptional pathway features reconstructed from secondary effects of RNA interference.

Bioinformatics 2005 Nov 13;21(21):4026-32. Epub 2005 Sep 13.

Department of Computational Molecular Biology, Computational Diagnostics Group, Max Planck Institute for Molecular Genetics Ihnestrasse 63-73, 14195 Berlin, Germany.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/bti662DOI Listing
November 2005

Detecting common gene expression patterns in multiple cancer outcome entities.

Biomed Microdevices 2005 Sep;7(3):247-51

Computational Diagnostics Group, Department of Computational Molecular Biology, MPI for Molecular Genetics, Ihnestr. 73, 14195 Berlin, Germany.

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http://link.springer.com/10.1007/s10544-005-3032-7
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http://dx.doi.org/10.1007/s10544-005-3032-7DOI Listing
September 2005

stam--a Bioconductor compliant R package for structured analysis of microarray data.

BMC Bioinformatics 2005 Aug 25;6:211. Epub 2005 Aug 25.

Max Planck Institute for Molecular Genetics, Berlin Center for Genome Based Bioinformatics, Ihnestr. 73, D-14195 Berlin, Germany.

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http://dx.doi.org/10.1186/1471-2105-6-211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1208856PMC
August 2005

twilight; a Bioconductor package for estimating the local false discovery rate.

Bioinformatics 2005 Jun 7;21(12):2921-2. Epub 2005 Apr 7.

Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, Ihnestrasse 63-73, D-14195 Berlin, Germany.

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http://dx.doi.org/10.1093/bioinformatics/bti436DOI Listing
June 2005

Molecular decomposition of complex clinical phenotypes using biologically structured analysis of microarray data.

Bioinformatics 2005 May 27;21(9):1971-8. Epub 2005 Jan 27.

Max Planck Institute for Molecular Genetics and Berlin Center for Genome Based Bioinformatics, Germany.

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http://dx.doi.org/10.1093/bioinformatics/bti292DOI Listing
May 2005

Diagnostic signatures from microarrays: a bioinformatics concept for personalized medicine.

Authors:
Rainer Spang

Drug Discov Today 2004 Dec;9(24 Suppl):S32-6

Max Planck Institute for Molecular Genetics, Ihnestr. 73, D-14195 Berlin, Germany.

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December 2004