Rainer Spanagel

Rainer Spanagel

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Rainer Spanagel

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Reduced sensitivity to ethanol and excessive drinking in a mouse model of neuropathic pain.

Addict Biol 2019 Sep 25;24(5):1008-1018. Epub 2019 Jun 25.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty of Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1111/adb.12784DOI Listing
September 2019

The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice.

J Neurosci 2019 Aug 10;39(32):6325-6338. Epub 2019 Jun 10.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim 68159, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.1120-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687905PMC
August 2019

Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats.

Front Behav Neurosci 2019 18;13:129. Epub 2019 Jun 18.

Institute of Psychopharmacology, Central Institute of Mental Health (CIMH), Heidelberg University, Faculty of Medicine Mannheim, Mannheim, Germany.

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http://dx.doi.org/10.3389/fnbeh.2019.00129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591257PMC
June 2019

Drinking Levels and Profiles of Alcohol Addicted Rats Predict Response to Nalmefene.

Front Pharmacol 2019 7;10:471. Epub 2019 May 7.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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https://www.frontiersin.org/article/10.3389/fphar.2019.00471
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http://dx.doi.org/10.3389/fphar.2019.00471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513880PMC
May 2019

Alcohol reduces muscle fatigue through atomistic interactions with nicotinic receptors.

Commun Biol 2018 3;1:159. Epub 2018 Oct 3.

6Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First St. SW, Rochester, MN 55905 USA.

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http://dx.doi.org/10.1038/s42003-018-0157-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170420PMC
October 2018

Longitudinal Structural and Functional Brain Network Alterations in a Mouse Model of Neuropathic Pain.

Neuroscience 2018 09 22;387:104-115. Epub 2018 Apr 22.

Translational Imaging Research Group, Central Institute of Mental Health, Medical Faculty of Mannheim, University of Heidelberg, J5, 68159 Mannheim, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03064522183027
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http://dx.doi.org/10.1016/j.neuroscience.2018.04.020DOI Listing
September 2018

c-Fos marking of identified midbrain neurons coactive after nicotine administration in-vivo.

J Comp Neurol 2018 09 2;526(13):2019-2031. Epub 2018 Aug 2.

Neurobiology, Interdisciplinary Center for Neurosciences (IZN), University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/cne.24471DOI Listing
September 2018

Dopamine and opioid systems adaptation in alcoholism revisited: Convergent evidence from positron emission tomography and postmortem studies.

Neurosci Biobehav Rev 2018 Sep 19. Epub 2018 Sep 19.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Mannheim, Germany; Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Mannheim, Germany.

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http://dx.doi.org/10.1016/j.neubiorev.2018.09.010DOI Listing
September 2018

Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics.

Mol Neurobiol 2018 Aug 30;55(8):7049-7061. Epub 2018 Jan 30.

Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Box 591, BMC Husargatan 3, SE-75124, Uppsala, Sweden.

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http://dx.doi.org/10.1007/s12035-017-0844-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061161PMC
August 2018

Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system.

J Neurochem 2018 08 1;146(4):374-389. Epub 2018 Aug 1.

Institute of Integrative Neuroanatomy, Charité-Universitätsmedizin, Berlin, Germany.

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http://doi.wiley.com/10.1111/jnc.14460
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http://dx.doi.org/10.1111/jnc.14460DOI Listing
August 2018

Dnmt3a2 in the Nucleus Accumbens Shell Is Required for Reinstatement of Cocaine Seeking.

J Neurosci 2018 Aug 20;38(34):7516-7528. Epub 2018 Jul 20.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim 68159, Germany, and.

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http://dx.doi.org/10.1523/JNEUROSCI.0600-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596133PMC
August 2018

Efficacy and side effects of baclofen and the novel GABA receptor positive allosteric modulator CMPPE in animal models for alcohol and cocaine addiction.

Psychopharmacology (Berl) 2018 07 12;235(7):1955-1965. Epub 2018 Apr 12.

Institute of Psychopharmacology, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim, Heidelberg University, J5, 68159, Mannheim, Germany.

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http://dx.doi.org/10.1007/s00213-018-4893-9DOI Listing
July 2018

Alterations of the Biological Clock May Contribute to the Emergence of Mental Disorders During Adolescence.

Authors:
Rainer Spanagel

Biol Psychiatry 2018 06;83(12):978-980

Department of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.04.004DOI Listing
June 2018

Aberrant choice behavior in alcoholism.

Authors:
Rainer Spanagel

Science 2018 06;360(6395):1298-1299

Institute of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1126/science.aau0668DOI Listing
June 2018

Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol-Dependent Rats and Humans.

Neuropsychopharmacology 2018 05 1;43(6):1235-1246. Epub 2017 Nov 1.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1038/npp.2017.257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916348PMC
May 2018

Targeting Glycine Reuptake in Alcohol Seeking and Relapse.

J Pharmacol Exp Ther 2018 04 24;365(1):202-211. Epub 2018 Jan 24.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (V.V., M.R., T.T.T., R.S.); Roche Pharma Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases, Roche Innovation Center Basel, Basel, Switzerland (D.A.); Department of Pharmacology, Neuroscience Research, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany (B.B., A.B.); and Department of Psychopharmacology, Pavlov Medical University, St. Petersburg, Russia (A.B.).

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http://dx.doi.org/10.1124/jpet.117.244822DOI Listing
April 2018

In vivo structural imaging in rats reveals neuroanatomical correlates of behavioral sub-dimensions of cocaine addiction.

Addict Biol 2018 01 23;23(1):182-195. Epub 2017 Feb 23.

Institute of Psychopharmacology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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http://doi.wiley.com/10.1111/adb.12500
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http://dx.doi.org/10.1111/adb.12500DOI Listing
January 2018

Mechanismen der Suchtentwicklung.

Authors:
Rainer Spanagel

Drug Res (Stuttg) 2017 Nov 25;67(S 01):S17. Epub 2017 Oct 25.

Institut für Psychopharmakologie, Zentralinstitut für Seelische Gesundheit, Mannheim.

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http://dx.doi.org/10.1055/s-0043-116532DOI Listing
November 2017

Building Bridges through Science.

Authors:
Thomas Lissek Michelle Adams John Adelman Ehud Ahissar Mohammed Akaaboune Huda Akil Mustafa al'Absi Fazal Arain Juan Carlos Arango-Lasprilla Deniz Atasoy Jesus Avila Ashraf Badawi Hilmar Bading Abdul Mannan Baig Jimena Baleriola Carlos Belmonte Ilaria Bertocchi Heinrich Betz Colin Blakemore Olaf Blanke Philipp Boehm-Sturm Tobias Bonhoeffer Paolo Bonifazi Nils Brose Patrizia Campolongo Tansu Celikel Cathy C Chang Ta-Yuan Chang Ami Citri Hollis T Cline Jesus M Cortes Kathleen Cullen Kellie Dean José M Delgado-Garcia Mathieu Desroches John F Disterhoft John E Dowling Andreas Draguhn Sherif F El-Khamisy Abdeljabbar El Manira S Ather Enam Juan M Encinas Asier Erramuzpe José A Esteban Isabel Fariñas Edmond Fischer Izumi Fukunaga Iñigo Gabilondo Detlev Ganten Albert Gidon Juan Carlos Gomez-Esteban Paul Greengard Valery Grinevich Agnés Gruart Roger Guillemin Ahmad R Hariri Bassem Hassan Michael Häusser Yasunori Hayashi Natasha K Hussain Adnan Abdul Jabbar Mohamed Jaber Reinhardt Jahn Essam Mohammed Janahi Mohamed Kabbaj Helmut Kettenmann Merel Kindt Shira Knafo Georg Köhr Shoji Komai Harm Krugers Bernd Kuhn Nouria Lakhdar Ghazal Matthew E Larkum Mickey London Beat Lutz Carlos Matute Luis Martinez-Millan Mouna Maroun James McGaugh Ahmed A Moustafa Anwar Nasim Klaus-Armin Nave Erwin Neher Karoly Nikolich Tiago Outeiro Lucy M Palmer Olga Penagarikano Isabel Perez-Otano Donald W Pfaff Bruno Poucet Atta-Ur Rahman Pedro Ramos-Cabrer Ali Rashidy-Pour Richard J Roberts Serafim Rodrigues Joshua R Sanes Andreas T Schaefer Menahem Segal Idan Segev Saad Shafqat Nikhat Ahmed Siddiqui Hermona Soreq Eduardo Soriano-García Rainer Spanagel Rolf Sprengel Greg Stuart Thomas C Südhof Jan Tønnesen Mario Treviño Basim M Uthman J Craig Venter Alexei Verkhratsky Craig Weiss Torsten N Wiesel Emre Yaksi Ofer Yizhar Larry J Young Paul Young Nasser H Zawia José L Zugaza Mazahir T Hasan

Neuron 2017 Nov;96(4):730-735

Achucarro Basque Center for Neuroscience, 48940 Leioa, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.09.028DOI Listing
November 2017

[18F]-Fluorodeoxyglucose-Positron Emission Tomography in Rats with Prolonged Cocaine Self-Administration Suggests Potential Brain Biomarkers for Addictive Behavior.

Front Psychiatry 2017 1;8:218. Epub 2017 Nov 1.

Medical Faculty Mannheim, Institute of Psychopharmacology, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.3389/fpsyt.2017.00218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671955PMC
November 2017

Dissociable Role of Corticotropin Releasing Hormone Receptor Subtype 1 on Dopaminergic and D1 Dopaminoceptive Neurons in Cocaine Seeking Behavior.

Front Behav Neurosci 2017 13;11:221. Epub 2017 Nov 13.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.3389/fnbeh.2017.00221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693884PMC
November 2017

Adaptive dynamics of the 5-HT systems following chronic administration of selective serotonin reuptake inhibitors: a meta-analysis.

J Neurochem 2017 09 14;142(5):747-755. Epub 2017 Jul 14.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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http://doi.wiley.com/10.1111/jnc.14114
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http://dx.doi.org/10.1111/jnc.14114DOI Listing
September 2017

Animal models of addiction.

Authors:
Rainer Spanagel

Dialogues Clin Neurosci 2017 09;19(3):247-258

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741108PMC
September 2017

Dynamical state transitions into addictive behaviour and their early-warning signals.

Proc Biol Sci 2017 Aug;284(1860)

Department of Physical and Health Education, Graduate School of Education, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-0033 Tokyo, Japan

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http://dx.doi.org/10.1098/rspb.2017.0882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563804PMC
August 2017

A multiscale cerebral neurochemical connectome of the rat brain.

PLoS Biol 2017 Jul 3;15(7):e2002612. Epub 2017 Jul 3.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1371/journal.pbio.2002612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507471PMC
July 2017

mPer1 promotes morphine-induced locomotor sensitization and conditioned place preference via histone deacetylase activity.

Psychopharmacology (Berl) 2017 Jun 28;234(11):1713-1724. Epub 2017 Feb 28.

Central Institute for Mental Health, Institute of Psychopharmacology, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00213-017-4574-0DOI Listing
June 2017

Melatonin reduces motivation for cocaine self-administration and prevents relapse-like behavior in rats.

Psychopharmacology (Berl) 2017 Jun 28;234(11):1741-1748. Epub 2017 Feb 28.

Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, Heidelberg University, J5, 68159, Mannheim, Germany.

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http://dx.doi.org/10.1007/s00213-017-4576-yDOI Listing
June 2017

Changes in cerebral [F]-FDG uptake induced by acute alcohol administration in a rat model of alcoholism.

Behav Brain Res 2017 06 27;327:29-33. Epub 2017 Mar 27.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01664328173021
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http://dx.doi.org/10.1016/j.bbr.2017.03.038DOI Listing
June 2017

Differential Roles for L-Type Calcium Channel Subtypes in Alcohol Dependence.

Neuropsychopharmacology 2017 Apr 1;42(5):1058-1069. Epub 2016 Dec 1.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1038/npp.2016.266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506795PMC
April 2017

Low μ-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis.

Neuropsychopharmacology 2017 02 11;42(3):606-614. Epub 2016 Aug 11.

Institute of Psychopharmacology, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1038/npp.2016.145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240173PMC
February 2017

Persistent strengthening of the prefrontal cortex - nucleus accumbens pathway during incubation of cocaine-seeking behavior.

Neurobiol Learn Mem 2017 Feb 5;138:281-290. Epub 2016 Oct 5.

Physiology of Neural Networks, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Germany; Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Germany; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747427163024
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http://dx.doi.org/10.1016/j.nlm.2016.10.003DOI Listing
February 2017

Altered neural oscillations and elevated dopamine levels in the reward pathway during alcohol relapse.

Behav Brain Res 2017 01 25;316:131-135. Epub 2016 Aug 25.

Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2016.08.045DOI Listing
January 2017

Association of plasma calcium concentrations with alcohol craving: New data on potential pathways.

Eur Neuropsychopharmacol 2017 01 25;27(1):42-47. Epub 2016 Nov 25.

Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1016/j.euroneuro.2016.11.007DOI Listing
January 2017

The Cannabinoid Receptor 1 as a Key Mediator of Adolescent Behavior.

Neuropsychopharmacology 2017 01;42(1):367

Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1038/npp.2016.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143490PMC
January 2017

The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research.

Curr Top Behav Neurosci 2016;28:151-71

Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/7854_2015_5006DOI Listing
December 2016

Reduced oxytocin receptor gene expression and binding sites in different brain regions in schizophrenia: A post-mortem study.

Schizophr Res 2016 11 25;177(1-3):59-66. Epub 2016 Apr 25.

Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University (LMU) Munich, Nußbaumstrasse 7, 80336 München, Germany; Laboratory of Neuroscience (LIM27), Institute of Psychiatry, University of Sao Paulo, Rua Dr. Ovidio Pires de Campos 785, 05453-010 São Paulo, SP, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2016.04.019DOI Listing
November 2016

Adverse Social Experiences in Adolescent Rats Result in Enduring Effects on Social Competence, Pain Sensitivity and Endocannabinoid Signaling.

Front Behav Neurosci 2016 20;10:203. Epub 2016 Oct 20.

Research Group Developmental Neuropsychopharmacology, Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of HeidelbergMannheim, Germany; Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of HeidelbergMannheim, Germany.

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http://journal.frontiersin.org/article/10.3389/fnbeh.2016.00
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http://dx.doi.org/10.3389/fnbeh.2016.00203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071316PMC
October 2016

Largely overlapping neuronal substrates of reactivity to drug, gambling, food and sexual cues: A comprehensive meta-analysis.

Eur Neuropsychopharmacol 2016 09 7;26(9):1419-1430. Epub 2016 Jul 7.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S0924977X163009
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http://dx.doi.org/10.1016/j.euroneuro.2016.06.013DOI Listing
September 2016

Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse.

Psychopharmacology (Berl) 2016 Sep 30;233(18):3449-59. Epub 2016 Jul 30.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1007/s00213-016-4384-9DOI Listing
September 2016

Disruption of reconsolidation processes is a balancing act - can it really account for change in psychotherapy?

Behav Brain Sci 2015 ;38:e25

Department of Psychosomatics and Psychotherapeutic Medicine,Central Institute of Mental Health,Faculty of Medicine Mannheim,Heidelberg University,J5,D-68159

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http://dx.doi.org/10.1017/S0140525X14000405DOI Listing
August 2016

Adolescent social rejection alters pain processing in a CB1 receptor dependent manner.

Eur Neuropsychopharmacol 2016 07 2;26(7):1201-12. Epub 2016 May 2.

Research Group Developmental Neuropsychopharmacology, Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2016.04.007DOI Listing
July 2016

A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males.

J Psychiatry Neurosci 2016 04;41(3):192-202

From the Discipline of Psychiatry, University of Adelaide, Australia (Stacey); the Institute of Psychiatry, King's College, London, UK (Lourdusamy, Ruggeri, Maroteaux, Jia, Cattrell, Nymberg, Barker, Carvalho, Conrod, Desrivières, Easton, Loth, Müller, Schumann); the MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, UK (Lourdusamy, Ruggeri, Jia, Nymberg, Carvalho, Desrivières, Easton, Loth, Müller, Schumann); the Institut du Fer à Moulin, UMR-S 839, INSERM and Université Pierre et Marie Curie, Paris, France (Maroteaux, Mameli, Girault); the Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany (Banaschewski); the University of Nebraska Medical Center, Omaha, USA (Bhattacharyya, Band); the Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland (Bokde, Garavan); the Institute for Systemic Neuroscience, UMC Hamburg Eppendorf, Hamburg, Germany (Büchel); the Department of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, Montreal, Canada (Conrod); the Department of Addiction Medicine, Central Institute of Mental Health, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany (Fauth-Buehler, Mann); the CIC-IBMCC, University of Salamanca - CSIC, Spain (Fernandez-Medarde, Santos); Department of Neuropsychiatry and Cognitive Psychology, Central Institute of Mental Health, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany (Flor, Nees); the CEA, DSV, I2BM, Neurospin Bât 145 Gif-sur-Yvette, France (Frouin); the Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Germany (Gallinat); the Departments of Psychiatry and Psychology, University of Vermont, Burlington, USA (Garavan); the Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany (Ittermann); the McGill University and Genome Quebec Innovation Centre, Mon

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853210PMC
April 2016

The Calpain Inhibitor A-705253 Attenuates Alcohol-Seeking and Relapse with Low Side-Effect Profile.

Neuropsychopharmacology 2016 Mar 28;41(4):979-88. Epub 2015 Jul 28.

Department of Neuroscience Research, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany.

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http://dx.doi.org/10.1038/npp.2015.225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748423PMC
March 2016

Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence.

Proc Natl Acad Sci U S A 2016 Mar 22;113(11):3024-9. Epub 2016 Feb 22.

Institute for Psychopharmacology at Central Institute for Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany;

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http://dx.doi.org/10.1073/pnas.1506012113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801269PMC
March 2016

Reply to: Does acamprosate really produce its anti-relapse effects via calcium? No support from the PREDICT study in human alcoholics.

Neuropsychopharmacology 2016 Feb;41(3):661-2

Department of Addictive Behavior and Addiction Medicine, Central Institute for Mental Health, University of Heidelberg, Medical Faculty, Mannheim, Germany.

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http://dx.doi.org/10.1038/npp.2015.263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707840PMC
February 2016

Activation of Melatonin Receptors Reduces Relapse-Like Alcohol Consumption.

Neuropsychopharmacology 2015 Dec 21;40(13):2897-906. Epub 2015 May 21.

Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1038/npp.2015.143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864625PMC
December 2015

Long-lasting effect of NMDA receptor antagonist memantine on ethanol-cue association and relapse.

J Neurochem 2015 Dec 22;135(6):1080-5. Epub 2015 Sep 22.

Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1111/jnc.13350DOI Listing
December 2015

Corrigendum: CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects.

Front Behav Neurosci 2014 9;8:239. Epub 2014 Jul 9.

Department of Molecular Biology of the Cell I, DKFZ-ZMBH Alliance, German Cancer Research Center Heidelberg, Germany ; Department of Molecular Neuropharmacology, Institute of Pharmacology of the Polish Academy of Sciences Krakow, Poland.

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http://dx.doi.org/10.3389/fnbeh.2014.00239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089353PMC
November 2015

Quantification of alcohol drinking patterns in mice.

Addict Biol 2015 Nov 30;20(6):1001-11. Epub 2015 Oct 30.

Institute of Psychopharmacology.

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http://dx.doi.org/10.1111/adb.12325DOI Listing
November 2015

Glutamate Receptors within the Mesolimbic Dopamine System Mediate Alcohol Relapse Behavior.

J Neurosci 2015 Nov;35(47):15523-38

Institute of Psychopharmacology and Behavioral Genetics Research Group, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, J5, 68159 Mannheim, Germany, and

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http://dx.doi.org/10.1523/JNEUROSCI.2970-15.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705467PMC
November 2015

Sex differences in dopamine binding and modafinil conditioned place preference in mice.

Drug Alcohol Depend 2015 Oct 28;155:37-44. Epub 2015 Aug 28.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, J5, 68159, Mannheim, Germany.

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http://dx.doi.org/10.1016/j.drugalcdep.2015.08.016DOI Listing
October 2015

Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit.

Borderline Personal Disord Emot Dysregul 2014 9;1:12. Epub 2014 Sep 9.

Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim / Heidelberg University, J 5, 68159 Mannheim, Germany.

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http://dx.doi.org/10.1186/2051-6673-1-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579501PMC
September 2015

Increased mesolimbic cue-reactivity in carriers of the mu-opioid-receptor gene OPRM1 A118G polymorphism predicts drinking outcome: a functional imaging study in alcohol dependent subjects.

Eur Neuropsychopharmacol 2015 Aug 18;25(8):1128-35. Epub 2015 Apr 18.

Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Square J5, D-68159 Mannheim, Germany.

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http://dx.doi.org/10.1016/j.euroneuro.2015.04.013DOI Listing
August 2015

Effects of D-cycloserine on extinction of mesolimbic cue reactivity in alcoholism: a randomized placebo-controlled trial.

Psychopharmacology (Berl) 2015 Jul 21;232(13):2353-62. Epub 2015 Feb 21.

Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, 68159, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00213-015-3882-5DOI Listing
July 2015

Losing Control: Excessive Alcohol Seeking after Selective Inactivation of Cue-Responsive Neurons in the Infralimbic Cortex.

J Neurosci 2015 Jul;35(30):10750-61

Institute of Psychopharmacology, Addiction Medicine at Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Germany, and

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http://dx.doi.org/10.1523/JNEUROSCI.0684-15.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605108PMC
July 2015

Clock genes × stress × reward interactions in alcohol and substance use disorders.

Alcohol 2015 Jun 24;49(4):351-7. Epub 2015 Apr 24.

Institute of Psychopharmacology, Central Institute for Mental Health, Medical Faculty of Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1016/j.alcohol.2015.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457607PMC
June 2015

Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis.

Am J Psychiatry 2015 Jun 18;172(6):543-52. Epub 2015 May 18.

From the Institute of Psychiatry, King's College London; the MRC Social, Genetic, and Developmental Psychiatry Centre, London; the Department of Public Health, the Department of Mental Health and Substance Abuse Services, and the Institute for Molecular Medicine, University of Helsinki, Helsinki; the National Institute for Health and Welfare, Helsinki; the Central Institute of Mental Health, Medical Faculty Mannheim, the Department of Addictive Behaviour and Addiction Medicine, and the Department of Cognitive and Clinical Neuroscience, Heidelberg University, Mannheim, Germany; the Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland; Universitaetsklinikum Hamburg Eppendorf, Hamburg, Germany; the Department of Psychiatry, University of Montreal, and CHU Sainte-Justine Hospital, Montreal; NeuroSpin, Alternative Energies and Atomic Energy Commission (CEA), Paris; the Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Germany; the Departments of Psychiatry and Psychology, University of Vermont, Middlebury; the School of Physics and Astronomy and the School of Psychology, University of Nottingham, Nottingham, United Kingdom; Physikalisch-Technische Bundesanstalt, Braunschweig und Berlin, Germany; Institut National de la Santé et de la Recherche Médicale, INSERM CEA Unit 1000 "Imaging and Psychiatry," University Paris Sud, Orsay, and AP-HP Department of Adolescent Psychopathology and Medicine, Maison de Solenn, University Paris Descartes, Paris; Hospital for Sick Children and Rotman Research Institute, University of Toronto, Toronto; Montreal Neurological Institute, McGill University, Montreal; the Behavioural and Clinical Neuroscience Institute and the Department of Psychology, University of Cambridge, Cambridge, United Kingdom; the Department of Psychiatry and Psychotherapy and the Neuroimaging Center, Department of Psychology, Technische Universität Dresden, Germany; the Division of Biological Resea

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http://dx.doi.org/10.1176/appi.ajp.2014.14030382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827248PMC
June 2015

A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice.

Biol Psychiatry 2015 May 8;77(10):850-8. Epub 2014 Sep 8.

Department of Clinical and Experimental Medicine, Linköpings Universitet, Linköping, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2014.08.021DOI Listing
May 2015

Chronic intermittent ethanol exposure in mice leads to an up-regulation of CRH/CRHR1 signaling.

Alcohol Clin Exp Res 2015 Apr;39(4):752-62

Behavioral Genetics Research Group, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany; Institute of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1111/acer.12686DOI Listing
April 2015

New regulations for animal research - a chance to shine for in silico approaches.

In Silico Pharmacol 2015 10;3. Epub 2015 Feb 10.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1186/s40203-015-0006-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329123PMC
February 2015

In silico pharmacology: drug design and discovery's gate to the future.

In Silico Pharmacol 2013 12;1. Epub 2013 Feb 12.

Institute of Psychopharmacology, Central Institute for Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68159 Germany.

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http://dx.doi.org/10.1186/2193-9616-1-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230818PMC
December 2014

Ethanol-induced alterations of amino acids measured by in vivo microdialysis in rats: a meta-analysis.

In Silico Pharmacol 2013 17;1. Epub 2013 May 17.

Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, J5, 68159 Mannheim, Germany.

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http://dx.doi.org/10.1186/2193-9616-1-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230485PMC
December 2014

Convergent functional genomics in addiction research - a translational approach to study candidate genes and gene networks.

Authors:
Rainer Spanagel

In Silico Pharmacol 2013 13;1:18. Epub 2013 Dec 13.

Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, J5, 68159 Mannheim, Germany.

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http://dx.doi.org/10.1186/2193-9616-1-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230431PMC
December 2014

A two-injection protocol for nicotine sensitization.

Behav Brain Res 2014 Dec 1;275:11-4. Epub 2014 Sep 1.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, J5, 68159 Mannheim, Germany.

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http://dx.doi.org/10.1016/j.bbr.2014.08.048DOI Listing
December 2014

Enhanced extinction of contextual fear conditioning in ClockΔ19 mutant mice.

Behav Neurosci 2014 Aug 26;128(4):468-73. Epub 2014 May 26.

Institute of Psychopharmacology, Central Institute of Mental Health.

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http://doi.apa.org/getdoi.cfm?doi=10.1037/a0037020
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August 2014

Transcriptional regulation of L-type calcium channel subtypes Cav1.2 and Cav1.3 by nicotine and their potential role in nicotine sensitization.

Nicotine Tob Res 2014 Jun 27;16(6):774-85. Epub 2014 Jan 27.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim /University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1093/ntr/ntt274DOI Listing
June 2014

CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects.

Front Behav Neurosci 2014 11;8:212. Epub 2014 Jun 11.

Department of Molecular Biology of the Cell I, DKFZ-ZMBH Alliance, German Cancer Research Center Heidelberg, Germany ; Department of Molecular Neuropharmacology, Institute of Pharmacology of the Polish Academy of Sciences Krakow, Poland.

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http://dx.doi.org/10.3389/fnbeh.2014.00212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052973PMC
June 2014

Basal activity level in mice predicts the initial and sensitized locomotor response to nicotine only in high responders.

Behav Brain Res 2014 May 5;264:143-50. Epub 2014 Feb 5.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, J5 68159 Mannheim, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01664328140006
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http://dx.doi.org/10.1016/j.bbr.2014.01.046DOI Listing
May 2014

The alcohol deprivation effect model for studying relapse behavior: a comparison between rats and mice.

Alcohol 2014 May 1;48(3):313-20. Epub 2014 Apr 1.

Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine, Mannheim, University of Heidelberg, J5, 68159 Mannheim, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S07418329140005
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http://dx.doi.org/10.1016/j.alcohol.2014.03.002DOI Listing
May 2014

Stress and alcohol interactions: animal studies and clinical significance.

Trends Neurosci 2014 Apr 11;37(4):219-27. Epub 2014 Mar 11.

Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, USA.

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http://dx.doi.org/10.1016/j.tins.2014.02.006DOI Listing
April 2014

Acamprosate produces its anti-relapse effects via calcium.

Neuropsychopharmacology 2014 Mar 30;39(4):783-91. Epub 2013 Sep 30.

Department of Addictive Behavior and Addiction Medicine, Central Institute for Mental Health, Mannheim, Germany.

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http://dx.doi.org/10.1038/npp.2013.264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924515PMC
March 2014

Cluster and meta-analyses on factors influencing stress-induced alcohol drinking and relapse in rodents.

Addict Biol 2014 Mar;19(2):225-32

Institute of Psychopharmacology, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim, University of Heidelberg, Germany.

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http://dx.doi.org/10.1111/adb.12125DOI Listing
March 2014

Adolescent peer-rejection persistently alters pain perception and CB1 receptor expression in female rats.

Eur Neuropsychopharmacol 2014 Feb 10;24(2):290-301. Epub 2013 May 10.

Research Group Developmental Neuropsychopharmacology, Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2013.04.004DOI Listing
February 2014

The effects of xenon and nitrous oxide gases on alcohol relapse.

Alcohol Clin Exp Res 2014 Feb 7;38(2):557-63. Epub 2013 Oct 7.

Faculty of Medicine Mannheim, Institute of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1111/acer.12264DOI Listing
February 2014

Incubation of cocaine seeking following brief cocaine experience in mice is enhanced by mGluR1 blockade.

J Neurosci 2014 Jan;34(5):1781-90

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.1076-14.2014DOI Listing
January 2014

Global ethanol-induced enhancements of monoaminergic neurotransmission: a meta-analysis study.

Alcohol Clin Exp Res 2013 Dec 28;37(12):2048-57. Epub 2013 Jun 28.

Institute of Psychopharmacology , Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1111/acer.12207DOI Listing
December 2013

The ClockΔ19 mutation in mice fails to alter the primary and secondary reinforcing properties of nicotine.

Drug Alcohol Depend 2013 Dec 5;133(2):733-9. Epub 2013 Sep 5.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03768716130034
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http://dx.doi.org/10.1016/j.drugalcdep.2013.08.024DOI Listing
December 2013

Glutamatergic targets for new alcohol medications.

Psychopharmacology (Berl) 2013 Oct 1;229(3):539-54. Epub 2013 Sep 1.

Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA,

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http://dx.doi.org/10.1007/s00213-013-3226-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811052PMC
October 2013

The mGluR2/3 agonist LY379268 induced anti-reinstatement effects in rats exhibiting addiction-like behavior.

Neuropsychopharmacology 2013 Sep 29;38(10):2048-56. Epub 2013 Apr 29.

Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1038/npp.2013.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746689PMC
September 2013

Quantum modeling of common sense.

Behav Brain Sci 2013 Jun;36(3):302

Institute of Psychopharmacology, Central Institute for Mental Health, Medical Faculty Mannheim, University of Heidelberg, J 5, 68159 Mannheim, Germany.

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http://dx.doi.org/10.1017/S0140525X1200307XDOI Listing
June 2013

Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence.

J Neurosci 2013 Feb;33(7):2794-806

Institute of Psychopharmacology at Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.4062-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711176PMC
February 2013

Oleoylethanolamide dose-dependently attenuates cocaine-induced behaviours through a PPARα receptor-independent mechanism.

Addict Biol 2013 Jan 19;18(1):78-87. Epub 2012 Nov 19.

Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty of Mannheim, University of Heidelberg, Germany.

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http://dx.doi.org/10.1111/adb.12006DOI Listing
January 2013