Rainer Lehtonen

Rainer Lehtonen

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Rainer Lehtonen

Rainer Lehtonen

Publications by authors named "Rainer Lehtonen"

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Distinct subtypes of diffuse large B-cell lymphoma defined by hypermutated genes.

Leukemia 2019 Jun 11. Epub 2019 Jun 11.

Research Programs Unit, Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

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http://www.nature.com/articles/s41375-019-0509-6
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http://dx.doi.org/10.1038/s41375-019-0509-6DOI Listing
June 2019

PerPAS: Topology-Based Single Sample Pathway Analysis Method.

IEEE/ACM Trans Comput Biol Bioinform 2018 May-Jun;15(3):1022-1027. Epub 2017 Mar 8.

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http://dx.doi.org/10.1109/TCBB.2017.2679745DOI Listing
May 2019

Identifying differentially methylated sites in samples with varying tumor purity.

Bioinformatics 2018 09;34(18):3078-3085

Research Programs Unit, Genome-Scale Biology, Medicum and Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1093/bioinformatics/bty310DOI Listing
September 2018

Mathematical Modeling Predicts Response to Chemotherapy and Drug Combinations in Ovarian Cancer.

Cancer Res 2018 07 16;78(14):4036-4044. Epub 2018 May 16.

Genome-Scale Biology Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3746DOI Listing
July 2018

Genetic effects on life-history traits in the Glanville fritillary butterfly.

PeerJ 2017 25;5:e3371. Epub 2017 May 25.

Department of Biosciences, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.7717/peerj.3371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446771PMC
May 2017

Expressional profiling of prostate cancer risk SNPs at 11q13.5 identifies DGAT2 as a new target gene.

Genes Chromosomes Cancer 2016 08 24;55(8):661-73. Epub 2016 May 24.

BioMediTech and Prostate Cancer Research Center, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1002/gcc.22368DOI Listing
August 2016

SePIA: RNA and small RNA sequence processing, integration, and analysis.

BioData Min 2016 20;9:20. Epub 2016 May 20.

Research Programs Unit, Genome-Scale Biology, Medicum and Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, POB 63, Helsinki, 00014 Finland.

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http://dx.doi.org/10.1186/s13040-016-0099-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875694PMC
May 2016

Data integration to prioritize drugs using genomics and curated data.

BioData Min 2016 26;9:21. Epub 2016 May 26.

Genome Scale Biology Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, P.O. Box 63 (Haartmaninkatu 8), Helsinki, FI-00014 Finland.

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http://dx.doi.org/10.1186/s13040-016-0097-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881054PMC
May 2016

Predictable allele frequency changes due to habitat fragmentation in the Glanville fritillary butterfly.

Proc Natl Acad Sci U S A 2016 03 22;113(10):2678-83. Epub 2016 Feb 22.

Department of Biosciences, University of Helsinki, FI-00014 Helsinki, Finland

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http://dx.doi.org/10.1073/pnas.1600951113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791001PMC
March 2016

Identification of sample-specific regulations using integrative network level analysis.

BMC Cancer 2015 Apr 28;15:319. Epub 2015 Apr 28.

Research Programs Unit, Genome-Scale Biology Research Program and Institute of Biomedicine, University of Helsinki, Haartmaninkatu 8, Helsinki, FI-00014, Finland.

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http://dx.doi.org/10.1186/s12885-015-1265-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424448PMC
April 2015

Genomic profile of pseudomyxoma peritonei analyzed using next-generation sequencing and immunohistochemistry.

Int J Cancer 2015 Mar 13;136(5):E282-9. Epub 2014 Oct 13.

Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.

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http://doi.wiley.com/10.1002/ijc.29245
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http://dx.doi.org/10.1002/ijc.29245DOI Listing
March 2015

Phenotypic plasticity in thermal tolerance in the Glanville fritillary butterfly.

J Therm Biol 2014 May 7;42:33-9. Epub 2014 Mar 7.

Department of Biosciences, PL 65, Viikinkaari 1, FI-00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jtherbio.2014.02.018DOI Listing
May 2014

Lep-MAP: fast and accurate linkage map construction for large SNP datasets.

Bioinformatics 2013 Dec 26;29(24):3128-34. Epub 2013 Sep 26.

Department of Biosciences, Metapopulation Research Group, University of Helsinki, P.O. Box 65, FI-00014, Finland and Institute of Biotechnology, University of Helsinki, P.O. Box 56, FI-00014, Finland.

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http://dx.doi.org/10.1093/bioinformatics/btt563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433499PMC
December 2013

Fine mapping of 11q13.5 identifies regions associated with prostate cancer and prostate cancer death.

Eur J Cancer 2013 Oct 2;49(15):3335-43. Epub 2013 Jul 2.

Institute of Biomedical Technology/BioMediTech and Prostate Cancer Research Center, University of Tampere and Fimlab Laboratories, Biokatu 8, FI-33014 Tampere, Finland.

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http://dx.doi.org/10.1016/j.ejca.2013.06.006DOI Listing
October 2013

Plastic larval development in a butterfly has complex environmental and genetic causes and consequences for population dynamics.

J Anim Ecol 2013 May 24;82(3):529-39. Epub 2013 Jan 24.

Metapopulation Research Group, Department of Biosciences, University of Helsinki, PO Box 65 (Viikinkaari 1), Helsinki, FI-00014, Finland.

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http://dx.doi.org/10.1111/1365-2656.12034DOI Listing
May 2013

Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer.

Fam Cancer 2012 Sep;11(3):525-8

Department of Medical Genetics, Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.

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http://link.springer.com/10.1007/s10689-012-9532-8
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http://dx.doi.org/10.1007/s10689-012-9532-8DOI Listing
September 2012

High genetic load in an old isolated butterfly population.

Proc Natl Acad Sci U S A 2012 Sep 20;109(37):E2496-505. Epub 2012 Aug 20.

Metapopulation Research Group, Department of Biosciences, University of Helsinki, FI-00014 Helsinki, Finland.

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http://dx.doi.org/10.1073/pnas.1205789109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443129PMC
September 2012

Rule-based induction method for haplotype comparison and identification of candidate disease loci.

Genome Med 2012 Mar 19;4(3):21. Epub 2012 Mar 19.

Research Programs Unit, Genome-Scale Biology, and Institute of Biomedicine, Biochemistry and Developmental Biology, University of Helsinki, Haartmaninkatu 8, Helsinki, FIN-00014, Finland.

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http://dx.doi.org/10.1186/gm320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446271PMC
March 2012

Computational identification of cancer susceptibility loci.

Methods Mol Biol 2010 ;653:87-103

Computational Systems Biology Laboratory, Institute of Biomedicine and Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1007/978-1-60761-759-4_6DOI Listing
December 2010

BMPR2 mutation in a patient with pulmonary arterial hypertension and suspected hereditary hemorrhagic telangiectasia.

Am J Med Genet A 2008 Oct;146A(19):2551-6

Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1002/ajmg.a.32468DOI Listing
October 2008

Stress-induced expression of a novel variant of human fumarate hydratase (FH).

Gene Expr 2007 ;14(2):59-69

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042040PMC
March 2008

Computational identification of candidate loci for recessively inherited mutation using high-throughput SNP arrays.

Bioinformatics 2007 Aug 17;23(15):1952-61. Epub 2007 May 17.

Computational Systems Biology Laboratory, Institute of Biomedicine, University of Helsinki, Finland.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btm263DOI Listing
August 2007

Background mutation frequency in microsatellite-unstable colorectal cancer.

Cancer Res 2007 Jun;67(12):5691-8

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4314DOI Listing
June 2007

Analysis of fumarate hydratase mutations in a population-based series of early onset uterine leiomyosarcoma patients.

Int J Cancer 2006 Jul;119(2):283-7

Department of Medical Genetics, University of Helsinki, Biomedicum Helsinki, Haartmaninkatu 8, Finland.

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http://doi.wiley.com/10.1002/ijc.21798
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http://dx.doi.org/10.1002/ijc.21798DOI Listing
July 2006

Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma.

Eur J Hum Genet 2006 Jul 26;14(7):880-3. Epub 2006 Apr 26.

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/sj.ejhg.5201630DOI Listing
July 2006

EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis.

BMC Cancer 2006 Jun 1;6:145. Epub 2006 Jun 1.

Department of Medical Genetics, Molecular and Cancer Biology Research Program, P,O, BOX 63, 00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1186/1471-2407-6-145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513590PMC
June 2006

A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis.

Hum Mutat 2005 Oct;26(4):393

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/humu.9368DOI Listing
October 2005

No germline FH mutations in familial breast cancer patients.

Eur J Hum Genet 2005 Apr;13(4):506-9

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, P.O. Box 63 (Haartmaninkatu 8), FIN-00014 Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/sj.ejhg.5201326DOI Listing
April 2005

Little evidence for involvement of MLH3 in colorectal cancer predisposition.

Int J Cancer 2003 Aug;106(2):292-6

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/ijc.11218DOI Listing
August 2003