Rahul S Desikan

Rahul S Desikan

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Rahul S Desikan

Publications by authors named "Rahul S Desikan"

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Precision neuroradiology: mapping the nodes and networks that link genes to behaviour.

Br J Radiol 2019 Jul 11:20190093. Epub 2019 Jul 11.

1 Departments of Radiology and Biomedical Imaging, University California , San Francisco , USA.

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http://dx.doi.org/10.1259/bjr.20190093DOI Listing
July 2019

What Are Polygenic Scores and Why Are They Important?

JAMA 2019 May;321(18):1820-1821

Department of Radiology and Biomedical Imaging, University California, San Francisco.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2019.3893DOI Listing
May 2019

Identification of genetic heterogeneity of Alzheimer's disease across age.

Neurobiol Aging 2019 Mar 12. Epub 2019 Mar 12.

Center for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.02.022DOI Listing
March 2019

Challenges in pediatric neuroimaging.

Neuroimage 2019 01 22;185:793-801. Epub 2018 Apr 22.

Department of Radiology and Diagnostic Imaging, University of California, San Francisco 505 Parnassus Avenue, Room L352, San Francisco, CA 94143-0628, United States; UCSF-Benioff Children's Hospital, 1975 4th St, San Francisco, CA 94158, United States.

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http://dx.doi.org/10.1016/j.neuroimage.2018.04.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197938PMC
January 2019

Abnormal Morphology of Select Cortical and Subcortical Regions in Neurofibromatosis Type 1.

Radiology 2018 11 4;289(2):499-508. Epub 2018 Sep 4.

From the Departments of Radiology and Biomedical Imaging (M.J.B., C.H.T., R.M.N., Y.L., D.X., C.M.G., O.A.G., W.P.D., C.P.H., L.P.S., A.J.B., R.S.D.), Pediatrics (S.M., C.K., A.J.B., R.S.D.), and Neurology (S.M., C.K., R.S.D.), University of California, San Francisco, 505 Parnassus Ave, Room L352, San Francisco, CA 94143-0628; and Department of Cognitive Science (A.M.D., T.L.J.), Multimodal Imaging Laboratory (A.M.D.), and Department of Radiology (A.M.D., T.L.J.), University of California, San Diego School of Medicine, La Jolla, Calif.

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http://dx.doi.org/10.1148/radiol.2018172863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209062PMC
November 2018

Protein network analysis reveals selectively vulnerable regions and biological processes in FTD.

Neurol Genet 2018 Oct 1;4(5):e266. Epub 2018 Oct 1.

Department of Neurology (L.W.B., N.Z.R.S., E.G.G., Z.A.M., B.L.M., W.W.S., J.S.Y.), Memory and Aging Center, University of California, San Francisco; Department of Psychiatry (C.M.K., N.W., A.O.-K.), Washington University, St. Louis, MO; School of Pharmacy (C.M., P.L.), University of Reading, Reading, UK; Laboratory of Neurogenetics (P.M.), Texas Tech University Health Science Center, Lubbock; Department of Molecular Neuroscience (C.M., J.H., P.L., R.F.), UCL Institute of Neurology, London, UK; Department of Radiology and Biomedical Imaging, Neuroradiology Section (C.P.H., R.S.D.), University of California, San Francisco; and Department of Neurology (S.E.B.), University of California, San Francisco.

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http://ng.neurology.org/lookup/doi/10.1212/NXG.0000000000000
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http://dx.doi.org/10.1212/NXG.0000000000000266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167176PMC
October 2018

Interpreting Alzheimer disease polygenic scores.

Ann Neurol 2018 03 13;83(3):443-445. Epub 2018 Mar 13.

Neuroradiology Section, Department of Radiology and Biomedical Imaging and Department of Neurology, University of California, San Francisco San Francisco, CA.

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http://dx.doi.org/10.1002/ana.25164DOI Listing
March 2018

Pediatric neuro MRI: tricks to minimize sedation.

Pediatr Radiol 2018 01 22;48(1):50-55. Epub 2017 Apr 22.

Department of Radiology and Diagnostic Imaging, University of California, San Francisco, 505 Parnassus Ave., Room L352, San Francisco, CA, 94143-0628, USA.

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http://dx.doi.org/10.1007/s00247-017-3785-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651215PMC
January 2018

Hazards of Neurological Nomenclature: Observations From Neurodevelopmental and Neurodegenerative Disorders.

JAMA Neurol 2017 10;74(10):1165-1166

Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco.

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http://dx.doi.org/10.1001/jamaneurol.2017.1747DOI Listing
October 2017

Polygenic hazard scores in preclinical Alzheimer disease.

Ann Neurol 2017 Sep;82(3):484-488

Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1002/ana.25029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758043PMC
September 2017

Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.

JAMA Neurol 2017 07;74(7):780-792

Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany30Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1001/jamaneurol.2017.0469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710535PMC
July 2017

Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors.

Mult Scler 2016 12 26;22(14):1783-1793. Epub 2016 Feb 26.

NORMENT, K.G. Jebsen Psychosis Research Centre, Institute of Clinical Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway/Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway/Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1177/1352458516635873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001937PMC
December 2016

Malformations of cortical development.

Ann Neurol 2016 12 11;80(6):797-810. Epub 2016 Nov 11.

Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1002/ana.24793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177533PMC
December 2016

Association of Alzheimer Disease Susceptibility Variants and Gene Expression in the Human Brain-Reply.

JAMA Neurol 2016 10;73(10):1255

Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco.

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http://dx.doi.org/10.1001/jamaneurol.2016.2799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140007PMC
October 2016

Genetic Markers of Human Evolution Are Enriched in Schizophrenia.

Biol Psychiatry 2016 08 21;80(4):284-292. Epub 2015 Oct 21.

NORMENT, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Department of Psychiatry, University of California, San Diego, La Jolla, California. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2015.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397584PMC
August 2016

The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer's disease.

Acta Neuropathol Commun 2016 06 29;4(1):65. Epub 2016 Jun 29.

Memory and Aging Center, Department of Neurology, University of California, San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, 94158, USA.

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http://dx.doi.org/10.1186/s40478-016-0339-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928261PMC
June 2016

Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms.

PLoS One 2015 8;10(4):e0123057. Epub 2015 Apr 8.

Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, United States of America; Multimodal Imaging Laboratory, University of California San Diego, La Jolla, CA 92093, United States of America; Department of Radiology, University of California San Diego, La Jolla, CA 92093, United States of America; Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123057PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390360PMC
March 2016

Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes With Several Cardiovascular Risk Factors.

Circ Res 2016 Jan 20;118(1):83-94. Epub 2015 Oct 20.

From the Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway (M.L., B.K.A.); Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, University of Oslo, and Research Support Services, Oslo University Hospital, Oslo, Norway (M.L., A.F.); NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway (V.Z., A.W., F.B., Y.W., S.D., O.A.A.); Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (V.Z., A.W., F.B., S.D., O.A.A.); Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, University of Oslo, Oslo, Norway (B.K.A.); Deutsches Herzzentrum München, Technische Universität München, Munich, Germany (L.Z., H.S.); Deutsches Zentrum für Herz-Kreislauf-Forschung, partner site Munich Heart Alliance, Munich, Germany (L.Z., H.S.); Multimodal Imaging Laboratory, University of California at San Diego, La Jolla (Y.W., L.K.M., A.J.S., R.S.D., A.M.D., O.A.A.); Department of Neurosciences, University of California, San Diego, La Jolla, (Y.W., A.M.D.); Department of Radiology, University of California, San Diego, La Jolla (L.K.M., R.S.D., A.M.D.); Department of Psychiatry, University of California, San Diego, La Jolla (W.K.T., A.M.D.); Cognitive Sciences Graduate Program, University of California, San Diego, La Jolla, (A.J.S.); Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway (S.R.); Department of Medical Biochemistry, Lovisenberg Diakonale Hospital, Oslo, Norway (S.R., K.M.G.); Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (S.R., K.M.G.); Family and Preventive Medicine, Division of Epidemiology, University of California, San Diego, La Jolla (E.B.-C.); Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands (S.L., A.D.); Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom (C.P.N.,

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http://dx.doi.org/10.1161/CIRCRESAHA.115.306629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609485PMC
January 2016

Large-scale genomics unveil polygenic architecture of human cortical surface area.

Nat Commun 2015 Jul 20;6:7549. Epub 2015 Jul 20.

1] Multimodal Imaging Laboratory, Department of Radiology, University of California San Diego, La Jolla, California 92037, USA. [2] Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA. [3] Department of Psychiatry, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/ncomms8549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518289PMC
July 2015

Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2.

Alzheimers Dement 2015 Jul;11(7):740-56

Department of Radiology and Biomedical Imaging, Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Psychiatry, University of California at San Francisco, San Francisco, CA, USA; Department of Radiology, University of California at San Francisco, San Francisco, CA, USA; Department of Medicine, University of California at San Francisco, San Francisco, CA, USA; Department of Neurology, University of California at San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.jalz.2015.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523217PMC
July 2015

Genetic variation of oxidative phosphorylation genes in stroke and Alzheimer's disease.

Neurobiol Aging 2014 Aug 5;35(8):1956.e1-8. Epub 2014 Feb 5.

Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.01.141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329419PMC
August 2014

Shared common variants in prostate cancer and blood lipids.

Int J Epidemiol 2014 Aug 30;43(4):1205-14. Epub 2014 Apr 30.

NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway, Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway, Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA, Multimodal Imaging Laboratory, University of California at San Diego, La Jolla, CA, USA, Cognitive Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA, Center for Human Development, University of California at San Diego, La Jolla, CA, USA, the participants acknowledged in Supplementary data, available at IJE online, Department of Medical Genetics, Oslo University Hospital, Oslo, Norway, Department of Radiology, University of California, San Diego, La Jolla, CA, USA, Department of Cancer Prevention, Institute of Cancer Research and Department of Urology, Oslo University Hospital, Oslo, Norway and Department of Neurosciences, University of California, San Diego, La Jolla, CA, USANORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway, Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway, Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA, Multimodal Imaging Laboratory, University of California at San Diego, La Jolla, CA, USA, Cognitive Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA, Center for Human Development, University of California at San Diego, La Jolla, CA, USA, the participants acknowledged in Supplementary data, available at IJE online, Department of Medical Genetics, Oslo University Hospital, Oslo

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http://dx.doi.org/10.1093/ije/dyu090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121563PMC
August 2014

Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes.

Hypertension 2014 Apr 6;63(4):819-26. Epub 2014 Jan 6.

Department of Radiology, University of California, San Diego, 8950 Villa La Jolla Dr, Suite C101, La Jolla, CA 92037-0841. and Ole A. Andreassen, NORMENT, KG Jebsen Centre for Psychosis Research, Oslo University Hospital, Ullevål, PO Box 4956 Nydalen, 0424 Oslo, Norway. Email

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.113.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.02077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984909PMC
April 2014

Neuropsychiatric symptoms and regional neocortical atrophy in mild cognitive impairment and Alzheimer's disease.

Am J Alzheimers Dis Other Demen 2014 Mar 27;29(2):159-65. Epub 2013 Oct 27.

1Department of Neurosciences, University of California, San Diego, CA, USA.

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http://dx.doi.org/10.1177/1533317513507373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351414PMC
March 2014

The role of clusterin in amyloid-β-associated neurodegeneration.

JAMA Neurol 2014 Feb;71(2):180-7

Department of Radiology, University of California, San Diego, La Jolla2Department of Psychiatry, University of California, San Diego, La Jolla.

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http://dx.doi.org/10.1001/jamaneurol.2013.4560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118752PMC
February 2014

Heart fatty acid binding protein and Aβ-associated Alzheimer's neurodegeneration.

Mol Neurodegener 2013 Oct 2;8:39. Epub 2013 Oct 2.

Department of Radiology, University of California, San Diego, 8950 Villa La Jolla Drive, Suite C101, La Jolla, CA 92037-0841, USA.

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http://dx.doi.org/10.1186/1750-1326-8-39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850652PMC
October 2013

Enrichment and stratification for predementia Alzheimer disease clinical trials.

PLoS One 2012 17;7(10):e47739. Epub 2012 Oct 17.

Department of Neurosciences, University of California San Diego, La Jolla, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047739PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474753PMC
April 2013

Rates of decline in Alzheimer disease decrease with age.

PLoS One 2012 2;7(8):e42325. Epub 2012 Aug 2.

Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042325PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410919PMC
January 2013

Amyloid-β--associated clinical decline occurs only in the presence of elevated P-tau.

Arch Neurol 2012 Jun;69(6):709-13

Department of Radiology, University of California–San Diego, 8950 Villa La Jolla Dr, Ste C101, La Jolla, CA 92037-0841, USA.

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http://dx.doi.org/10.1001/archneurol.2011.3354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423526PMC
June 2012

Amyloid-β associated volume loss occurs only in the presence of phospho-tau.

Ann Neurol 2011 Oct 14;70(4):657-61. Epub 2011 Oct 14.

Department of Radiology, University of California-San Diego, La Jolla 92037, CA.

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http://dx.doi.org/10.1002/ana.22509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368003PMC
October 2011

Selective disruption of the cerebral neocortex in Alzheimer's disease.

PLoS One 2010 Sep 23;5(9):e12853. Epub 2010 Sep 23.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012853PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944799PMC
September 2010

Automated MRI measures predict progression to Alzheimer's disease.

Neurobiol Aging 2010 Aug 8;31(8):1364-74. Epub 2010 Jun 8.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902697PMC
August 2010

Genetic variation and neuroimaging measures in Alzheimer disease.

Arch Neurol 2010 Jun;67(6):677-85

Center for Human Genetic Research, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1001/archneurol.2010.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956757PMC
June 2010

Automated MRI measures identify individuals with mild cognitive impairment and Alzheimer's disease.

Brain 2009 Aug 21;132(Pt 8):2048-57. Epub 2009 May 21.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1093/brain/awp123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714061PMC
August 2009

Thinning of the cerebral cortex in aging.

Cereb Cortex 2004 Jul 28;14(7):721-30. Epub 2004 Mar 28.

MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.

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http://dx.doi.org/10.1093/cercor/bhh032DOI Listing
July 2004