Publications by authors named "Rahul Hegde"

41 Publications

Chylous ascites in cirrhosis from retroperitoneal lymphoma.

Proc (Bayl Univ Med Cent) 2020 Oct 1;34(1):138-140. Epub 2020 Oct 1.

Department of Radiology, Yale New Haven Health Bridgeport Hospital, Bridgeport, Connecticut.

Chylous ascites occurs due to processes that elevate pressures within or obstruct the lymphatics in the retroperitoneum. In cirrhosis, spontaneous chylous ascites can occur but is uncommon. We describe a case of a 74-year-old man with cirrhosis from nonalcoholic steatohepatitis who presented with worsening abdominal distension and chylous ascites on paracentesis; an infiltrating retroperitoneal lymphoma was subsequently detected on computed tomography imaging.
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http://dx.doi.org/10.1080/08998280.2020.1814597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785197PMC
October 2020

Relationship between chronological age, dental age, and body height using Demirjian method among children aged 4-14 years in Pune - A radiographic study.

J Indian Soc Pedod Prev Dent 2020 Oct-Dec;38(4):338-342

Department of Oral Medicine and Radiology, D Y Patil Dental School, Pune, Maharashtra, India.

Context: The assessment of dental age is useful in the planning of orthodontic treatment, in pediatric dentistry, pediatric endocrinology, and forensic medicine. It is essential for a pediatric dentist to formulate treatment plan and it is a source of complementary information for pediatrician. Changes in the body proportion and composition are the essential elements of growth, especially maturation.

Aims: The present study was aimed to correlate the chronological age, dental age, and body height in children from Pune region of Maharashtra, India.

Subjects And Methods: : Four hundred and thirty-one panoramic radiographs of 177 boys and 254 girls in the age group of 4-14 years were obtained. Chronological age was assessed by recording date of birth. Dental age assessment was done using orthopantamogram following the method described by Demirjian. Body height was recorded using a measuring tape.

Results: Chronological age and dental age showed significant positive correlation between male and female sample, i.e., r = 0.905 for males and r = 0.901 for females. Statistically significant correlation was observed between calculated dental age and body height.

Conclusions: In the present study, it can be concluded that the Demirjian method of dental age assessment showed high accuracy when applied to pediatric population in Pune.
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http://dx.doi.org/10.4103/JISPPD.JISPPD_410_20DOI Listing
January 2021

Clinical and imaging features of idiopathic granulomatous mastitis - The diagnostic challenges and a brief review.

Clin Imaging 2021 Jan 15;69:126-132. Epub 2020 Jun 15.

Department of Radiology, Columbia University at Bassett Healthcare, Cooperstown, NY, USA.

Idiopathic granulomatous mastitis (IGM), or granulomatous lobular mastitis is a rare, benign, inflammatory condition of the breast, without an identifiable underlying etiology. The clinical and imaging diagnosis of this entity is challenging with the presentation frequently mimicking inflammatory breast carcinoma (IBC). Mammography and breast ultrasound (US) have an important role in its detection, however, biopsy is imperative for histopathological confirmation. We present three cases of biopsy proven IGM, highlighting the variability of the clinical and imaging features,brieflyreview the relevant literature and discuss the challenges associated with its diagnosis and management.
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http://dx.doi.org/10.1016/j.clinimag.2020.06.022DOI Listing
January 2021

Oral submucous fibrosis in children and adolescents: Analysis of 36 cases.

J Indian Soc Pedod Prev Dent 2020 Apr-Jun;38(2):190-199

Department of Pedodontics and Preventive Dentistry, Maulana Azad Institute of Dental Sciences, New Delhi, India.

Oral submucous fibrosis (OSMF) is a chronic debilitating irreversible oral potentially malignant disorder affecting any part of the oral cavity. It is usually seen in adults but rarely noticed in children and adolescents. Since the paucity of the cases, there exists a gap of knowledge in the causative habits, root reasons of habit initiation, age of habit initiation, and the common clinical representation of this disorder. The current article aims to bridge this gap by presenting unusual 36 cases of children and adolescents reported at the tertiary care hospital of Vadodara, Gujarat, India, with specific areca nut chewing habit and distinct features of OSMF. Furthermore, the present case series is the first of its kind in the scientific literature with a high number of OSMF cases in children and adolescents.
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http://dx.doi.org/10.4103/JISPPD.JISPPD_173_20DOI Listing
July 2020

Imaging right lower quadrant pain: Not always appendicitis.

Clin Imaging 2020 Jul 25;63:65-82. Epub 2020 Feb 25.

Department of Radiology, Yale New Haven Health - Bridgeport Hospital, Bridgeport, CT, United States of America.

Although acute appendicitis (AA) is one of the commonest causes of right lower quadrant abdominal pain (RLQP), there are numerous other conditions in the abdomen and pelvis that can simulate the clinical presentation of AA for which imaging is essential in detection. We discuss the approach to evaluation of patients presenting with acute onset RLQP and the choice of various imaging modalities that can be utilized. Although CT remains the workhorse in evaluation, US and MRI, given lack of radiation, play an important ancillary role, particularly in the pediatric and pregnant patients. We present a spectrum of conditions presenting with RLQP which we have classified systematically ranging from conditions affecting the bowel, mesentery/omentum/peritoneum, vasculature, urinary and reproductive systems to give the reader a checklist of conditions to consider when evaluating a case of RLQP.
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http://dx.doi.org/10.1016/j.clinimag.2020.02.012DOI Listing
July 2020

Traumatic vertebral artery injury: a review of the screening criteria, imaging spectrum, mimics, and pitfalls.

Pol J Radiol 2019 20;84:e307-e318. Epub 2019 Aug 20.

Bassett Medical Center, New York, USA.

Purpose: Traumatic vertebral artery injury (TVAI) can have a varied clinical presentation and appearance on imaging. In this review, we present the screening criteria, spectrum of imaging features, grading, and imaging pitfalls of TVAI. Our review focuses on the imaging of TVAI on computed tomography angiography (CTA), magnetic resonance angiography (MRA), and cases of TVAI mimics.

Imaging: The imaging spectrum on CTA can range from either focal or long segment luminal stenosis (the most common findings), smooth or tapered narrowing of lumen, string of pearls appearance, concentric intramural haematoma, intimal flap (the most definite sign), and double lumen of the artery. On time-of-flight MRA, the most common findings include loss of flow void within the vessel due to slow flow, thrombosis or occlusion, and hyperintense signal within the vessel wall due to intramural haematoma on T1 fat-saturated images.

Conclusion: The reader should be aware of the screening criteria, common and uncommon findings, variant anatomy, artifacts, and mimics of TVAI when evaluating cases of craniocervical trauma, to be competent in calling in or ruling out injury.
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http://dx.doi.org/10.5114/pjr.2019.88023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798777PMC
August 2019

Rhombencephalitis in cocaine-induced nasal septal perforation and skull base erosion.

Proc (Bayl Univ Med Cent) 2019 Jan 24;32(1):82-84. Epub 2019 Jan 24.

Department of Radiology, Yale New Haven Health Bridgeport HospitalBridgeportConnecticut.

Rhombencephalitis is a rare and potentially fatal condition involving the brainstem, with infectious, autoimmune, and paraneoplastic etiologies. We present a patient presenting with left-extremity weakness and dysphonia who had brainstem imaging findings suggestive of rhombencephalitis. We suspect that the case was due to inoculation of the brainstem from nasopharyngeal adenoviral infection. Due to heavy cocaine use, extensive basiocciput erosion led to direct contact between the brainstem and the nasopharyngeal mucosa. The patient's milder clinical course might have been due to some degree of pre-existing immunity against adenovirus. Additionally, clinicians need to be aware of the proximity of the brainstem to the nasopharynx when there is basiocciput erosion, due to the potential risk of injury during instrumentation.
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http://dx.doi.org/10.1080/08998280.2018.1536586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442913PMC
January 2019

A correlative analysis of dental age, chronological age, and body mass index and its impact on dental development in 6-13 year old children of Navi Mumbai, India.

J Indian Soc Pedod Prev Dent 2018 Oct-Dec;36(4):376-380

Department of Pedodontics and Preventive Dentistry, Bharati Vidyapeeth Dental College and Hospital, Navi Mumbai, Maharashtra, India.

Purpose: Nutrition has a great impact on children's health. Of great concern are the underweight children because of the risk of illness and mortality in them. Being overweight can also have long-lasting adverse effect on development of the child. The purpose of this study was to determine body mass index (BMI) and dental development in normal and underweight children and to carry out a correlative analysis of calculated dental age, chronological age, and BMI in normal and underweight children of age group of 6-13 years of Navi Mumbai, India.

Materials And Methods: The sample for the study consisted of 301 participants, that is, 171 boys and 130 girls who were divided into two groups, namely, normal and underweight.

Results: When BMI was less than normal, calculated dental age was less and thus the dental development was retarded and vice versa.

Conclusion: The following conclusions were drawn from the study: (1) a significant positive correlation was found between chronological age and dental age and (2) along with the chronological age and dental age, the calculated dental age difference must also be taken into consideration.
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http://dx.doi.org/10.4103/JISPPD.JISPPD_189_18DOI Listing
May 2019

Aortic Intramural Hemorrhage Secondary to Penetrating Atherosclerotic Ulcers.

Am J Med Sci 2018 Feb 18;355(2):e5-e6. Epub 2017 Oct 18.

Department of Radiology, Bridgeport Hospital-Yal`e New Haven Health System, Bridgeport, Connecticut.

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http://dx.doi.org/10.1016/j.amjms.2017.10.004DOI Listing
February 2018

Bilateral External Auditory Exostoses Causing Conductive Hearing Loss: A Case Report and Literature Review of the Surfer's Ear.

Cureus 2017 Oct 30;9(10):e1810. Epub 2017 Oct 30.

Department of Internal Medicine, St. Vincent Medical Center, Bridgeport, Ct.

In patients with repeated exposure to cold water, such as cold water surfers and kayakers, the reactive exostoses can occur in the external auditory canal. The external auditory canal exostoses are multiple, benign bony growths. They can cause external auditory canal stenosis, leading to repeated otitis externa and potentially conductive hearing loss. It is vital to consider this entity in susceptible patients who report hearing loss, as timely intervention such as proper ear protection equipment can lower the risk of developing severe external auditory canal exostoses. We present a case of a 42-year-old male, cold water surfer with conductive hearing loss and bilateral external auditory canal (EAC) stenosis demonstrated on the computed tomography.
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http://dx.doi.org/10.7759/cureus.1810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749938PMC
October 2017

Comparative evaluation of the effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and xylitol-containing chewing gum on salivary flow rate, pH and buffering capacity in children: An study.

J Indian Soc Pedod Prev Dent 2017 Oct-Dec;35(4):332-337

Department of Pedodontics and Preventive Dentistry, Bharati Vidyapeeth Deemed University Dental College and Hospital, Navi Mumbai, Maharashtra, India.

Aim: This study aimed to compare and evaluate the changes in the salivary flow rate, pH, and buffering capacity before and after chewing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and xylitol-containing chewing gums in children.

Materials And Methods: Sixty children aged between 8 and 12 years were selected for the study. They were randomly divided into Group 1 (CPP-ACP chewing gum) and Group 2 (xylitol-containing chewing gum) comprising thirty children each. Unstimulated and stimulated saliva samples at 15 and 30 min interval were collected from all children. All the saliva samples were estimated for salivary flow rate, pH, and buffering capacity.

Results: Significant increase in salivary flow rate, pH, and buffering capacity from baseline to immediately after spitting the chewing gum was found in both the study groups. No significant difference was found between the two study groups with respect to salivary flow rate and pH. Intergroup comparison indicated a significant increase in salivary buffer capacity in Group 1 when compared to Group 2.

Conclusion: Chewing gums containing CPP-ACP and xylitol can significantly increase the physiochemical properties of saliva. These physiochemical properties of saliva have a definite relation with caries activity in children.
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http://dx.doi.org/10.4103/JISPPD.JISPPD_147_17DOI Listing
June 2018

Prevalence of Traumatic Dental Injuries to the Permanent Anterior Teeth among 9- to 14-year-old Schoolchildren of Navi Mumbai (Kharghar-Belapur Region), India.

Int J Clin Pediatr Dent 2017 Apr-Jun;10(2):177-182. Epub 2017 Jun 1.

Assistant Professor, Department of Pedodontics and Preventive Dentistry, Bharati Vidyapeeth Deemed University Dental College & Hospital, Navi Mumbai, Maharashtra, India.

Aims And Objectives: To measure the prevalence of anterior teeth trauma in 9- to 14-year-old schoolchildren and their association with predisposing factors, such as lip competence, molar relationship, overjet, and variables, such as age, gender, and cause of trauma.

Materials And Methods: Epidemiological cross-sectional study was carried out among 3,012 schoolchildren aged 9 to 14 years in Navi Mumbai (Kharghar-Belapur region). The sample size was derived using the stratified random sampling method; we picked six schools from the region. These schools had 3,000 students in the acceptable age group of the study which constituted our final sample size. All children were examined for traumatic dental injuries, and the children with positive findings were further examined for lip competence, Angle's molar relationship, and overjet. The results were statistically analyzed using cross-tabulation and Chi-square test.

Results: The prevalence of dental injuries was 7.3%, and the ratio of male to female children was found to be 1.6:1. The maximum number of traumatic dental injuries was found with class I molar relationship and overjet less than 3.5 mm in children with competent lips. Maximum number of injuries occurred in the age group of 13-14 years. The most predominant type of injury was the enamel fracture and the most common cause determined was due to fall.

Conclusion: The present study is a collection of data on traumatic injuries to anterior teeth, which is seen very commonly in day-to-day practice. The frequency and cause of traumatic injuries to anterior teeth is important for identification of risk groups, treatment needs, and cost involved in order for establishing effective preventive measures.

How To Cite This Article: Hegde R, Agrawal G. Prevalence of Traumatic Dental Injuries to the Permanent Anterior Teeth among 9- to 14-year-old Schoolchildren of Navi Mumbai (Kharghar-Belapur Region), India. Int J Clin Pediatr Dent 2017;10(2):177-182.
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http://dx.doi.org/10.5005/jp-journals-10005-1430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571388PMC
June 2017

Comparison of the and colony count changes in saliva following chlorhexidine (0.12%) mouth rinse, combination mouth rinse, and green tea extract (0.5%) mouth rinse in children.

J Indian Soc Pedod Prev Dent 2017 Apr-Jun;35(2):150-155

Department of Pedodontics and Preventive Dentistry, Bharati Vidyapeeth University Dental College and Hospital, Navi Mumbai, Maharashtra, India.

Background: Compounds present in green tea have been shown to inhibit the growth and activity of bacteria associated with oral infections. The purpose of this study was to compare the efficacy of chlorhexidine (0.12%) mouth rinse and combination (chlorhexidine and sodium fluoride) mouth rinse to that of green tea extract (0.5%) mouth rinse in reducing the salivary count of Streptococcus mutans and Lactobacillus in children.

Materials And Methods: The sample for the study consisted of 75 school children aged 8-12 years with four or more (decay component) of decayed, missing, and filled teeth index. Children were divided randomly into three equal groups and were asked to rinse with the prescribed mouth rinse once daily for 2 weeks after breakfast under supervision. Nonstimulated whole salivary sample (2 ml) was collected at baseline and postrinsing and tested for the colony forming units of S. mutans and Lactobacillus.

Results: The results of the study indicate that there was a statistically significant reduction in S. mutans and lactobacilli count in all the three study groups. The statistically significant reduction in the mean S. mutans and lactobacilli counts were more in 0.12% chlorhexidine group than in the combination mouth rinse and 0.5% green tea mouth rinse group. There was no statistically significant difference in the reduction of S. mutans and lactobacilli count between combination mouth rinse group and 0.5% green tea mouth rinse group.

Conclusion: Green tea mouth rinse can be a promising preventive therapy worldwide for the prevention of dental caries.
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http://dx.doi.org/10.4103/JISPPD.JISPPD_13_17DOI Listing
March 2018

Evaluation of the influence of parental anxiety on children's behavior and understanding children's dental anxiety after sequential dental visits.

Indian J Dent Res 2017 Jan-Feb;28(1):22-26

Department of Pedodontics and Preventive Dentistry, Bharati Vidyapeeth Deemed University Dental College and Hospital, Sector 7, Navi Mumbai, Maharashtra, India.

Background: Identifying anxiety levels of parents accompanying their children can help the clinician in designing the behavior management strategies for the child. In addition, continued dental experience can improve the child's response, indicating desensitization to dental stress.

Aims: To evaluate the influence of parental anxiety on children's behavior and understanding children's dental anxiety after sequential dental visits.

Materials And Methods: A total of 175 children of age 6-12 years, 98 were boys and 77 were girls, were randomly selected from various schools of Navi Mumbai. Parental dental anxiety was assessed using the Corah's dental anxiety scale (DAS), and child anxiety level was measured using children fear survey schedule-dental subscale (CFSS-DS).

Statistical Analysis Used: Pearson's correlation coefficient analysis, ANOVA, and Friedman test.

Results: There is a significant positive correlation (P < 0.0001) between DAS scores and CFSS-DS scores at all three dental visits. The mean ± standard deviation, CFSS-DS scores at the first, second, and third dental visits are (34.07 ± 11.97), (31.04 ± 10.94), and (27.26 ± 9.39), respectively, showing the score is more during the first dental visit than the second and third visits.

Conclusion: The dental anxiety levels in parents may influence the anxiety levels of children and also all children exhibited an improvement in the levels of dental anxiety from the first dental visit to the subsequent dental visits.
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http://dx.doi.org/10.4103/ijdr.IJDR_181_16DOI Listing
May 2018

An insight into the role of dentists against the new epidemic of "Drug Abuse".

Authors:
Rahul Hegde

Indian J Dent 2016 Sep;7(3):115

Dean, Faculty of Dentistry, Bharati Vidyapeeth University, Pune, Maharashtra, India.

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http://dx.doi.org/10.4103/0975-962X.189341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015559PMC
September 2016

Imaging of Spinal Cord Injury: Acute Cervical Spinal Cord Injury, Cervical Spondylotic Myelopathy, and Cord Herniation.

Semin Ultrasound CT MR 2016 Oct 6;37(5):431-47. Epub 2016 May 6.

Section of Neuroradiology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.

We review the pathophysiology and imaging findings of acute traumatic spinal cord injury (SCI), cervical spondylotic myelopathy, and briefly review the much less common cord herniation as a unique cause of myelopathy. Acute traumatic SCI is devastating to the patient and the costs to society are staggering. There are currently no "cures" for SCI and the only accepted pharmacologic treatment regimen for traumatic SCI is currently being questioned. Evaluation and prognostication of SCI is a demanding area with significant deficiencies, including lack of biomarkers. Accurate classification of SCI is heavily dependent on a good clinical examination, the results of which can vary substantially based upon the patient׳s condition or comorbidities and the skills of the examiner. Moreover, the full extent of a patients׳ neurologic injury may not become apparent for days after injury; by then, therapeutic response may be limited. Although magnetic resonance imaging (MRI) is the best imaging modality for the evaluation of spinal cord parenchyma, conventional MR techniques do not appear to differentiate edema from axonal injury. Recently, it is proposed that in addition to characterizing the anatomic extent of injury, metrics derived from conventional MRI and diffusion tensor imaging, in conjunction with the neurological examination, can serve as a reliable objective biomarker for determination of the extent of neurologic injury and early identification of patients who would benefit from treatment. Cervical spondylosis is a common disorder affecting predominantly the elderly with a potential to narrow the spinal canal and thereby impinge or compress upon the neural elements leading to cervical spondylotic myelopathy and radiculopathy. It is the commonest nontraumatic cause of spinal cord disorder in adults. Imaging plays an important role in grading the severity of spondylosis and detecting cord abnormalities suggesting myelopathy.
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http://dx.doi.org/10.1053/j.sult.2016.05.007DOI Listing
October 2016

Comparison of removal of endodontic smear layer using ethylene glycol bis (beta-amino ethyl ether)-N, N, N', N'-tetraacetic acid and citric acid in primary teeth: A scanning electron microscopic study.

Contemp Clin Dent 2016 Apr-Jun;7(2):216-20

Department of Pedodontics and Preventive Dentistry, Bharati Vidyapeeth Deemed University Dental College and Hospital, Navi Mumbai, Mumbai, Maharashtra, India.

Background: Root canal irrigants are considered momentous in their tissue dissolving property, eliminating microorganisms, and removing smear layer. The present study was aimed to compare the removal of endodontic smear layer using ethylene glycol bis (beta-amino ethyl ether)-N, N, N', N'-tetraacetic acid (EGTA) and citric acid solutions with saline as a control in primary anterior teeth.

Materials And Methods: Thirty primary anterior teeth were chosen for the study. The teeth were distributed into three groups having ten teeth each. Following instrumentation, root canals of the first group were treated with 17% EGTA and the second group with 6% citric acid. Only saline was used as an irrigant for the control group. Then, the teeth were subjected to scanning electron microscopy (SEM) study. The scale given by Rome et al. for the smear layer removal was used in the present study.

Results: The pictures from the SEM showed that among the tested irrigants, 17% EGTA + 5% sodium hypochlorite (NaOCl) group showed the best results when compared to other groups.

Conclusion: The results advocate that the sequential irrigation of the pulp canal walls with 17% EGTA followed by 5% NaOCl produced efficacious and smear-free root canal walls.
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http://dx.doi.org/10.4103/0976-237X.183064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906866PMC
June 2016

Comparison of different methods of cleaning and preparing occlusal fissure surface before placement of pit and fissure sealants: An in vivo study.

J Indian Soc Pedod Prev Dent 2016 Apr-Jun;34(2):111-4

Department of Pedodontics and Preventive Dentistry, Bharati Vidyapeeth Deemed University Dental College and Hospital, Navi Mumbai, Maharashtra, India.

Aim: To evaluate an individual method of cleaning and preparing occlusal fissure surface before placement of pit and fissure sealant and to determine a method for better retention of the sealant.

Materials And Methods: The present study consisted of 100 young permanent molar teeth divided into four equal groups: Group 1-Brushing only, Group 2-Application of pumice slurry, Group 3-Surface conditioning, and Group 4-Control (without any preparation). Subsequent to fissure preparation, the fissures were etched using 37% phosphoric acid except for Group 3, which was etched using 10% maleic acid for 30 s. The samples were then rinsed for 10 s using air water spray of the three-way syringe and dried using oil-free compressed air with a hand pump air pressure syringe. After ensuring a frosted appearance of the enamel at the fissure entrance, pit and fissure sealants were applied on the surface according to manufacturer's instructions. All the cases were clinically evaluated for retention after 3 months, 6 months, and 12 months of application and the retention rate was assessed based on the criteria proposed by Simonsen.

Results: The pumice slurry group and surface conditioning group showed results with 100%, 96%, and 92% complete retention seen at 3 months, 6 months, and 12 months, respectively.

Conclusion: The pumice slurry group and surface conditioning group showed a significantly higher retention when compared to the brushing group, whereas the control group (without any preparation) showed the least retention when compared to all the other groups.
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http://dx.doi.org/10.4103/0970-4388.180403DOI Listing
July 2017

Helicobacter pylori: past, current and future treatment strategies with gastroretentive drug delivery systems.

J Drug Target 2016 12 19;24(10):897-915. Epub 2016 Apr 19.

c Department of Pharmaceutics , Institute of Technology, Banaras Hindu University , Varanasi , Uttar Pradesh , India.

Helicobacter pylori have been subject to intense investigation since its discovery from gastric biopsy in 1982. This gastropathogen has been regarded as serious public health problem due to its association with dyspepsia, gastritis, gastroduodenal ulcers, mucus-associated lymphoid tissue lymphoma and gastric carcinoma. In vivo eradication of established H. pylori infections is difficult due to several factors such as gastric niche, coccoid form due to sub-minimum inhibitory concentration of antimicrobials, bacterial load, primary antibiotic resistance, patient compliance and stability of therapeutics in gastric acid secretion. Considering these factors, a logical way to improve the outcome of the treatment is to develop dosage forms which are able to deliver the anti-helicobacter agents in the gastric niche for both local and systemic actions, simultaneously taking care of stability of therapeutics in acidic environment. Such dosage forms, which are popularly known as gastro retentive drug delivery systems (GRDDS), have the immense potential to effectively counter the problem of high bacterial load; prevent induction of coccoid bacteria thereby improving treatment outcome and compliance. This review describes efficacy of various therapeutic agents, treatment strategies and status of different GRDDS until now.
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http://dx.doi.org/10.3109/1061186X.2016.1171326DOI Listing
December 2016

Presurgical nasoalveolar molding in unilateral cleft lip and palate.

Contemp Clin Dent 2015 Oct-Dec;6(4):567-9

Department of Pedodontics and Preventive Dentistry, Bharati Vidyapeeth Dental College and Hospital, Navi Mumbai, Maharashtra, India.

Unilateral cleft lip and palate (UCLP) patients have an esthetic and functional compromise of the middle third of the face and nasal structures. To improve the esthetic result of lip repair, the concept of presurgical nasoalveolar molding (PNAM) was brought into conception. PNAM is an easy and passive method of bringing the alveolus and lips together by redirecting the forces of natural growth. This case report documents a 2-year follow-up of PNAM in UCLP.
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http://dx.doi.org/10.4103/0976-237X.169865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678561PMC
December 2015

Leuckart Synthesis and Pharmacological Assessment of Novel Acetamide Derivatives.

Anticancer Agents Med Chem 2016 ;16(7):898-906

Department of Chemistry, School of Sciences, IFTM University Moradabad, Uttar Pradesh, India.

A new concatenation of N-(1-(4-bromophenyl)ethyl)-2-phenoxyacetamide and N-(1-(4-methoxyphenyl) ethyl)-2-phenoxyacetamide derivatives having 2-phenoxy-N-(1-phenylethyl)acetamide nucleus as common in both the types was synthesized for the sake of achieve titled compounds as potential cytotoxic, anti-inflammatory, analgesic and antipyretic agents. All the novel derivatives have been synthesized through multi-step reaction sequence starting from Leuckart reaction. The structural assignments of the new compounds have been determined by virtue of their IR, 1H NMR, 13C NMR, elemental analysis and mass spectrum analysis. All the synthesized compounds were assessed for cytotoxicity and anti-inflammatory, analgesic and antipyretic effects. Among the series, compounds 3a, 3c, 3g and 3h possess cytotoxic, anti-inflammatory, analgesic and antipyretic activities comparable with standard drugs. The synthesized compounds were found to be active because of the presence of bromo, tert- butyl and nitro groups at position 4 of phenoxy nucleus.
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http://dx.doi.org/10.2174/1871520616666151111115327DOI Listing
June 2017

Evaluation of isoamyl 2-cyanoacrylate tissue adhesive in management of pediatric lacerations: An alternative to suturing.

Ann Maxillofac Surg 2015 Jan-Jun;5(1):49-54

Department of Paediatric and Preventive Dentistry, Bharati Vidyapeeth Dental College and Hospital, Navi Mumbai, Maharashtra, India.

Aims: A study was conducted to evaluate the benefits of cyanoacrylate tissue adhesive as an alternative to suturing in management of pediatric lacerations.

Materials And Methods: A total of 7 patients were evaluated and followed for 3-month. The wound was evaluated on 1(st), 3(rd), and 7(th) postoperative day for swelling, infection, gaping and pain and at 1(st) and 3(rd) postoperative month for scar evaluation. The evaluation was based on different superficial facial wound repairs (i.e., low tension) with an average length <3 cm; and if the surgeon subjectively felt that subcuticular sutures were justified to reduce wound tension, then these were used. Isoamyl 2-cyanoacrylate glue was applied over lacerated wound margins after cleaning the wound and holding together for 15 s by means of tissue holding forceps.

Statistical Analysis: Statistical analysis was done using Chi-square test after collection of data. Mean and standard error were estimated from the sample.

Results: The mean total time taken for skin closure was 1-2.5 min. There was no wound infection in any of the cases; only one case showed wound dehiscence on 3rd postoperative day. The cosmetic was better as there were no suture marks.

Conclusion: Isoamyl 2-cyanoacrylate can be considered as excellent "no needle" alternative for closure of selected pediatric lacerations, those that are short, clean and under low tension.
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http://dx.doi.org/10.4103/2231-0746.161059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555949PMC
September 2015

Evaluation of the accuracy of Demirjian method for estimation of dental age among 6-12 years of children in Navi Mumbai: A radiographic study.

J Indian Soc Pedod Prev Dent 2015 Oct-Dec;33(4):319-23

Department of Pedodontics and Preventive Dentistry, Bharati Vidyapeeth Dental College and Hospital, Navi Mumbai, Maharashtra, India.

Background: Dental formation is superior to eruption as a method of dental age (DA) assessment. Eruption is only a brief occurrence, whereas formation may be related at different chronologic age levels, thereby providing a precise index for determining DA. The study was designed to determine the nature of inter-relationship between chronologic and DA.

Materials And Methods: Age estimation depending upon tooth formation was done by Demirjian method and accuracy of Demirjian method was also evaluated. The sample for the study consisted of 197 children of Navi Mumbai.

Results: Significant positive correlation was found between chronologic age and DA that is, (r = 0.995), (P < 0.0001) for boys and (r = 0.995), (P < 0.0001) for girls. When age estimation was done by Demirjian method, mean the difference between true age (chronologic age) and assessed (DA) was 2 days for boys and 37 days for girls. Demirjian method showed high accuracy when applied to Navi Mumbai (Maharashtra - India) population.

Conclusion: Demirjian method showed high accuracy when applied to Navi Mumbai (Maharashtra - India) population.
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http://dx.doi.org/10.4103/0970-4388.165693DOI Listing
April 2017

Acetamides: chemotherapeutic agents for inflammation-associated cancers.

J Chemother 2016 Aug;28(4):255-65

d Department of Chemistry , School of Pharmaceutical Sciences, IFTM University Moradabad , Uttar Pradesh , India.

Now clear evidences are available to support the hypothesis that inflammation accelerates the conditions including events and molecules that reach to various types of cancers. Inflammation is a normal response to infection containing the innate and adaptive immune systems. However, when allowed to continue, unresolved, perturbation of cellular microenvironment takes place; therefore, it leads to adaptations in genes that are linked to cancer. In addition, a lot of data are accessible confirming the concept that tumour microenvironment is orchestrated by various inflammatory cells and goes to neoplastic process and finally invasion, migration and metastasis. However, infiltrations of leucocytes lead to angiogenesis, propagation and invasion. An inflammatory microenvironment that perhaps fostering impact of angiogenesis include cytokines, chemokines, enzymes and growth factors that play key role for expansion and invasion of cancer cells. This insight highlights the pathogenesis of inflammation-associated cancers and also touches and fosters the role of acetamides for the treatment and chemoprevention of carcinomas that are allied with inflammation.
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http://dx.doi.org/10.1179/1973947815Y.0000000060DOI Listing
August 2016

Temporomandibular joint ankylosis in child: a case report.

J Indian Soc Pedod Prev Dent 2015 Apr-Jun;33(2):166-9

Department of Pediatric and Preventive Dentistry, Bharati Vidyapeeth Dental College and Hospital, Navi Mumbai, Maharashtra, India.

Background: Ankylosis of the temporomandibular joint (TMJ) is an intracapsular union of the disc-condyle complex to the temporal articular surface that restricts mandibular movements, including the fibrous adhesions or bony fusion between condyle, disc, glenoid fossa, and eminence. It is a serious and disabling condition that may cause problems in mastication, digestion, speech, appearance, and hygiene.

Case Report: This report describes a case of a 12-year-old girl with inability to open her mouth, diagnosed with unilateral right bony TMJ ankylosis. The surgical approach consisted of gap arthroplasty with interpositional temporalis muscle flap followed by vigorous physiotherapy.

Conclusion: The treatment of TMJ ankylosis poses a significant challenge because of technical difficulties and a high incidence of recurrence. Its treatment includes the orthodontist, oral and maxillofacial surgeon, pediatric dentist, and psychologist and physical therapist as part of the healthcare team.
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http://dx.doi.org/10.4103/0970-4388.155136DOI Listing
January 2017

Intratesticular and scrotal wall air: Emphysematous epididymo-orchitis or Fournier's gangrene: A dilemma.

Indian J Radiol Imaging 2015 Jan-Mar;25(1):74

Department of Medicine, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.

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http://dx.doi.org/10.4103/0971-3026.150174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329694PMC
February 2015

A Rare Case of Pulmonary Atresia with Ventricular Septal Defect with a Right Sided Aortic Arch and a Calcified Pulmonary AVM Presenting in an Adult without Cyanosis.

Case Rep Radiol 2014 15;2014:614647. Epub 2014 Dec 15.

Department of Radiology, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Sion, Mumbai 400022, India.

Pulmonary atresia with ventricular septal defect (PA-VSD) with pulmonary arterial supply arising from the aorta representing large MAPCAs associated with a right sided aortic arch is an uncommon anomaly. Most of the patients succumb to severe respiratory compromise or congestive cardiac failure very early. We report the clinical details and imaging findings of a case of PA-VSD with a right sided aortic arch and a calcified pulmonary arteriovenous malformation (AVM) in a 21-year-old postpartum female with no previous episodes of cyanosis who was diagnosed as having a cardiac anomaly on echocardiography when she presented with breathlessness during the 8th month of the pregnancy.
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http://dx.doi.org/10.1155/2014/614647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279784PMC
January 2015

Anticancer, anti-inflammatory, and analgesic activities of synthesized 2-(substituted phenoxy) acetamide derivatives.

Biomed Res Int 2014 14;2014:386473. Epub 2014 Aug 14.

Department of Chemistry, School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh, India.

The aphorism was to develop new chemical entities as potential anticancer, anti-inflammatory, and analgesic agents. The Leuckart synthetic pathway was utilized in development of novel series of 2-(substituted phenoxy)-N-(1-phenylethyl)acetamide derivatives. The compounds containing 1-phenylethylamine as basic moiety attached to substituted phenols were assessed for their anticancer activity against MCF-7 (breast cancer), SK-N-SH (neuroblastoma), anti-inflammatory activity, and analgesic activity. These investigations revealed that synthesized products 3a-j with halogens on the aromatic ring favors as the anticancer and anti-inflammatory activity. Among all, compound 3c N-(1-(4-chlorophenyl)ethyl)-2-(4-nitrophenoxy)acetamide exhibited anticancer, anti-inflammatory, and analgesic activities. In conclusion, 3c may have potential to be developed into a therapeutic agent.
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http://dx.doi.org/10.1155/2014/386473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150437PMC
June 2015

Transient angioedema of small bowel secondary to intravenous iodinated contrast medium.

Indian J Radiol Imaging 2014 Jul;24(3):303-5

Department of Radiology, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, Maharashtra, India.

We report the clinical details and imaging findings of a case of transient angioedema of the small bowel following intravenous administration of non-ionic iodinated contrast material in a 17 year old female with no predisposing risk factors. Findings included long segment, symmetric, circumferential, low-density, bowel wall thickening involving the duodenum, jejunum, and most of the ileum on computed tomography scan obtained at 7 min following intravenous contrast material injection. This entity is self-limiting with a favourable clinical outcome and requires no specific treatment but only aggressive clinical monitoring.
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http://dx.doi.org/10.4103/0971-3026.137065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126148PMC
July 2014

Conservative management of unicystic ameloblastoma in a young child: a case report.

J Indian Soc Pedod Prev Dent 2014 Jul-Sep;32(3):251-4

Department of Paediatric and Preventive Dentistry, Bharati Vidyapeeth Dental College and Hospital, Navi Mumbai, Maharashtra, India.

Unicystic ameloblastoma is a rare, benign, locally invasive odontogenic neoplasm of young age that shows clinical, radiographical or gross features of an odontogenic cyst, but it histologically shows typical ameloblastomatous epithelium lining part of the cyst cavity, with or without luminal and/or mural tumor growth. A case of asymptomatic unicystic ameloblastoma in an 11- year-old-female, who was treated by surgical enucleation followed by Carnoy's solution application for 5 minutes, is presented. The present case report describes the clinical and radiological behaviors, its importance and complexity of a differential diagnosis and treatment protocol of lesions in the mandibular molar-ramus area considering the special problems in children.
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http://dx.doi.org/10.4103/0970-4388.135842DOI Listing
May 2016