Ragnhild A Lothe

Ragnhild A Lothe

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Ragnhild A Lothe

Ragnhild A Lothe

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Biomarker-guided therapy for colorectal cancer: strength in complexity.

Nat Rev Clin Oncol 2020 Jan 9;17(1):11-32. Epub 2019 Jul 9.

Department of Molecular Oncology, Institute for Cancer Research & K.G. Jebsen Colorectal Cancer Research Centre, Division for Cancer Medicine, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1038/s41571-019-0241-1DOI Listing
January 2020

Technical differences between sequencing and microarray platforms impact transcriptomic subtyping of colorectal cancer.

Cancer Lett 2020 Jan 31;469:246-255. Epub 2019 Oct 31.

Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway; K. G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, P.O. Box 1171 Blindern, NO-0318, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.10.040DOI Listing
January 2020

Heterogeneous radiological response to neoadjuvant therapy is associated with poor prognosis after resection of colorectal liver metastases.

Eur J Surg Oncol 2019 Dec 17;45(12):2340-2346. Epub 2019 Jul 17.

K.G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, POB 4950 Nydalen, N-0424, Oslo, Norway; Institute for Clinical Medicine, University of Oslo, POB 1171 Blindern, N-0318, Oslo, Norway; Department of Gastrointestinal Surgery, Oslo University Hospital, POB 4950 Nydalen, N-0424, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.ejso.2019.07.017DOI Listing
December 2019

Tumour-infiltrating CD8 lymphocytes and colorectal cancer recurrence by tumour and nodal stage.

Br J Cancer 2019 Sep 7;121(6):474-482. Epub 2019 Aug 7.

Cancer Genomics and Immunology Group, The Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1038/s41416-019-0540-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738075PMC
September 2019

Interfocal heterogeneity challenges the clinical usefulness of molecular classification of primary prostate cancer.

Sci Rep 2019 Sep 19;9(1):13579. Epub 2019 Sep 19.

Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway.

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http://dx.doi.org/10.1038/s41598-019-49964-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753093PMC
September 2019

Gene expression profiles of CMS2-epithelial/canonical colorectal cancers are largely driven by DNA copy number gains.

Oncogene 2019 08 15;38(33):6109-6122. Epub 2019 Jul 15.

Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.

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http://dx.doi.org/10.1038/s41388-019-0868-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756070PMC
August 2019

Long noncoding RNA MIR31HG is a bona fide prognostic marker with colorectal cancer cell-intrinsic properties.

Int J Cancer 2019 06 12;144(11):2843-2853. Epub 2019 Jan 12.

Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.

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http://doi.wiley.com/10.1002/ijc.31998
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http://dx.doi.org/10.1002/ijc.31998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590447PMC
June 2019

Re-assessing as a DNA methylation biomarker for colorectal cancer.

Clin Epigenetics 2018 29;10:70. Epub 2018 May 29.

1Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Norwegian Radium Hospital, Oslo, Norway.

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http://dx.doi.org/10.1186/s13148-018-0503-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975481PMC
May 2019

Combination therapies with HSP90 inhibitors against colorectal cancer.

Biochim Biophys Acta Rev Cancer 2019 04 30;1871(2):240-247. Epub 2019 Jan 30.

Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Colorectal Cancer Research Centre, Division for Cancer Medicine, Oslo University Hospital, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0304419X183020
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http://dx.doi.org/10.1016/j.bbcan.2019.01.002DOI Listing
April 2019

Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity.

Eur Urol 2019 03 1;75(3):498-505. Epub 2018 Sep 1.

Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway; Norwegian Cancer Genomics Consortium, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2018.08.009DOI Listing
March 2019

A robust internal control for high-precision DNA methylation analyses by droplet digital PCR.

Clin Epigenetics 2018 21;10:24. Epub 2018 Feb 21.

1Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, the Norwegian Radium Hospital, PO Box 4950, Nydalen, NO-0424 Oslo, Norway.

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https://clinicalepigeneticsjournal.biomedcentral.com/article
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http://dx.doi.org/10.1186/s13148-018-0456-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822558PMC
February 2019

Alternative splicing expands the prognostic impact of KRAS in microsatellite stable primary colorectal cancer.

Int J Cancer 2019 02 30;144(4):841-847. Epub 2018 Oct 30.

Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1002/ijc.31809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587976PMC
February 2019

Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer.

Mol Oncol 2018 09 15;12(9):1639-1655. Epub 2018 Aug 15.

Department of Molecular Oncology, Institute for Cancer Research, the Norwegian Radium Hospital, Oslo University Hospital, Norway.

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http://dx.doi.org/10.1002/1878-0261.12347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120232PMC
September 2018

CMScaller: an R package for consensus molecular subtyping of colorectal cancer pre-clinical models.

Sci Rep 2017 11 30;7(1):16618. Epub 2017 Nov 30.

Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, NO-0424, Norway.

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http://dx.doi.org/10.1038/s41598-017-16747-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709354PMC
November 2017

CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers.

Int J Cancer 2017 09 2;141(5):967-976. Epub 2017 Jun 2.

Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital - Norwegian Radium Hospital, Oslo, Norway.

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http://dx.doi.org/10.1002/ijc.30796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518206PMC
September 2017

The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions.

J Cell Sci 2017 Sep 21;130(17):2867-2882. Epub 2017 Jul 21.

Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway

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http://dx.doi.org/10.1242/jcs.202408DOI Listing
September 2017

Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies.

Mol Cancer 2017 07 6;16(1):116. Epub 2017 Jul 6.

Department of Molecular Oncology, Institute for Cancer Research & K.G.Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, P.O.Box 4953 Nydalen, -0424, Oslo, NO, Norway.

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http://dx.doi.org/10.1186/s12943-017-0691-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498998PMC
July 2017

Epigenetic disruption of miR-130a promotes prostate cancer by targeting SEC23B and DEPDC1.

Cancer Lett 2017 01 27;385:150-159. Epub 2016 Oct 27.

Cancer Biology and Epigenetics Group, IPO Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP), Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.10.028DOI Listing
January 2017

Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding.

Cell Cycle 2016 Nov 13;15(21):2943-2957. Epub 2016 Sep 13.

a Department of Molecular Oncology , Institute for Cancer Research, Oslo University Hospital , Oslo , Norway.

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http://dx.doi.org/10.1080/15384101.2016.1231280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105929PMC
November 2016

MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer.

Oncotarget 2016 Feb;7(6):6476-505

Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.18632/oncotarget.6390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872728PMC
February 2016

Identification of Novel Fusion Genes in Testicular Germ Cell Tumors.

Cancer Res 2016 Jan 9;76(1):108-16. Epub 2015 Dec 9.

Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Norwegian Radium Hospital, Oslo, Norway. Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway.

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http://cancerres.aacrjournals.org/content/76/1/108.full.pdf+
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http://cancerres.aacrjournals.org/content/early/2015/12/09/0
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-15-1790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704135PMC
January 2016

Novel RNA variants in colorectal cancers.

Oncotarget 2015 Nov;6(34):36587-602

Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Norwegian Radium Hospital, Oslo, Norway.

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http://dx.doi.org/10.18632/oncotarget.5500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742197PMC
November 2015

Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer.

Clin Cancer Res 2015 Aug 24;21(16):3759-70. Epub 2015 Apr 24.

Department for Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. K.G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, Oslo, Norway. Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway. Department of Molecular Biosciences, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-3294DOI Listing
August 2015

Connexins in colorectal cancer pathogenesis.

Int J Cancer 2015 Jul 5;137(1):1-11. Epub 2014 May 5.

Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway; Faculty of Medicine, Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1002/ijc.28911DOI Listing
July 2015

Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection.

Mol Oncol 2015 Jun 18;9(6):1129-39. Epub 2015 Feb 18.

Department of Molecular Oncology, Institute for Cancer Research, Division of Cancer Medicine Surgery and Transplantation, Oslo University Hospital, Oslo, Norway; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528761PMC
June 2015

Four DNA methylation biomarkers in biliary brush samples accurately identify the presence of cholangiocarcinoma.

Hepatology 2015 May 24;61(5):1651-9. Epub 2015 Feb 24.

Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Norwegian PSC Research Center, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1002/hep.27707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832263PMC
May 2015

Exome sequencing of bilateral testicular germ cell tumors suggests independent development lineages.

Neoplasia 2015 Feb;17(2):167-74

Department of Molecular Oncology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway; Center for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14765586140019
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http://dx.doi.org/10.1016/j.neo.2014.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351294PMC
February 2015

Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis.

Neuro Oncol 2015 Jan 19;17(1):63-9. Epub 2014 Jul 19.

Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway (S.A.D., G.E.L., M.K., M.H., R.A.L.); Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway (S.A.D., G.E.L., M.K., M.H., R.A.L.); Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway (M.H., S.S.); Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway (S.A.D., G.E.L., R.A.L.); Department of Pathology (B.B), Division of Diagnostics and Intervention and Department of Oncology, Division of Cancer, Surgery and Transplantation, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway (K.S.H., S.S.); Department of Medical Genetics, University Hospital of Groningen, The Netherlands (E.v.d.B.); Department of Clinical Genetics, Skåne University Hospital, Lund, Sweden (F.M.); Laboratory of Oncologic Research of the Istituto Ortopedico Rizzoli, Bologna, Italy (P.P.).

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https://academic.oup.com/neuro-oncology/article-lookup/doi/1
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http://dx.doi.org/10.1093/neuonc/nou140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416132PMC
January 2015

Portrait of the PI3K/AKT pathway in colorectal cancer.

Biochim Biophys Acta 2015 Jan 22;1855(1):104-21. Epub 2014 Nov 22.

Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2014.09.008DOI Listing
January 2015

A novel transcript, VNN1-AB, as a biomarker for colorectal cancer.

Int J Cancer 2014 Nov 29;135(9):2077-84. Epub 2014 Mar 29.

Department of Cancer Prevention, Institute for Cancer Research, the Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Biosciences, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1002/ijc.28855DOI Listing
November 2014

Epigenetic regulation of EFEMP1 in prostate cancer: biological relevance and clinical potential.

J Cell Mol Med 2014 Nov 11;18(11):2287-97. Epub 2014 Sep 11.

Cancer Biology and Epigenetics Group, Research Center of the Portuguese Oncology Institute - Porto, Porto, Portugal.

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http://dx.doi.org/10.1111/jcmm.12394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224561PMC
November 2014

Transcriptome instability as a molecular pan-cancer characteristic of carcinomas.

BMC Genomics 2014 Aug 10;15:672. Epub 2014 Aug 10.

Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, P,O, Box 4953 Nydalen, Oslo NO-0424, Norway.

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http://dx.doi.org/10.1186/1471-2164-15-672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137096PMC
August 2014

Chromosome 19 rearrangements in ovarian carcinomas: zinc finger genes are particularly targeted.

Genes Chromosomes Cancer 2014 Jul 14;53(7):558-67. Epub 2014 Mar 14.

Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway; Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1002/gcc.22166DOI Listing
July 2014

Prognostic Significance of β-Catenin, E-Cadherin, and SOX9 in Colorectal Cancer: Results from a Large Population-Representative Series.

Front Oncol 2014 21;4:118. Epub 2014 May 21.

Department for Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital , Oslo , Norway ; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo , Oslo , Norway ; Department of Molecular Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo , Oslo , Norway.

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http://dx.doi.org/10.3389/fonc.2014.00118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033250PMC
June 2014

Assessment of fusion gene status in sarcomas using a custom made fusion gene microarray.

PLoS One 2013 13;8(8):e70649. Epub 2013 Aug 13.

Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070649PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742753PMC
May 2014

Colorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma.

Epigenetics 2014 Mar 20;9(3):428-36. Epub 2013 Dec 20.

Centre for Cancer Biomedicine; University of Oslo; Oslo, Norway; Department of Cancer Prevention; Institute for Cancer Research; Oslo University Hospital; Oslo, Norway.

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http://dx.doi.org/10.4161/epi.27554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053461PMC
March 2014

The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer.

Epigenetics 2014 Mar 2;9(3):346-50. Epub 2014 Jan 2.

Department of Cancer Prevention; Institute for Cancer Research; Oslo University Hospital-Norwegian Radium Hospital; Oslo, Norway; Centre for Cancer Biomedicine; University of Oslo; Oslo, Norway.

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http://dx.doi.org/10.4161/epi.27582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053453PMC
March 2014

Sequencing IDH1/2 glioma mutation hotspots in gliomas and malignant peripheral nerve sheath tumors.

Neuro Oncol 2014 Jan 4;16(2):320-2. Epub 2013 Dec 4.

Corresponding author: Petter Brandal, MD, PhD, Section for Cancer Cytogenetics, Institute for Medical Informatics, Oslo University Hospital, The Norwegian Radium Hospital, P.O. Box 4950 Nydalen, N-0424 Oslo, Norway.

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http://dx.doi.org/10.1093/neuonc/not230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895390PMC
January 2014

Anticipating the clinical use of prognostic gene expression-based tests for colon cancer stage II and III: is Godot finally arriving?

Clin Cancer Res 2013 Dec 28;19(24):6669-77. Epub 2013 Oct 28.

Authors' Affiliations: Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital; Departments of Gastrointestinal Surgery and Oncology, Oslo University Hospital; and Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1769DOI Listing
December 2013

Common fusion transcripts identified in colorectal cancer cell lines by high-throughput RNA sequencing.

Transl Oncol 2013 1;6(5):546-53. Epub 2013 Oct 1.

Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway ; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799197PMC
http://dx.doi.org/10.1593/tlo.13457DOI Listing
October 2013

Transforming pluripotency: an exon-level study of malignancy-specific transcripts in human embryonal carcinoma and embryonic stem cells.

Stem Cells Dev 2013 Apr 4;22(7):1136-46. Epub 2013 Jan 4.

Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1089/scd.2012.0369DOI Listing
April 2013

Survival meta-analyses for >1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1.

Neuro Oncol 2013 Feb 15;15(2):135-47. Epub 2012 Nov 15.

Department of Cancer Prevention, Institute for Cancer Research, the Norwegian Radium Hospital, Montebello, Oslo University Hospital, NO-0424 Oslo, Norway.

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http://dx.doi.org/10.1093/neuonc/nos287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548581PMC
February 2013

Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes.

Breast Cancer Res Treat 2013 Feb 18;138(1):37-45. Epub 2013 Jan 18.

Department of Genetics, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.

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http://dx.doi.org/10.1007/s10549-013-2408-2DOI Listing
February 2013

NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.

Cell Signal 2013 Jan 5;25(1):12-8. Epub 2012 Sep 5.

Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1016/j.cellsig.2012.08.012DOI Listing
January 2013

Survey of 548 oncogenic fusion transcripts in thyroid tumors supports the importance of the already established thyroid fusions genes.

Genes Chromosomes Cancer 2012 Dec 7;51(12):1154-64. Epub 2012 Sep 7.

Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1002/gcc.22003DOI Listing
December 2012

A tissue-based comparative effectiveness analysis of biomarkers for early detection of colorectal tumors.

Clin Transl Gastroenterol 2012 Dec 6;3:e27. Epub 2012 Dec 6.

1] Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway [2] Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1038/ctg.2012.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535074PMC
December 2012

ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis.

Gut 2012 Nov 2;61(11):1560-7. Epub 2012 Jan 2.

Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Nydalen, Oslo, Norway.

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http://dx.doi.org/10.1136/gutjnl-2011-301179DOI Listing
November 2012

Novel target genes and a valid biomarker panel identified for cholangiocarcinoma.

Epigenetics 2012 Nov 14;7(11):1249-57. Epub 2012 Sep 14.

Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radiumhospital, Oslo, Norway.

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http://dx.doi.org/10.4161/epi.22191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499326PMC
November 2012

ColoGuidePro: a prognostic 7-gene expression signature for stage III colorectal cancer patients.

Clin Cancer Res 2012 Nov 18;18(21):6001-10. Epub 2012 Sep 18.

Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-3302DOI Listing
November 2012

[Genome sequencing for personalized cancer treatment].

Tidsskr Nor Laegeforen 2012 Nov;132(21):2406-8

Genombiologigruppa, Seksjon for kreftforebygging, Institutt for kreftforskning, Oslo universitetssykehus, -Radiumhospitalet, Oslo, Norway.

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http://dx.doi.org/10.4045/tidsskr.12.0784DOI Listing
November 2012

Vimentin in upper gastrointestinal pathologies--letter.

Cancer Epidemiol Biomarkers Prev 2012 Oct 28;21(10):1889; author reply 1890. Epub 2012 Aug 28.

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http://dx.doi.org/10.1158/1055-9965.EPI-12-0894DOI Listing
October 2012

The exon-level biomarker SLC39A14 has organ-confined cancer-specificity in colorectal cancer.

Int J Cancer 2012 Sep 11;131(6):1479-85. Epub 2012 Jan 11.

Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1002/ijc.27399DOI Listing
September 2012

MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer.

Neoplasia 2012 Sep;14(9):868-79

Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1593/neo.121094DOI Listing
September 2012

Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome.

Int J Cancer 2012 Aug 20;131(3):570-81. Epub 2011 Oct 20.

Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

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http://doi.wiley.com/10.1002/ijc.26392
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August 2012

FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer.

Genes Chromosomes Cancer 2012 Mar 12;51(3):240-9. Epub 2011 Nov 12.

Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.

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http://dx.doi.org/10.1002/gcc.20948DOI Listing
March 2012

Oncogenicity of the developmental transcription factor Sox9.

Cancer Res 2012 Mar 13;72(5):1301-15. Epub 2012 Jan 13.

Division of Stem Cell Biology and Developmental Genetics, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378515PMC
March 2012

MGMT promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR.

J Transl Med 2012 Mar 6;10:36. Epub 2012 Mar 6.

Section for Cancer Cytogenetics, Institute for Medical Informatics, Oslo University Hospital-The Norwegian Radium Hospital, P,O, Box 4950 Nydalen, N-0424 Oslo, Norway.

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http://translational-medicine.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/1479-5876-10-36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311573PMC
March 2012

Peritoneal carcinomatosis of colon cancer origin: highest incidence in women and in patients with right-sided tumors.

J Surg Oncol 2011 Dec 5;104(7):792-7. Epub 2011 May 5.

Department of Gastrointestinal Surgery, Oslo University Hospital, Aker, Oslo, Norway.

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http://dx.doi.org/10.1002/jso.21959DOI Listing
December 2011

Quantitative validation of GJC1 promoter hypermethylation in benign and malignant colorectal tumors.

Endocr Relat Cancer 2011 Oct 27;18(6):C31-4. Epub 2011 Oct 27.

Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, PO Box 4953 Nydalen, NO-0424 Oslo, Norway.

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http://dx.doi.org/10.1530/ERC-11-0204DOI Listing
October 2011

TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers.

Epigenetics 2011 Sep 1;6(9):1120-30. Epub 2011 Sep 1.

Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute, Porto, Portugal.

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http://dx.doi.org/10.4161/epi.6.9.16376DOI Listing
September 2011

Fusion gene microarray reveals cancer type-specificity among fusion genes.

Genes Chromosomes Cancer 2011 May 8;50(5):348-57. Epub 2011 Feb 8.

Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1002/gcc.20860DOI Listing
May 2011

DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer.

Epigenetics 2011 May 1;6(5):602-9. Epub 2011 May 1.

Department of Cancer Prevention, Institute for Cancer Research, Radiumhospitalet - Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.4161/epi.6.5.15237DOI Listing
May 2011

Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival.

Genome Med 2011 May 27;3(5):32. Epub 2011 May 27.

Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, PO Box 4953 Nydalen, NO-0424 Oslo, Norway.

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http://dx.doi.org/10.1186/gm248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219073PMC
May 2011

MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines.

BMC Cancer 2011 May 30;11:211:1-11. Epub 2011 May 30.

Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, P O Box 4953 Nydalen, NO-0424 Oslo, Norway.

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http://dx.doi.org/10.1186/1471-2407-11-211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128006PMC
May 2011

Array-CGH analysis of microdissected chromosome 19 markers in ovarian carcinoma identifies candidate target genes.

Genes Chromosomes Cancer 2010 Nov;49(11):1046-53

Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway.

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http://dx.doi.org/10.1002/gcc.20813DOI Listing
November 2010

UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy.

Autophagy 2010 Oct 16;6(7):863-70. Epub 2010 Oct 16.

Institute of Basic Medical Sciences, University of Oslo, Norway.

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http://dx.doi.org/10.4161/auto.6.7.13033DOI Listing
October 2010