Publications by authors named "Rafick-Pierre Sekaly"

100Publications

Intestinal Stem Cell Niche Defects Result in Impaired 3D Organoid Formation in Mouse Models of Crohn's Disease-like Ileitis.

Stem Cell Reports 2020 08 16;15(2):389-407. Epub 2020 Jul 16.

Department of Medicine, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106-5066, USA; Department of Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Division of Gastroenterology & Hepatology University of California Davis, School of Medicine, Institute for Regenerative Cures, 2921 Stockton Boulevard, Suite 1615, Sacramento, CA 95817, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2020.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419719PMC
August 2020

Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.

Cell 2018 01 14;172(3):517-533.e20. Epub 2017 Dec 14.

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; The Francis Crick Institute, London NW1A 1AT, UK; Department of Microbiology and Immunobiology & HMS Center for Immune Imaging, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.11.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786505PMC
January 2018

CTLA-4PD-1 Memory CD4 T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques.

Immunity 2017 10;47(4):776-788.e5

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679306PMC
October 2017

Maternal BCG scar is associated with increased infant proinflammatory immune responses.

Vaccine 2017 01 30;35(2):273-282. Epub 2016 Nov 30.

MRC/UVRI Uganda Research Unit on AIDS, P.O. Box 49, Entebbe, Uganda; London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

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http://dx.doi.org/10.1016/j.vaccine.2016.11.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357573PMC
January 2017

The sooner the better: innate immunity as a path toward the HIV cure.

Curr Opin Virol 2016 08 3;19:85-91. Epub 2016 Aug 3.

Case Western Reserve University, Department of Pathology, Cleveland, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coviro.2016.07.003DOI Listing
August 2016

Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques.

J Immunol 2016 08 18;197(4):1183-98. Epub 2016 Jul 18.

Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006;

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http://dx.doi.org/10.4049/jimmunol.1600065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976006PMC
August 2016

Systems biology and the quest for correlates of protection to guide the development of an HIV vaccine.

Curr Opin Immunol 2016 08 5;41:91-97. Epub 2016 Jul 5.

Department of Pathology, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2016.06.010DOI Listing
August 2016

Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study.

BMC Med 2016 May 16;14:76. Epub 2016 May 16.

South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1186/s12916-016-0617-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869393PMC
May 2016

Current topics in HIV-1 pathogenesis: The emergence of deregulated immuno-metabolism in HIV-infected subjects.

Cytokine Growth Factor Rev 2015 Dec 8;26(6):603-13. Epub 2015 Sep 8.

INRS-Institut Armand Frappier, 531 boulevard des Prairies, Laval, Quebec H7V 1B7, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13596101153000
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http://dx.doi.org/10.1016/j.cytogfr.2015.09.001DOI Listing
December 2015

Beyond adjuvants: Antagonizing inflammation to enhance vaccine immunity.

Vaccine 2015 Jun;33 Suppl 2:B55-9

Case Western Reserve University, Cleveland, OH, United States.

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http://dx.doi.org/10.1016/j.vaccine.2015.03.058DOI Listing
June 2015

Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow.

J Exp Med 2015 Mar 16;212(3):385-99. Epub 2015 Feb 16.

Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032

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http://dx.doi.org/10.1084/jem.20141442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354373PMC
March 2015

Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy.

PLoS Pathog 2014 Oct 13;10(10):e1004473. Epub 2014 Nov 13.

Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Victoria, Australia; Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia; Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1371/journal.ppat.1004473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231123PMC
October 2014

Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection.

PLoS Comput Biol 2014 May 22;10(5):e1003630. Epub 2014 May 22.

INSERM, Unité U955, Créteil, France; Université Paris-Est, Faculté de Médecine, UMR-S955 Creteil, France; AP-HP, Groupe Henri-Mondor Albert-Chenevier, Immunologie Clinique, Creteil, France.

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http://dx.doi.org/10.1371/journal.pcbi.1003630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031052PMC
May 2014

CD80 and CD86 IgC domains are important for quaternary structure, receptor binding and co-signaling function.

Immunol Lett 2014 Sep 15;161(1):65-75. Epub 2014 May 15.

Department of Microbiology and Immunology, McGill University, Montréal, Canada; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Hôpital St-Luc, Montréal, Québec, Canada; Département de Microbiologie et Immunologie, Université de Montréal, Montréal, Canada; Vaccine and Gene Therapy Institute Florida, Port St. Lucie, FL, United States. Electronic address:

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http://dx.doi.org/10.1016/j.imlet.2014.05.002DOI Listing
September 2014

A randomized controlled trial of palifermin (recombinant human keratinocyte growth factor) for the treatment of inadequate CD4+ T-lymphocyte recovery in patients with HIV-1 infection on antiretroviral therapy.

J Acquir Immune Defic Syndr 2014 Aug;66(4):399-406

*Division of Infectious Diseases and HIV Medicine, Drexel University College of Medicine, Philadelphia, PA; †AIDS Clinical Trials Group, Statistical and Data Analysis Center, Harvard University School of Public Health, Boston, MA; ‡Vaccine and Gene Therapy Institute, Port Saint Lucie, FL; §Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI; ‖Department of Immunology/Microbiology, Rush University School of Medicine, Chicago, IL; ¶Division of Hematology and Chronic Viral Illness Service, McGill University Health Centre, Montreal, CA; #Division of Infectious Diseases, Department of Medicine, University of California, San Diego, School of Medicine, San Diego, CA; **Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; ††Division of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, PA; ‡‡Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; §§Social and Scienti\x{fb01}c Systems, Inc., Silver Springs, MD; ‖‖Frontier Sciences, Buffalo, NY; and ¶¶Division of AIDS, NIAID, Bethesda, MD.

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http://dx.doi.org/10.1097/QAI.0000000000000195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216663PMC
August 2014

MMTV superantigens coerce an unconventional topology between the TCR and MHC class II.

J Immunol 2014 Feb 22;192(4):1896-906. Epub 2014 Jan 22.

Laboratoire d'Immunologie Moléculaire, Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec HC3 3J7, Canada;

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http://dx.doi.org/10.4049/jimmunol.1203130DOI Listing
February 2014

Myeloid dendritic cells induce HIV-1 latency in non-proliferating CD4+ T cells.

PLoS Pathog 2013 5;9(12):e1003799. Epub 2013 Dec 5.

Department of Infectious Diseases, Monash University, Melbourne, Victoria, Australia ; Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1371/journal.ppat.1003799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855553PMC
September 2014

Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection.

J Immunol 2013 Sep 5;191(5):2194-204. Epub 2013 Aug 5.

Laboratoire d'Immunologie, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Saint-Luc, Montreal, Quebec H2X 1P1, Canada.

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http://dx.doi.org/10.4049/jimmunol.1200646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815464PMC
September 2013

Systems immunogenetics of vaccines.

Semin Immunol 2013 Apr 22;25(2):124-9. Epub 2013 Jul 22.

Division of Bioinformatics & Computational Biology, Department of Medical Informatics & Clinical Epidemiology, Oregon Health & Science University, Oregon, United States.

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http://dx.doi.org/10.1016/j.smim.2013.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815469PMC
April 2013

The immunological synapse: the gateway to the HIV reservoir.

Immunol Rev 2013 Jul;254(1):305-25

Division of Infectious Diseases, Vaccine and Gene Therapy Institute-Florida (VGTI-FL), Port Saint Lucie, FL 34987, USA.

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http://dx.doi.org/10.1111/imr.12080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707302PMC
July 2013

PD-1 coinhibitory signals: the link between pathogenesis and protection.

Semin Immunol 2013 Oct 31;25(3):219-27. Epub 2013 Mar 31.

Division of Infectious Diseases, Vaccine and Gene Therapy Institute-Florida (VGTI-FL), Port Saint Lucie, FL, United States.

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http://dx.doi.org/10.1016/j.smim.2013.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795833PMC
October 2013

Intrinsic role of FoxO3a in the development of CD8+ T cell memory.

J Immunol 2013 Feb 31;190(3):1066-75. Epub 2012 Dec 31.

National Research Council of Canada, Institute for Biological Sciences, Ottawa, Ontario K1A 0R6, Canada.

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http://dx.doi.org/10.4049/jimmunol.1200639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815477PMC
February 2013

Foxo3a: an integrator of immune dysfunction during HIV infection.

Cytokine Growth Factor Rev 2012 Aug-Oct;23(4-5):215-21. Epub 2012 Jun 27.

Vaccine and Gene Therapy Institute of Florida, 9801 SW Discovery Way, Port St. Lucie, FL 34987, USA.

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http://dx.doi.org/10.1016/j.cytogfr.2012.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418405PMC
January 2013

A conserved polylysine motif in CD86 cytoplasmic tail is necessary for cytoskeletal association and effective co-stimulation.

Biochem Biophys Res Commun 2012 Jun 30;423(2):301-7. Epub 2012 May 30.

Department of Microbiology and Immunology, McGill University, Montréal, Canada.

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http://dx.doi.org/10.1016/j.bbrc.2012.05.116DOI Listing
June 2012

Type I IFN induced by adenovirus serotypes 28 and 35 has multiple effects on T cell immunogenicity.

J Immunol 2012 Jun 14;188(12):6109-18. Epub 2012 May 14.

Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.1103717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370104PMC
June 2012

Dissecting the HIV-specific immune response: a systems biology approach.

Curr Opin HIV AIDS 2012 Jan;7(1):17-23

ImmuneCarta Services, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1097/COH.0b013e32834ddb0eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627479PMC
January 2012

CD4 T cell nadir independently predicts the magnitude of the HIV reservoir after prolonged suppressive antiretroviral therapy.

J Clin Virol 2012 Jan 22;53(1):29-32. Epub 2011 Oct 22.

Division of Hematology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.jcv.2011.09.018DOI Listing
January 2012

Ex vivo measurement of the cytotoxic capacity of human primary antigen-specific CD8 T cells.

J Immunol Methods 2012 Jan 5;375(1-2):252-7. Epub 2011 Oct 5.

Vaccine and Gene Therapy Institute - Florida, Port Saint Lucie, FL 34987, USA.

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http://dx.doi.org/10.1016/j.jim.2011.09.008DOI Listing
January 2012

Solving vaccine mysteries: a systems biology perspective.

Nat Immunol 2011 Jul 19;12(8):729-31. Epub 2011 Jul 19.

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http://dx.doi.org/10.1038/ni.2078DOI Listing
July 2011

Unique features of memory T cells in HIV elite controllers: a systems biology perspective.

Curr Opin HIV AIDS 2011 May;6(3):188-96

Vaccine and Gene Therapy Institute-Florida, Port Sainte-Lucie, Florida, USA.

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http://dx.doi.org/10.1097/COH.0b013e32834589a1DOI Listing
May 2011

Immunogenicity and tolerability of an inactivated and adjuvanted pandemic H1N1 influenza vaccine, in HIV-1-infected patients.

Vaccine 2011 Feb 23;29(7):1359-63. Epub 2010 Dec 23.

Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Qc, Canada.

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http://dx.doi.org/10.1016/j.vaccine.2010.12.023DOI Listing
February 2011

New approaches to design HIV-1 T-cell vaccines.

Curr Opin HIV AIDS 2010 Sep;5(5):368-76

Vaccine and Gene Therapy Institute - Florida, Port Saint Lucie, Florida, USA.

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http://dx.doi.org/10.1097/COH.0b013e32833d2cc0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972542PMC
September 2010

Th17 lineage commitment and HIV-1 pathogenesis.

Curr Opin HIV AIDS 2010 Mar;5(2):158-65

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Saint-Luc Hospital, Pavillon Edouard Asselin, 264 Blvd. René-Lévesque East, Montréal, Québec, Canada.

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https://insights.ovid.com/crossref?an=01222929-201003000-000
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http://dx.doi.org/10.1097/COH.0b013e3283364733DOI Listing
March 2010

Dendritic cell inhibition is connected to exhaustion of CD8+ T cell polyfunctionality during chronic hepatitis C virus infection.

J Immunol 2010 Mar 19;184(6):3134-44. Epub 2010 Feb 19.

Département de Microbiologie et Immunologie, Centre de Recherche du Centre Hospitalier de Université de Montréal, Montréal, Québec, Canada.

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http://www.jimmunol.org/content/184/6/3134.full.pdf
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0902522
Publisher Site
http://dx.doi.org/10.4049/jimmunol.0902522DOI Listing
March 2010

Differential modulation of CCR5-tropic human immunodeficiency virus-1 transfer from macrophages towards T cells under interleukin-4/interleukin-13 microenvironment.

Hum Immunol 2010 Jan;71(1):1-13

Unité INSERM Internationale U743 Immunologie Humaine, Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomédicales des Cordeliers, Paris, France.

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http://linkinghub.elsevier.com/retrieve/pii/S019888590900224
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http://dx.doi.org/10.1016/j.humimm.2009.08.011DOI Listing
January 2010

siRNA knockdown of PD-L1 and PD-L2 in monocyte-derived dendritic cells only modestly improves proliferative responses to Gag by CD8(+) T cells from HIV-1-infected individuals.

J Clin Immunol 2009 Sep 27;29(5):637-45. Epub 2009 Jun 27.

Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1007/s10875-009-9313-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933267PMC
September 2009