Publications

Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1-targeted therapy in lung cancer patients.
Proc Natl Acad Sci U S A 2017 May 26;114(19):4993-4998. Epub 2017 Apr 26.
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322;

Metabolic Phenotypes of Response to Vaccination in Humans.
Cell 2017 May 11;169(5):862-877.e17. Epub 2017 May 11.
Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA; Department of Pathology, School of Medicine, Emory University, Atlanta, GA 30329, USA. Electronic address:


Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection.
Proc Natl Acad Sci U S A 2017 Feb 3;114(8):1976-1981. Epub 2017 Feb 3.
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322;


Cardiac allograft rejection as a complication of PD-1 checkpoint blockade for cancer immunotherapy: a case report.
Cancer Immunol Immunother 2017 Jan 22;66(1):45-50. Epub 2016 Oct 22.
Department of Hematology and Medical Oncology, Emory University School of Medicine, 1365-C Clifton Road, NE, Suite C3080, Atlanta, GA, 30322, USA.



Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer.
Cell Rep 2016 Nov;17(9):2195-2209
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA; Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address:



Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus.
Proc Natl Acad Sci U S A 2016 Jul 27;113(28):7852-7. Epub 2016 Jun 27.
Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322; Division of Infectious Disease, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322;

B Cell Responses during Secondary Dengue Virus Infection Are Dominated by Highly Cross-Reactive, Memory-Derived Plasmablasts.
J Virol 2016 Jun 27;90(12):5574-85. Epub 2016 May 27.
Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, Georgia, USA Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA


CXCL13 is a plasma biomarker of germinal center activity.
Proc Natl Acad Sci U S A 2016 Mar 23;113(10):2702-7. Epub 2016 Feb 23.
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA 92037;


Immune history profoundly affects broadly protective B cell responses to influenza.
Sci Transl Med 2015 Dec;7(316):316ra192
Department of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA. Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA.

Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures.
Immunity 2015 Dec;43(6):1186-98
Department of Pathology, School of Medicine, Emory University, 1648 Pierce Drive NE, Atlanta, GA 30307, USA; Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA. Electronic address:

Two heads better than one? Ipilimumab immunotherapy and radiation therapy for melanoma brain metastases.
Neuro Oncol 2015 Oct 25;17(10):1312-21. Epub 2015 May 25.
Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia (K.R.P., D.O.-D., M.K.K.); Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia (D.H.L., R.R.K., B.C.C.); School of Medicine, Emory University, Atlanta, Georgia (D.E.O.); Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia (R.A.).

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.
Immunity 2015 Oct 22;43(4):690-702. Epub 2015 Sep 22.
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Medicine (Rheumatology), Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:


High Affinity Antibodies against Influenza Characterize the Plasmablast Response in SLE Patients After Vaccination.
PLoS One 2015 7;10(5):e0125618. Epub 2015 May 7.
Committee on Immunology, The University of Chicago, Chicago, Illinois, United States of America; Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology, The University of Chicago, Chicago, Illinois, United States of America.


Antibody effector functions mediated by Fcγ-receptors are compromised during persistent viral infection.
Immunity 2015 Feb 10;42(2):367-78. Epub 2015 Feb 10.
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection.
Science 2015 Jan;347(6219):278-82
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Ragon Institute of MGH, MIT, and Harvard, Boston, MA 02114, USA.


An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction.
Nat Commun 2015 Jan 23;6:6072. Epub 2015 Jan 23.
Evergrande Center for Immunologic Diseases, Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

Autophagy is essential for effector CD8(+) T cell survival and memory formation.
Nat Immunol 2014 Dec 2;15(12):1152-61. Epub 2014 Nov 2.
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.



Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.
J Exp Med 2014 Aug 11;211(9):1905-18. Epub 2014 Aug 11.
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322

Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation.
Cell Host Microbe 2014 Jul 26;16(1):115-27. Epub 2014 Jun 26.
Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology & Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address:

Biogenesis of influenza a virus hemagglutinin cross-protective stem epitopes.
PLoS Pathog 2014 Jun 12;10(6):e1004204. Epub 2014 Jun 12.
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions.
J Virol 2014 Mar 18;88(5):2508-18. Epub 2013 Dec 18.
Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Broadly reactive human CD8 T cells that recognize an epitope conserved between VZV, HSV and EBV.
PLoS Pathog 2014 Mar 27;10(3):e1004008. Epub 2014 Mar 27.
Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.

Molecular signatures of antibody responses derived from a systems biology study of five human vaccines.
Nat Immunol 2014 Feb 15;15(2):195-204. Epub 2013 Dec 15.
1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3] Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.

Identification of novel markers for mouse CD4(+) T follicular helper cells.
Eur J Immunol 2013 Dec 14;43(12):3219-32. Epub 2013 Oct 14.
Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.

PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria.
Cell Rep 2013 Dec 5;5(5):1204-13. Epub 2013 Dec 5.
QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD 4029, Australia. Electronic address:



Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells.
J Virol 2013 Jul 1;87(13):7737-46. Epub 2013 May 1.
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.


Comparative analysis of simian immunodeficiency virus gag-specific effector and memory CD8+ T cells induced by different adenovirus vectors.
J Virol 2013 Feb 21;87(3):1359-72. Epub 2012 Nov 21.
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.





Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells.
Proc Natl Acad Sci U S A 2012 Jun 21;109(23):9047-52. Epub 2012 May 21.
Emory Vaccine Center, Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA 30322, USA.


Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function.
Immunity 2012 Apr;36(4):586-99
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674, USA.


Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy.
Nature 2016 09 2;537(7620):417-421. Epub 2016 Aug 2.
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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