Raffi Karshafian

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Raffi Karshafian

Publications by authors named "Raffi Karshafian"

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32Publications

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Analysis of the cytotoxic effects of combined ultrasound, microbubble and nucleoside analog combinations on pancreatic cells in vitro.

Ultrasonics 2018 Sep 5;89:110-117. Epub 2018 May 5.

Department of Physics, Ryerson University, Toronto, ON M5B 2K3, Canada; St. Michael's Hospital, Keenan Research Centre of LKSKI, 209 Victoria Street, Toronto, ON M5B 1W8, Canada; Institute for Biomedical Engineering, Science and Technology (iBEST), a partnership between Ryerson University and St. Michael's Hospital, Toronto, Ontario, Canada. Electronic address:

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September 2018

Ultrasound Microbubble Treatment Enhances Clathrin-Mediated Endocytosis and Fluid-Phase Uptake through Distinct Mechanisms.

PLoS One 2016 8;11(6):e0156754. Epub 2016 Jun 8.

Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada.

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July 2017

Honey, I shrunk the bubbles: microfluidic vacuum shrinkage of lipid-stabilized microbubbles.

Soft Matter 2017 Jun;13(22):4011-4016

Department of Mechanical and Industrial Engineering, Ryerson University, Toronto, Canada.

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June 2017

Ultrasound and microbubble induced release from intracellular compartments.

BMC Biotechnol 2017 05 18;17(1):45. Epub 2017 May 18.

Department of Physics, Ryerson University, 350 Victoria Street Toronto, Ontario, M5B 2K3, Canada.

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May 2017

USMB-induced synergistic enhancement of aminoglycoside antibiotics in biofilms.

Ultrasonics 2016 07 31;69:182-90. Epub 2016 Mar 31.

Department of Physics, Ryerson University, Toronto, Ontario, Canada. Electronic address:

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July 2016

Microvascular contrast enhancement in optical coherence tomography using microbubbles.

J Biomed Opt 2016 Jul;21(7):76014

University of Toronto, Department of Medical Biophysics, Toronto Medical Discovery Tower, MaRS Centre, 101 College Street, Room 15-701, Toronto, Ontario M5G 1L7, CanadadUniversity Health Network, Princess Margaret Cancer Centre, 610 University Avenue, Tor.

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July 2016

Quantitative ultrasound characterization of tumor cell death: ultrasound-stimulated microbubbles for radiation enhancement.

PLoS One 2014 22;9(7):e102343. Epub 2014 Jul 22.

Department of Physical Sciences, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Physics, Ryerson University, Toronto, Ontario, Canada.

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March 2016

Enhancing laser therapy using PEGylated gold nanoparticles combined with ultrasound and microbubbles.

Ultrasonics 2015 Mar 19;57:36-43. Epub 2014 Oct 19.

Department of Physics, Ryerson University, Toronto, Canada. Electronic address:

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March 2015

Quantifying vascular heterogeneity using microbubble disruption-replenishment kinetics in patients with renal cell cancer.

Invest Radiol 2014 Feb;49(2):116-23

From the *Department of Medical Biophysics, University of Toronto; †Imaging Research, Sunnybrook Research Institute; ‡Department of Physics, Ryerson University; §Medical Imaging, Sunnybrook Health Sciences Centre; ∥Department of Medical Imaging, Toronto General Hospital; and ¶Medical Oncology, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada.

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February 2014

In vivo feasibility study of ultrasound potentiated collagenase therapy of chronic total occlusions.

Ultrasonics 2014 Jan 29;54(1):20-4. Epub 2013 Jul 29.

Department of Medical Biophysics, University of Toronto, Canada; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada. Electronic address:

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January 2014

Effects of biophysical parameters in enhancing radiation responses of prostate tumors with ultrasound-stimulated microbubbles.

Ultrasound Med Biol 2013 Aug 30;39(8):1376-87. Epub 2013 Apr 30.

Department of Medical Biophysics, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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August 2013

Low-frequency quantitative ultrasound imaging of cell death in vivo.

Med Phys 2013 Aug;40(8):082901

Imaging Research-Physical Science, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada.

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August 2013

Enhancing laser thermal-therapy using ultrasound-microbubbles and gold nanorods of in vitro cells.

Ultrasonics 2013 Mar 10;53(3):793-8. Epub 2012 Dec 10.

Ryerson University, Department of Physics, Toronto, Ontario, Canada.

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March 2013

Bioeffects of ultrasound-stimulated microbubbles on endothelial cells: gene expression changes associated with radiation enhancement in vitro.

Ultrasound Med Biol 2012 Nov 12;38(11):1958-69. Epub 2012 Sep 12.

Radiation Oncology and Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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November 2012

Quantitative ultrasound for the monitoring of novel microbubble and ultrasound radiosensitization.

Ultrasound Med Biol 2012 Jul 12;38(7):1212-21. Epub 2012 May 12.

Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, and University of Toronto, Toronto, Ontario, Canada.

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July 2012

Tumor radiation response enhancement by acoustical stimulation of the vasculature.

Proc Natl Acad Sci U S A 2012 Jul 9;109(30):E2033-41. Epub 2012 Jul 9.

Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

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July 2012

Does hepatic vein transit time performed with contrast-enhanced ultrasound predict the severity of hepatic fibrosis?

Ultrasound Med Biol 2011 Dec 26;37(12):1963-9. Epub 2011 Oct 26.

Department of Medical Imaging, University of Toronto, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

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December 2011

Microbubble mediated sonoporation of cells in suspension: clonogenic viability and influence of molecular size on uptake.

Ultrasonics 2010 Jun 25;50(7):691-7. Epub 2010 Jan 25.

Medical Biophysics, University of Toronto, Toronto, ON, Canada.

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June 2010

Quantification of flow using ultrasound and microbubbles: a disruption replenishment model based on physical principles.

Ultrasound Med Biol 2009 Dec 12;35(12):2007-20. Epub 2009 Oct 12.

Department of Medical Biophysics, University of Toronto, Toronto, Canada; and Sunnybrook Health Sciences Centre, Toronto, Canada.

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December 2009

Sonoporation by ultrasound-activated microbubble contrast agents: effect of acoustic exposure parameters on cell membrane permeability and cell viability.

Ultrasound Med Biol 2009 May 24;35(5):847-60. Epub 2008 Dec 24.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

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May 2009

The influence of fragmentation on the acoustic response from shrinking bubbles.

Ultrasound Med Biol 2008 Jul 14;34(7):1152-62. Epub 2008 Mar 14.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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July 2008

Radial modulation imaging of microbubble contrast agents at high frequency.

Ultrasound Med Biol 2008 Jun 21;34(6):949-62. Epub 2008 Feb 21.

Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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June 2008

Quantitative measurement of ultrasound disruption of polymer-shelled microbubbles.

Ultrasound Med Biol 2007 Nov 25;33(11):1777-86. Epub 2007 Jul 25.

Department of Medical Biophyscs, University of Toronto, Toronto, ON, Canada.

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November 2007

Insonation of the eye in the presence of microbubbles: preliminary study of the duration and degree of vascular bioeffects--work in progress.

J Ultrasound Med 2007 Jun;26(6):731-8

Department of Medical Biophysics, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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June 2007

Contrast-enhanced triggered harmonic sonography for assessment of periarticular hemodynamic changes in experimental arthritis.

Pediatr Radiol 2006 Dec 19;36(12):1242-51. Epub 2006 Oct 19.

Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G1X8, Canada.

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December 2006

High frequency nonlinear B-scan imaging of microbubble contrast agents.

IEEE Trans Ultrason Ferroelectr Freq Control 2005 Jan;52(1):65-79

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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January 2005

Transit time kinetics in ordered and disordered vascular trees.

Phys Med Biol 2003 Oct;48(19):3225-37

Department of Medical Biophysics, University of Toronto, Sunnybrook & Women's College, Health Sciences Centre, Toronto, Ontario, Canada.

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October 2003