Publications by authors named "Raffaella Amici"

10Publications

Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.

Authors:
Florian Thaler Loris Moretti Raffaella Amici Agnese Abate Andrea Colombo Giacomo Carenzi Maria Carmela Fulco Roberto Boggio Giulio Dondio Stefania Gagliardi Saverio Minucci Luca Sartori Mario Varasi Ciro Mercurio

Eur J Med Chem 2016 Jan 11;108:53-67. Epub 2015 Nov 11.

Genextra Group, DAC Srl, Genextra Group, Via Adamello 16, 20139 Milan, Italy. Electronic address:

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January 2016

Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo.

Authors:
Daniele Fancelli Agnese Abate Raffaella Amici Paolo Bernardi Marco Ballarini Anna Cappa Giacomo Carenzi Andrea Colombo Cristina Contursi Fabio Di Lisa Giulio Dondio Stefania Gagliardi Eva Milanesi Saverio Minucci Gilles Pain Pier Giuseppe Pelicci Alessandra Saccani Mariangela Storto Florian Thaler Mario Varasi Manuela Villa Simon Plyte

J Med Chem 2014 Jun 11;57(12):5333-47. Epub 2014 Jun 11.

Genextra Group, Congenia s.r.l. , Via Adamello 16, 20139 Milan, Italy.

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June 2014

Chiral resolution and pharmacological characterization of the enantiomers of the Hsp90 inhibitor 2-amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime.

Authors:
Raffaella Amici Chiara Bigogno Roberto Boggio Andrea Colombo Stephen M Courtney Roberto Dal Zuffo Giulio Dondio Fulvia Fusar Stefania Gagliardi Saverio Minucci Marco Molteni Christian A G N Montalbetti Annalisa Mortoni Mario Varasi Stefania Vultaggio Ciro Mercurio

ChemMedChem 2014 Jul 17;9(7):1574-85. Epub 2014 Apr 17.

Genextra Group, Congenia s.r.l., Via Adamello 16, 20139 Milan (Italy); Current address: Drug Discovery Program, Department of Experimental Oncology, IEO-European Institute of Oncology, Via Adamello 16, 20139 Milan (Italy).

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July 2014

Optimization of 6,6-dimethyl pyrrolo[3,4-c]pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing.

Authors:
Maria Gabriella Brasca Clara Albanese Rachele Alzani Raffaella Amici Nilla Avanzi Dario Ballinari James Bischoff Daniela Borghi Elena Casale Valter Croci Francesco Fiorentini Antonella Isacchi Ciro Mercurio Marcella Nesi Paolo Orsini Wilma Pastori Enrico Pesenti Paolo Pevarello Patrick Roussel Mario Varasi Daniele Volpi Anna Vulpetti Marina Ciomei

Bioorg Med Chem 2010 Mar 25;18(5):1844-53. Epub 2010 Jan 25.

Nerviano Medical Sciences Srl, Business Unit Oncology, Viale Pasteur 10, 20014 Nerviano (MI), Italy.

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March 2010

Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors.

Authors:
Florian Thaler Andrea Colombo Antonello Mai Raffaella Amici Chiara Bigogno Roberto Boggio Anna Cappa Simone Carrara Tiziana Cataudella Fulvia Fusar Eleonora Gianti Samuele Joppolo di Ventimiglia Maurizio Moroni Davide Munari Gilles Pain Nickolas Regalia Luca Sartori Stefania Vultaggio Giulio Dondio Stefania Gagliardi Saverio Minucci Ciro Mercurio Mario Varasi

J Med Chem 2010 Jan;53(2):822-39

Genextra Group, Congenia s.r.l., Via Adamello 16, 20139 Milan, Italy.

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January 2010

Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships.

Authors:
Ermes Vanotti Raffaella Amici Alberto Bargiotti Jens Berthelsen Roberta Bosotti Antonella Ciavolella Alessandra Cirla Cinzia Cristiani Roberto D'Alessio Barbara Forte Antonella Isacchi Katia Martina Maria Menichincheri Antonio Molinari Alessia Montagnoli Paolo Orsini Antonio Pillan Fulvia Roletto Alessandra Scolaro Marcellino Tibolla Barbara Valsasina Mario Varasi Daniele Volpi Corrado Santocanale

J Med Chem 2008 Feb 18;51(3):487-501. Epub 2008 Jan 18.

Nerviano Medical Sciences Srl, Viale Pasteur 10, 20014 Nerviano, Milano, Italy.

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February 2008

6-Substituted pyrrolo[3,4-c]pyrazoles: an improved class of CDK2 inhibitors.

Authors:
Maria Gabriella Brasca Clara Albanese Raffaella Amici Dario Ballinari Luca Corti Valter Croci Daniele Fancelli Francesco Fiorentini Marcella Nesi Paolo Orsini Fabrizio Orzi Wilma Pastori Ettore Perrone Enrico Pesenti Paolo Pevarello Federico Riccardi-Sirtori Fulvia Roletto Patrick Roussel Mario Varasi Anna Vulpetti Ciro Mercurio

ChemMedChem 2007 Jun;2(6):841-52

Oncology Business Unit, Department of Chemistry, Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano MI, Italy.

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June 2007

3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: a new class of CDK2 inhibitors.

Authors:
Paolo Pevarello Daniele Fancelli Anna Vulpetti Raffaella Amici Manuela Villa Valeria Pittalà Paola Vianello Alexander Cameron Marina Ciomei Ciro Mercurio James R Bischoff Fulvia Roletto Mario Varasi Maria Gabriella Brasca

Bioorg Med Chem Lett 2006 Feb 14;16(4):1084-90. Epub 2005 Nov 14.

Department of Chemistry, Nerviano Medical Science, BU-Oncology, Via Pasteur 10, 20014 Nerviano MI, Italy.

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February 2006

Structure-based drug design to the discovery of new 2-aminothiazole CDK2 inhibitors.

Authors:
Anna Vulpetti Elena Casale Fulvia Roletto Raffaella Amici Manuela Villa Paolo Pevarello

J Mol Graph Model 2006 Mar 2;24(5):341-8. Epub 2005 Nov 2.

Department of Chemistry, Nerviano Medical Sciences, Discovery Research Oncology, Viale Pasteur 10, 20014 Nerviano (MI), Italy.

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March 2006

3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding.

Authors:
Paolo Pevarello Maria Gabriella Brasca Raffaella Amici Paolo Orsini Gabriella Traquandi Luca Corti Claudia Piutti Pietro Sansonna Manuela Villa Betsy S Pierce Maurizio Pulici Patrizia Giordano Katia Martina Edward L Fritzen Richard A Nugent Elena Casale Alexander Cameron Marina Ciomei Fulvia Roletto Antonella Isacchi GianPaolo Fogliatto Enrico Pesenti Wilma Pastori Aurelio Marsiglio Karen L Leach Paula M Clare Francesco Fiorentini Mario Varasi Anna Vulpetti Martha A Warpehoski

J Med Chem 2004 Jun;47(13):3367-80

Chemistry Department, Pharmacia Italia, Viale Pasteur 10, 20014 Nerviano (MI), Italy.

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June 2004