Raffaele De Francesco

Raffaele De Francesco

UNVERIFIED PROFILE

Are you Raffaele De Francesco?   Register this Author

Register author
Raffaele De Francesco

Raffaele De Francesco

Publications by authors named "Raffaele De Francesco"

Are you Raffaele De Francesco?   Register this Author

81Publications

1857Reads

16Profile Views

The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance?

Trends Immunol 2017 07 23;38(7):498-512. Epub 2017 May 23.

INGM, Istituto Nazionale Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy; DISCCO, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.it.2017.04.006DOI Listing
July 2017

NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains.

PLoS Pathog 2017 Jun 8;13(6):e1006343. Epub 2017 Jun 8.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1006343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464671PMC
June 2017

Interleukin 28B genotype and insulin resistance in chronic hepatitis C patients.

Antivir Ther 2014 12;19(8):747-53. Epub 2014 Feb 12.

Centro A.M. e A. Migliavacca, First Division of Gastroenterology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Università degli Studi di Milano, Milan, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3851/IMP2743DOI Listing
September 2015

Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C.

PLoS One 2014 29;9(8):e106022. Epub 2014 Aug 29.

Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Milano, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106022PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149487PMC
June 2015

Daclatasvir: a team player rather than a prima donna in the treatment of hepatitis C.

Gut 2015 Jun 5;64(6):860-2. Epub 2014 Sep 5.

Fondazione INGM, Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi", Milan, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2014-307958DOI Listing
June 2015

In vitro antibiofilm activity of bioactive glass S53P4.

Future Microbiol 2014 ;9(5):593-601

Laboratory of Clinical Chemistry & Microbiology, IRCCS Galeazzi Orthopaedic Institute, Via R. Galeazzi 4, 20161 Milan, Italy.

View Article

Download full-text PDF

Source
https://www.futuremedicine.com/doi/10.2217/fmb.14.20
Publisher Site
http://dx.doi.org/10.2217/fmb.14.20DOI Listing
April 2015

Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.

Gastroenterology 2014 Aug 22;147(2):453-62.e7. Epub 2014 Apr 22.

Departments of Medicine and Microbiology and Immunology and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2014.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107048PMC
August 2014

Photodynamic antibacterial and antibiofilm activity of RLP068/Cl against Staphylococcus aureus and Pseudomonas aeruginosa forming biofilms on prosthetic material.

Int J Antimicrob Agents 2014 Jul 21;44(1):47-55. Epub 2014 May 21.

Laboratory of Clinical Chemistry and Microbiology, IRCCS Galeazzi Orthopaedic Institute, Milan, Italy; Laboratory of Technical Sciences for Laboratory Medicine, Department of Biomedical Science for Health, University of Milan, Milan, Italy. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijantimicag.2014.03.012DOI Listing
July 2014

Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.

Gastroenterology 2014 May 8;146(5):1373-85.e1-11. Epub 2014 Feb 8.

Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan; Division of Gastroenterology, Department of Internal Medicine, Ann Arbor Veterans Administration Health System, Ann Arbor, Michigan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2014.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992183PMC
May 2014

The association of IL28B genotype with the histological features of chronic hepatitis C is HCV genotype dependent.

Int J Mol Sci 2014 Apr 25;15(5):7213-24. Epub 2014 Apr 25.

Division of Gastroenterology and Hepatology, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan 20100, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms15057213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057668PMC
April 2014

Cirrhosis and rapid virological response to peginterferon plus ribavirin determine treatment outcome in HCV-1 IL28B rs12979860 CC patients.

Biomed Res Int 2013 9;2013:580796. Epub 2013 Jul 9.

Centro AM e A Migliavacca, First Division of Gastroenterology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Università degli Studi di Milano, Milano, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2013/580796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722882PMC
March 2014

Hepatitis C virus-specific directly acting antiviral drugs.

Curr Top Microbiol Immunol 2013 ;369:289-320

Rega Institute for Medical Research, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-642-27340-7_12DOI Listing
August 2013

New horizons in hepatitis C antiviral therapy with direct-acting antivirals.

Hepatology 2013 Jul 31;58(1):428-38. Epub 2013 May 31.

A.M. e A. Migliavacca Center for the Study of Liver Disease 1st Division of Gastroenterology, Fondazione IRCCS Cá Granda Ospedale Maggiore Policlinico Milan Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.26371DOI Listing
July 2013

IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B.

Hepatology 2013 Mar 20;57(3):890-6. Epub 2012 Dec 20.

Migliavacca Center for the Study of Liver Disease, First Division of Gastroenterology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.25749DOI Listing
March 2013

Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4.

Hepatology 2012 Feb 3;55(2):336-42. Epub 2012 Jan 3.

Centro AM e A Migliavacca, First Division of Gastroenterology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Università degli Studi di Milano, Milan, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.24683DOI Listing
February 2012

Mechanism of hepatitis C virus RNA polymerase inhibition with dihydroxypyrimidines.

Antimicrob Agents Chemother 2010 Mar 22;54(3):977-83. Epub 2009 Dec 22.

Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada H3A 2B4.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01216-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825958PMC
March 2010

Naturally occurring hepatitis C virus subgenomic deletion mutants replicate efficiently in Huh-7 cells and are trans-packaged in vitro to generate infectious defective particles.

J Virol 2009 Sep 8;83(18):9079-93. Epub 2009 Jul 8.

Istituto di Ricerche di Biologia Molecolare P. Angeletti, Merck Research Laboratories, Via Pontina km 30,600, I-00040 Pomezia, Roma, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00308-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738267PMC
September 2009

Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture.

Bioorg Med Chem Lett 2009 Mar 27;19(6):1779-83. Epub 2009 Jan 27.

Department of Medicinal Chemistry, Istituto di Ricerche di Biologia Molecolare "P. Angeletti" S.p.A., Merck Research Laboratories Rome, 00040 Pomezia, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2009.01.066DOI Listing
March 2009

Binding of a noncovalent inhibitor exploiting the S' region stabilizes the hepatitis C virus NS3 protease conformation in the absence of cofactor.

J Mol Biol 2009 Jan 24;385(4):1142-55. Epub 2008 Nov 24.

Department of Chemical Science and Technology, Università di Roma Tor Vergata Via della Ricerca Scientifica 1, 00133 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2008.11.017DOI Listing
January 2009

Development and optimization of a binding assay for histone deacetylase 4 using surface plasmon resonance.

Anal Biochem 2008 Jun 22;377(2):267-9. Epub 2008 Mar 22.

Istituto di Ricerche di Biologia Molecolare P. Angeletti, Via Pontina Km 30.600, 00040 Pomezia (Rome), Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2008.03.028DOI Listing
June 2008

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.

Bioorg Med Chem Lett 2008 Mar 14;18(6):1814-9. Epub 2008 Feb 14.

IRBM/Merck Research Laboratories, Via Pontina km 30,600, 00040 Pomezia, Italy.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0960894X080020
Publisher Site
http://dx.doi.org/10.1016/j.bmcl.2008.02.025DOI Listing
March 2008

Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3.

Biochim Biophys Acta 2008 Feb 21;1783(2):334-44. Epub 2007 Nov 21.

IRBM P. Angeletti, via Pontina, Pomezia, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamcr.2007.11.004DOI Listing
February 2008

Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus.

Adv Drug Deliv Rev 2007 Oct 11;59(12):1242-62. Epub 2007 Aug 11.

Istituto di Ricerche di Biologia Molecolare, P. Angeletti, Via Pontina Km 30,600, 00040 Pomezia (Rome), Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.addr.2007.04.016DOI Listing
October 2007

Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex.

EMBO Rep 2007 Sep 10;8(9):879-84. Epub 2007 Aug 10.

Istituto di Ricerche di Biologia Molecolare P. Angeletti, Via Pontina Km 30.600, 00040 Pomezia, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.embor.7401047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1973954PMC
September 2007

Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication?

Virology 2007 Jul 2;364(1):1-9. Epub 2007 Apr 2.

Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S004268220700062
Publisher Site
http://dx.doi.org/10.1016/j.virol.2007.01.042DOI Listing
July 2007

Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors.

J Biol Chem 2007 Feb 13;282(8):5536-44. Epub 2006 Dec 13.

Istituto di Ricerche di Biologia Molecolare "P. Angeletti," Via Pontina Km 30.6, 00040 Pomezia, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M610486200DOI Listing
February 2007

The alpha isoform of protein kinase CKI is responsible for hepatitis C virus NS5A hyperphosphorylation.

J Virol 2006 Nov 30;80(22):11305-12. Epub 2006 Aug 30.

Istituto di Ricerche di Biologia Molecolare "P. Angeletti," 00040 Pomezia (Roma), Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01465-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1642135PMC
November 2006

Challenges and successes in developing new therapies for hepatitis C.

Nature 2005 Aug;436(7053):953-60

Istituto di Ricerche di Biologia Molecolare P. Angeletti, Via Pontina km 30.600, 00040 Pomezia-Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature04080DOI Listing
August 2005

The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase.

Bioorg Med Chem Lett 2004 Jun;14(12):3257-61

Department of Medicinal Chemistry and Biochemistry, IRBM-MRL Rome, Via Pontina, Km 30.600, 00040 Pomezia (Rome), Italy.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0960894X040046
Publisher Site
http://dx.doi.org/10.1016/j.bmcl.2004.03.087DOI Listing
June 2004

Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase.

Antiviral Res 2003 Mar;58(1):1-16

Instituto di Ricerche di Biologia Molecolare, P. Angeletti, 00040 Pomezia-Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0166-3542(03)00028-7DOI Listing
March 2003

New therapies on the horizon for hepatitis C: are we close?

Clin Liver Dis 2003 Feb;7(1):211-42, xi

Istituto di Ricerche di Biologia Molecolare P. Angeletti, Via Pontina KM 30,600, 00040 Pomezia, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1089-3261(02)00069-7DOI Listing
February 2003

A scintillation proximity active site binding assay for the hepatitis C virus serine protease.

Anal Biochem 2002 Aug;307(1):99-104

Department of Biochemistry, Istituto di Ricerche di Biologia Molecolare P.Angeletti (IRBM), Merck Research Laboratories, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0003-2697(02)00013-1DOI Listing
August 2002

Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides.

J Virol 2002 Apr;76(7):3482-92

Laboratoire de Virologie Moléculaire Structurale, Génétique des Virus, UMR 1157, CNRS-INRA, F-91198 Gif-sur-Yvette Cedex, France.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136026PMC
http://dx.doi.org/10.1128/jvi.76.7.3482-3492.2002DOI Listing
April 2002

A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease.

Bioorg Med Chem Lett 2002 Feb;12(4):701-4

Department of Chemistry, IRBM, MRL Rome, Via Pontina Km 30.600, Pomezia, 00040, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0960-894x(01)00842-3DOI Listing
February 2002