Raffaela Rametta

Raffaela Rametta

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Raffaela Rametta

Raffaela Rametta

Publications by authors named "Raffaela Rametta"

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Genetic and Epigenetic Modifiers of Alcoholic Liver Disease.

Int J Mol Sci 2018 Dec 3;19(12). Epub 2018 Dec 3.

General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad. Granelli, via F Sforza 35, 20122 Milan, Italy.

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http://www.mdpi.com/1422-0067/19/12/3857
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http://dx.doi.org/10.3390/ijms19123857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320903PMC
December 2018

GNPAT p.D519G variant and iron metabolism during oral iron tolerance test.

Hepatology 2017 01 24;65(1):384-385. Epub 2016 Aug 24.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale, Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.1002/hep.28745DOI Listing
January 2017

The role of insulin resistance in nonalcoholic steatohepatitis and liver disease development--a potential therapeutic target?

Expert Rev Gastroenterol Hepatol 2016 5;10(2):229-42. Epub 2015 Dec 5.

a Department of Pathophysiology and Transplantation , Università degli Studi di Milano, and Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano , Milano , Italy.

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http://dx.doi.org/10.1586/17474124.2016.1110018DOI Listing
November 2016

Hepcidin resistance in dysmetabolic iron overload.

Liver Int 2016 10 6;36(10):1540-8. Epub 2016 Apr 6.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1111/liv.13124DOI Listing
October 2016

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.

Gastroenterology 2016 05 2;150(5):1219-1230.e6. Epub 2016 Feb 2.

Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden; Clinical Nutrition Unit, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy; Cardiology Department, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844071PMC
May 2016

High fat diet subverts hepatocellular iron uptake determining dysmetabolic iron overload.

PLoS One 2015 3;10(2):e0116855. Epub 2015 Feb 3.

Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Policlinico, Milano, Italy; Department of Pathophysiology and Transplantation, Metabolic Liver Diseases Research Center, Università degli Studi di Milano, Milano, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116855PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315491PMC
January 2016

Increased circulating adiponectin in males with chronic HCV hepatitis.

Eur J Intern Med 2015 Oct 17;26(8):635-9. Epub 2015 Aug 17.

Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Department of Pathophysiology and Transplantation, Centro Malattie Metaboliche del Fegato, Università degli Studi di Milano, Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2015.08.001DOI Listing
October 2015

Statin use and non-alcoholic steatohepatitis in at risk individuals.

J Hepatol 2015 Sep 14;63(3):705-12. Epub 2015 May 14.

Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Milan, Italy; Department of Pathophysiology and Transplantation (R.R., S.F., L.V.), Università degli Studi di Milano, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.05.006DOI Listing
September 2015

PNPLA3 I148M Variant Influences Circulating Retinol in Adults with Nonalcoholic Fatty Liver Disease or Obesity.

J Nutr 2015 Aug 1;145(8):1687-91. Epub 2015 Jul 1.

Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Medical and Surgical Sciences, Clinical Nutrition Unit, University Magna Graecia of Catanzaro, Catanzaro, Italy; and Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden

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http://dx.doi.org/10.3945/jn.115.210633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516767PMC
August 2015

Juvenile hemochromatosis associated with heterozygosity for novel hemojuvelin mutations and with unknown cofactors.

Ann Hepatol 2014 Sep-Oct;13(5):568-71

Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Policlinico, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

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May 2015

The UCP2 -866 G>A promoter region polymorphism is associated with nonalcoholic steatohepatitis.

Liver Int 2015 May 20;35(5):1574-80. Epub 2014 Nov 20.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Milan, Italy.

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http://dx.doi.org/10.1111/liv.12707DOI Listing
May 2015

Paradoxical dissociation between hepatic fat content and de novo lipogenesis due to PNPLA3 sequence variant.

J Clin Endocrinol Metab 2015 May 12;100(5):E821-5. Epub 2015 Mar 12.

Department of Molecular and Clinical Medicine (R.M.M, C.M, S.R., J.B.), University of Gothenburg, S-413 45 Gothenburg, Sweden; Department of Medicine, Cardiovascular Research Unit, Diabetes and Obesity Research Program (N.M., S.S., M.-R.T.), Heart and Lung Centre and Division of Endocrinology and Helsinki University Central Hospital, University of Helsinki, 00100 Helsinki, Finland; Department of Radiology, HUS Medical Imaging Center (N.L., A.H.), Helsinki University Central Hospital, University of Helsinki, 00100 Helsinki, Finland; Departments of Internal Medicine (R.R, S.F., L.V.), and General Surgery (E.M.), Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Policlinico, and Department of Pathophysiology and Transplantation Università degli Studi di Milano, 20122 Milano, Italy; and Department of Medical and Surgical Sciences (S.R.), Clinical Nutrition Unit, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.

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http://dx.doi.org/10.1210/jc.2014-4464DOI Listing
May 2015

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells.

Hum Mol Genet 2014 Aug 25;23(15):4077-85. Epub 2014 Mar 25.

Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory and Department of Medical and Surgical Sciences, Clinical Nutrition Unit, University Magna Graecia of Catanzaro, Catanzaro, Italy

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http://dx.doi.org/10.1093/hmg/ddu121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082369PMC
August 2014

Hepatic steatosis and PNPLA3 I148M variant are associated with serum Fetuin-A independently of insulin resistance.

Eur J Clin Invest 2014 Jul;44(7):627-33

Department of Pathophysiology and Transplantation, Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Università degli Studi di Milano, Milano, Italy.

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http://dx.doi.org/10.1111/eci.12280DOI Listing
July 2014

PNPLA3 I148M polymorphism, clinical presentation, and survival in patients with hepatocellular carcinoma.

PLoS One 2013 14;8(10):e75982. Epub 2013 Oct 14.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy ; Internal Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda - Ospedale Maggiore Policlinico Milano, Milano, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075982PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796509PMC
June 2014

A randomized trial of iron depletion in patients with nonalcoholic fatty liver disease and hyperferritinemia.

World J Gastroenterol 2014 Mar;20(11):3002-10

Luca Valenti, Anna Ludovica Fracanzani, Paola Dongiovanni, Serena Rovida, Raffaela Rametta, Erika Fatta, Edoardo Alessandro Pulixi, Silvia Fargion, Department of Pathophysiology and Transplantation, Metabolic Liver Diseases Research Center, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Policlinico, via F Sforza 35, 20122, Milano, Italy.

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http://www.wjgnet.com/1007-9327/full/v20/i11/3002.htm
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http://dx.doi.org/10.3748/wjg.v20.i11.3002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961977PMC
March 2014

Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease.

Diabetes 2013 Dec 29;62(12):4052-62. Epub 2013 Aug 29.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Internal Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda, Milano, Italy.

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http://dx.doi.org/10.2337/db13-0769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837035PMC
December 2013

A novel alpha1-antitrypsin null variant (PiQ0Milano ).

World J Hepatol 2013 Aug;5(8):458-61

Raffaela Rametta, Silvia Fargion, Luca Valenti, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milano, Italy.

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http://dx.doi.org/10.4254/wjh.v5.i8.458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767846PMC
August 2013

Dietary iron overload induces visceral adipose tissue insulin resistance.

Am J Pathol 2013 Jun 8;182(6):2254-63. Epub 2013 Apr 8.

Department of Pathophysiology and Transplantation, Centro Malattie Metaboliche del Fegato, Università degli Studi di Milano, and Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.

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http://dx.doi.org/10.1016/j.ajpath.2013.02.019DOI Listing
June 2013

The A736V TMPRSS6 polymorphism influences hepatic iron overload in nonalcoholic fatty liver disease.

PLoS One 2012 5;7(11):e48804. Epub 2012 Nov 5.

Department of Pathophysiology and Transplantation, Section Internal Medicine, Università degli Studi, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico, Milano, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048804PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489825PMC
May 2013

Liver transplantation for hepatocellular carcinoma in a patient with a novel telomerase mutation and steatosis.

J Hepatol 2013 Feb 19;58(2):399-401. Epub 2012 Sep 19.

Section of Internal Medicine, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Italy.

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http://dx.doi.org/10.1016/j.jhep.2012.09.011DOI Listing
February 2013

The A736V TMPRSS6 polymorphism influences hepcidin and iron metabolism in chronic hemodialysis patients: TMPRSS6 and hepcidin in hemodialysis.

BMC Nephrol 2013 Feb 22;14:48. Epub 2013 Feb 22.

Department of Pathophysiology and Transplantation, Internal Medicine, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Milano, Italy.

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http://dx.doi.org/10.1186/1471-2369-14-48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585892PMC
February 2013

Effect of the A736V TMPRSS6 polymorphism on the penetrance and clinical expression of hereditary hemochromatosis.

J Hepatol 2012 Dec 8;57(6):1319-25. Epub 2012 Aug 8.

Department of Internal Medicine, UO Medicina Interna 1B, Università degli Studi, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico, Milano, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S016882781200617
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http://dx.doi.org/10.1016/j.jhep.2012.07.041DOI Listing
December 2012

The I148M PNPLA3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls.

BMC Gastroenterol 2012 Aug 16;12:111. Epub 2012 Aug 16.

Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.1186/1471-230X-12-111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444917PMC
August 2012

LPIN1 rs13412852 polymorphism in pediatric nonalcoholic fatty liver disease.

J Pediatr Gastroenterol Nutr 2012 May;54(5):588-93

Department of Internal Medicine, Università degli Studi, Ospedale Maggiore Policlinico Ca' Granda IRCCS, Milan, Italy.

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http://dx.doi.org/10.1097/MPG.0b013e3182442a55DOI Listing
May 2012

The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver.

J Hepatol 2011 Dec 21;55(6):1409-14. Epub 2011 Jul 21.

Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Ospedale Maggiore Ca' Granda Fondazione Policlinico IRCCS, Milan, Italy.

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http://dx.doi.org/10.1016/j.jhep.2011.03.035DOI Listing
December 2011

Serum hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in patients with metabolic syndrome alterations.

Arterioscler Thromb Vasc Biol 2011 Mar 23;31(3):683-90. Epub 2010 Dec 23.

Centro Malattie Metaboliche del Fegato, Department of Internal Medicine, Università degli Studi, Ospedale Maggiore Policlinico Ca' Granda IRCCS, Milano, Via F Sforza 35, 20122 Milano, Italy.

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http://dx.doi.org/10.1161/ATVBAHA.110.214858DOI Listing
March 2011

Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C.

Hepatology 2011 Mar 11;53(3):791-9. Epub 2011 Feb 11.

Department of Internal Medicine, Università degli Studi, Fondazione IRCCS Ospedale Maggiore Policlinico "Ca' Granda" IRCCS, Milan, Italy.

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http://doi.wiley.com/10.1002/hep.24123
Publisher Site
http://dx.doi.org/10.1002/hep.24123DOI Listing
March 2011

Beta-globin mutations are associated with parenchymal siderosis and fibrosis in patients with non-alcoholic fatty liver disease.

J Hepatol 2010 Nov 25;53(5):927-33. Epub 2010 Jul 25.

Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Fondazione Ospedale Policlinico MaRE IRCCS, Milan, Italy.

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http://dx.doi.org/10.1016/j.jhep.2010.05.023DOI Listing
November 2010

Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study.

BMC Gastroenterol 2010 Sep 8;10:102. Epub 2010 Sep 8.

Department of Internal Medicine, Metabolic Liver Diseases Research Center, Università degli Studi di Milano, Fondazione Ospedale Policlinico Ca' Granda IRCCS, Milano, Italy.

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http://dx.doi.org/10.1186/1471-230X-10-102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944335PMC
September 2010

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.

Hepatology 2010 Apr;51(4):1209-17

Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Fondazione Ospedale Policlinico MaRE Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.

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http://dx.doi.org/10.1002/hep.23622DOI Listing
April 2010

Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis.

Am J Pathol 2010 Feb 17;176(2):1006-17. Epub 2009 Dec 17.

Center of Metabolic and Liver Diseases, Department of Internal Medicine, University of Milano, Ospedale Policlinico Mangiagalli e Regina Elena Fondazione IRCCS, 20122 Milano, Italy.

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http://dx.doi.org/10.2353/ajpath.2010.090249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808103PMC
February 2010

HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients.

Clin J Am Soc Nephrol 2009 Aug 18;4(8):1331-7. Epub 2009 Jun 18.

Center for Metabolic and Liver Diseases, Department of Internal Medicine, Universitá degli Studi di Milano,Fondazione Ospedale Maggiore Policlinico MaRE IRCCS, Via F Sforza 35, 20122 Milano, Italy.

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http://dx.doi.org/10.2215/CJN.01370209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723967PMC
August 2009

HFE genotype influences erythropoiesis support requirement in hemodialysis patients: a prospective study.

Am J Nephrol 2008 16;28(2):311-6. Epub 2007 Nov 16.

Department of Internal Medicine, University of Milan, Ospedale Policlinico Mangiagalli e Regina Elena Fondazione IRCCS, Milan, Italy.

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http://dx.doi.org/10.1159/000111387DOI Listing
May 2008

Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis.

Diabetes 2008 May 3;57(5):1355-62. Epub 2008 Mar 3.

Department of Internal Medicine, Ospedale Maggiore Policlinico Mangiagalli Regina Elena IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), University of Milan, Milan, Italy.

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http://dx.doi.org/10.2337/db07-0714DOI Listing
May 2008

HFE gene mutations and oxidative stress influence serum ferritin, associated with vascular damage, in hemodialysis patients.

Am J Nephrol 2007 13;27(1):101-7. Epub 2007 Feb 13.

Department of Internal Medicine, University of Milano, Ospedale Policlinico Mangiagalli e Regina Elena Fondazione IRCCS, Milano, Italy.

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http://dx.doi.org/10.1159/000099635DOI Listing
April 2007

Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70.

FASEB J 2004 Nov 2;18(14):1713-5. Epub 2004 Sep 2.

Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

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http://dx.doi.org/10.1096/fj.04-1621fjeDOI Listing
November 2004