Rafael Simo

Rafael Simo

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Rafael Simo

Rafael Simo

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Adipocyte MTERF4 regulates non-shivering adaptive thermogenesis and sympathetic-dependent glucose homeostasis.

Biochim Biophys Acta Mol Basis Dis 2019 Jun 26;1865(6):1298-1312. Epub 2019 Jan 26.

Laboratory of Metabolism and Obesity, Vall d'Hebron - Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain; CIBERDEM, CIBER on Diabetes and Associated Metabolic Diseases, Instituto de Salud Carlos III, Barcelona, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439193002
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http://dx.doi.org/10.1016/j.bbadis.2019.01.025DOI Listing
June 2019

Sex Hormone-Binding Globulin Expression Correlates With Acetyl-Coenzyme A Carboxylase and Triglyceride Content in Human Liver.

J Clin Endocrinol Metab 2019 May;104(5):1500-1507

Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca, Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain.

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http://dx.doi.org/10.1210/jc.2018-00740DOI Listing
May 2019

Glutamate interactions with obesity, insulin resistance, cognition and gut microbiota composition.

Acta Diabetol 2019 May 19;56(5):569-579. Epub 2019 Mar 19.

Department of Diabetes, Endocrinology and Nutrition, Hospital of Girona "Dr Josep Trueta", Institut d'Investigació Biomèdica de Girona (IDIBGI), Avinguda de França s/n, 17007, Girona, Spain.

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http://dx.doi.org/10.1007/s00592-019-01313-wDOI Listing
May 2019

Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR.

Invest Ophthalmol Vis Sci 2019 May;60(6):2257-2262

Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d'Hebron (VHIR), Barcelona, Spain.

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http://dx.doi.org/10.1167/iovs.18-26487DOI Listing
May 2019

Effect of Glucose Improvement on Spirometric Maneuvers in Patients With Type 2 Diabetes: The Sweet Breath Study.

Diabetes Care 2019 Apr 31;42(4):617-624. Epub 2019 Jan 31.

Endocrinology and Nutrition Department, Hospital Universitari Arnau de Vilanova, Obesity, Diabetes and Metabolism Research Group (ODIM), Institut de Recerca Biomèdica de Lleida (IRBLleida), and Universitat de Lleida, Lleida, Catalonia, Spain

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http://dx.doi.org/10.2337/dc18-1948DOI Listing
April 2019

Lung function measurements in the prediabetes stage: data from the ILERVAS Project.

Acta Diabetol 2019 Apr 15. Epub 2019 Apr 15.

Endocrinology and Nutrition Department, Hospital Universitari Vall d'Hebron, Diabetes and Metabolism Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.

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http://link.springer.com/10.1007/s00592-019-01333-6
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http://dx.doi.org/10.1007/s00592-019-01333-6DOI Listing
April 2019

Association between diabetic eye disease and other complications of diabetes: Implications for care. A systematic review.

Diabetes Obes Metab 2019 Mar 29;21(3):467-478. Epub 2018 Oct 29.

University Hospital Llandough, Llandough, Wales, UK.

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http://doi.wiley.com/10.1111/dom.13550
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http://dx.doi.org/10.1111/dom.13550DOI Listing
March 2019

Comment on: "Glucagon-like peptide-1 receptor expression in the human eye".

Diabetes Obes Metab 2019 02 2;21(2):446-447. Epub 2018 Oct 2.

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1111/dom.13521DOI Listing
February 2019

Calorie restriction prevents diet-induced insulin resistance independently of PGC-1-driven mitochondrial biogenesis in white adipose tissue.

FASEB J 2019 Feb 2;33(2):2343-2358. Epub 2018 Oct 2.

Laboratory of Metabolism and Obesity, Vall d'Hebron-Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain.

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https://www.fasebj.org/doi/10.1096/fj.201800310R
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http://dx.doi.org/10.1096/fj.201800310RDOI Listing
February 2019

Effects of Topically Administered Neuroprotective Drugs in Early Stages of Diabetic Retinopathy: Results of the EUROCONDOR Clinical Trial.

Diabetes 2019 Feb 2;68(2):457-463. Epub 2018 Nov 2.

Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal, and Faculty of Medicine, University of Coimbra, Ophthalmology Department, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal.

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db18
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http://dx.doi.org/10.2337/db18-0682DOI Listing
February 2019

Usefulness of Eye Fixation Assessment for Identifying Type 2 Diabetic Subjects at Risk of Dementia.

J Clin Med 2019 Jan 8;8(1). Epub 2019 Jan 8.

Diabetes and Metabolism Research Unit. Vall d'Hebron Research Institute, 08035 Barcelona, Spain.

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http://dx.doi.org/10.3390/jcm8010059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352169PMC
January 2019

Assessment of advanced glycation end-products as a biomarker of diabetic outcomes.

Endocrinol Diabetes Nutr 2018 Nov 2;65(9):540-545. Epub 2018 Aug 2.

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.

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http://dx.doi.org/10.1016/j.endinu.2018.06.003DOI Listing
November 2018

The ERM complex: a new player involved in diabetes-induced vascular leakage.

Curr Med Chem 2018 Oct 16. Epub 2018 Oct 16.

Diabetes and Metabolism Research Unit. Vall d'Hebron Research Institute. Barcelona. Spain.

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http://dx.doi.org/10.2174/0929867325666181016162327DOI Listing
October 2018

Neurodegeneration in diabetic retinopathy: does it really matter?

Diabetologia 2018 09 20;61(9):1902-1912. Epub 2018 Jul 20.

Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1007/s00125-018-4692-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096638PMC
September 2018

Association of HMGB1 with oxidative stress markers and regulators in PDR.

Mol Vis 2017 5;23:853-871. Epub 2017 Dec 5.

Diabetes and Metabolism Research Unit and CIBERDEM (ISCIII).Vall d'Hebron Research Institute. Barcelona, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723152PMC
May 2018

Semaglutide, reduction in glycated haemoglobin and the risk of diabetic retinopathy.

Diabetes Obes Metab 2018 04 8;20(4):889-897. Epub 2018 Jan 8.

Department of Ophthalmology, Rigshospitalet and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

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http://doi.wiley.com/10.1111/dom.13172
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http://dx.doi.org/10.1111/dom.13172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888154PMC
April 2018

Silymarin prevents diabetes-induced hyperpermeability in human retinal endothelial cells.

Endocrinol Diabetes Nutr 2018 Apr 13;65(4):200-205. Epub 2018 Feb 13.

Diabetes and Metabolism Research Unit. Vall d'Hebron Research Institute. Universitat Autònoma de Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.endinu.2017.12.004DOI Listing
April 2018

Somatostatin and diabetic retinopathy: an evolving story.

Endocrine 2018 04 20;60(1):1-3. Epub 2018 Feb 20.

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, Barcelona, Spain.

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http://dx.doi.org/10.1007/s12020-018-1561-0DOI Listing
April 2018

Author Correction: Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox.

Sci Rep 2018 Mar 19;8(1):5046. Epub 2018 Mar 19.

Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca (VHIR). Universitat Autònoma de Barcelona and Biomedical Network Research Centre on Diabetes and Metabolic Diseases (CIBERDEM, ISCIII), Barcelona, Spain.

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http://dx.doi.org/10.1038/s41598-018-23159-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859090PMC
March 2018

Somatostatin protects photoreceptor cells against high glucose-induced apoptosis.

Mol Vis 2016 30;22:1522-1531. Epub 2016 Dec 30.

Alberto Sols Biomedical Research Institute (IIBm) (CSIC/UAM), 28029 Madrid, Spain; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERdem), ISCIII, Madrid, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204461PMC
January 2018

Response to oral sucrosomial iron supplementation in patients undergoing bariatric surgery. The BARI-FER study.

Endocrinol Diabetes Nutr 2018 Jan 7;65(1):17-20. Epub 2017 Dec 7.

Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Spain; Endocrinology and Nutrition Department, Vall d'Hebron University Hospital, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.endinu.2017.10.007DOI Listing
January 2018

Effects of Sotagliflozin Added to Insulin in Patients with Type 1 Diabetes.

N Engl J Med 2017 12 13;377(24):2337-2348. Epub 2017 Sep 13.

From the University of Colorado Denver, Aurora (S.K.G.); the University of California at San Diego, San Diego (R.R.H.); Lexicon Pharmaceuticals, The Woodlands (P.B., D.G.-P., P.L., P.S.), the University of Texas Southwestern Medical Center, Dallas (D.K.M.), and Baylor College of Medicine and Texas Children's Hospital, Houston (J.A.K.) - all in Texas; the Diabetes Research Center, University of North Carolina School of Medicine, Durham (J.B.B.); the University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, United Kingdom (M.J.D.); the University of Sydney, Sydney (G.R.F.); University Campus Bio-Medico of Rome, Rome (P.P.); Vall d'Hebron Research Institute, Barcelona, and CIBERDEM-Instituto de Salud Carlos III, Madrid (R.S.); Diabetes Center Auf der Bult, Hannover Medical School, Hannover, Germany (T.D.); and the University of Southern California, Los Angeles (A.P.).

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http://dx.doi.org/10.1056/NEJMoa1708337DOI Listing
December 2017

Pulmonary Function and Sleep Breathing: Two New Targets for Type 2 Diabetes Care.

Endocr Rev 2017 12;38(6):550-573

Respiratory Department, Hospital Universitari Arnau de Vilanova-Santa María, Institut de Recerca Biomédica de Lleida, Universitat de Lleida, Spain.

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http://dx.doi.org/10.1210/er.2017-00173DOI Listing
December 2017

A compartmentalized microfluidic chip with crisscross microgrooves and electrophysiological electrodes for modeling the blood-retinal barrier.

Lab Chip 2017 12;18(1):95-105

Institut de Microelectrònica de Barcelona, IMB-CNM (CSIC), 08193, Bellaterra, Barcelona, Spain.

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http://dx.doi.org/10.1039/c7lc00795gDOI Listing
December 2017

Topical administration of DPP-IV inhibitors prevents retinal neurodegeneration in experimental diabetes.

Diabetologia 2017 Nov 4;60(11):2285-2298. Epub 2017 Aug 4.

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, Pg. Vall d'Hebron 119-129, 08035, Barcelona, Spain.

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http://dx.doi.org/10.1007/s00125-017-4388-yDOI Listing
November 2017

Serum Surfactant Protein D as a Biomarker for Measuring Lung Involvement in Obese Patients With Type 2 Diabetes.

J Clin Endocrinol Metab 2017 11;102(11):4109-4116

Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, 28029 Madrid, Spain.

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http://academic.oup.com/jcem/article/102/11/4109/4157553
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http://dx.doi.org/10.1210/jc.2017-00913DOI Listing
November 2017

Calcium dobesilate prevents the oxidative stress and inflammation induced by diabetes in the retina of db/db mice.

J Diabetes Complications 2017 Oct 26;31(10):1481-1490. Epub 2017 Jul 26.

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2017.07.009DOI Listing
October 2017

Mechanisms of retinal neuroprotection of calcium dobesilate: therapeutic implications.

Neural Regen Res 2017 Oct;12(10):1620-1622

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, CIBERDEM (Instituto de Salud Carlos III), Barcelona, Spain.

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http://dx.doi.org/10.4103/1673-5374.217333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696841PMC
October 2017

Calcium Dobesilate Prevents Neurodegeneration and Vascular Leakage in Experimental Diabetes.

Curr Eye Res 2017 09 2;42(9):1273-1286. Epub 2017 Jun 2.

a Diabetes and Metabolism Research Unit , Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona , Barcelona , Spain.

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http://dx.doi.org/10.1080/02713683.2017.1302591DOI Listing
September 2017

Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox.

Sci Rep 2017 09 25;7(1):12284. Epub 2017 Sep 25.

Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca (VHIR). Universitat Autònoma de Barcelona and Biomedical Network Research Centre on Diabetes and Metabolic Diseases (CIBERDEM, ISCIII), Barcelona, Spain.

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http://dx.doi.org/10.1038/s41598-017-12509-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612985PMC
September 2017

Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment.

J Diabetes Complications 2017 Aug 19;31(8):1272-1274. Epub 2017 Apr 19.

Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10568727173031
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http://dx.doi.org/10.1016/j.jdiacomp.2017.04.018DOI Listing
August 2017

Global Assessment of the Impact of Type 2 Diabetes on Sleep through Specific Questionnaires. A Case-Control Study.

PLoS One 2016 17;11(6):e0157579. Epub 2016 Jun 17.

CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Diabetes and Metabolism Research Unit, Institut de Recerca i Hospital Universitari Vall d'Hebron (VHIR), Universitat Autònoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157579PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912108PMC
July 2017

Vision related quality of life in patients with type 2 diabetes in the EUROCONDOR trial.

Endocrine 2017 Jul 14;57(1):83-88. Epub 2016 Sep 14.

Laboratory of Clinical Pedagogy, Department of Medical Sciences, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1007/s12020-016-1097-0DOI Listing
July 2017

Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology.

J Diabetes Res 2016 8;2016:5263798. Epub 2016 Jun 8.

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Barcelona, Spain.

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http://dx.doi.org/10.1155/2016/5263798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916280PMC
June 2017

GLP-1R as a Target for the Treatment of Diabetic Retinopathy: Friend or Foe?

Diabetes 2017 06;66(6):1453-1460

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain, and Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain

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http://dx.doi.org/10.2337/db16-1364DOI Listing
June 2017

Osteoprotegerin Is a New Regulator of Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy.

Invest Ophthalmol Vis Sci 2017 06;58(7):3189-3201

Diabetes and Metabolism Research Unit and Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólica Asociada (CIBERDEM), Vall d'Hebron Research Institute, Barcelona, Spain.

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http://dx.doi.org/10.1167/iovs.16-20993DOI Listing
June 2017

Cognitive impairment and dementia: a new emerging complication of type 2 diabetes-The diabetologist's perspective.

Acta Diabetol 2017 May 16;54(5):417-424. Epub 2017 Feb 16.

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Pg. Vall d'Hebron 119-129, 08035, Barcelona, Spain.

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http://dx.doi.org/10.1007/s00592-017-0970-5DOI Listing
May 2017

Local and Systemic Inflammatory Biomarkers of Diabetic Retinopathy: An Integrative Approach.

Invest Ophthalmol Vis Sci 2017 05;58(6):BIO68-BIO75

Diabetes and Metabolism Research Unit, Institut de Recerca Hospital, Universitari Vall d'Hebron (VHIR), Barcelona, Spain 4CIBERDEM (Instituto de Salud Carlos III), Madrid, Spain.

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http://dx.doi.org/10.1167/iovs.17-21769DOI Listing
May 2017

Diabetic Retinopathy Phenotypes of Progression to Macular Edema: Pooled Analysis From Independent Longitudinal Studies of up to 2 Years' Duration.

Invest Ophthalmol Vis Sci 2017 05;58(6):BIO206-BIO210

Vall d'Hebron Research Institute (VHIR) and CIBERDEM (Instituto de Salud Carlos III), Barcelona, Spain.

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http://dx.doi.org/10.1167/iovs.17-21780DOI Listing
May 2017

Sex Hormone-Binding Globulin Reduction in Metabolic Disorders May Play a Role in NAFLD Development.

Endocrinology 2017 03;158(3):545-559

Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain.

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http://dx.doi.org/10.1210/en.2016-1668DOI Listing
March 2017

Type 2 diabetes, risk of sleep apnea-hypopnea syndrome, and quality of life associated to sleep breathing disorders.

Endocrinol Diabetes Nutr 2017 03 13;64(3):174-176. Epub 2017 Feb 13.

CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Spain; Diabetes and Metabolism Research Unit, Institut de Recerca i Hospital Universitari Vall d'Hebron (VHIR), Universitat Autònoma de Barcelona, Pg Vall d'Hebron 119-129, 08035 Barcelona, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S25300164173002
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http://dx.doi.org/10.1016/j.endinu.2016.10.009DOI Listing
March 2017

Diabetic macular oedema.

Lancet Diabetes Endocrinol 2017 02 3;5(2):143-155. Epub 2016 Aug 3.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(16)30052-3DOI Listing
February 2017

Development of a Normative Database for Multifocal Electroretinography in the Context of a Multicenter Clinical Trial.

Ophthalmic Res 2017 5;57(2):107-117. Epub 2017 Jan 5.

Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal.

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http://dx.doi.org/10.1159/000450958DOI Listing
February 2017

Effects of depressive symptoms on clinical outcomes, inflammatory markers and quality of life after a significant weight loss in a bariatric surgery sample.

Nutr Hosp 2017 Feb 1;34(1):81-87. Epub 2017 Feb 1.

Endocrinology and Nutrition Department. Hospital Son Llàtzer. Palma de Mallorca, Spain. University Institute of Health Sciences Research (IUNICS) and Health Research Institute of Palma (IdISPa). Palma de Mallorca.

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http://dx.doi.org/10.20960/nh.979DOI Listing
February 2017

Serum 1,25-Dihydroxyvitamin D as a Biomarker of the Absence of Hypercalciuria in Postsurgical Hypoparathyroidism.

J Clin Endocrinol Metab 2017 01;102(1):259-266

Diabetes Research and Metabolism Unit, Institut de Recerca Hospital Universitari Vall d'Hebron, Barcelona, 08035 Spain; and.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2016-2987DOI Listing
January 2017

Neuroprotection as a Therapeutic Target for Diabetic Retinopathy.

J Diabetes Res 2016 31;2016:9508541. Epub 2016 Mar 31.

Department of Biology, University of Pisa, Via San Zeno 31, 56127 Pisa, Italy; Interdepartmental Research Center Nutrafood "Nutraceuticals and Food for Health", University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.

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http://dx.doi.org/10.1155/2016/9508541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830713PMC
December 2016

Effects of the neuroprotective drugs somatostatin and brimonidine on retinal cell models of diabetic retinopathy.

Acta Diabetol 2016 Dec 23;53(6):957-964. Epub 2016 Aug 23.

Department of Medical Sciences, University of Turin, Corso AM Dogliotti 14, 10126, Turin, Italy.

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http://dx.doi.org/10.1007/s00592-016-0895-4DOI Listing
December 2016

New Treatments for Type 2 Diabetes Mellitus and Cardiovascular Disease. The Revolution Has Begun.

Rev Esp Cardiol (Engl Ed) 2016 Nov 19;69(11):1005-1007. Epub 2016 Sep 19.

Grupo de Investigación en Diabetes y Metabolismo y CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Instituto de Investigación Hospital Vall d'Hebron (VHIR), Barcelona, Spain.

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http://dx.doi.org/10.1016/j.rec.2016.07.009DOI Listing
November 2016

EndoG Knockout Mice Show Increased Brown Adipocyte Recruitment in White Adipose Tissue and Improved Glucose Homeostasis.

Endocrinology 2016 Oct 22;157(10):3873-3887. Epub 2016 Aug 22.

Laboratory of Metabolism and Obesity (R.P., M.V., J.A.V.) and Group of Diabetes and Metabolism (R.S.), Vall d'Hebron-Institut de Recerca, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain; Cell Signaling and Apoptosis Group (N.B., D.S.), Biomedical Research Institute of Lleida, University of Lleida, 25003 Lleida, Spain; Department of Physiology (D.B., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, Universidad de Santiago de Compostela, and Centro de Investigación Biomédica en Red on Physiopathology of Obesity and Nutrition (D.B., R.N.), 15705 Santiago de Compostela, Spain; Laboratory Animal Applied Research Platform (X.C.), Scientific Park of Barcelona, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red on Diabetes and Associated Metabolic Diseases (J.A.V. R.S.), 08003 Barcelona, Spain.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2015-1334DOI Listing
October 2016

Modulation of microglia polarization dynamics during diabetic retinopathy in db/db mice.

Biochim Biophys Acta 2016 09 4;1862(9):1663-74. Epub 2016 Jun 4.

Alberto Sols Biomedical Research Institute (IIBm) (CSIC/UAM), 28029 Madrid, Spain; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERdem), ISCIII, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.05.024DOI Listing
September 2016

Gene expression profiling in hearts of diabetic mice uncovers a potential role of estrogen-related receptor γ in diabetic cardiomyopathy.

Mol Cell Endocrinol 2016 07 7;430:77-88. Epub 2016 Apr 7.

Laboratory of Metabolism and Obesity, Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain; CIBER on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2016.04.004DOI Listing
July 2016

Obesity Determines the Immunophenotypic Profile and Functional Characteristics of Human Mesenchymal Stem Cells From Adipose Tissue.

Stem Cells Transl Med 2016 Apr 8;5(4):464-75. Epub 2016 Mar 8.

Hospital Universitari de Tarragona Joan XXIII, Institut d´Investigació Sanitària Pere Virgili Universitat Rovira i Virgili, Tarragona, Spain CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain

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http://dx.doi.org/10.5966/sctm.2015-0161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798735PMC
April 2016

The progress in understanding and treatment of diabetic retinopathy.

Prog Retin Eye Res 2016 Mar 18;51:156-86. Epub 2015 Aug 18.

Centre for Experimental Medicine, Queen's University Belfast, Northern Ireland, UK.

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http://dx.doi.org/10.1016/j.preteyeres.2015.08.001DOI Listing
March 2016

Diabetic retinopathy.

Nat Rev Dis Primers 2016 03 17;2:16012. Epub 2016 Mar 17.

Vall d'Hebron Research Institute and CIBERDEM (ISCIII), Barcelona, Spain.

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http://www.nature.com/articles/nrdp201612
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http://dx.doi.org/10.1038/nrdp.2016.12DOI Listing
March 2016

Fenofibrate prevents the disruption of the outer blood retinal barrier through downregulation of NF-κB activity.

Acta Diabetol 2016 Feb 5;53(1):109-18. Epub 2015 May 5.

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Pg. Vall d'Hebron 119-129, 08035, Barcelona, Spain.

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http://dx.doi.org/10.1007/s00592-015-0759-3DOI Listing
February 2016

Non-traditional systemic treatments for diabetic retinopathy: an evidence-based review.

Curr Med Chem 2015 ;22(21):2580-9

Diabetes and Metabolism Reseach Unit. Vall d'Hebron Research Institute. Universitat Autonoma de Barcelona and Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII). Barcelona, Spain Pg. Vall d'Hebron 119-129. 08035 Barcelona, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997935PMC
January 2016

Topical Administration of GLP-1 Receptor Agonists Prevents Retinal Neurodegeneration in Experimental Diabetes.

Diabetes 2016 Jan 17;65(1):172-87. Epub 2015 Sep 17.

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain CIBERDEM, Instituto de Salud Carlos III, Madrid, Spain.

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db15
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http://dx.doi.org/10.2337/db15-0443DOI Listing
January 2016

geoRge: A Computational Tool To Detect the Presence of Stable Isotope Labeling in LC/MS-Based Untargeted Metabolomics.

Anal Chem 2016 Jan 18;88(1):621-8. Epub 2015 Dec 18.

Centre for Omic Sciences, Universitat Rovira i Virgili , Avinguda Universitat 1, 43204 Reus, Spain.

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http://dx.doi.org/10.1021/acs.analchem.5b03628DOI Listing
January 2016

Eating disorders are frequent among type 2 diabetic patients and are associated with worse metabolic and psychological outcomes: results from a cross-sectional study in primary and secondary care settings.

Acta Diabetol 2015 Dec 5;52(6):1037-44. Epub 2015 Apr 5.

Endocrinology and Nutrition Department, Hospital Son LLàtzer, University Institute of Health Sciences Research (IUNICS) and Health Research Institute of Palma (IdISPa), Ctra, Manacor km 4, 07198, Palma de Mallorca, Baleares, Spain.

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http://link.springer.com/10.1007/s00592-015-0742-z
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http://dx.doi.org/10.1007/s00592-015-0742-zDOI Listing
December 2015

SHBG-C57BL/ksJ-db/db: A New Mouse Model to Study SHBG Expression and Regulation During Obesity Development.

Endocrinology 2015 Dec 6;156(12):4571-81. Epub 2015 Oct 6.

Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca, Universitat Autònoma de Barcelona and Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (Instituto Carlos III), 08035 Barcelona, Spain.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2015-1677DOI Listing
December 2015

Characterization of sleep breathing pattern in patients with type 2 diabetes: sweet sleep study.

PLoS One 2015 11;10(3):e0119073. Epub 2015 Mar 11.

CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Endocrinology Department, Diabetes and Metabolism Research Unit, Institut de Recerca i Hospital Universitari Vall d'Hebron (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356580PMC
November 2015

Beneficial effects of fenofibric acid on overexpression of extracellular matrix components, COX-2, and impairment of endothelial permeability associated with diabetic retinopathy.

Exp Eye Res 2015 Nov 18;140:124-129. Epub 2015 Aug 18.

Department of Medicine, Boston University School of Medicine, Boston, MA, USA; Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144835153000
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http://dx.doi.org/10.1016/j.exer.2015.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646846PMC
November 2015

Novel approaches for treating diabetic retinopathy based on recent pathogenic evidence.

Prog Retin Eye Res 2015 Sep 30;48:160-80. Epub 2015 Apr 30.

CIBERDEM (CIBER de Diabetes y Enfermedades Metabólicas Asociadas) and Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca (VHIR), Universitat Autónoma de Barcelona, 08035 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.preteyeres.2015.04.003DOI Listing
September 2015

Obesity induced by high fat diet attenuates postinfarct myocardial remodeling and dysfunction in adult B6D2F1 mice.

J Mol Cell Cardiol 2015 Jul 5;84:154-61. Epub 2015 May 5.

Laboratory of Experimental Cardiology, Department of Cardiology, Vall d'Hebron Research Institute, Autonomous University of Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.04.023DOI Listing
July 2015

Novel insights in SHBG regulation and clinical implications.

Trends Endocrinol Metab 2015 Jul 1;26(7):376-83. Epub 2015 Jun 1.

Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain. Electronic address:

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http://www.cell.com/trends/endocrinology-metabolism/pdf/S104
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http://dx.doi.org/10.1016/j.tem.2015.05.001DOI Listing
July 2015

Photocoagulation of human retinal pigment epithelium in vitro: unravelling the effects on ARPE-19 by transcriptomics and proteomics.

Acta Ophthalmol 2015 Jun 21;93(4):348-54. Epub 2015 Jan 21.

Unit on Vascular Diabetic Complications, Department of Clinical Sciences, Lund University Diabetes Center, Malmö, Sweden.

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http://dx.doi.org/10.1111/aos.12649DOI Listing
June 2015

Is fenofibrate a reasonable treatment for diabetic microvascular disease?

Curr Diab Rep 2015 May;15(5):24

Diabetes and Metabolism Research Unit. Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain,

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http://dx.doi.org/10.1007/s11892-015-0599-0DOI Listing
May 2015

[Decalogue of clinical recommendations on atherogenic dyslipidemia].

Clin Investig Arterioscler 2014 Jan-Feb;26(1):38-40. Epub 2013 Dec 21.

Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.

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http://dx.doi.org/10.1016/j.arteri.2013.11.007DOI Listing
April 2015

Effect of fenofibrate on retinal neurodegeneration in an experimental model of type 2 diabetes.

Acta Diabetol 2015 Feb 17;52(1):113-22. Epub 2014 Jul 17.

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Pg. Vall d'Hebron 119-129, 08035, Barcelona, Spain.

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http://link.springer.com/10.1007/s00592-014-0610-2
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http://dx.doi.org/10.1007/s00592-014-0610-2DOI Listing
February 2015

The db/db mouse: a useful model for the study of diabetic retinal neurodegeneration.

PLoS One 2014 16;9(5):e97302. Epub 2014 May 16.

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023966PMC
January 2015

Effect of glycemic control on nocturnal arterial oxygen saturation: a case-control study in type 2 diabetic patients.

J Diabetes 2015 Jan 10;7(1):133-8. Epub 2014 Sep 10.

CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Endocrinology Department, Diabetes and Metabolism Research Unit, Universitat Autònoma de Barcelona, Barcelona, Spain; Endocrinology and Nutrition Department, Arnau de Vilanova University Hospital, Universitat de Lleida, Lleida, Spain.

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http://dx.doi.org/10.1111/1753-0407.12197DOI Listing
January 2015

Thyroid hormone upregulates zinc-α2-glycoprotein production in the liver but not in adipose tissue.

PLoS One 2014 21;9(1):e85753. Epub 2014 Jan 21.

Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897515PMC
October 2014

Impact of glucose-lowering agents on the risk of cancer in type 2 diabetic patients. The Barcelona case-control study.

PLoS One 2013 21;8(11):e79968. Epub 2013 Nov 21.

Grup de Recerca en Diabetis i Metabolisme i CIBER de Diabetis i Malalties Metabòliques Associades (CIBERDEM), Institut de Recerca Hospital Vall d'Hebron, Barcelona, Spain ; Universitat Autònoma de Barcelona, Bellaterra, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836986PMC
September 2014

Glycogen storage in the human retinal pigment epithelium: a comparative study of diabetic and non-diabetic donors.

Acta Diabetol 2014 Aug 24;51(4):543-52. Epub 2014 Jan 24.

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Pg. Vall d'Hebron 119-129, 08035, Barcelona, Spain,

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http://dx.doi.org/10.1007/s00592-013-0549-8DOI Listing
August 2014

Adiponectin upregulates SHBG production: molecular mechanisms and potential implications.

Endocrinology 2014 Aug 14;155(8):2820-30. Epub 2014 May 14.

Diabetes and Metabolism Research Unit (R.S., C.S.-L., C.H., D.M.S.), Vall d'Hebron Institut de Recerca, 08035 Barcelona, Universitat Autónoma de Barcelona, 08193 Barcelona, Centro de Investigación Biomédica en Red, 28029 Madrid, Spain Endocrinology and Nutrition Unit (A.L.), Hospital Universitari Arnau de Vilanova, 25198 Lleida, Spain; Endocrine, Metabolic and Bariatric Unit (J.M.F.), General Surgery Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.

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http://dx.doi.org/10.1210/en.2014-1072DOI Listing
August 2014

Somatostatin and diabetic retinopathy: current concepts and new therapeutic perspectives.

Endocrine 2014 Jun 14;46(2):209-14. Epub 2014 Mar 14.

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Pg. Vall d'Hebron 119-129.08035, Barcelona, Spain.

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http://dx.doi.org/10.1007/s12020-014-0232-zDOI Listing
June 2014

Advanced glycation end products are associated with arterial stiffness in type 1 diabetes.

J Endocrinol 2014 Jun 28;221(3):405-13. Epub 2014 Mar 28.

Department of DiabetesEndocrinology and Nutrition, Hospital de Sabadell, Corporació Sanitària i Universitària Parc Taulí (Universitat Autònoma de Barcelona), Parc Taul s/n, 08208 Sabadell, SpainCentro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y la Nutrición (CIBERobn)Hospital Clínico Virgen de la Victoria, Málaga, SpainDiabetesEndocrinology and Nutrition Unit, Hospital Sant Joan de Déu de Manresa, Xarxa Assistencial Althaia, Manresa, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) and Diabetes and Metabolism Research UnitInstitut de Recerca Hospital Universitari Vall d'Hebrón (VHIR), Universitat Autònoma de Barcelona, Barcelona, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)Hospital Universitari Joan XXIII de Tarragona, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain

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http://joe.endocrinology-journals.org/cgi/doi/10.1530/JOE-13
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http://dx.doi.org/10.1530/JOE-13-0407DOI Listing
June 2014

Association between plasma triglycerides and high-density lipoprotein cholesterol and microvascular kidney disease and retinopathy in type 2 diabetes mellitus: a global case-control study in 13 countries.

Circulation 2014 Mar 18;129(9):999-1008. Epub 2013 Dec 18.

Nutrition Department, Harvard School of Public Health, Boston, MA (F.M.S., L.B.); Cliniques universitaires Saint Luc, Université catholique de Louvain, Brussels, Belgium (M.P.H.); Department of Medicine, University of Padova, Padova, Italy (P.F., I.B.); Department of Endocrinology Diabetology Nutrition, Jean Verdier Hospital, AP-HP, Le Centre de Recherché en Nutrition Humaine d'Ille de France, Paris Nord University, Bondy, France (P.V.); University of Western Australia, Crawley, Australia (T.D.); Harvard Medical School, Joslin Diabetes Center, Boston, MA (E.H., S.H.-B.); University of Würzburg, Würzburg, Germany (C.W.); College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia (K.A.-R.); LMC Diabetes and Endocrinology, Toronto, Ontario, Canada (R.A.); Department of Medicine, Section of Endocrinology, University of Verona, Verona, Italy (E.B., G.Z.); Ramathibodi Hospital, Bangkok, Thailand (P.B.); Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (L.-M.C., Y.-D.J.); Rangsit School of Medicine, Rajavithi Hospital, Bangkok, Thailand (C.D.); North York General Hospital and LMC Diabetes and Endocrinology Centres, Toronto, Ontario, Canada (R.G.); Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA (B.H., N.L., V.J.C.); CIBERDEM and Vall d'Hebron Research Institute, Barcelona, Spain (C.H., R.S.); Keio University School of Medicine, Tokyo, Japan (H.I., M.T.); Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Jiaotong University, Affiliated Sixth People's Hospital, Shanghai, China (W.J.); Department of Diabetes and Metabolic Diseases, The University of Tokyo, Tokyo, Japan (T.K.); University of Toronto, Toronto, Ontario, Canada (L.L.); Tokyo Medical University, Tokyo, Japan (T.M., M.O.); Department of General Internal Medicine, National Cancer Center Hospital, Tokyo, Japan (K.O.); Tokyo Medical University Hachioji Medical Center, Tokyo, Japan (A.O.); Beijing 301 Mili

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March 2014

Use of expert consensus to improve atherogenic dyslipidemia management.

Rev Esp Cardiol (Engl Ed) 2014 Jan 8;67(1):36-44. Epub 2013 Nov 8.

Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.rec.2013.06.011DOI Listing
January 2014

Genetics in diabetic retinopathy: current concepts and new insights.

Curr Genomics 2013 Aug;14(5):289-99

Diabetes and Metabolism Research Unit. Vall d'Hebron Research Institute. Universitat Autònoma de Barcelona, Spain; ; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Spain.

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http://dx.doi.org/10.2174/13892029113149990008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763680PMC
August 2013