Publications by authors named "Rafael Salguero-Bodes"

23 Publications

  • Page 1 of 1

Potential Role of Natriuretic Response to Furosemide Stress Test During Acute Heart Failure.

Circ Heart Fail 2021 Jun 15;14(6):e008166. Epub 2021 Jun 15.

Servicio de Cardiología, Hospital Universitario 12 de Octubre, Madrid, Spain (P.C.P., J.N., L.M.F., Z.B.-B., J.C.L.-A., J.d.J.B., M.D.G.-C.C., P.E.S., R.S.-B., F.A.Y., J.F.D.).

Background: Poor natriuresis has been associated with a poorer response to diuretic treatment and worse prognosis in acute heart failure. Recommendations on how and when to measure urinary sodium (UNa) are lacking. We aim to evaluate UNa quantification after a furosemide stress test (FST) capacity to predict appropriate decongestion during acute heart failure hospitalization.

Methods: Patients underwent an FST on day-1 of admission, and UNa was measured 2 hours after, dividing patients into low or high UNa based on the sample median value. A semiquantitative composite congestive score (CCS; 0-9) and NT pro-BNP (N-terminal pro-B-type natriuretic peptide) quantification were assessed before the FST and at day 5 after the FST.

Results: Median UNa after FST in the 65 patients included was 113 (97-122) mmol/L. At day 5, a lower proportion of patients with a low UNa reached a 30% decrease in NT-proBNP levels (21 [66%] for low UNa versus 31 [94%] for high UNa; =0.005) and an appropriate grade of decongestion (CCS<3) (20 [62%] for low UNa versus 32 [97%] for high UNa; <0.001). A UNa>83 mmol/L 2 hours after FST had a 96% sensitivity to predict an NT-proBNP reduction ≥30% and 95% to predict a CCS<3 at day 5. Low UNa patients presented a lower cumulative diuresis and weight loss and presented more often with prolonged hospitalization, worsening heart failure, and readmission because of acute heart failure or death at 6 months.

Conclusions: Low natriuresis after an FST identified patients at a higher risk of an inadequate diuretic response and an inappropriate decongestion. FST-guided diuretic treatment might help to improve decongestion, shorten hospitalizations, and to reduce adverse outcomes.
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.120.008166DOI Listing
June 2021

Cardiovascular effects of mexiletine for treatment of myotonia in myotonic dystrophy type 1.

Rev Esp Cardiol (Engl Ed) 2021 Jun 10. Epub 2021 Jun 10.

Servicio de Cardiología, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain; Centro de Investigación Biomédica en Red de enfermedades Cardiovasculares (CIBERCV), Spain; Departamento de Medicina, Facultad de Medicina, Universidad Complutense, Madrid, Spain.

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http://dx.doi.org/10.1016/j.rec.2021.04.016DOI Listing
June 2021

Percutaneous left atrial appendage closure in the presence of thrombus: a single-center experience.

Rev Esp Cardiol (Engl Ed) 2021 May 24. Epub 2021 May 24.

Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario 12 de Octubre, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Departamento de Medicina, Facultad de Medicina, Universidad Complutense, Madrid, Spain.

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http://dx.doi.org/10.1016/j.rec.2021.04.011DOI Listing
May 2021

Electrocardiogram Changes in the Spectrum of TTNtv Dilated Cardiomyopathy: Accuracy and Predictive Value of a New Index for LV-Changes Identification.

Heart Lung Circ 2021 May 13. Epub 2021 May 13.

Cardiology Department, 12 de Octubre University Hospital, Madrid, Spain; Research Institute i+12, 12 de Octubre University Hospital, Madrid, Spain; CIBER-CV (Biomedical Research Networking Centres, Cardiovascular Diseases), Institute of Health Carlos III, Madrid, Spain; Faculty of Medicine, Complutense University of Madrid, Spain.

Background: Truncating TTN variants (TTNtv) are the main cause of dilated cardiomyopathy (DCM). The dynamic nature of this entity has previously been described. Based on own empirical observations and previous evidences, this study assessed repolarisation patterns and the possible association with morphological and functional status of TTNtv-DCM patients.

Methods: Electrocardiograms (ECGs) of index patients with TTNtv-DCM and their relatives were included and matched in time with an echocardiogram. All individuals were classified into five phenotype groups: 1) Reduced left ventricle ejection fraction (LVEF <50%); 2) Recovered LVEF: at least 10% increase and LVEF >30% after optimal medical treatment; 3) Borderline phenotype (mildly enlarged ventricle and/or hyper-trabeculation); 4) Genotype positive, phenotype negative; and 5) Non-carriers. All electrocardiograms were evaluated by two blinded observers in qualitative and quantitative terms [T index (mm)=Σ T-wave amplitude (V5, V6, II, aVF)] and these data were compared with demographic and clinical information. The Δ T-index was calculated in those individuals with more than one electrocardiogram.

Results: Seventy-eight (78) electrocardiograms were included (46% female, mean age 50 years). T-index and prevalence of an abnormal T-wave had significantly different results among the groups (p<0.0001). Age and haemodynamic factors were shown to be ECG-modifiers, especially in phenotype-negative patients. T-index enabled individuals with reduced LVEF (<2.5) to be identified and to differentiate patients with favourable and unfavourable responses to treatment (Δ T index >3.5 and ≤2, respectively).

Conclusion: Repolarisation changes enabled characterisation of the spectrum of TTNtv-DCM. The T-index identified potential carriers and patients with the worst profiles of the spectrum of the disease.
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http://dx.doi.org/10.1016/j.hlc.2021.04.011DOI Listing
May 2021

Metabolic "ace of spades" in apical hypertrophic cardiomyopathy.

Rev Esp Cardiol (Engl Ed) 2021 03 7;74(3):264. Epub 2020 Nov 7.

Servicio de Cardiología, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain; Centro de Investigación en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Departamento de Medicina, Facultad de Medicina, Universidad Complutense, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.rec.2020.08.030DOI Listing
March 2021

First experience in Spain of cardiac contractility modulation. A new alternative for patients with heart failure.

Rev Esp Cardiol (Engl Ed) 2020 Oct 6;73(10):855-857. Epub 2020 May 6.

Servicio de Cardiología, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain; Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares, CIBERCV, Madrid, Spain; Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.

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http://dx.doi.org/10.1016/j.rec.2020.04.003DOI Listing
October 2020

Clinical characteristics and determinants of the phenotype in TMEM43 arrhythmogenic right ventricular cardiomyopathy type 5.

Heart Rhythm 2020 06 13;17(6):945-954. Epub 2020 Feb 13.

Department of Cardiology, Hospital Universitario Puerta de Hierro, Madrid, Spain; CIBERCV, Madrid, Spain; Universidad Francisco de Vitoria (UFV), Pozuelo de Alarcón, Spain. Electronic address:

Background: Arrhythmogenic right ventricular cardiomyopathy type V (ARVC-5) is the most aggressive heterozygous form of ARVC. It is predominantly caused by a fully penetrant mutation (p.S358L) in the nondesmosomal gene TMEM43-endemic to Newfoundland, Canada. To date, all familial cases reported worldwide share a common ancestral haplotype. It is unknown whether the p.S358L mutation by itself causes ARVC-5 or whether the disease is influenced by genetic or environmental factors.

Objective: The purpose of this study was to examine the phenotype, clinical course, and the impact of exercise on patients with p.S358L ARVC-5 without the Newfoundland genetic background.

Methods: We studied 62 affected individuals and 73 noncarriers from 3 TMEM43-p.S358L Spanish families. The impact of physical activity on the phenotype was also evaluated.

Results: Haplotype analysis revealed that the 3 Spanish families were unrelated to patients with ARVC-5 with the Newfoundland genetic background. Two families shared 10 microsatellite markers in a 4.9 cM region surrounding TMEM43; the third family had a distinct haplotype. The affected individuals showed a 38.7% incidence of sudden cardiac death, which was higher in men. Left ventricular involvement was common, with 40% of mutation carriers showing a left ventricular ejection fraction of <50%. Compared with noncarriers, the R-wave voltage in lead V was lower (3.2 ± 2.8 mV vs 7.5 ± 3.6 mV; P < .001) and QRS complex in right precordial leads wider (104.7 ± 24.0 ms vs 88.2 ± 7.7 ms; P = .001). A history of vigorous exercise showed a trend toward more ventricular arrhythmias only in women (P = .053).

Conclusion: ARVC-5 is associated with a high risk of sudden cardiac death and characteristic clinical and electrocardiographic features irrespective of geographical origin and genetic background. Our data suggest that, as in desmosomal ARVC, vigorous physical activity could aggravate the phenotype of TMEM43 mutation carriers.
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http://dx.doi.org/10.1016/j.hrthm.2020.01.035DOI Listing
June 2020

Truncating titin variants in dilated cardiomyopathy: not only LVEF recovery, but also maintenance.

Rev Esp Cardiol (Engl Ed) 2020 Jul 5;73(7):589-592. Epub 2020 Feb 5.

Servicio de Cardiología, Hospital Universitario 12 de Octubre, Madrid, Spain; Instituto de Investigación i+12, Hospital Universitario 12 de Octubre, Madrid, Spain; Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain.

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http://dx.doi.org/10.1016/j.rec.2019.12.005DOI Listing
July 2020

A novel complex structural genetic variant in DSP causing a form of arrhythmogenic cardiomyopathy.

Rev Esp Cardiol (Engl Ed) 2020 Mar 29;73(3):269-271. Epub 2019 Aug 29.

Unidad de Cardiopatías Heredables, Servicio de Cardiología, Hospital Universitario 12 de Octubre, Madrid, Spain; Instituto de investigación 12 de Octubre i+12, Madrid, Spain; Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.

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http://dx.doi.org/10.1016/j.rec.2019.07.011DOI Listing
March 2020

A new mutation affecting the converter region of the beta-myosin heavy chain related to hypertrophic cardiomyopathy with poor prognosis.

Rev Esp Cardiol (Engl Ed) 2020 Feb 12;73(2):180-183. Epub 2019 Aug 12.

Servicio de Cardiología, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain; Centro de Investigación Biomédica en Red de enfermedades CardioVasculares (CIBERCV), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.rec.2019.07.001DOI Listing
February 2020

Response by Roldan-Sevilla to Letter Regarding Article, "Missense Mutations in the FLNC Gene Causing Familial Restrictive Cardiomyopathy".

Circ Genom Precis Med 2019 07 15;12(7):e002622. Epub 2019 Jul 15.

Cardiology department, Hospital Universitario 12 de Octubre, Instituto de Investigación i+12 (Á.R.-S., R.S.-B., M.V.-G., J.D., F.A.-Y., J.P.-D.).

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http://dx.doi.org/10.1161/CIRCGEN.119.002622DOI Listing
July 2019

Myocardial Extracellular Volume Is Not Associated With Malignant Ventricular Arrhythmias in High-risk Hypertrophic Cardiomyopathy.

Rev Esp Cardiol (Engl Ed) 2017 Nov 22;70(11):933-940. Epub 2017 Mar 22.

Área de Fisiopatología del Miocardio, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Instituto de Salud Carlos III, Madrid, Spain; CIBER de enfermedades CardioVasculares (CIBERCV), Spain; Departamento de Cardiología, IIS-Hospital Fundación Jiménez Díaz, Madrid, Spain. Electronic address:

Introduction And Objectives: Myocardial interstitial fibrosis, a hallmark of hypertrophic cardiomyopathy (HCM), has been proposed as an arrhythmic substrate. Fibrosis is associated with increased extracellular volume (ECV), which can be quantified by computed tomography (CT). We aimed to analyze the association between CT-determined ECV and malignant ventricular arrhythmias.

Methods: A retrospective case-control observational study was conducted in HCM patients with implantable cardioverter-defibrillator, undergoing a CT-protocol with continuous iodine contrast infusion to determine equilibrium ECV. Left ventricular septal and lateral CT-determined ECV was compared between prespecified cases (malignant arrhythmia any time before CT scan) and controls (no prior malignant arrhythmias) and among ECV tertiles.

Results: A total of 78 implantable cardioverter-defibrillator HCM patients were included; 24 were women, with a mean age of 52.1 ± 15.6 years. Mean ECV ± standard deviation in the septal left ventricular wall and was 29.8% ± 6.3% in cases (n = 24) vs 31.9% ± 8.5% in controls (n = 54); P = .282. Mean ECV in the lateral wall was 24.5% ± 6.8% in cases vs 28.2% ± 7.4% in controls; P = .043. On comparison of the entire population according to septal ECV tertiles, no significant differences were found in the number of patients receiving appropriate shocks. Conversely, we found a trend (P = .056) for a higher number of patients receiving appropriate shocks in the lateral ECV lowest tertile.

Conclusions: Extracellular volume was not increased in implantable cardioverter-defibrillator HCM patients with malignant ventricular arrhythmias vs those without arrhythmias. Our findings do not support the use of ECV (a surrogate of diffuse fibrosis) as a predictor of arrhythmias in high-risk HCM patients.
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http://dx.doi.org/10.1016/j.rec.2017.01.026DOI Listing
November 2017

Association Between Mutations in the NKX2.5 Homeobox, Atrial Septal Defects, Ventricular Noncompaction and Sudden Cardiac Death.

Rev Esp Cardiol (Engl Ed) 2018 Jan 17;71(1):53-55. Epub 2017 Mar 17.

Unidad de Cardiopatías Familiares, Hospital Universitario 12 de Octubre, Madrid, Spain.

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http://dx.doi.org/10.1016/j.rec.2017.02.032DOI Listing
January 2018

Delayed positive response to a flecainide test in a patient with suspected Brugada syndrome: a worrisome finding.

Rev Esp Cardiol (Engl Ed) 2014 Aug 14;67(8):674-5. Epub 2014 Jun 14.

Unidad de Arritmias y Electrofisiología, Servicio de Cardiología, Hospital 12 de Octubre, Madrid, Spain.

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http://dx.doi.org/10.1016/j.rec.2014.03.007DOI Listing
August 2014

Usefulness of exercise test in cardiac resynchronization therapy follow-up.

Rev Esp Cardiol (Engl Ed) 2013 Nov 31;66(11):912-3. Epub 2013 Aug 31.

Unidad de Arritmias, Servicio de Cardiología, Hospital 12 de Octubre, Madrid, Spain.

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http://dx.doi.org/10.1016/j.rec.2013.05.021DOI Listing
November 2013

Assessment of myocardial ischemia and viability using cardiac magnetic resonance.

Curr Cardiol Rep 2004 Jan;6(1):62-9

Clinical Cardiac MR/CT Imaging Program, Mount Sinai School of Medicine, Box 1030, One Gustave L. Levy Place, New York, NY 10029, USA.

Cardiac magnetic resonance (CMR) is a burgeoning area of noninvasive cardiac imaging. Today, its clinical utility spans from the qualitative and quantitative assessment of cardiac function and morphology to the challenging task of determining the severity and reversibility of coronary heart disease. Advances in magnet and coil design, pulse sequence, and contrast media have contributed greatly, helping CMR become the multipurpose tool of today's cardiac imaging. This article reviews and explores some of the most exciting clinical applications of CMR in the assessment of coronary artery disease.
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http://dx.doi.org/10.1007/s11886-004-0066-zDOI Listing
January 2004

[Primary cardiac lymphoma: diagnosis by transjugular biopsy].

Rev Esp Cardiol 2003 Nov;56(11):1141-4

Unidad de Hemodinámica y Cardiología Intervencionista. Hospital 12 de Octubre. Madrid. Spain.

Primary cardiac lymphoma, defined as a non-Hodgkin's lymphoma involving only the heart and pericardium, is an extremely rare malignancy. It should be suspected in patients with a heart mass and heart failure, unexplained refractory pericardial effusion or rhythm disturbances. Transvenous intracardiac tumor biopsy under fluoroscopic or transesophageal echocardiographic guidance, is a minimally invasive technique which makes definite diagnosis possible. We describe a patient in whom primary cardiac lymphoma was diagnosed by this technique. He also underwent percutaneous balloon pericardiotomy because of severe refractory pericardial effusion. Seven months after diagnosis and treatment with standard chemotherapy, the patient remained free of disease.
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http://dx.doi.org/10.1016/s0300-8932(03)77026-2DOI Listing
November 2003

[Dual left anterior descending coronary artery type IV].

Rev Esp Cardiol 2003 Sep;56(9):915

Unidad de Hemodinámica. Servicio de Cardiología. Hospital 12 de Octubre. Madrid. España.

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http://dx.doi.org/10.1016/s0300-8932(03)76980-2DOI Listing
September 2003
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