Rafael Maldonado

Rafael Maldonado

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Rafael Maldonado

Publications by authors named "Rafael Maldonado"

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Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain.

Elife 2020 Jan 14;9. Epub 2020 Jan 14.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.7554/eLife.50356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977967PMC
January 2020

Behavioral sensitization and cellular responses to psychostimulants are reduced in D2R knockout mice.

Addict Biol 2019 Dec 12:e12840. Epub 2019 Dec 12.

Instituto Cajal, Consejo Superior de Investigaciones Científicas, Madrid, Spain.

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http://dx.doi.org/10.1111/adb.12840DOI Listing
December 2019

THC exposure during adolescence does not modify nicotine reinforcing effects and relapse in adult male mice.

Psychopharmacology (Berl) 2019 Dec 19. Epub 2019 Dec 19.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, C/ Doctor Aiguader 88, 08003, Barcelona, Spain.

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http://dx.doi.org/10.1007/s00213-019-05416-8DOI Listing
December 2019

Auricular transcutaneous vagus nerve stimulation improves memory persistence in naïve mice and in an intellectual disability mouse model.

Brain Stimul 2020 Mar - Apr;13(2):494-498. Epub 2019 Dec 31.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain; IMIM Hospital Del Mar Research Institute, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.12.024DOI Listing
December 2019

Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2.

Brain Behav Immun 2019 Oct 25;81:399-409. Epub 2019 Jun 25.

Laboratory of Neuropharmacology-NeuroPhar, Department of Experimental and Health Sciences, University Pompeu Fabra, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2019.06.036DOI Listing
October 2019

Mu and delta opioid receptors play opposite nociceptive and behavioural roles on nerve-injured mice.

Br J Pharmacol 2019 Oct 26. Epub 2019 Oct 26.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1111/bph.14911DOI Listing
October 2019

Why mu-opioid agonists have less analgesic efficacy in neuropathic pain?

Eur J Pain 2019 03 25;23(3):435-454. Epub 2018 Nov 25.

Department of Experimental and Health Sciences, Laboratory of Neuropharmacology, Universitat Pompeu Fabra, Barcelona, Spain.

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http://doi.wiley.com/10.1002/ejp.1328
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http://dx.doi.org/10.1002/ejp.1328DOI Listing
March 2019

Cerebral oxidative metabolism mapping in four genetic mouse models of anxiety and mood disorders.

Behav Brain Res 2019 01 7;356:435-443. Epub 2018 Jun 7.

Division of Neuropsychopharmacology, Department of Psychology, University of Tartu, Ravila 14A Chemicum, 50411 Tartu, Estonia. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2018.05.031DOI Listing
January 2019

Anti-inflammatory agents for smoking cessation? Focus on cognitive deficits associated with nicotine withdrawal in male mice.

Brain Behav Immun 2019 01 2;75:228-239. Epub 2018 Nov 2.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, 08003 Barcelona, Spain; Faculty of Experimental Sciences, Universidad Francisco de Vitoria, UFV, 28223 Pozuelo de Alarcón, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2018.11.003DOI Listing
January 2019

Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood.

Neuropharmacology 2019 01 12;144:345-357. Epub 2018 Nov 12.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, 08003, Barcelona, Spain; Faculty of Experimental Sciences, Universidad Francisco de Vitoria, UFV, 28223, Pozuelo de Alarcón, Madrid, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00283908183085
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http://dx.doi.org/10.1016/j.neuropharm.2018.11.016DOI Listing
January 2019

Role of the endocannabinoid system in drug addiction.

Biochem Pharmacol 2018 11 12;157:108-121. Epub 2018 Sep 12.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Pompeu Fabra University, PRBB, C/ Doctor Aiguader 88, 08003 Barcelona, Spain; IMIM (Hospital del Mar, Medical Research Institute), Barcelona, Spain; Cooperative Health Research Thematic Network, Addictive Disorders Network, Heatlh Institute Carlos III, MICINN and FEDER, Madrid, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00062952183039
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http://dx.doi.org/10.1016/j.bcp.2018.09.013DOI Listing
November 2018

Red Bull® energy drink increases consumption of higher concentrations of alcohol.

Addict Biol 2018 09 22;23(5):1094-1105. Epub 2017 Sep 22.

Department of Psychobiology, School of Psychology, Campus de Somosaguas, Complutense University of Madrid, Spain.

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http://dx.doi.org/10.1111/adb.12560DOI Listing
September 2018

Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks.

Biol Psychiatry 2018 08 9;84(3):202-212. Epub 2018 Feb 9.

Département de Médecine Translationnelle et Neurogénétique, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U-964, Centre National de la Recherche Scientifique UMR-7104, University of Strasbourg, Illkirch-Graffenstaden, Strasbourg, France; Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054571PMC
August 2018

Usefulness of knockout mice to clarify the role of the opioid system in chronic pain.

Br J Pharmacol 2018 07 6;175(14):2791-2808. Epub 2018 Jan 6.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1111/bph.14088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016633PMC
July 2018

The CRISPR conundrum: evolve and maybe die, or survive and risk stagnation.

Microb Cell 2018 May 16;5(6):262-268. Epub 2018 May 16.

Departamento de Fisiología, Genética y Microbiología. Universidad de Alicante, Campus de San Vicente, 03690 San Vicente del Raspeig (Alicante), Spain.

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http://dx.doi.org/10.15698/mic2018.06.634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972030PMC
May 2018

Hippocampal Protein Kinase C Signaling Mediates the Short-Term Memory Impairment Induced by Delta9-Tetrahydrocannabinol.

Neuropsychopharmacology 2018 04 17;43(5):1021-1031. Epub 2017 Aug 17.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, University Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1038/npp.2017.175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854793PMC
April 2018

Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation.

Addict Biol 2018 03 5;23(2):735-749. Epub 2017 Sep 5.

Laboratory of Neuropharmacology (DCEXS), Parc de Recerca Biomèdica de Barcelona/Universitat Pompeu Fabra (PRBB/UPF), Spain.

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http://dx.doi.org/10.1111/adb.12541DOI Listing
March 2018

Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake.

Neuropharmacology 2018 03 2;130:62-70. Epub 2017 Dec 2.

Instituto de Salud Carlos III, CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Department of Physiology, CIMUS - University of Santiago de Compostela, Santiago de Compostela 15782 Spain; Instituto de Investigaciones Sanitarias (IDIS), University of Santiago de Compostela, Spain.

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http://dx.doi.org/10.1016/j.neuropharm.2017.11.040DOI Listing
March 2018

Extinction and reinstatement of an operant responding maintained by food in different models of obesity.

Addict Biol 2018 03 28;23(2):544-555. Epub 2017 Dec 28.

Laboratori de Neurofarmacologia. Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1111/adb.12597DOI Listing
March 2018

Time-course and dynamics of obesity-related behavioral changes induced by energy-dense foods in mice.

Addict Biol 2018 03 10;23(2):531-543. Epub 2018 Jan 10.

Cellular and Systems Neurobiology, Systems Biology Program, The Barcelona Institute of Science and Technology, Centre for Genomic Regulation (CRG), Spain.

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http://dx.doi.org/10.1111/adb.12595DOI Listing
March 2018

Role of DOR in neuronal plasticity changes promoted by food-seeking behaviour.

Addict Biol 2017 Sep 21;22(5):1179-1190. Epub 2016 Apr 21.

Laboratori de Neurofarmacologia, Departament de Ciències Experimentals i de la Salut, PRBB, Universitat Pompeu Fabra, Spain.

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http://dx.doi.org/10.1111/adb.12401DOI Listing
September 2017

Facilitation of Contextual Fear Extinction by Orexin-1 Receptor Antagonism Is Associated with the Activation of Specific Amygdala Cell Subpopulations.

Int J Neuropsychopharmacol 2017 08;20(8):654-659

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain (Drs Flores, Maldonado, and Berrendero); INSERM, Neurocentre Magendie, Bordeaux, France (Dr Herry); University Bordeaux, Neurocentre Magendie, Bordeaux, France (Dr Herry); Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Madrid, Spain (Dr Berrendero).

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http://dx.doi.org/10.1093/ijnp/pyx029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570099PMC
August 2017

Mu Opioid Receptors in Gamma-Aminobutyric Acidergic Forebrain Neurons Moderate Motivation for Heroin and Palatable Food.

Biol Psychiatry 2017 05 26;81(9):778-788. Epub 2016 Dec 26.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université de Strasbourg, Illkirch; Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2016.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386808PMC
May 2017

Involvement of the dynorphin/KOR system on the nociceptive, emotional and cognitive manifestations of joint pain in mice.

Neuropharmacology 2017 04 24;116:315-327. Epub 2016 Aug 24.

Laboratory of Neuropharmacology, Department of Experimental and Health Science, Pompeu Fabra University (CEXS-UPF), Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.08.026DOI Listing
April 2017

CB Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal.

Biol Psychiatry 2017 04 16;81(7):625-634. Epub 2016 Jul 16.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2016.07.007DOI Listing
April 2017

Cannabinoids therapeutic use: what is our current understanding following the introduction of THC, THC:CBD oromucosal spray and others?

Expert Rev Clin Pharmacol 2017 Apr 28;10(4):443-455. Epub 2017 Feb 28.

h Multiple Sclerosis Clinical and Research Center, Tor Vergata University, Rome & Unit of Neurology , IRCCS Istituto Neurologico Mediterraneo Neuromed , Pozzilli , Italy.

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http://dx.doi.org/10.1080/17512433.2017.1292849DOI Listing
April 2017

Effects of repeated social defeat on adolescent mice on cocaine-induced CPP and self-administration in adulthood: integrity of the blood-brain barrier.

Addict Biol 2017 Jan 16;22(1):129-141. Epub 2015 Sep 16.

Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de València, Spain.

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http://dx.doi.org/10.1111/adb.12301DOI Listing
January 2017

Cannabinoid Receptor 2 Participates in Amyloid-β Processing in a Mouse Model of Alzheimer's Disease but Plays a Minor Role in the Therapeutic Properties of a Cannabis-Based Medicine.

J Alzheimers Dis 2016 ;51(2):489-500

Institut de Neuropatologia, Servei d'Anatomia Patològica, IDIBELL-Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.3233/JAD-150913DOI Listing
December 2016

Production of Star Fruit Alcoholic Fermented Beverage.

Indian J Microbiol 2016 Dec 28;56(4):476-481. Epub 2016 May 28.

Municipal College Professor Franco Montoro (CMPFM), R. dos Estudantes, s.n., Mogi Guaçu, SP 13.843-971 Brazil ; Technical College of Campinas (COTUCA), University of Campinas (UNICAMP), R. Jorge Figueiredo Corrêa, 735, Pq. Taquaral, Campinas, São Paulo 13.087-261 Brazil.

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http://dx.doi.org/10.1007/s12088-016-0601-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061694PMC
December 2016

CB2 cannabinoid receptors modulate HIF-1α and TIM-3 expression in a hypoxia-ischemia mouse model.

Eur Neuropsychopharmacol 2016 12 27;26(12):1972-1988. Epub 2016 Oct 27.

Laboratory of Neuropharmacology, Pompeu Fabra University, PRBB, Barcelona, Spain; Integrative Pharmacology and Systems Neuroscience, IMIM-Hospital del Mar Research Institute, PRBB, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2016.10.003DOI Listing
December 2016

Morphine-induced locomotor sensitization produces structural plasticity in the mesocorticolimbic system dependent on CB1-R activity.

Addict Biol 2016 11 15;21(6):1113-1126. Epub 2015 Jul 15.

Laboratory of Neuropharmacology, Parc de Recerca Biomèdica de Barcelona/Universitat Pompeu Fabra, Spain.

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http://dx.doi.org/10.1111/adb.12281DOI Listing
November 2016

Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease.

Brain Behav Immun 2016 Oct 16;57:94-105. Epub 2016 Jun 16.

Program of Neurosciences, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona 31008, Spain; Department of Biochemistry and Genetics, School of Science, University of Navarra, Pamplona 31008, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona 31008, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2016.06.010DOI Listing
October 2016

Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation.

Proc Natl Acad Sci U S A 2016 08 15;113(35):9904-9. Epub 2016 Aug 15.

Laboratory of Neuropharmacology-NeuroPhar, Department of Experimental and Health Sciences, University Pompeu Fabra, 08003 Barcelona, Spain;

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http://dx.doi.org/10.1073/pnas.1525066113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024630PMC
August 2016

Possible Therapeutic Doses of Cannabinoid Type 1 Receptor Antagonist Reverses Key Alterations in Fragile X Syndrome Mouse Model.

Genes (Basel) 2016 Aug 31;7(9). Epub 2016 Aug 31.

Laboratory of Neuropharmacology-NeuroPhar, Department of Experimental and Health Sciences, Program of Genetics and Neurosciences, University Pompeu Fabra, Barcelona 08003, Spain.

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http://dx.doi.org/10.3390/genes7090056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042387PMC
August 2016

Role of β4* Nicotinic Acetylcholine Receptors in the Habenulo-Interpeduncular Pathway in Nicotine Reinforcement in Mice.

Neuropsychopharmacology 2016 06 20;41(7):1790-802. Epub 2015 Nov 20.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), Barcelona, Spain.

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http://dx.doi.org/10.1038/npp.2015.346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869047PMC
June 2016

Epigenetics, behavior and early nicotine.

Nat Neurosci 2016 06;19(7):863-4

Laboratory of Neuropharmacology, Parc de Recerca Biomèdica de Barcelona, Universitat Pompeu Fabra (PRBB/UPF), Barcelona, Spain.

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http://dx.doi.org/10.1038/nn.4330DOI Listing
June 2016

Involvement of the orexin/hypocretin system in the pharmacological effects induced by Δ(9) -tetrahydrocannabinol.

Br J Pharmacol 2016 Apr 3;173(8):1381-92. Epub 2016 Mar 3.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, Barcelona, Spain.

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http://dx.doi.org/10.1111/bph.13440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940815PMC
April 2016

The endocannabinoid system and neuropathic pain.

Pain 2016 Feb;157 Suppl 1:S23-32

Laboratori de Neurofarmacologia, Departament de Ciències Experimentals i de la Salut (CEXS), Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1097/j.pain.0000000000000428DOI Listing
February 2016

The endocannabinoid system in guarding against fear, anxiety and stress.

Nat Rev Neurosci 2015 12;16(12):705-18

Department of Pharmacology and Toxicology, Neuroscience Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA.

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http://dx.doi.org/10.1038/nrn4036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871913PMC
December 2015

Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain.

Pain 2015 Oct;156(10):2001-12

aLaboratory of Neuropharmacology, Department of Experimental and Health Sciences, Pompeu Fabra University (CEXS-UPF), Barcelona, Spain bDepartment of Experimental and Health Sciences, Pompeu Fabra University (CEXS-UPF), Barcelona, Spain cCell Research Group on Inflammation and Cartilage, Hospital del Mar Medical Research Institute, Rheumatology Department, Hospital del Mar, Barcelona, Spain dHuman Pharmacology and Clinical Neurosciences Research Group, Neuroscience Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain eDepartment of Pharmacology, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain fInstituto de Neurociencias, Universidad Miguel Hernández-CSIC, Alicante, Spain gCIBER de Fisiopatología Obesidad y Nutrición, Santiago de Compostela, Spain hDepartment of Rheumatology, Universitat Autònoma de Barcelona, Hospital del Mar, Barcelona, Spain (A. S. Bura is now with the Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, München, Germany).

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http://dx.doi.org/10.1097/j.pain.0000000000000260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770330PMC
October 2015

Differential regulation of mGlu5 R and ΜOPr by priming- and cue-induced reinstatement of cocaine-seeking behaviour in mice.

Addict Biol 2015 Sep 17;20(5):902-12. Epub 2014 Dec 17.

Sleep, Chronobiology & Addiction Group, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, UK.

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http://dx.doi.org/10.1111/adb.12208DOI Listing
September 2015

Orexins and fear: implications for the treatment of anxiety disorders.

Trends Neurosci 2015 Sep 24;38(9):550-9. Epub 2015 Jul 24.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, C/Doctor Aiguader 88, 08003 Barcelona, Spain. Electronic address:

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http://www.cell.com/trends/neurosciences/pdf/S0166-2236(15)0
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http://dx.doi.org/10.1016/j.tins.2015.06.005DOI Listing
September 2015

Cannabis-based medicine reduces multiple pathological processes in AβPP/PS1 mice.

J Alzheimers Dis 2015 ;43(3):977-91

Institut de Neuropatologia, Servei d'Anatomia Patològica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto Carlos III, Spain.

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http://dx.doi.org/10.3233/JAD-141014DOI Listing
August 2015

A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons.

Biol Psychiatry 2015 Feb 27;77(4):404-15. Epub 2014 Aug 27.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université de Strasbourg, Illkirch, France.; Douglas Hospital Research Center, Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2014.07.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297504PMC
February 2015

Genetically modified mice as tools to understand the neurobiological substrates of depression.

Curr Pharm Des 2014 ;20(23):3718-37

Neuropharmacology Laboratory Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, Doctor Aiguader, 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.2174/13816128113196660741DOI Listing
January 2015

Frustrated expected reward induces differential transcriptional changes in the mouse brain.

Addict Biol 2015 Jan 6;20(1):22-37. Epub 2014 Oct 6.

Laboratori de Neurofarmacologia, Departament de Ciències Experimentals i de la Salut, PRBB, Universitat Pompeu Fabra, Spain.

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http://dx.doi.org/10.1111/adb.12188DOI Listing
January 2015

Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice.

Brain 2015 Jan 11;138(Pt 1):94-109. Epub 2014 Nov 11.

1 Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain 8 Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA 9 Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

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https://academic.oup.com/brain/article-lookup/doi/10.1093/br
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http://dx.doi.org/10.1093/brain/awu310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285189PMC
January 2015

Effects of genetic deletion of endogenous opioid system components on the reinstatement of cocaine-seeking behavior in mice.

Neuropsychopharmacology 2014 Dec 19;39(13):2974-88. Epub 2014 Jun 19.

Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1038/npp.2014.149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229567PMC
December 2014

The hypocretin/orexin system mediates the extinction of fear memories.

Neuropsychopharmacology 2014 Nov 16;39(12):2732-41. Epub 2014 Jun 16.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, C/ Doctor Aiguader 88, Barcelona, Spain.

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http://dx.doi.org/10.1038/npp.2014.146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200503PMC
November 2014

Looking for prosocial genes: ITRAQ analysis of proteins involved in MDMA-induced sociability in mice.

Eur Neuropsychopharmacol 2014 Nov 27;24(11):1773-83. Epub 2014 Aug 27.

Laboratory of Neuropharmacology, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.euroneuro.2014.08.007DOI Listing
November 2014

5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: from behavioral to cellular evidence.

Int J Neuropsychopharmacol 2014 Oct 31;18(3). Epub 2014 Oct 31.

Paris Descartes, Univ Paris 05, Paris, France (Drs CBP Martin, VS Martin, Chevarin, Hamon, Lanfumey, and Mongeau); UPMC, Univ Paris 06, Paris, France (Drs CBP Martin, VS Martin, Chevarin, Hamon, Lanfumey, and Mongeau); INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Paris, France (Drs CBP Martin, VS Martin, Chevarin, Hamon, Lanfumey, and Mongeau); Laboratori de Neurofarmacologia, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain (Drs Trigo and Maldonado); Center for Addiction Research and Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX (Drs Fink and Cunningham).

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http://dx.doi.org/10.1093/ijnp/pyu056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360241PMC
October 2014

Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine.

Eur J Pharmacol 2014 Sep 2;738:200-5. Epub 2014 Jun 2.

Instituto de Investigaciones Farmacológicas (CONICET). Junín 956 5° Piso, Buenos Aires C1113AAD, Argentina; Cátedra de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 5° Piso, Buenos Aires C1113AAD, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2014.05.039DOI Listing
September 2014

Sex-dependent psychoneuroendocrine effects of THC and MDMA in an animal model of adolescent drug consumption.

PLoS One 2013 4;8(11):e78386. Epub 2013 Nov 4.

Departamento de Fisiología (Fisiología Animal II), Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain ; Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078386PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817254PMC
August 2014

Attenuation by baclofen of nicotine rewarding properties and nicotine withdrawal manifestations.

Psychopharmacology (Berl) 2014 Aug 20;231(15):3031-40. Epub 2014 Feb 20.

Instituto de Investigaciones Farmacológicas (CONICET), Junín 956 5° Piso, Buenos Aires, C1113AAD, Argentina.

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http://dx.doi.org/10.1007/s00213-014-3469-6DOI Listing
August 2014

New insights into the molecular pathophysiology of fragile X syndrome and therapeutic perspectives from the animal model.

Int J Biochem Cell Biol 2014 Aug 14;53:121-6. Epub 2014 May 14.

Departament de Ciències Experimentals i de la Salut. Universitat Pompeu Fabra, 08003 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2014.05.004DOI Listing
August 2014

Relationships between serotonergic and cannabinoid system in depressive-like behavior: a PET study with [11C]-DASB.

J Neurochem 2014 Jul 30;130(1):126-35. Epub 2014 Apr 30.

Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB, Barcelona, Spain.

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http://dx.doi.org/10.1111/jnc.12716DOI Listing
July 2014

The hypocretin/orexin receptor-1 as a novel target to modulate cannabinoid reward.

Biol Psychiatry 2014 Mar 26;75(6):499-507. Epub 2013 Jul 26.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2013.06.012DOI Listing
March 2014

The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism.

Int J Neuropsychopharmacol 2014 Mar 29;17(3):455-68. Epub 2013 Oct 29.

Laboratorio de Medicina Regenerativa, IBIMA, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario Carlos Haya, Avenida Carlos Haya, 82, 29010 Málaga, Spain.

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http://dx.doi.org/10.1017/S1461145713001259DOI Listing
March 2014

Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer's disease.

Nat Commun 2014 Mar 6;5:3443. Epub 2014 Mar 6.

1] Department of Cell Biology, University of Barcelona, Barcelona 08028, Spain [2] Centro de Investigación en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid 28031, Spain [3] Institute for Research in Biomedicine, Barcelona (IRB Barcelona), Barcelona 08028, Spain [4] Vall D'Hebrón Institut de Recerca (VHIR), Barcelona 08035, Spain [5] CIEN Foundation, Madrid 28031, Spain.

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http://dx.doi.org/10.1038/ncomms4443DOI Listing
March 2014

Involvement of the endocannabinoid system in osteoarthritis pain.

Eur J Neurosci 2014 Feb;39(3):485-500

Laboratori de Neurofarmacologia, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, C/Dr. Aiguader, 88, Barcelona, 08003, Spain.

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http://doi.wiley.com/10.1111/ejn.12468
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http://dx.doi.org/10.1111/ejn.12468DOI Listing
February 2014

CB2 cannabinoid receptor agonist ameliorates Alzheimer-like phenotype in AβPP/PS1 mice.

J Alzheimers Dis 2013 ;35(4):847-58

Institut de Neuropatologia, Servei d'Anatomia Patològica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.3233/JAD-130137DOI Listing
December 2013

An investigation of interactions between hypocretin/orexin signaling and glutamate receptor surface expression in the rat nucleus accumbens under basal conditions and after cocaine exposure.

Neurosci Lett 2013 Dec 26;557 Pt B:101-6. Epub 2013 Oct 26.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, C/ Doctor Aiguader 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.neulet.2013.10.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869201PMC
December 2013

Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far.

Front Neurosci 2013 Dec 20;7:256. Epub 2013 Dec 20.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra Barcelona, Spain.

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http://dx.doi.org/10.3389/fnins.2013.00256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868890PMC
December 2013

Role of CB2 cannabinoid receptors in the rewarding, reinforcing, and physical effects of nicotine.

Neuropsychopharmacology 2013 Nov 2;38(12):2515-24. Epub 2013 Jul 2.

1] Instituto de Neurociencias, Universidad Miguel Hernández (UMH)-CSIC, Alicante, Spain [2] Red Temática de Investigación Cooperativa en Salud (RETICS-Trastornos Adictivos), Instituto de Salud Carlos III, MICINN and FEDER, Madrid, Spain.

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http://dx.doi.org/10.1038/npp.2013.157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799072PMC
November 2013

Synaptic plasticity alterations associated with memory impairment induced by deletion of CB2 cannabinoid receptors.

Neuropharmacology 2013 Oct 21;73:388-96. Epub 2013 Jun 21.

Instituto de Neurociencias, Campus de San Juan, Universidad Miguel Hernández-CSIC, San Juan de Alicante, Alicante, Spain.

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http://dx.doi.org/10.1016/j.neuropharm.2013.05.034DOI Listing
October 2013

Involvement of the opioid and cannabinoid systems in pain control: new insights from knockout studies.

Eur J Pharmacol 2013 Sep 20;716(1-3):142-57. Epub 2013 Mar 20.

Laboratori de Neurofarmacologia, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, C/Dr. Aiguader, 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.ejphar.2013.01.077DOI Listing
September 2013

Endocannabinoid system and drug addiction: new insights from mutant mice approaches.

Curr Opin Neurobiol 2013 Aug 13;23(4):480-6. Epub 2013 Mar 13.

Laboratory of Neuropharmacology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, C/Dr. Aiguader, 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.conb.2013.02.004DOI Listing
August 2013

A role for hypocretin/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behavior.

Neuropsychopharmacology 2013 Aug 21;38(9):1724-36. Epub 2013 Mar 21.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1038/npp.2013.72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717542PMC
August 2013

Comparison of the pharmacokinetics and clinical efficacy of new extended-release formulations of methylphenidate.

Authors:
Rafael Maldonado

Expert Opin Drug Metab Toxicol 2013 Aug 23;9(8):1001-14. Epub 2013 Apr 23.

Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB, C/Dr. Aiguader 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1517/17425255.2013.786041DOI Listing
August 2013

Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice.

J Neuroimmunol 2013 Aug 31;261(1-2):53-9. Epub 2013 May 31.

Laboratori de Neurofarmacologia, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jneuroim.2013.05.003DOI Listing
August 2013

Microglial activation underlies cerebellar deficits produced by repeated cannabis exposure.

J Clin Invest 2013 Jul 24;123(7):2816-31. Epub 2013 Jun 24.

Laboratori de Neurofarmacologia, Facultat de Ciències de Salut i de Vida, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1172/JCI67569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696568PMC
July 2013

Dissociation of the pharmacological effects of THC by mTOR blockade.

Neuropsychopharmacology 2013 Jun 28;38(7):1334-43. Epub 2013 Jan 28.

Laboratori de Neurofarmacologia, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1038/npp.2013.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656376PMC
June 2013

Targeting the endocannabinoid system in the treatment of fragile X syndrome.

Nat Med 2013 May 31;19(5):603-7. Epub 2013 Mar 31.

Departament de Ciències Experimentals i de la Salut (DCEXS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.

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http://dx.doi.org/10.1038/nm.3127DOI Listing
May 2013

Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate.

Pain 2013 Jan 23;154(1):160-74. Epub 2012 Oct 23.

Laboratori de Neurofarmacologia, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, C/Dr. Aiguader, 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.pain.2012.10.009DOI Listing
January 2013

Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids.

Philos Trans R Soc Lond B Biol Sci 2012 Dec;367(1607):3254-63

Departament de Ciències Experimentals i de la Salut, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1098/rstb.2011.0384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481526PMC
December 2012

Influence of δ-opioid receptors in the behavioral effects of nicotine.

Neuropsychopharmacology 2012 Sep 6;37(10):2332-44. Epub 2012 Jun 6.

Department of Experimental and Health Sciences, Laboratory of Neuropharmacology, Universitat Pompeu Fabra, PRBB, Barcelona, Spain.

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http://dx.doi.org/10.1038/npp.2012.88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422497PMC
September 2012