Publications by authors named "Rafael Aleixandre-Benavent"

63 Publications

Financed research from Government Delegation grants for the National Plan on Drugs: research assessment and scientific impact.

Adicciones 2021 Mar 11;0(0):1550. Epub 2021 Mar 11.

CSIC-Universitat de València. CSIC-Universitat Politècnica de València.

Addictive disorders are a serious health problem to which large amounts of research resources are devoted. This study aims to analyze the evolution and scientific impact of the publications derived from the funding of research projects by the Spanish National Plan on Drugs (PNSD). The list of grants awarded was provided by the PNSD. Derived publications were obtained by asking the principal investigators of the grants and searching in the Web of Science and Scopus. Bibliometric indicators and evolutive trends of scientific production per project were calculated. On average, the PNSD conferred 15 annual grants to research projects, with an annual amount close to one million euros (€944,200.64) and an average amount per grant of just over €60,000, being higher in basic research and in alcohol. 71,9% of the grants had derived publications and almost half of them produced between one and three publications, with basic research being the most prolific. The international journal in which most articles were published was Psychopharmacology (50) and among Spanish journals, Adicciones stood out (28). A high level of co-authorship and international collaboration was identified. Most of the PNSD-funded projects produced research articles, many of them in journals belonging to the first and second quartiles of the Journal Citation Reports. The results of this study have revealed the scientific impact of the PNSD research projects funding and may contribute to determining future funding priorities.
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http://dx.doi.org/10.20882/adicciones.1550DOI Listing
March 2021

The most 100 cited papers in addiction research on cannabis, heroin, cocaine and psychostimulants. A bibliometric cross-sectional analysis.

Drug Alcohol Depend 2021 Apr 15;221:108616. Epub 2021 Feb 15.

Research Unit of Social and Health Information, UISYS Group, Universitat de València, Valencia, Spain; Ingenio (CSIC-Universitat Politècnica de València), Valencia, Spain. Electronic address:

The number of citations a peer-reviewed article receives is often used as a measure of its importance and scientific impact. This paper identifies, describes and categorizes the highly cited papers in addiction research on cannabis, heroin, cocaine and psychostimulants. Highly cited papers were identified in the Web of Science Core Collection database. Several bibliometric indicators were calculated. Social network analysis was applied to draw groups of authors and institutions with the greatest number of collaborations and co-words. The number of citations for the top 100 cited articles ranged from 649 to 4,672. The articles were published in 40 journals. The subject category Substance Abuse included 10 papers. The United States was the most productive country (79 papers), followed by the United Kingdom (9). The main funding institutions were the National Institutes of Health in the United States. The network of collaboration between authors distributes the 352 researchers into 53 groups. The three most cited works address the neural basis of drug craving as an incentive-sensitization theory of addiction, the clinical and research uses of the Addiction Severity Index, and the neurocircuitry of addiction. Scientific literature on addictions is widely dispersed both in multidisciplinary and specific journals of neurology, psychiatry and addictions, with relatively few publications providing most of the citations. An ongoing challenge for this field is the concentration of highly cited papers coming from a select number of countries, with the United States being the research hub of the world, with the highest volume of publications and total citations.
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http://dx.doi.org/10.1016/j.drugalcdep.2021.108616DOI Listing
April 2021

Reply to "Smoker, Former Smoker and COVID-19".

Arch Bronconeumol 2021 Apr 25;57 Suppl 2:67-68. Epub 2021 Jan 25.

Servicio de Neumología, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, España. Electronic address:

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http://dx.doi.org/10.1016/j.arbres.2021.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830217PMC
April 2021

Trends in funding research and international collaboration on greenhouse gas emissions: a bibliometric approach.

Environ Sci Pollut Res Int 2021 Feb 23. Epub 2021 Feb 23.

UISYSJoint Research Unit, Universitat de València-CSIC, València, Spain.

The Web of Science Core Collection platform was used to withdraw the papers included in this study. The studied period comprised from inception till 2018. Trends in research, journals of publication, subject areas of research, keywords most frequently used, countries of publication, international collaboration, and trends of funding research were also analyzed. A total of 3902 articles were published, most of them (52.5%) during the five-year period 2014-2018. The area with the highest number of papers was environmental sciences (41%), followed by energy fuels (16.6%) and engineering environmental (15.7%). "Nitrous oxide emissions" was the most frequent word, followed by "Carbon dioxide emissions" and "Methane emissions". Other words that stood out were "Life cycle assessment", "Climate change" and "Environmental impacts". The United States was the country with the highest productivity (27.9%), followed by China (12.8%) and the United Kingdom (9.6%). There was a concentration of research in recent years, as more than 80% of the papers were published in the last 10 years. The journals that published the largest number of publications were devoted mainly to environmental studies (sciences and engineering), sustainable and green science and technology, energy and fuels, economics, and agriculture. Half of the works were published in Europe and the other half between North America and Asia. Two thirds of the works (67%) were financed compared to a third that were not financed. The percentage of funded works has been increasing over the last decade, which is seen as an indication of the importance of GHGE.
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http://dx.doi.org/10.1007/s11356-021-12776-2DOI Listing
February 2021

The impact of Ibero-American science on global bioethical thinking.

Dev World Bioeth 2021 Feb 20. Epub 2021 Feb 20.

The bioethics research conducted in Ibero-American countries has been very much restricted to its own realm. The aim of this study was to perform a bibliometric evaluation of bioethics papers by authors affiliated with Ibero-American institutions, and to determine how their work influences global bioethics literature. We performed a literature search in the Web of Science Core Collection (WoS CC) and Scopus. We identified a total of 5,975 documents, of which 84.3% were articles, 11.6% reviews and 4.1% book chapters. The median number of citations per paper was higher in English-language journals. Only 10 articles published between 2010 and 2019 in peer-reviewed bioethics journals and produced exclusively by authors from Ibero-American institutions garnered more than 15 citations. Our study suggests that if researchers from Ibero-American institutions want to influence global bioethical thinking, they must make the required leap in quality to be able to publish in high-quality bioethics and mainstream journals.
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http://dx.doi.org/10.1111/dewb.12309DOI Listing
February 2021

Trend in Spanish cardiology research and global comparative analysis of major topics.

Rev Esp Cardiol (Engl Ed) 2020 Dec 31. Epub 2020 Dec 31.

Unidad de Investigación e Información Social y Sanitaria (UISYS), Universitat de València, Valencia, Spain; INGENIO, CSIC-Universitat Politècnica de València, Valencia, Spain.

Introduction And Objectives: We used bibliometric techniques to analyze the participation of Spanish institutions in research on major cardiovascular topics during the last 4 decades.

Methods: Bibliometric indicators of production, collaboration and impact were obtained from the Science Citation Index Expanded (SCIE) database. Search strategies were used in major topics and institutional collaboration networks were identified, represented using the Kamada-Kawai algorithm.

Results: Global cardiovascular publications doubled from 2000 to 2018. In 2018, those by Spanish authors represented 2.33%, with a participation of between 7% and 1.84%, depending on the topics analyzed. The offset with respect to global production was between 0 and 7 years. Annual growth rates were higher in more recent topics. Revista Española de Cardiología published the largest number of articles from Spanish institutions. The journals generating the highest number of citations in the chosen topics were the Journal of the American College of Cardiology, Europace, and the European Heart Journal. Analysis of collaboration revealed a close interrelation between Spanish and foreign institutions, as well as groups with high production publishing independently.

Conclusions: The analysis disaggregated by subject showed the sustained growth of Spanish cardiovascular scientific production and more rapid growth in recently appearing topics. Collaboration networks showed a high degree of interrelation between Spanish and foreign institutions, including hospitals, universities, research institutes, and scientific societies.
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http://dx.doi.org/10.1016/j.rec.2020.12.001DOI Listing
December 2020

Gender inequalities on editorial boards of indexed pediatrics journals.

Pediatr Res 2020 Nov 25. Epub 2020 Nov 25.

UISYS, Unidad Mixta de Investigación, Universitat de València, Valencia, Spain.

Background: The presence of women in decision-making positions, such as on editorial committees of biomedical journals, is not the same as that of men. This paper analyzes the gender composition of editorial committees (EBMs) and editors-in-chief (ECs) positions of pediatric journals.

Methods: The gender of EBMs and ECs of 125 journals classified in the pediatrics area of the Journal Citation Report (JCR) was analyzed. The following indicators were calculated: gender distribution of ECs and EBMs by journal, publisher, subject speciality, country, quartile of the journal in JCR and country of affiliation of the members.

Results: The total number of EBMs was 4242. The distribution by sex of the ECs was 19.44% women and 80.56% men, while that of the EBMs were 33.05% women and 66.95% men. Twenty journals exhibited a greater representation of women than of men, and in four there was parity. Journals with greater participation of women specialized in nursing and physical therapy and were related to nutrition (lactation and breastfeeding).

Conclusions: Only one-fifth of ECs and one-third of EBMs are females. Women's participation is higher in journals related to nursing, physical and occupational therapy, and nutrition. The United States has the highest number of EBMs, followed by the European Union.

Impact: Only one-fifth of Editors-in-chief in pediatrics journals are female. Only one-third of Editorial Board Members in pediatrics journals are female. Women's participation is higher in editorials committees in pediatrics journals related to nursing, physical and occupational therapy, and nutrition. Medical and pediatric associations and societies must work together to eliminate the disparities that exist between women and men. Achieving gender equity and empowering all women is one of the World Health Organization's Sustainable Development Goals.
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http://dx.doi.org/10.1038/s41390-020-01286-5DOI Listing
November 2020

COVID-19 and Smoking: A Systematic Review and Meta-Analysis of the Evidence.

Arch Bronconeumol 2021 Jan 25;57 Suppl 1:21-34. Epub 2020 Jul 25.

Servicio de Neumología, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, España. Electronic address:

Objective: The aim of this study was to determine if tobacco use in patients with Covid-19 is associated with a negative disease course and adverse outcome, and if smoking, current and past, is associated with a greater possibility of developing COVID-19.

Material And Methods: A systematic review (SR) and meta-analysis (MA) of previously published works were performed. The search strategy included all known descriptors for Covid-19 and tobacco and was conducted in different databases. Appropriate statistical models were used to address the effect size in meta-analysis, namely random effects and fixed effects model.

Results: Thirty-four articles were identified in the SR of which 19 were included in the MA. Being a smoker or former smoker was shown to be a risk factor for worse progression of Covid-19 infection (OR 1.96, 95% CI, 1.36 - 2.83) and a greater probability of presenting a more critical condition (OR 1.79 95% CI, 1.19 - 2.70). As limitations of the MA, we found that most of the studies analyzed were observational with limited publication bias. Two studies that disagreed with the rest were included, although after withdrawing them from the MA, smoking was maintained as a risk factor for worse progress.

Conclusion: Current and past smoking produces a more serious clinical form of Covid-19 and more frequently leads to intensive care admission, intubation, and death.
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http://dx.doi.org/10.1016/j.arbres.2020.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381922PMC
January 2021

Worldwide Scientific Research on Nanotechnology: A Bibliometric Analysis of Tendencies, Funding, and Challenges.

J Agric Food Chem 2020 Aug 15;68(34):9158-9170. Epub 2020 Aug 15.

Unidad de Información e Investigación Social y Sanitaria (UISYS), Unidad Mixta de Investigación, Consejo Superior de Investigaciones Científicas (CSIC)-Universitat de València, 46003 València, Spain.

The main objective of this investigation was to analyze the scientific production in global research on nanotechnology, integrating scientific production, funding of studies, collaborations between countries, and the most cited publications. The source for obtaining the research papers for our analysis was the Science Citation Index Expanded from the Web of Science. A total of 3546 documents were extracted during the period of 1997-2018. Food science & technology, chemistry (applied and analytical), spectroscopy, and agriculture appeared as the main areas where the articles were published. Most prolific and cited journals were , , and . The co-word analysis showed the relationships between "nanoparticles", which is the central word, and "silver nanoparticles", "delivery systems", and "zinc-nanoparticles". The most productive countries were China (1089 papers), the United States (523), Iran (427), and India (359). The main cited topics deal with the biomedical applications of nanoparticles, its synthesis from plants, and its applications in food science. The results highlight an important collaboration between institutions and countries. The availability of funding for research in nanotechnology was remarkable compared to other fields. The multidisciplinarity of the nanotechnology field is one of the main features as well as one of the central findings.
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http://dx.doi.org/10.1021/acs.jafc.0c02141DOI Listing
August 2020

[Scientific impact and bibliometric contextualisation of Paediatrics compared to other specialities].

An Pediatr (Barc) 2020 Mar 14;92(3):172.e1-172.e12. Epub 2020 Feb 14.

UISYS, Unidad Mixta de Investigación, Universitat de València-CSIC, Valencia, España; Instituto de Gestión de la Innovación y del Conocimiento-Ingenio (CSIC-Universitat Politècnica de València), Valencia, España. Electronic address:

Introduction: The purpose of this paper is twofold. On the one hand, to identify and characterise the production, citation, impact and collaboration indicators of the Pediatrics area of the Journal Citation Reports, and on the other hand, to place the journal Anales de Pediatría in the context of the Spanish journals of another twenty areas and medical specialties.

Material And Method: The sources of information used to obtain the indicators were Science Citation Index-Expanded, Journal Citation Reports, and Scimago Journal & Country Rank. A regression analysis was performed to determine the correlation between the citation and other variables.

Results: Pediatrics ranked 8th in scientific production during the period 2009-2018. In citations per journal it ranks 17th, and the average citations per article approaches 27, occupying, in this case, the 18th position. Below Pediatrics are Emergency Medicine, Rehabilitation, and Primary Health Care. There are no citations for 12.47% of the articles. The average impact factor places the area in 18th place and its h index was 197, reaching 14th position, and standing above seven other areas. The percentage of works carried out with international collaboration was 17.71%, above Primary Health Care (12.88%), Oncology (16.37%), and Emergency Medicine (17.03%). Among the Spanish journals, Anales de Pediatría was the fourth most productive journal, and occupied an intermediate position in terms of the number of citations.

Conclusions: The indicators of citation and impact of the Pediatrics area tend to be above areas such as Emergency Medicine, Primary Health Care, Dentistry, Oral Surgery & Medicine, and Rehabilitation. Professional practice outside large hospitals, together with poor funding, as well as the low number of clinical trials due to the ethical requirements imposed on studies with children, may be the causes that result in moderate citation and impact indicators.
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http://dx.doi.org/10.1016/j.anpedi.2019.12.009DOI Listing
March 2020

Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis.

Trials 2020 Jan 7;21(1):34. Epub 2020 Jan 7.

Information and Social and Health Research Unit (UISYS), University of Valencia and Spanish National Research Council (CSIC), Valencia, Spain.

Background: Randomised controlled trials (RCTs) provide the most reliable information to inform clinical practice and patient care. We aimed to map global clinical research publication activity through RCT-related articles in high-impact-factor medical journals over the past five decades.

Methods: We conducted a cross-sectional analysis of articles published in the highest ranked medical journals with an impact factor > 10 (according to Journal Citation Reports published in 2017). We searched PubMed/MEDLINE (from inception to December 31, 2017) for all RCT-related articles (e.g. primary RCTs, secondary analyses and methodology papers) published in high-impact-factor medical journals. For each included article, raw metadata were abstracted from the Web of Science. A process of standardization was conducted to unify the different terms and grammatical variants and to remove typographical, transcription and/or indexing errors. Descriptive analyses were conducted (including the number of articles, citations, most prolific authors, countries, journals, funding sources and keywords). Network analyses of collaborations between countries and co-words are presented.

Results: We included 39,305 articles (for the period 1965-2017) published in forty journals. The Lancet (n = 3593; 9.1%), the Journal of Clinical Oncology (n = 3343; 8.5%) and The New England Journal of Medicine (n = 3275 articles; 8.3%) published the largest number of RCTs. A total of 154 countries were involved in the production of articles. The global productivity ranking was led by the United States (n = 18,393 articles), followed by the United Kingdom (n = 8028 articles), Canada (n = 4548 articles) and Germany (n = 4415 articles). Seventeen authors who had published 100 or more articles were identified; the most prolific authors were affiliated with Duke University (United States), Harvard University (United States) and McMaster University (Canada). The main funding institutions were the National Institutes of Health (United States), Hoffmann-La Roche (Switzerland), Pfizer (United States), Merck Sharp & Dohme (United States) and Novartis (Switzerland). The 100 most cited RCTs were published in nine journals, led by The New England Journal of Medicine (n = 78 articles), The Lancet (n = 9 articles) and JAMA (n = 7 articles). These landmark contributions focused on novel methodological approaches (e.g. the "Bland-Altman method") and trials on the management of chronic conditions (e.g. diabetes control, hormone replacement therapy in postmenopausal women, multiple therapies for diverse cancers, cardiovascular therapies such as lipid-lowering statins, antihypertensive medications, and antiplatelet and antithrombotic therapy).

Conclusions: Our analysis identified authors, countries, funding institutions, landmark contributions and high-impact-factor medical journals publishing RCTs. Over the last 50 years, publication production in leading medical journals has increased, with Western countries leading in research but with low- and middle-income countries showing very limited representation.
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http://dx.doi.org/10.1186/s13063-019-3944-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947860PMC
January 2020

Tendencies and Challenges in Worldwide Scientific Research on Probiotics.

Probiotics Antimicrob Proteins 2020 09;12(3):785-797

UISYS, Unidad Mixta de Investigación, CSIC-Universidad de Valencia, Valencia, Spain.

The central goal of this study was to analyze scientific trends in the research on probiotics, including the number of papers, funding, country collaborations, and most cited publications. The study makes use of bibliometric and social network analysis of papers included in the Science Citation Index Expanded from the Web of Science database. A total of 7221 papers were retrieved, from which 64% were funded papers. Papers were published in journals covering several areas, such as Food Science & Technology, Microbiology, Biotechnology and Applied Microbiology, Nutrition & Dietetics and Agriculture, and Dairy & Animal Science. Coword analysis shows the relationships between microorganisms, diseases, physiological phenomena, and other key words related to food, population, or type of study. The USA appeared as the world leader in the number of articles produced (n = 919), followed by China (n = 689), India (n = 633), and Brazil (n = 506). The most cited papers related to the consensus on the scope and appropriate use of the term probiotic, its effects on the prevention and treatment of some intestinal diseases, its effects on the suppression of immune disorders, the role of probiotics and prebiotics in obesity, the assessment of psychotropic-like properties, and the application for type 2 diabetes.
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http://dx.doi.org/10.1007/s12602-019-09591-0DOI Listing
September 2020

Trends in scientific research in Insights into Imaging: a bibliometric review.

Insights Imaging 2019 Aug 28;10(1):79. Epub 2019 Aug 28.

UISYS, Joint Research Unit, Universitat de València-CSIC, Palacio Cerveró, Plaza Cisneros, 4, 46003, Valencia, Spain.

Objectives: To analyse the coverage and main bibliometric indicators of Insights into Imaging in Scopus and the Emerging Sources Citation Index (ESCI) from the Web of Science Core Collection database.

Methods: The evolution of journal production in the Scopus database was analysed according to document types, collaboration indexes between authors and institutions, and citation indicators (number of citations, SCImago Journal Rank, quartile, h-index, and most cited works). Networks of collaboration among authors, institutions, and countries were also analysed, as well as those of co-word networks. As a complementary source of information, the Emerging Source Citation Index from the Web of Science database was also considered.

Results: Four hundred seventy-four papers were included in Scopus and 292 in ESCI. The index of collaboration was 5.18 for authors and 2.74 for institutions. International collaboration occurred in 24.7% of the papers. The number of citations received in Scopus (4295) exceeds the number of citations received in ESCI (1177). The average number of citations per paper was 9.06 in Scopus versus 4.03 in ESCI. The h-index was 29 in Scopus and 16 in ESCI. Several collaborative groups were identified at the national and international level.

Conclusions: There is a progression of Insights into Imaging in the ranking of journals in the area that, if maintained, will allow it to remain in the first quartile in the Scopus database. The main topics of interest were technologies such as 'Magnetic resonance imaging', 'Computed tomography', 'Radiology', and 'Ultrasonography' and diseases such as 'Breast cancer' and those related to 'Paediatrics'.
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http://dx.doi.org/10.1186/s13244-019-0766-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712199PMC
August 2019

Prevalence and comorbidity of autism spectrum disorder in Spain: study protocol for a systematic review and meta-analysis of observational studies.

Syst Rev 2019 06 14;8(1):141. Epub 2019 Jun 14.

Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia, Spain.

Background: Autism spectrum disorder (ASD) is a complex developmental disorder characterised by impaired social interaction and communication, and restrictive and repetitive behaviour. Previous systematic reviews have traditionally assessed the prevalence of ASD on global or regional context, with very few meta-analyses at the country level. The objective of this study will be to systematically evaluate published and unpublished observational studies that present prevalence and comorbidity of ASD among children, adolescent and adult population in Spain.

Methods/design: We designed and registered a study protocol for a systematic review and meta-analysis of descriptive epidemiology data. Observational studies (cohort, cross-sectional) reporting the prevalence of ASD and conducted in a wide range of people (e.g. general population, outpatient and/or school settings) will be included. The primary outcome will be the prevalence of ASD. Secondary outcomes will be the prevalence of any physical or mental comorbidity in association with ASD. No limitations will be imposed on publication status, study conduct period, and language of dissemination. Comprehensive literature searches will be conducted in seven electronic databases (from January 1980 onwards), including PubMed/MEDLINE, EMBASE, Scopus, Web of Science, PsycINFO, IME-Spanish Medical Index and IBECS-Spanish Bibliographic Index of Health Sciences. Grey literature will be identified through searching dissertation databases, Google Scholar and conference abstracts. Two team members will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The study methodological quality (or bias) will be appraised using an appropriate tool. If feasible, we will conduct random effects meta-analysis of observational data. Prevalence estimates will be stratified according to gender, age and geographical location. Additional analyses will be conducted to explore the potential sources of heterogeneity (e.g. methodological quality, sample size, diagnostic criteria).

Discussion: This systematic review and meta-analysis of observational data will identify, evaluate and integrate the epidemiological knowledge underlying the prevalence of ASD in Spain. The results of this study will be of interest to multiple audiences including patients, their families, caregivers, healthcare professional, scientists and policy makers. Results will be published in a peer-reviewed journal. Implications for future epidemiological research will be discussed.

Systematic Review Registration: PROSPERO CRD42018090372.
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http://dx.doi.org/10.1186/s13643-019-1061-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570970PMC
June 2019

Reporting guidelines for health research: protocol for a cross-sectional analysis of the EQUATOR Network Library.

BMJ Open 2019 03 4;9(3):e022769. Epub 2019 Mar 4.

School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.

Introduction: Transparency and completeness of health research is highly variable, with important deficiencies in the reporting of methods and results of studies. Reporting guidelines aim to improve transparency and quality of research reports, and are often developed by consortia of journal editors, peer reviewers, authors, consumers and other key stakeholders. The objective of this study will be to investigate the characteristics of scientific collaboration among developers and the citation metrics of reporting guidelines of health research.

Methods And Analysis: This is the study protocol for a cross-sectional analysis of completed reporting guidelines indexed in the Enhancing the QUAlity and Transparency Of health Research Network Library. We will search PubMed/MEDLINE and the Web of Science. Screening, selection and data abstraction will be conducted by one researcher and verified by a second researcher. Potential discrepancies will be resolved via discussion. We will include published papers of reporting guidelines written in English. Published papers will have to meet the definition of a reporting guideline related to health research (eg, a checklist, flow diagram or explicit text), with no restrictions by study design, medical specialty, disease or condition. Raw data from each included paper (including title, publication year, journal, subject category, keywords, citations, and the authors' names, author's affiliated institution and country) will be exported from the Web of Science. Descriptive analyses will be conducted (including the number of papers, citations, authors, countries, journals, keywords and main collaboration metrics). We will identify the most prolific authors, institutions, countries, journals and the most cited papers. Network analyses will be carried out to study the structure of collaborations.

Ethics And Dissemination: No ethical approval will be required. Findings from this study will be published in peer-reviewed journals. All data will be deposited in a cross-disciplinary public repository. It is anticipated the study findings could be relevant to a variety of audiences.
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http://dx.doi.org/10.1136/bmjopen-2018-022769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429992PMC
March 2019

[Half a century of ANALES DE PEDIATRÍA. Evolution of its main bibliometric indicators in the Web of Science and Scopus international databases].

An Pediatr (Barc) 2019 Mar 15;90(3):194.e1-194.e11. Epub 2019 Feb 15.

UISYS, Unidad Mixta de Investigación, Universitat de València-CSIC, Valencia, España; Instituto de Gestión de la Innovación y del Conocimiento-Ingenio (CSIC-Universitat Politècnica de València), Valencia, España.

Purpose: To analyse the coverage and main bibliometric indicators of ANALES DE PEDIATRÍA in Scopus and Science Citation Index Expanded of the Web of Science (SCIE) databases.

Material And Method: The evolution of the journal production was identified according to the document types, collaboration indexes between authors and institutions, and citations, and impact indicators (number of citations, impact factor, 5-years impact factor and without self-citations, Scimago Journal Rank, quartile, h index and most cited works).

Results: A total of 10,128 papers were included in Scopus (a mean of around 225 per year) and 1,861 in SCIE (a mean of around 207 per year). The index of collaboration was 4.4 for authors and 2 for institutions. There was international collaboration in 4.2% of the papers. The number of citations received in Scopus (619) exceeded the number of citations received in SCIE (385) by 234. The mean number of citations per paper was lower in SCIE (2.27 in Scopus compared to 1.5 in SCIE). The h index was 18 in Scopus and 14 in SCIE.

Conclusions: Discrepancies were observed in the indicators obtained in both databases due to the different indexation policies, coverage, and classification methods of the papers. The number of citations, the mean number of citations per work, and the h index were higher in Scopus due to the longer life of the journal in that database. There is a positive evolution of the impact factor in SCIE, of the impact factor excluding self-citations, and of the 5-year impact factor.
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http://dx.doi.org/10.1016/j.anpedi.2018.12.012DOI Listing
March 2019

Prevalence and comorbidity of attention deficit hyperactivity disorder in Spain: study protocol for extending a systematic review with updated meta-analysis of observational studies.

Syst Rev 2019 02 11;8(1):49. Epub 2019 Feb 11.

Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia, Spain.

Background: Attention deficit hyperactivity disorder (ADHD) is a childhood-onset disorder characterized by a persistent pattern of symptoms of developmentally inappropriate and impaired inattention and/or hyperactivity/impulsivity, with difficulties often continuing into adulthood. ADHD can come with other comorbid conditions. The aim of this study will be to quantify the prevalence and comorbidity of ADHD among children, adolescent, and adult population in Spain.

Methods/design: We designed and registered a study protocol for an update and expansion of a systematic review and meta-analysis of pooled prevalence data. We will include cross-sectional observational studies reporting prevalence of ADHD in Spain and conducted in the general population, outpatient, and/or school settings. The primary outcome will be the prevalence of ADHD. Secondary outcomes will be the prevalence of any physical or mental comorbidity in association with ADHD. No limitations will be imposed on publication status, study conduct period, and language of dissemination. Comprehensive literature searches will be conducted in multiple electronic databases, including PubMed/MEDLINE, EMBASE, Scopus, Web of Science, PsycINFO, IME - Spanish Medical Index, and IBECS - Spanish Bibliographic Index of Health Sciences. We will also search Google Scholar, dissertation databases, and conference abstracts. Two team members will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The methodological quality (or risk of bias) of individual studies will be appraised using an appropriate tool. If feasible, we will conduct random effects meta-analysis. Prevalence estimates will be stratified according to gender, age, and geographical location. Additional analyses will be conducted to explore the potential sources of heterogeneity (e.g., methodological quality, sample size, diagnostic criteria).

Discussion: This systematic review and meta-analysis of observational data will provide an updated synthesis of the prevalence and comorbidity of ADHD in Spain. This study will also examine factors that may explain potential variations in prevalence data. The findings of this study will be published in a peer-reviewed journal.

Systematic Review Registration: PROSPERO CRD42018106082 .
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http://dx.doi.org/10.1186/s13643-019-0967-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371515PMC
February 2019

The Sharing of Research Data in the Cell & Tissue Engineering Area: Is It a Common Practice?

Stem Cells Dev 2018 06 7;27(11):717-722. Epub 2018 May 7.

1 UISYS, Joint Research Unit (CSIC-University of Valencia) , Valencia, Spain .

The availability of research data sets is an important milestone because it can enhance the dynamics of research. This study aims to analyze the PubMed Central repository to determine the availability and type of raw data sets in Cell & Tissue Engineering journals indexed in Journal Citation Reports. The number and types of files were registered. The main finding of this study is that, beyond the mandatory deposit of data in specific repositories that some journals require, the exchange of data as supplementary material in the Cell & Tissue Engineering journals is not a common practice since researchers are still reticent to do so.
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http://dx.doi.org/10.1089/scd.2018.0036DOI Listing
June 2018

Mapping of global scientific research in comorbidity and multimorbidity: A cross-sectional analysis.

PLoS One 2018 3;13(1):e0189091. Epub 2018 Jan 3.

Unidad de Información e Investigación Social y Sanitaria-UISYS, University of Valencia and Spanish National Research Council (CSIC), Valencia, Spain.

Background: The management of comorbidity and multimorbidity poses major challenges to health services around the world. Analysis of scientific research in comorbidity and multimorbidity is limited in the biomedical literature. This study aimed to map global scientific research in comorbidity and multimorbidity to understand the maturity and growth of the area during the past decades.

Methods And Findings: This was a cross-sectional analysis of the Web of Science. Searches were run from inception until November 8, 2016. We included research articles or reviews with no restrictions by language or publication date. Data abstraction was done by one researcher. A process of standardization was conducted by two researchers to unify different terms and grammatical variants and to remove typographical, transcription, and/or indexing errors. All potential discrepancies were resolved via discussion. Descriptive analyses were conducted (including the number of papers, citations, signatures, most prolific authors, countries, journals and keywords). Network analyses of collaborations between countries and co-words were presented. During the period 1970-2016, 85994 papers (64.0% in 2010-2016) were published in 3500 journals. There was wide diversity in the specialty of the journals, with psychiatry (16558 papers; 19.3%), surgery (9570 papers; 11.1%), clinical neurology (9275 papers; 10.8%), and general and internal medicine (7622 papers; 8.9%) the most common. PLOS One (1223 papers; 1.4%), the Journal of Affective Disorders (1154 papers; 1.3%), the Journal of Clinical Psychiatry (727 papers; 0.8%), the Journal of the American Geriatrics Society (634 papers; 0.7%) and Obesity Surgery (588 papers; 0.7%) published the largest number of papers. 168 countries were involved in the production of papers. The global productivity ranking was headed by the United States (37624 papers), followed by the United Kingdom (7355 papers), Germany (6899 papers) and Canada (5706 papers). Twenty authors who published 100 or more papers were identified; the most prolific authors were affiliated with Harvard Medical School, State University of New York Upstate Medical University, National Taiwan Normal University and China Medical University. The 50 most cited papers ("citation classics" with at least 1000 citations) were published in 20 journals, led by JAMA Psychiatry (11 papers) and JAMA (10 papers). The most cited papers provided contributions focusing on methodological aspects (e.g. Charlson Comorbidity Index, Elixhauser Comorbidity Index, APACHE prognostic system), but also important studies on chronic diseases (e.g. epidemiology of mental disorders and its correlates by the U.S. National Comorbidity Survey, Fried's frailty phenotype or the management of obesity).

Conclusions: Ours is the first analysis of global scientific research in comorbidity and multimorbidity. Scientific production in the field is increasing worldwide with research leadership of Western countries, most notably, the United States.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189091PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751979PMC
February 2018

Productivity trends and collaboration patterns: A diachronic study in the eating disorders field.

PLoS One 2017 29;12(8):e0182760. Epub 2017 Aug 29.

INGENIO (CSIC-Universidad Politécnica de Valencia) & UISYS (CSIC-Universidad de Valencia), Valencia, Spain.

Objective: The present study seeks to extend previous bibliometric studies on eating disorders (EDs) by including a time-dependent analysis of the growth and evolution of multi-author collaborations and their correlation with ED publication trends from 1980 to 2014 (35 years).

Methods: Using standardized practices, we searched Web of Science (WoS) Core Collection (WoSCC) (indexes: Science Citation Index-Expanded [SCIE], & Social Science Citation Index [SSCI]) and Scopus (areas: Health Sciences, Life Sciences, & Social Sciences and Humanities) to identify a large sample of articles related to EDs. We then submitted our sample of articles to bibliometric and graph theory analyses to identify co-authorship and social network patterns.

Results: We present a large number of detailed findings, including a clear pattern of scientific growth measured as number of publications per five-year period or quinquennium (Q), a tremendous increase in the number of authors attracted by the ED subject, and a very high and steady growth in collaborative work.

Conclusions: We inferred that the noted publication growth was likely driven by the noted increase in the number of new authors per Q. Social network analyses suggested that collaborations within ED follow patters of interaction that are similar to well established and recognized disciplines, as indicated by the presence of a "giant cluster", high cluster density, and the replication of the "small world" phenomenon-the principle that we are all linked by short chains of acquaintances.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182760PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574555PMC
October 2017

Public availability of research data in dentistry journals indexed in Journal Citation Reports.

Clin Oral Investig 2018 Jan 26;22(1):275-280. Epub 2017 Mar 26.

Ingenio (CSIC-Politechnic University of Valencia), UISYS (CSIC-University of Valencia), Pza Cisneros 4, 46003, Valencia, Spain.

Objectives: Dentistry is a medical discipline with an increasing scientific production in the last years. Due to the importance of data sharing in science, this study aims at analyzing the availability of raw data in articles from scientific journals indexed in the Dentistry category of the 2014 edition of the Journal Citation Reports.

Material And Methods: A review of the 88 websites of journals from the Dentistry category was conducted to determine the data-sharing editorial policies. Furthermore, a search in the PubMed Central repository to collect information about the characteristics of the supplementary material of articles from those journals was carried out.

Results: The possibility of publishing a supplementary material was higher in the first quartile journals. A percentage of 7.6% of the articles registered in PubMed Central contained a supplementary material, especially text documents, but the presence of spreadsheets was scarce.

Conclusions: There is a relationship between openness policies and the impact of the journals according to their quartile or position ranking by the impact factor in the JCR, but the willingness of sharing raw data in spreadsheets format is still limited.

Clinical Relevance: This study will reveal the resources of raw data which will improve quality of research and clinical practice.
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http://dx.doi.org/10.1007/s00784-017-2108-0DOI Listing
January 2018

Patterns and Trends in Scientific Research on Generic Drugs.

Clin Ther 2016 Dec 12;38(12):2684-2689.e1. Epub 2016 Nov 12.

Ingenio-Spanish National Research Council (CSIC) and UISYS-University of Valencia, Valencia, Spain.

Purpose: The purpose of this study to investigate the evolution and current status of peer-reviewed publications concerning generic drugs during the past few decades.

Methods: Scientific articles about generic drugs published until 2012 were retrieved through the PubMed/MEDLINE database, and a content analysis was performed.

Findings: Our study revealed an increasing number of publications on generics since 1984. Statins, antiretroviral therapies, and antiepileptics, followed by immunosuppressants and antithrombotic agents, were the most common therapeutic drug categories.

Implications: Almost 60% of the generics detailed in studies indexed in MEDLINE were acting on the cardiovascular system as anti-infectives and on the nervous system, which is not surprising considering the leading causes of death and disability worldwide.
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http://dx.doi.org/10.1016/j.clinthera.2016.10.010DOI Listing
December 2016

The Global Research Collaboration of Network Meta-Analysis: A Social Network Analysis.

PLoS One 2016;11(9):e0163239. Epub 2016 Sep 29.

Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China.

Background And Objective: Research collaborations in biomedical research have evolved over time. No studies have addressed research collaboration in network meta-analysis (NMA). In this study, we used social network analysis methods to characterize global collaboration patterns of published NMAs over the past decades.

Methods: PubMed, EMBASE, Web of Science and the Cochrane Library were searched (at 9th July, 2015) to include systematic reviews incorporating NMA. Two reviewers independently selected studies and cross-checked the standardized data. Data was analyzed using Ucinet 6.0 and SPSS 17.0. NetDraw software was used to draw social networks.

Results: 771 NMAs published in 336 journals from 3459 authors and 1258 institutions in 49 countries through the period 1997-2015 were included. More than three-quarters (n = 625; 81.06%) of the NMAs were published in the last 5-years. The BMJ (4.93%), Current Medical Research and Opinion (4.67%) and PLOS One (4.02%) were the journals that published the greatest number of NMAs. The UK and the USA (followed by Canada, China, the Netherlands, Italy and Germany) headed the absolute global productivity ranking in number of NMAs. The top 20 authors and institutions with the highest publication rates were identified. Overall, 43 clusters of authors (four major groups: one with 37 members, one with 12 members, one with 11 members and one with 10 members) and 21 clusters of institutions (two major groups: one with 62 members and one with 20 members) were identified. The most prolific authors were affiliated with academic institutions and private consulting firms. 181 consulting firms and pharmaceutical industries (14.39% of institutions) were involved in 199 NMAs (25.81% of total publications). Although there were increases in international and inter-institution collaborations, the research collaboration by authors, institutions and countries were still weak and most collaboration groups were small sizes.

Conclusion: Scientific production on NMA is increasing worldwide with research leadership of Western countries (most notably, the UK, the USA and Canada). More authors, institutions and nations are becoming involved in research collaborations, but frequently with limited international collaborations.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163239PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042468PMC
September 2016

[Global funding for papers of excellence on smoking, 2010-2014].

Rev Panam Salud Publica 2015 Nov;38(5):410-7

Instituto de Gestión de la Innovación y del Conocimiento - Ingenio, Universitat Politècnica de València.

Objective: The objective of this study was to investigate the funding received by papers of excellence on smoking at the global level between 2010 and 2014 through the Web of Science, and to find out if funding is associated with greater impact.

Method: We searched the Science Citation Index Expanded (SCIE) and the Social Sciences Citation Index (SSCI) through the Web of Science platform on 20 May 2015 (typology consisting of originals and reviews for the period from 2010 to 2014). The search strategy was "smok*" OR "tobac*." To select the papers of excellence, we picked those that had an h index (i.e., number of articles having at least that many citations) from among the papers in the overall sample generated by the strategy.

Results: Of the 193 papers of excellence on smoking that were identified, 158 had received funding from 279 different financing institutions that intervened 522 times. The funding came primarily from government agencies, private foundations, and the pharmaceutical industry. Public funding declined and private funding increased over the years included in the analysis. Receipt of funding was not associated with greater impact at a later date.

Conclusions: Most of the papers of excellence on smoking received external funding primarily from government agencies, private foundations, and the pharmaceutical industry. Public funding has decreased, while private funding has increased. Receipt of funding was not associated with greater impact at a later date.
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November 2015

The quality of reporting methods and results of cost-effectiveness analyses in Spain: a methodological systematic review.

Syst Rev 2016 Jan 7;5. Epub 2016 Jan 7.

Clinical Epidemiology Program, Ottawa Hospital Research Institute (OHRI), Ottawa, ON, Canada.

Background: Cost-effectiveness analysis has been recognized as an important tool to determine the efficiency of healthcare interventions and services. There is a need for evaluating the reporting of methods and results of cost-effectiveness analyses and establishing their validity. We describe and examine reporting characteristics of methods and results of cost-effectiveness analyses conducted in Spain during more than two decades.

Methods: A methodological systematic review was conducted with the information obtained through an updated literature review in PubMed and complementary databases (e.g. Scopus, ISI Web of Science, National Health Service Economic Evaluation Database (NHS EED) and Health Technology Assessment (HTA) databases from Centre for Reviews and Dissemination (CRD), Índice Médico Español (IME) Índice Bibliográfico Español en Ciencias de la Salud (IBECS)). We identified cost-effectiveness analyses conducted in Spain that used quality-adjusted life years (QALYs) as outcome measures (period 1989-December 2014). Two reviewers independently extracted the data from each paper. The data were analysed descriptively.

Results: In total, 223 studies were included. Very few studies (10; 4.5 %) reported working from a protocol. Most studies (200; 89.7 %) were simulation models and included a median of 1000 patients. Only 105 (47.1 %) studies presented an adequate description of the characteristics of the target population. Most study interventions were categorized as therapeutic (189; 84.8 %) and nearly half (111; 49.8 %) considered an active alternative as the comparator. Effectiveness of data was derived from a single study in 87 (39.0 %) reports, and only few (40; 17.9 %) used evidence synthesis-based estimates. Few studies (42; 18.8 %) reported a full description of methods for QALY calculation. The majority of the studies (147; 65.9 %) reported that the study intervention produced "more costs and more QALYs" than the comparator. Most studies (200; 89.7 %) reported favourable conclusions. Main funding source was the private for-profit sector (135; 60.5 %). Conflicts of interest were not disclosed in 88 (39.5 %) studies.

Conclusions: This methodological review reflects that reporting of several important aspects of methods and results are frequently missing in published cost-effectiveness analyses. Without full and transparent reporting of how studies were designed and conducted, it is difficult to assess the validity of study findings and conclusions.
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http://dx.doi.org/10.1186/s13643-015-0181-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731991PMC
January 2016

Trends in clinical reproductive medicine research: 10 years of growth.

Fertil Steril 2015 Jul 30;104(1):131-7.e5. Epub 2015 Apr 30.

Department of Reproductive Medicine & Gynecology, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address:

Objective: To study the most important metrics of publication in the field of reproductive medicine over the decade 2003-2012 to aid in discerning the clinical, social, and epidemiologic implications of this relatively new but rapidly emerging area in medical sciences.

Design: Bibliometric analysis of most-cited publications from Web of Science databases.

Setting: Not applicable.

Patient(s): None.

Intervention(s): None.

Main Outcome Measure(s): Most productive and frequently cited investigators, institutions, and countries and specific areas of research, scientific collaborations, and comparison of the growth of reproductive medicine research compared with other areas of medical investigation such as obstetrics and gynecology and related science categories.

Result(s): We found that 90 investigators with more than 1,000 citations had jointly published 4,010 articles. A continued rise in the impact factor of reproductive medicine journals was seen. The number of publications in reproductive medicine grew more rapidly compared with other science categories. Presently 22% of highly cited articles in reproductive medicine research are published in journals belonging to science categories outside reproductive medicine. The most-cited study groups are situated in the Netherlands, Belgium, Spain, the United States, and the United Kingdom, and collaborative studies have been increasing.

Conclusion(s): Reproductive medicine research and subsequent clinical development have attained scientific growth and maturity. High-quality research is increasingly being published in high-impact journals. The increase in (inter)national collaborations seems to be key to the field's success.
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http://dx.doi.org/10.1016/j.fertnstert.2015.03.025DOI Listing
July 2015

Bibliographic searches for a bibliometric analysis on drug addiction.

Eur Addict Res 2015 28;21(1):31-2. Epub 2014 Oct 28.

Centro de Investigación de Seguridad y Emergencias (CISE), Instituto Valenciano de Seguridad Pública y Emergencias (IVASPE), Conselleria de Gobernación y Justicia, Generalitat Valenciana, Valencia, Spain.

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http://dx.doi.org/10.1159/000365081DOI Listing
May 2015

Bibliometric profile of the global scientific research on multiple sclerosis (2003-2012).

Mult Scler 2015 Feb 25;21(2):235-45. Epub 2014 Sep 25.

Instituto de Historia de la Medicina y de la Ciencia López Piñero, UISYS (Spanish Research Council-CSIC-Universitat de València), SpainUniversitat de València, SpainServicio de Pediatría, Hospital General Universitario de Alicante, Spain/Universidad Miguel Hernández, SpainUniversitat de València, SpainFacultad de Medicina y Odontología, Universidad de Valencia, SpainHospital General de Alicante, Spain.

Background And Objectives: The aim of this paper is to analyse the scientific research on multiple sclerosis using a bibliographic analysis of articles published during the period 2003-2012.

Methods: The items under study were obtained from the Science Citation Index-Expanded (SCI-E) database, which was accessed through the Web of Science (WOS) platform. All records with the term 'multiple sclerosis' in the title, plus all articles published in the journals Multiple Sclerosis and Multiple Sclerosis Journal, were analysed.

Results: A total of 9778 articles, with 160,966 citations, were retrieved on multiple sclerosis, and the majority of the articles were published in Multiple Sclerosis Journal (n = 1511). The articles were published in journals belonging to 135 different subject areas, with the greatest number of papers falling under the category of clinical neurology. The countries that published the largest numbers of articles were the United States (US) (n = 2786), Italy (n = 1263), the United Kingdom (n = 1147) and Germany (n = 1018). International collaborations produced 20.4% of the papers.

Conclusions: We emphasise the progressive growth of publications worldwide, the publication of articles in a wide variety of journals covering numerous subject areas, and the research leadership of Western countries, most notably European countries, the US and Canada.
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http://dx.doi.org/10.1177/1352458514540357DOI Listing
February 2015

Public availability of published research data in substance abuse journals.

Int J Drug Policy 2014 Nov 27;25(6):1143-6. Epub 2014 Jul 27.

Universidad Politécnica de Valencia, Camino de Vera, s/n, 46022 Valencia, Spain.

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http://dx.doi.org/10.1016/j.drugpo.2014.07.007DOI Listing
November 2014

[Promotion of public access and share of raw data from scientific research].

Med Clin (Barc) 2015 Mar 18;144(6):283-4. Epub 2014 Jun 18.

División de Farmacoepidemiología y Farmacovigilancia, Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Madrid, España; Fundación Instituto de Investigación en Servicios de Salud, Valencia, España.

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http://dx.doi.org/10.1016/j.medcli.2014.04.012DOI Listing
March 2015