Raf Sciot

Raf Sciot

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Raf Sciot

Raf Sciot

Publications by authors named "Raf Sciot"

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Assessment of the platelet-derived growth factor receptor alpha antibody olaratumab in a panel of patient-derived soft tissue sarcoma xenografts.

BMC Cancer 2019 Jul 22;19(1):724. Epub 2019 Jul 22.

Laboratory of Experimental Oncology, Department of Oncology and Department of General Medical Oncology, Leuven Cancer Institute, KU Leuven and University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1186/s12885-019-5872-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647161PMC
July 2019

Establishment and Characterization of Histologically and Molecularly Stable Soft-tissue Sarcoma Xenograft Models for Biological Studies and Preclinical Drug Testing.

Mol Cancer Ther 2019 Jun 8;18(6):1168-1178. Epub 2019 Apr 8.

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-1045DOI Listing
June 2019

Retrospective Analysis of Patients with Advanced Liposarcoma in a Tertiary Referral Center.

Oncol Res Treat 2019 6;42(7-8):396-404. Epub 2019 Jun 6.

Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.

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http://dx.doi.org/10.1159/000500608DOI Listing
June 2019

Robust Activity of Avapritinib, Potent and Highly Selective Inhibitor of Mutated KIT, in Patient-derived Xenograft Models of Gastrointestinal Stromal Tumors.

Clin Cancer Res 2019 Jan 1;25(2):609-618. Epub 2018 Oct 1.

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1858DOI Listing
January 2019

An uncommon histopathological diagnosis.

Breathe (Sheff) 2018 Dec;14(4):311-316

Dept of Respiratory Oncology, University Hospitals KU Leuven, Leuven, Belgium.

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http://breathe.ersjournals.com/lookup/doi/10.1183/20734735.0
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http://dx.doi.org/10.1183/20734735.027418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269173PMC
December 2018

Brain perfusion fixation in male pigs using a safer closed system.

Lab Anim 2018 Aug 10;52(4):413-417. Epub 2018 Jan 10.

1 Experimental Neurosurgery and Neuroanatomy, Neurosciences, KU Leuven, Belgium.

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http://dx.doi.org/10.1177/0023677217752747DOI Listing
August 2018

Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery.

Acta Neuropathol 2018 05 15;135(5):671-679. Epub 2018 Feb 15.

Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1007/s00401-018-1822-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904220PMC
May 2018

A rare case of atypical/anaplastic meningioma with MDM2 amplification.

Rare Tumors 2018 31;10:2036361318779511. Epub 2018 May 31.

Department of Pathology, University Hospitals KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1177/2036361318779511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985599PMC
May 2018

Primary myxoid mesenchymal tumour with intracranial location: report of a case with a EWSR1-ATF1 fusion.

Histopathology 2018 Apr 11;72(5):880-883. Epub 2018 Jan 11.

Department ofHuman Genetics, KU Leuven and University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/his.13437DOI Listing
April 2018

Characterization of PD-1 upregulation on tumor-infiltrating lymphocytes in human and murine gliomas and preclinical therapeutic blockade.

Int J Cancer 2017 11 19;141(9):1891-1900. Epub 2017 Jul 19.

Research group Experimental Neurosurgery and Neuroanatomy, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/ijc.30877DOI Listing
November 2017

A novel EWS-CREB3L3 gene fusion in a mesenteric sclerosing epithelioid fibrosarcoma.

Genes Chromosomes Cancer 2017 09 1;56(9):695-699. Epub 2017 Jul 1.

Department of Human Genetics, KU Leuven and University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/gcc.22474DOI Listing
September 2017

Fibrous dysplasia mimicking bone metastasis on GA-PSMA PET/MRI.

Eur J Nucl Med Mol Imaging 2017 08 9;44(9):1607-1608. Epub 2017 May 9.

Nuclear Medicine and Molecular Imaging, UZ Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00259-017-3712-6DOI Listing
August 2017

Antitumoral Efficacy of PhAc-ALGP-Doxorubicin, an Enzyme-Activated Doxorubicin Prodrug, in Patient-Derived Soft Tissue Sarcoma Xenograft Models.

Mol Cancer Ther 2017 08 31;16(8):1566-1575. Epub 2017 May 31.

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0832DOI Listing
August 2017

Identification of microRNA biomarkers for response of advanced soft tissue sarcomas to eribulin: Translational results of the EORTC 62052 trial.

Eur J Cancer 2017 04 16;75:33-40. Epub 2017 Feb 16.

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium; Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.ejca.2016.12.018DOI Listing
April 2017

Cabozantinib Is Active against Human Gastrointestinal Stromal Tumor Xenografts Carrying Different KIT Mutations.

Mol Cancer Ther 2016 12 24;15(12):2845-2852. Epub 2016 Oct 24.

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0224DOI Listing
December 2016

Imaging features of chondromyxoid fibroma: report of 15 cases and literature review.

Br J Radiol 2016 Aug 26;89(1064):20160088. Epub 2016 May 26.

2 Department of Pathology, University Hospital Leuven and KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1259/bjr.20160088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124884PMC
August 2016

The Filum Terminale: A Cadaver Study of Anatomy, Histology, and Elastic Properties.

World Neurosurg 2016 Jun 22;90:565-573.e1. Epub 2016 Jan 22.

Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.wneu.2015.12.103DOI Listing
June 2016

Cladophialophora bantiana osteomyelitis in a renal transplant patient.

Med Mycol Case Rep 2016 Jun 9;12:17-20. Epub 2016 Jul 9.

Department of Microbiology and Immunology, Laboratory of Nephrology, KU Leuven - University of Leuven, Belgium; Department of Nephrology, Dialysis and Renal Transplantation, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium.

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http://dx.doi.org/10.1016/j.mmcr.2016.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995601PMC
June 2016

A Mass Involving the Buccal Branch of the Facial Nerve.

JAMA Otolaryngol Head Neck Surg 2016 Feb;142(2):187-8

Department of Oral and Maxillofacial Surgery, KU Leuven, University Hospitals Leuven, Leuven, Belgium3Department of Imaging and Pathology, OMFS IMPATH Research Group, Leuven, Belgium.

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http://dx.doi.org/10.1001/jamaoto.2015.3077DOI Listing
February 2016

Angiomatoid fibrous histiocytoma - case series with emphasis on a late fibrotic variant.

J Dtsch Dermatol Ges 2015 May;13(5):441-8

Dermatohistological Laboratory, P.O. Box 4145, 90021, Nuernberg, Germany.

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http://doi.wiley.com/10.1111/ddg.12600
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http://dx.doi.org/10.1111/ddg.12600DOI Listing
May 2015

Therapeutic Efficacy Assessment of CK6, a Monoclonal KIT Antibody, in a Panel of Gastrointestinal Stromal Tumor Xenograft Models.

Transl Oncol 2015 Apr;8(2):112-8

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2015.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415139PMC
April 2015

Array CGH analysis identifies two distinct subgroups of primary angiosarcoma of bone.

Genes Chromosomes Cancer 2015 Feb 18;54(2):72-81. Epub 2014 Sep 18.

Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/gcc.22219DOI Listing
February 2015

Desmoid tumors in neurosurgery: a review of the literature.

Clin Neurol Neurosurg 2015 Feb 24;129:78-84. Epub 2014 Dec 24.

Department of Neurosurgery, University Hospitals Leuven, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.clineuro.2014.12.007DOI Listing
February 2015

Identification of an MLL4-GPS2 fusion as an oncogenic driver of undifferentiated spindle cell sarcoma in a child.

Genes Chromosomes Cancer 2014 Dec 19;53(12):991-8. Epub 2014 Aug 19.

Cancer Genetics Program, The National Children's Research Centre, Crumlin, Dublin 12, Ireland.

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http://dx.doi.org/10.1002/gcc.22208DOI Listing
December 2014

Phosphoinositide 3-kinase inhibitors combined with imatinib in patient-derived xenograft models of gastrointestinal stromal tumors: rationale and efficacy.

Clin Cancer Res 2014 Dec 14;20(23):6071-82. Epub 2014 Oct 14.

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium. Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1823DOI Listing
December 2014

Pazopanib, a Receptor Tyrosine Kinase Inhibitor, Suppresses Tumor Growth through Angiogenesis in Dedifferentiated Liposarcoma Xenograft Models.

Transl Oncol 2014 Dec;7(6):665-71

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2014.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311036PMC
December 2014

Metastatic potential is determined early in synovial sarcoma development and reflected by tumor molecular features.

Int J Biochem Cell Biol 2014 Aug 16;53:505-13. Epub 2014 May 16.

Department of Human Genetics, KU Leuven and University Hospitals Leuven, Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13572725140016
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http://dx.doi.org/10.1016/j.biocel.2014.05.006DOI Listing
August 2014

Cellular angiofibroma of the prostate: a rare tumor in an unusual location.

Case Rep Pathol 2014 1;2014:871530. Epub 2014 Jul 1.

Department of Pathology, KU Leuven and University Hospitals Leuven, UZ Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1155/2014/871530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102028PMC
August 2014

Characterization and assessment of the sensitivity and resistance of a newly established human gastrointestinal stromal tumour xenograft model to treatment with tyrosine kinase inhibitors.

Clin Sarcoma Res 2014 10;4:10. Epub 2014 Aug 10.

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Herestraat 49, Leuven, Belgium ; Department of General Medical Oncology, Leuven Cancer Institute, University Hospitals Leuven, Herestraat 49, Leuven, Belgium.

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http://dx.doi.org/10.1186/2045-3329-4-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134663PMC
August 2014

High-dosage tamoxifen as neoadjuvant treatment in minimally invasive surgery for Dupuytren disease in patients with a strong predisposition toward fibrosis: a randomized controlled trial.

J Bone Joint Surg Am 2014 Apr;96(8):655-62

Hand Unit, Orthopaedic Department, Pellenberg Campus, University Hospitals Leuven, Weligerveld 1, 3212 Pellenberg, Belgium. E-mail address for I. Degreef: E-mail address for L. De Smet:

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https://insights.ovid.com/crossref?an=00004623-201404160-000
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http://dx.doi.org/10.2106/JBJS.L.01623DOI Listing
April 2014

Active TGF-β signaling and decreased expression of PTEN separates angiosarcoma of bone from its soft tissue counterpart.

Mod Pathol 2013 Sep 19;26(9):1211-21. Epub 2013 Apr 19.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/modpathol.2013.56DOI Listing
September 2013

Pseudomyxoma peritonei originating from an intestinal duplication.

Case Rep Pathol 2013 19;2013:608016. Epub 2013 Aug 19.

Department of Imaging and Pathology, University Hospitals Leuven, Minderbroedersstraat 12, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1155/2013/608016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760268PMC
September 2013

Multiple pilomatricomas with somatic CTNNB1 mutations in children with constitutive mismatch repair deficiency.

Genes Chromosomes Cancer 2013 Jul 30;52(7):656-64. Epub 2013 Apr 30.

Department of Human Genetics, KU Leuven, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/gcc.22061DOI Listing
July 2013

Recurrent and novel SS18-SSX fusion transcripts in synovial sarcoma: description of three new cases.

Tumour Biol 2012 Dec 14;33(6):2245-53. Epub 2012 Sep 14.

Department of Molecular Biology, The Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, 5 WK Roentgen Street, 02-781 Warsaw, Poland.

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http://dx.doi.org/10.1007/s13277-012-0486-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501176PMC
December 2012

Stratification according to HGG-IMMUNO RPA model predicts outcome in a large group of patients with relapsed malignant glioma treated by adjuvant postoperative dendritic cell vaccination.

Cancer Immunol Immunother 2012 Nov 8;61(11):2105-12. Epub 2012 May 8.

Department of Neurosurgery, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00262-012-1271-zDOI Listing
November 2012

Paediatric lipoblastoma in the head and neck: three cases and review of literature.

Cancer Imaging 2012 Oct 31;12:484-7. Epub 2012 Oct 31.

Department of Radiology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1102/1470-7330.2012.0037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485648PMC
October 2012

Biallelic inactivation of NF1 in a sporadic plexiform neurofibroma.

Genes Chromosomes Cancer 2012 Sep 14;51(9):852-7. Epub 2012 May 14.

Department of Human Genetics, KU Leuven, Leuven, Belgium.

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http://doi.wiley.com/10.1002/gcc.21969
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http://dx.doi.org/10.1002/gcc.21969DOI Listing
September 2012

Apnea as the sole manifestation of a seizure attributable to meningioangiomatosis of the temporal lobe in an infant.

Pediatr Neurol 2012 Aug;47(2):144-6

Department of Pediatric Neurology, University Hospitals Leuven, Leuven, Belgium.

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http://linkinghub.elsevier.com/retrieve/pii/S088789941200185
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http://dx.doi.org/10.1016/j.pediatrneurol.2012.04.025DOI Listing
August 2012

Perineural spread of endometriosis along the obturator nerve into the adductor thigh compartment.

Jpn J Radiol 2012 Jun 21;30(5):446-9. Epub 2012 Feb 21.

Department of Radiology, University Hospitals of Leuven, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1007/s11604-012-0060-0DOI Listing
June 2012

Mitotic recombination of chromosome arm 17q as a cause of loss of heterozygosity of NF1 in neurofibromatosis type 1-associated glomus tumors.

Genes Chromosomes Cancer 2012 May 17;51(5):429-37. Epub 2012 Jan 17.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA.

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http://dx.doi.org/10.1002/gcc.21928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295917PMC
May 2012

FOSL1 as a candidate target gene for 11q12 rearrangements in desmoplastic fibroblastoma.

Lab Invest 2012 May 12;92(5):735-43. Epub 2012 Mar 12.

Department of Clinical Genetics, University and Regional Laboratories, Skåne University Hospital, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1038/labinvest.2012.46DOI Listing
May 2012

Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer.

Nucl Med Biol 2012 Apr 11;39(3):389-99. Epub 2011 Dec 11.

Laboratory for Radiopharmacy, K.U. Leuven, Leuven, Belgium BE3000.

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http://dx.doi.org/10.1016/j.nucmedbio.2011.09.005DOI Listing
April 2012

Delayed liver metastasis of a meningeal solitary fibrous tumor.

Acta Gastroenterol Belg 2011 Dec;74(4):567-9

Department of Radiology, University Hospitals Leuven, Belgium.

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December 2011

Paraganglioma of the cauda equina region: A report of three cases.

Surg Neurol Int 2011 18;2:96. Epub 2011 Jul 18.

Department of Neurosurgery, University Hospitals, Leuven, Belgium.

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http://dx.doi.org/10.4103/2152-7806.82989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144596PMC
November 2011

The heat shock protein 90 inhibitor IPI-504 induces KIT degradation, tumor shrinkage, and cell proliferation arrest in xenograft models of gastrointestinal stromal tumors.

Mol Cancer Ther 2011 Oct 8;10(10):1897-908. Epub 2011 Aug 8.

Laboratory of Experimental Oncology and Department of General Medical Oncology, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, bus 815, 3000 Leuven, Belgium.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-11
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http://dx.doi.org/10.1158/1535-7163.MCT-11-0148DOI Listing
October 2011

The Novel HSP90 inhibitor, IPI-493, is highly effective in human gastrostrointestinal stromal tumor xenografts carrying heterogeneous KIT mutations.

Clin Cancer Res 2011 Sep 7;17(17):5604-14. Epub 2011 Jul 7.

Laboratory of Experimental Oncology and Department of General Medical Oncology, University Hospital Gasthuisberg, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-0562DOI Listing
September 2011

Retroperitoneal dedifferentiated liposarcomas with production of β-human chorionic gonadotropin--a distinct sarcoma entity?

Onkologie 2011 21;34(3):122-5. Epub 2011 Feb 21.

Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Herestraat 49, Leuven, Belgium.

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http://dx.doi.org/10.1159/000324786DOI Listing
July 2011

Avascular necrosis of the scaphoid after three-ligament tenodesis for scapholunate dissociation: case report.

J Hand Surg Am 2011 Apr 23;36(4):587-90. Epub 2011 Feb 23.

Department of Orthopedic Surgery, University Hospitals, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.jhsa.2010.11.043DOI Listing
April 2011

Subacute trismus in a kidney transplant recipient.

J Orofac Pain 2010 ;24(4):412-6

Department of General Internal Medicine, Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium.

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March 2011

The t(X;6) in subungual exostosis results in transcriptional deregulation of the gene for insulin receptor substrate 4.

Int J Cancer 2011 Jan;128(2):487-91

Department of Clinical Genetics, University and Regional Laboratories, Lund University Hospital, Lund University, Lund, Sweden.

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http://doi.wiley.com/10.1002/ijc.25353
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http://dx.doi.org/10.1002/ijc.25353DOI Listing
January 2011

Genetic Creutzfeldt-Jakob disease associated with the E200K mutation: characterization of a complex proteinopathy.

Acta Neuropathol 2011 Jan 1;121(1):39-57. Epub 2010 Jul 1.

Institute of Neurology, Medical University of Vienna, and Austrian Reference Center for Human Prion Diseases, AKH 4J, Währinger Gürtel 18-20, 1097, Vienna, Austria.

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http://dx.doi.org/10.1007/s00401-010-0713-yDOI Listing
January 2011

Distinct histological features characterize primary angiosarcoma of bone.

Histopathology 2011 Jan;58(2):254-64

Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/j.1365-2559.2011.03750.xDOI Listing
January 2011

A patient with swelling of the eyelid: ancient schwannoma of the supraorbital nerve (2010:6b).

Eur Radiol 2010 Sep 3;20(9):2301-4. Epub 2010 Aug 3.

Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00330-009-1659-0DOI Listing
September 2010

Diagnosis, management, and complications of glomus tumours of the digits in neurofibromatosis type 1.

J Med Genet 2010 Aug 7;47(8):525-32. Epub 2010 Jun 7.

Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Building 49, Room 4A62, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1136/jmg.2009.073965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412429PMC
August 2010