Dr Raef F A Hafez, MD neurosurgery - International Medical Center - Prof of Neurosurgery and Gamma knife surgery

Dr Raef F A Hafez

MD neurosurgery

International Medical Center

Prof of Neurosurgery and Gamma knife surgery

Cairo | Egypt

Main Specialties: Neurological Surgery

Additional Specialties: Neurosurgery& gamma knife surgery

ORCID logohttps://orcid.org/0000-0002-2891-8134

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Dr Raef F A Hafez, MD neurosurgery - International Medical Center - Prof of Neurosurgery and Gamma knife surgery

Dr Raef F A Hafez

MD neurosurgery


Name Raef Farouk Ahmed.Hafez MD.Neurosurgery
Prof: of neurosurgery at the Egyptian Military Medical Academy
Current Post - Head of gamma knife center –International Medical center (IMC)
Marital status –married has 3 children
Work Address - International Medical Center Clinic Km 42, Cairo Ism. Desert Rd., Cairo Near To El Sherouk City, Gate 2 Cairo, Egypt
Tel – mob 00202 - 0101420086
Work 00202 - 24775902—or 24775903- Hotline: 16221
Fax: 02-24775908
Personal E-mail : raefhafez179@hotmail.com
Work Email: IMC@imc.org.eg Web: www.imc.org.eg

Educational Background:
Basic: - MBBCh, Cairo University, Egypt. 1981
- Master's degree in general surgery (MSc), Zagazic University 1985.
- MD. Neurosurgery, Ain -shams’ university, Cairo Egypt 1993

Clinical Interests: -Gamma knife surgery
-Cranial stereotaxy

Educational Background:
Professional Background: and training
? -Head of the Neurosurgical Department and Gamma knife Center at the International Medical center (I M C) - Cairo-Egypt-Cairo-Egypt -Since March 2003 till 2007-
? -Head of gamma knife center –International Medical center (IMC)
42 km Ismailia desert road –Cairo Egypt from 2007 till now 2018
? -Consultant Neurosurgeon- Maadi Armed Forces Hospital since1992
? -Senior Registrar of neurosurgery at Maadi Armed Forces Hospital since1987 till 1992
? -Senior Registrar of a neurosurgery-El-Sahel teaching hospital, Cairo Egypt on 1986
? -Registrar, general surgery and neurosurgery- Banha University Hospital 1981-1985
? -Senior house officer at Cairo University Hospitals from 1980-1981
? -Senior registrar visitor and Research Fellow, at the national hospital for neurology and
Neurosurgery London, UK-under supervision of Prof Alan crockard in 1991 for 3 months
And on1995 for 4 months
? -Visitor consultant at Walter reed army hospital USA Washington DC in 1998 for 3 months
? -Training on leksell stereotactic surgery on Karolinska in 1989 for a week
? -Training as consultant gamma knife surgeon, at Gamma knife center, Karolinska hospital Sweden on March 2003 and 0n October 2006.

Memberships / Societies:

- Egyptian society of neurological surgeons
- Arab society of neurological surgeons
- World federation of neurological surgeons-WFNS
- Congress of neurological surgeons
- The Military Medical Academy.
- Egyptian Society of Surgeons.
- Leksell gamma knife society

Primary Affiliation: International Medical Center - Cairo , Egypt


Additional Specialties:

Research Interests:

View Dr Raef F A Hafez’s Resume / CV


Jan 1993
Ein shams university
Jan 1973 - Jan 1984
Zagazic university
Msc master degree in surgery
Jan 1973 - Jan 1980
Cairo University


Apr 2006
Head of gamma knife center at the international medical center -Cairo-Egypt
Head of Gamma knife center
2006-2019 Edit
Jan 2006
Head of Neurosurgical depart. and Gamma knife center at the international medical center -Cairo-Egypt
Head of Neurosurgical depart. and Gamma knife center
Jun 1986
Neurosurgical consultant at Maadi Armed hospital-Cairo-Egypt
Consultant Neurosurgery




724Profile Views

9PubMed Central Citations

Gamma knife surgery efficacy in controlling postoperative residual clival chordoma growth.

Clin Neurol Neurosurg 2019 03 25;178:51-55. Epub 2019 Jan 25.

Department of Neurosurgery and Gamma Knife Center, International Medical Center (IMC), 42km. Ismailia Desert Road, Cairo, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.clineuro.2019.01.017DOI Listing
March 2019
12 Reads
1.248 Impact Factor

Gamma Knife Management of Skull Base Chordomas: Is it a Choice?

Asian J Neurosurg 2018 Oct-Dec;13(4):1037-1041

Department of Neurosurgery, Mansoura University Hospital, Mansoura, International Medical Center, Cairo, Egypt.

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http://dx.doi.org/10.4103/ajns.AJNS_61_17DOI Listing
November 2018
44 Reads

Long-term effectiveness and safety of stereotactic gamma knife surgery as a primary sole treatment in the management of glomus jagulare tumor.

Clin Neurol Neurosurg 2018 05 26;168:34-37. Epub 2018 Feb 26.

Department of Neurosurgery and Gamma Knife Center, International Medical Center (IMC), 42 km. Ismailia Desert Road, Cairo, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.clineuro.2018.02.037DOI Listing
May 2018
27 Reads
1.250 Impact Factor

Gamma knife management of skull base chordomas: Is it a choice?

Asian Journal of Neurosurgery

Background: Skull base chordomas are locally invasive tumors which able to extend in different directions with skull base invasion. Although they are histologically benign, they have invasive nature makes total resection virtually impossible to achieve in most cases and this lead to residual tumors after surgery. To decrease postoperative surgical resection morbidity of these tumors, gamma knife radiosurgery (GKRS) was performed as alternative management for these residual chordomas to evaluate its safety and efficacy. Materials and Methods: A retrospective study was made on eight residual skull base chordomas treated with GKRS between 2011 and 2015. The mean patient age was 49 years (range 30–73 years). Four patients harboring chordoma were male, and four patients were females with 1:1 ratio. All patients had undergone one prior surgery. Patients were treated with peripheral dose ranged between 12–15 gray (Gy) (mean 13.75 Gy) usually at 35% to 50% isodose curve (mean 38.8%). The maximum dose to the adjacent brain stem area ranged between 10 and 12 Gy. All patients were followed up from 8 to 39 months (mean 18 months). Results: The tumor control rate was 50% and 25% after 18 and 36 months, respectively, but we found that their wasdeclined in the tumor control rate with long follow-up time. Four tumors were stable in their size just for 18 months, and then there two of these tumors were progressed in their size, the other four patients showed progression in their tumors in their 1st year of treatment without sign of central tumor necrosis. Conclusion: Skull base chordoma patients complained from symptoms due to tumor mass effect which were not prospected to respond to GKRS alone as the aim of this type of treatment was the local tumor control, the tumor control rate declined with long follow-up time and this correlated with radioresistant nature of skull base chordoma. We advise a gross total resection to decrease the tumor volume, and this making gamma knife a reasonable treatment modality.

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April 2018
9 Reads

Gamma Knife Surgery Targeting the Neurovascular Contact Complex in Management of Refractory Idiopathic Trigeminal Neuralgia: Outcome and Long Term Efficiency

EC Neurology 7.2 (2017): 54-62.


Abstract Idiopathic trigeminal neuralgia (ITN) is considered to be one of the most severe forms of pain in the human experience. The presence of neurovascular contact complex (NVC) with trigeminal nerve on pre-treatment MRI predicts an increased likelihood of adequate response to Gamma Knife Surgery (GKS). The aim of study is to evaluate Gamma Knife Surgery effectiveness and complications in treatment of refractory ITN when targeting the NVC complex. 58 patients with refractory ITN treated with GKS at our center were followed between 2005 and 2014. Mean maximum dose was 78 Gy, the NVC complex delineated by 3D-T2 MRI long relaxation sequence was the target of GKS. Clinical response was categorized on basis of pain outcome using BNI pain scale, into Group I in 60.3% of patients (significant response without medication), Group II in 22.4% (adequate response with medication) and Group III represented in 17.2% with failure of GKS to control pain. Mean duration of follow-up was 66 months. At final outcome patients who achieved significant and adequate pain control (Group I and Group II) were 82.8% at 2 years, 80% at 3 years, 77% at 5 years and 66% at 10 years. Favorable response rates were higher in patients who had no previous surgery 82.2% and those with duration of symptoms < 10 years in 77%. New or worsening facial numbness reported in 27.5%. GKS targeting detected NVC complex as the main associative pathology for treatment of ITN resulted in favorable outcomes compared with surgery in terms of pain relief and complication rates. Keywords: Gamma Knife Surgery; Idiopathic Trigeminal Neuralgia; Radiosurgery; Rhizotomy

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July 2017
32 Reads

An intermediate term benefits and complications of gamma knife surgery in management of glomus jugulare tumor.

World J Surg Oncol 2016 Feb 15;14(1):36. Epub 2016 Feb 15.

Department of Neurosurgery and Gamma Knife center, International Medical Center (IMC), Cairo, Egypt.

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http://dx.doi.org/10.1186/s12957-016-0779-7DOI Listing
February 2016
195 Reads
2 Citations
1.200 Impact Factor

Stereotactic Gamma Knife surgery safety and efficacy in the management of symptomatic benign confined cavernous sinus meningioma.

Acta Neurochir (Wien) 2015 Sep 1;157(9):1559-64. Epub 2015 Aug 1.

Department of Neurosurgery and Gamma Knife center, International Medical Center (IMC), 42 km. Ismailia Desert Road, Cairo, Egypt,

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http://dx.doi.org/10.1007/s00701-015-2509-2DOI Listing
September 2015
18 Reads
1.790 Impact Factor


VOL 13 , NO 2 , APRIL 2015 SUPPL


In order to evaluate the results of radiosurgery for vestibular schwannomas (VS) and to identify optimum treatment parameters, an analysis of tumor control, as well as incidences of hearing loss, facial and trigeminal neuropathies was undertaken. Between January 2013 and May 2014, 16 patients with VS received stereotactic gamma knife radiosurgery at International Medical Center. Median follow-up was 12 months. Regarding tumor volumes, 14 patients (87.5%) were less than 3 cm3 and 2 patients (12.5%) were between 3-4 cm3. From one to ten isocenters were utilized per tumor treated (median = 3). Minimum tumor doses varied from 12 to 20 Gy (median = 17 Gy). The 1-year actuarial tumor control rate was 90%. Hearing was preserved (stationary as pre radiosurgery) in 12 patients (75%) of cases and deteriorated in (4 patients) 25% of them. Facial affection improved in 2 cases (50%) and remained stationary in another 2 cases (50%). Trigeminal neuropathy and cerebellar ataxia were improved in all cases. Radiosurgery is a safe and effective treatment for vestibular schwannomas with acceptable morbidity that may be lowered by the use of multiple isocenter treatment techniques and by earlier treatment of small tumors.

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April 2015
26 Reads

The safety and efficacy of gamma knife surgery in management of glomus jugulare tumor.

World J Surg Oncol 2010 Sep 6;8:76. Epub 2010 Sep 6.

Neurosurgery and Gamma knife department, International Medical Center, Cairo, Egypt.

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http://dx.doi.org/10.1186/1477-7819-8-76DOI Listing
September 2010
42 Reads
6 Citations
1.200 Impact Factor

Research Article. Failure of osseous conduction with cervical interbody BOP graft

British Journal of Neurosurgery

We report three patients treated for cervical radiculopathy by anterior cervical discectomy and BOP grafting. Because of recurrent symptoms re-exploration was carried out 30 months later in the first case, 10 months in second and 8 months in the third case. At reoperation the grafts were disrupted into easily separable fibres. Histologically, there were no osteoblast or fibroblast cells or new bone formation. We suggest that contrary to the manufacturer's claims, the material acts only as a "spacer" and does not conduct bone formation. Bop Graft, Cervical Spine, Fusion, Graft. DOI:10.1080/02688699746717

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July 2009
9 Reads

Stereotaxic gamma knife surgery in treatment of critically located pilocytic astrocytoma: preliminary result.

Raef F A Hafez

World J Surg Oncol 2007 Mar 29;5:39. Epub 2007 Mar 29.

International Medical Center, Gamma Knife Center, Cairo- Egypt.

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http://dx.doi.org/10.1186/1477-7819-5-39DOI Listing
March 2007
49 Reads
1 Citation
1.200 Impact Factor