Radek C Skoda

Radek C Skoda

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Radek C Skoda

Radek C Skoda

Publications by authors named "Radek C Skoda"

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65Publications

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Dual roles of in acute myeloid leukemia.

J Exp Med 2019 Apr 19;216(4):725-727. Epub 2019 Mar 19.

Department of Biomedicine, University Children's Hospital Basel and University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1084/jem.20190250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446873PMC
April 2019

Accelerating myelofibrosis through loss of .

Authors:
Radek C Skoda

Blood 2018 12;132(26):2703-2704

University Hospital Basel.

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http://dx.doi.org/10.1182/blood-2018-11-883470DOI Listing
December 2018

Anti-Platelet Factor 4/Heparin Antibody Formation Occurs Endogenously and at Unexpected High Frequency in Polycythemia Vera.

Biomed Res Int 2017 18;2017:9876819. Epub 2017 Jun 18.

Diagnostic Hematology, Department of Laboratory Medicine, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1155/2017/9876819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494054PMC
April 2018

A Gain-of-Function Mutation in EPO in Familial Erythrocytosis.

N Engl J Med 2018 03;378(10):924-930

From the Department of Biomedicine, Experimental Hematology, University Hospital Basel and University of Basel (J.Z., P.L., R.N., R.C.S.), and Diagnostic Hematology, University Hospital Basel (P.L.), Basel, Switzerland; and the Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (M.L.T., A.S., A.W.), and the Department of Hematology, St. Olavs Hospital (A.W.) - both in Trondheim, Norway.

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http://dx.doi.org/10.1056/NEJMoa1709064DOI Listing
March 2018

Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency.

Blood 2016 06 24;127(25):3253-9. Epub 2016 Mar 24.

Division of Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland;

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http://dx.doi.org/10.1182/blood-2016-02-696310DOI Listing
June 2016

Pathogenesis of myeloproliferative neoplasms.

Exp Hematol 2015 Aug 21;43(8):599-608. Epub 2015 Jul 21.

Department of Biomedicine, Experimental Hematology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.exphem.2015.06.007DOI Listing
August 2015

ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.

Proc Natl Acad Sci U S A 2015 Apr 30;112(15):4642-7. Epub 2015 Mar 30.

School of Medicine, University of Tampere, FI-33014 Tampere, Finland; Clinical Hematology, Department of Internal Medicine, Tampere University Hospital, FI-33520 Tampere, Finland

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http://dx.doi.org/10.1073/pnas.1423201112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403165PMC
April 2015

Haemorrhagic and thrombotic diatheses in mouse models with thrombocytosis.

Thromb Haemost 2015 Feb 9;113(2):414-25. Epub 2014 Oct 9.

François Lanza, UMR S_949 - EFS-Alsace, 10, rue Spielmann, 67065 Strasbourg Cedex, France, Tel.: +33 388 21 25 25, Fax: +33 388 21 25 21, E-mail:

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http://dx.doi.org/10.1160/TH14-08-0667DOI Listing
February 2015

Less Jak2 makes more platelets.

Authors:
Radek C Skoda

Blood 2014 Oct;124(14):2168-9

UNIVERSITY HOSPITAL BASEL.

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http://dx.doi.org/10.1182/blood-2014-08-596361DOI Listing
October 2014

Somatic mutations in calreticulin can be found in pedigrees with familial predisposition to myeloproliferative neoplasms.

Blood 2014 Apr;123(17):2744-5

Experimental Hematology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2014-01-550863DOI Listing
April 2014

The DEAH-box helicase RHAU is an essential gene and critical for mouse hematopoiesis.

Blood 2012 May 15;119(18):4291-300. Epub 2012 Mar 15.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66,Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2011-08-362954DOI Listing
May 2012

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling.

Nat Struct Mol Biol 2011 Aug 14;18(9):971-6. Epub 2011 Aug 14.

Institute of Biomedical Technology, University of Tampere, and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1038/nsmb.2099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504201PMC
August 2011

SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis.

Blood 2011 Jul 19;118(3):723-35. Epub 2011 May 19.

Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.

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http://www.bloodjournal.org/content/118/3/723.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-01-32
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http://dx.doi.org/10.1182/blood-2011-01-328765DOI Listing
July 2011

HiJAKing the methylosome in myeloproliferative disorders.

Cancer Cell 2011 Feb;19(2):161-3

Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

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https://linkinghub.elsevier.com/retrieve/pii/S15356108110005
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http://dx.doi.org/10.1016/j.ccr.2011.01.046DOI Listing
February 2011

JAK2 impairs stem cell function?

Authors:
Radek C Skoda

Blood 2010 Sep;116(9):1392-3

University Hospital Basel.

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http://dx.doi.org/10.1182/blood-2010-06-287318DOI Listing
September 2010

Thrombocytosis.

Authors:
Radek C Skoda

Hematology Am Soc Hematol Educ Program 2009 :159-67

Experimental Hematology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1182/asheducation-2009.1.159DOI Listing
March 2010

Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms.

Blood 2010 Mar 8;115(10):2003-7. Epub 2010 Jan 8.

Department of Biomedicine, Experimental Hematology, University Hospital Basel, Hebelstr 20, 4031 Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2009-09-245381DOI Listing
March 2010

The allele burden of JAK2 mutations remains stable over several years in patients with myeloproliferative disorders.

Haematologica 2008 Dec 11;93(12):1890-3. Epub 2008 Sep 11.

Experimental Hematology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

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http://www.haematologica.org/cgi/doi/10.3324/haematol.13074
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http://dx.doi.org/10.3324/haematol.13074DOI Listing
December 2008

Can we control JAK?

Authors:
Radek C Skoda

Blood 2008 Jun;111(12):5419-20

University Hospital Basel.

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http://dx.doi.org/10.1182/blood-2007-11-123810DOI Listing
June 2008

A de novo splice donor mutation in the thrombopoietin gene causes hereditary thrombocythemia in a Polish family.

Haematologica 2008 May 26;93(5):706-14. Epub 2008 Mar 26.

Department of Biomedicine, Experimental Hematology, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

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http://dx.doi.org/10.3324/haematol.11801DOI Listing
May 2008

Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice.

Blood 2008 Apr 26;111(8):3931-40. Epub 2007 Dec 26.

Department of Research, Experimental Hematology, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-08-10
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http://dx.doi.org/10.1182/blood-2007-08-107748DOI Listing
April 2008

Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations.

Blood 2008 Apr 14;111(7):3863-6. Epub 2008 Jan 14.

Department of Research, Experimental Hematology, University Hospital Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2007-09-111971DOI Listing
April 2008

Normal erythropoiesis but severe polyposis and bleeding anemia in Smad4-deficient mice.

Blood 2007 Oct 16;110(8):3049-55. Epub 2007 Jul 16.

Department of Research, Experimental Hematology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2007-02-074393DOI Listing
October 2007

Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo.

Blood 2007 Feb 10;109(4):1503-6. Epub 2006 Oct 10.

Department of Research and Experimental Hematology, University Hospital Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2006-04-020362DOI Listing
February 2007

Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders.

Blood 2006 Aug 4;108(4):1377-80. Epub 2006 May 4.

Department of Research, Experimental Hematology, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2005-11-009605DOI Listing
August 2006

Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2.

Blood 2005 Nov 4;106(10):3374-6. Epub 2005 Aug 4.

Experimental Hematology, Department of Research, Division of Clinical Hematology, Division of Pneumology, Basel University Hospital, Switzerland.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-05-18
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http://dx.doi.org/10.1182/blood-2005-05-1889DOI Listing
November 2005

A gain-of-function mutation of JAK2 in myeloproliferative disorders.

N Engl J Med 2005 Apr;352(17):1779-90

Department of Research, Experimental Hematology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1056/NEJMoa051113DOI Listing
April 2005

Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders.

Blood Rev 2005 Jan;19(1):1-13

Department of Research, Experimental Hematology, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S0268960X0400014
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http://dx.doi.org/10.1016/j.blre.2004.02.002DOI Listing
January 2005

Chronic myeloproliferative disorders: molecular markers and pathogenesis.

Authors:
Radek C Skoda

Hematol J 2004 ;5 Suppl 3:S122-5

Department of Research, Basel University Hospital, Basel, Switzerland.

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http://dx.doi.org/10.1038/sj.thj.6200437DOI Listing
November 2004

A truncated isoform of c-Mpl with an essential C-terminal peptide targets the full-length receptor for degradation.

J Biol Chem 2004 Aug 21;279(35):36397-404. Epub 2004 Jun 21.

Department of Research, Experimental Hematology, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M401386200
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http://dx.doi.org/10.1074/jbc.M401386200DOI Listing
August 2004

Gene silencing by lentivirus-mediated delivery of siRNA in human CD34+ cells.

Blood 2004 Jun 26;103(12):4511-3. Epub 2004 Feb 26.

Department of Research, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2003-07-2397DOI Listing
June 2004

Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders.

Blood 2003 Sep 1;102(5):1869-71. Epub 2003 May 1.

Department of Research, Experimental Hematology, Basel University Hospitals, Hebelstrasse 20, 4031 Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2003-03-0744DOI Listing
September 2003