Publications by authors named "Rachelle Gaudet"

61Publications

Selecting for Altered Substrate Specificity Reveals the Evolutionary Flexibility of ATP-Binding Cassette Transporters.

Curr Biol 2020 May 26;30(9):1689-1702.e6. Epub 2020 Mar 26.

Department of Molecular and Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2020.02.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243462PMC
May 2020

Transmembrane helix 6b links proton and metal release pathways and drives conformational change in an Nramp-family transition metal transporter.

J Biol Chem 2020 01 27;295(5):1212-1224. Epub 2019 Dec 27.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138

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http://dx.doi.org/10.1074/jbc.RA119.011336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996879PMC
January 2020

Unique structural features in an Nramp metal transporter impart substrate-specific proton cotransport and a kinetic bias to favor import.

J Gen Physiol 2019 12 16;151(12):1413-1429. Epub 2019 Oct 16.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA

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http://dx.doi.org/10.1085/jgp.201912428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888756PMC
December 2019

Mechanics and pharmacology of substrate selection and transport by eukaryotic ABC exporters.

Nat Struct Mol Biol 2019 09 26;26(9):792-801. Epub 2019 Aug 26.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41594-019-0280-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822692PMC
September 2019

Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis.

Proc Natl Acad Sci U S A 2019 09 20;116(36):17825-17830. Epub 2019 Aug 20.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138;

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http://dx.doi.org/10.1073/pnas.1821063116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731663PMC
September 2019

Homozygous mutation causes congenital distal spinal muscular atrophy and arthrogryposis.

Neurol Genet 2019 Apr 7;5(2):e312. Epub 2019 Mar 7.

Department of Molecular and Cellular Biology (J.V., R.G.), Harvard University, Cambridge; Division of Genetics (M.M.M., A.T.-P., C.G., A.H.B., N.C., B.T.D., N.Y.F., J.K., V.A.G.), Brigham Genomic Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; Division of Genetics (E.E.), Boston Children's Hospital; and Division of Neurology (B.T.D.), Boston Children's Hospital, Harvard Medical School, MA.

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http://dx.doi.org/10.1212/NXG.0000000000000312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454305PMC
April 2019

Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter.

Elife 2019 02 4;8. Epub 2019 Feb 4.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, United States.

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http://dx.doi.org/10.7554/eLife.41124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398981PMC
February 2019

Batrachotoxin acts as a stent to hold open homotetrameric prokaryotic voltage-gated sodium channels.

J Gen Physiol 2019 02 26;151(2):186-199. Epub 2018 Dec 26.

Department of Physiology & Pharmacology and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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http://dx.doi.org/10.1085/jgp.201812278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363421PMC
February 2019

Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP.

Structure 2018 12 20;26(12):1583-1593.e5. Epub 2018 Sep 20.

Institute for Pharmacy and Biochemistry, Johannes Gutenberg-Universität Mainz, 55128 Mainz, Germany; Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-Universität, 60438 Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281781PMC
December 2018

Applications of sequence coevolution in membrane protein biochemistry.

Biochim Biophys Acta Biomembr 2018 Apr 7;1860(4):895-908. Epub 2017 Oct 7.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, 02138, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2017.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807202PMC
April 2018

D-helix influences dimerization of the ATP-binding cassette (ABC) transporter associated with antigen processing 1 (TAP1) nucleotide-binding domain.

PLoS One 2017 23;12(5):e0178238. Epub 2017 May 23.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178238PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441636PMC
September 2017

A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15.

Structure 2017 03 23;25(3):482-495. Epub 2017 Feb 23.

Department of Chemistry and Biochemistry, The Ohio State University, 484 West 12(th) Avenue, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2017.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363953PMC
March 2017

Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter.

Structure 2016 12 10;24(12):2102-2114. Epub 2016 Nov 10.

Department of Molecular and Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143219PMC
December 2016

Conserved methionine dictates substrate preference in Nramp-family divalent metal transporters.

Proc Natl Acad Sci U S A 2016 09 29;113(37):10310-5. Epub 2016 Aug 29.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138;

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http://dx.doi.org/10.1073/pnas.1607734113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027461PMC
September 2016

Novel mutations highlight the key role of the ankyrin repeat domain in TRPV4-mediated neuropathy.

Neurol Genet 2015 Dec 22;1(4):e29. Epub 2015 Oct 22.

Department of Neurology (J.M.S., W.A., B.B., C.J.S.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Molecular and Cellular Biology (C.M.Z., R.G.), Harvard University, Cambridge, MA; Department of Neurology (D.-H.C., T.D.B.), University of Washington School of Medicine, Seattle, WA; Department of Neurology (J.W.D., C.E.S.), Stanford Health Care, Stanford, CA; and Department of Neuroscience (C.J.S.), Johns Hopkins University, Baltimore, MD.

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http://dx.doi.org/10.1212/NXG.0000000000000029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811381PMC
December 2015

Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity.

Structure 2015 Nov 15;23(11):2087-98. Epub 2015 Oct 15.

Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2015.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635037PMC
November 2015

How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy.

Bioessays 2015 Nov 21;37(11):1184-92. Epub 2015 Sep 21.

Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.

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http://dx.doi.org/10.1002/bies.201500085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862669PMC
November 2015

The Touching Tail of a Mechanotransduction Channel.

Cell 2015 Sep;162(6):1214-6

National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02458, USA; Volen Center for Complex Systems, Department of Biology, Brandeis University, Waltham, MA 02458, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.08.049DOI Listing
September 2015

Insights into the molecular foundations of electrical excitation.

J Mol Biol 2015 Jan;427(1):1-2

Cardiovascular Research Institute, Departments of Biochemistry and Biophysics, and Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research, University of California, San Francisco, CA 93858-2330 USA; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2014.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544904PMC
January 2015

Structural characterization of the late competence protein ComFB from Bacillus subtilis.

Biosci Rep 2015 Mar 31;35(2). Epub 2015 Mar 31.

*Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, U.S.A.

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http://dx.doi.org/10.1042/BSR20140174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381287PMC
March 2015

Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter.

Nat Commun 2014 Nov 7;5:5419. Epub 2014 Nov 7.

1] Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Max-von-Laue-Street 9, D-60438 Frankfurt/M., Germany [2] Cluster of Excellence Frankfurt-Macromolecular Complexes, Goethe-University Frankfurt, Max-von-Laue-Street 9, D-60438 Frankfurt/M., Germany.

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http://www.nature.com/articles/ncomms6419
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http://dx.doi.org/10.1038/ncomms6419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242082PMC
November 2014

High-resolution views of TRPV1 and their implications for the TRP channel superfamily.

Handb Exp Pharmacol 2014 ;223:991-1004

Harvard University, Cambridge, MA, USA,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075239PMC
http://dx.doi.org/10.1007/978-3-319-05161-1_11DOI Listing
November 2014

Structural biology of TRP channels.

Handb Exp Pharmacol 2014 ;223:963-90

Harvard University, Cambridge, MA, USA,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075240PMC
http://dx.doi.org/10.1007/978-3-319-05161-1_10DOI Listing
November 2014

Sorting out a promiscuous superfamily: towards cadherin connectomics.

Trends Cell Biol 2014 Sep 30;24(9):524-36. Epub 2014 Apr 30.

Howard Hughes Medical Institute, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2014.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294768PMC
September 2014

Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli.

Proc Natl Acad Sci U S A 2013 Jun 20;110(23):9553-8. Epub 2013 May 20.

Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08003, Spain.

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http://www.pnas.org/lookup/doi/10.1073/pnas.1220231110
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http://dx.doi.org/10.1073/pnas.1220231110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677448PMC
June 2013

What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?

FEBS J 2013 Nov 28;280(21):5471-87. Epub 2013 May 28.

Centre d'Estudis en Biofísica, Departament de Bioquímica i de Biologia Molecular, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, Spain.

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http://dx.doi.org/10.1111/febs.12302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783526PMC
November 2013

Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction.

Nature 2012 Dec 7;492(7427):128-32. Epub 2012 Nov 7.

Howard Hughes Medical Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature11590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518760PMC
December 2012

Distinct properties of Ca2+-calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel.

J Gen Physiol 2012 Nov;140(5):541-55

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1085/jgp.201210810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483115PMC
November 2012

Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel.

Biochemistry 2012 Aug 25;51(31):6195-206. Epub 2012 Jul 25.

Department of Molecular and Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA.

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http://pubs.acs.org/doi/10.1021/bi300279b
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http://dx.doi.org/10.1021/bi300279bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413242PMC
August 2012

Structural determinants of cadherin-23 function in hearing and deafness.

Neuron 2010 Apr;66(1):85-100

Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.neuron.2010.03.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948466PMC
April 2010

Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain.

J Biol Chem 2010 Jan 28;285(1):731-40. Epub 2009 Oct 28.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1074/jbc.M109.052548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804222PMC
January 2010

Antigen processing and presentation: TAPping into ABC transporters.

Curr Opin Immunol 2009 Feb 2;21(1):84-91. Epub 2009 Mar 2.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.coi.2009.02.003DOI Listing
February 2009

Divide and conquer: high resolution structural information on TRP channel fragments.

Authors:
Rachelle Gaudet

J Gen Physiol 2009 Mar;133(3):231-7

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 01238, USA.

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http://dx.doi.org/10.1085/jgp.200810137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654082PMC
March 2009

The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter.

FASEB J 2009 May 27;23(5):1287-302. Epub 2009 Jan 27.

Department of Molecular and Cellular Biology, Harvard University 7 Divinity Ave., Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1096/fj.08-121855DOI Listing
May 2009

Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels.

Channels (Austin) 2007 May-Jun;1(3):148-51. Epub 2007 Jul 9.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02318, USA.

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http://dx.doi.org/10.4161/chan.4716DOI Listing
October 2008

The ABCs of trans(porter) inhibition.

Authors:
Rachelle Gaudet

Nat Chem Biol 2008 Aug;4(8):454-5

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http://dx.doi.org/10.1038/nchembio0808-454DOI Listing
August 2008

TRP channels entering the structural era.

Authors:
Rachelle Gaudet

J Physiol 2008 Aug 5;586(15):3565-75. Epub 2008 Jun 5.

Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 01238, USA.

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http://dx.doi.org/10.1113/jphysiol.2008.155812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538826PMC
August 2008

Functionally important interactions between the nucleotide-binding domains of an antigenic peptide transporter.

Biochemistry 2008 May 2;47(21):5699-708. Epub 2008 May 2.

Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1021/bi7024854DOI Listing
May 2008

A primer on ankyrin repeat function in TRP channels and beyond.

Authors:
Rachelle Gaudet

Mol Biosyst 2008 May 26;4(5):372-9. Epub 2008 Mar 26.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 01238, USA.

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http://dx.doi.org/10.1039/b801481gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006086PMC
May 2008

Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels.

Biochemistry 2008 Feb 31;47(8):2476-84. Epub 2008 Jan 31.

Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 01238, USA.

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http://dx.doi.org/10.1021/bi702109wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006163PMC
February 2008

Genome-wide detection and characterization of positive selection in human populations.

Authors:
Pardis C Sabeti Patrick Varilly Ben Fry Jason Lohmueller Elizabeth Hostetter Chris Cotsapas Xiaohui Xie Elizabeth H Byrne Steven A McCarroll Rachelle Gaudet Stephen F Schaffner Eric S Lander Kelly A Frazer Dennis G Ballinger David R Cox David A Hinds Laura L Stuve Richard A Gibbs John W Belmont Andrew Boudreau Paul Hardenbol Suzanne M Leal Shiran Pasternak David A Wheeler Thomas D Willis Fuli Yu Huanming Yang Changqing Zeng Yang Gao Haoran Hu Weitao Hu Chaohua Li Wei Lin Siqi Liu Hao Pan Xiaoli Tang Jian Wang Wei Wang Jun Yu Bo Zhang Qingrun Zhang Hongbin Zhao Hui Zhao Jun Zhou Stacey B Gabriel Rachel Barry Brendan Blumenstiel Amy Camargo Matthew Defelice Maura Faggart Mary Goyette Supriya Gupta Jamie Moore Huy Nguyen Robert C Onofrio Melissa Parkin Jessica Roy Erich Stahl Ellen Winchester Liuda Ziaugra David Altshuler Yan Shen Zhijian Yao Wei Huang Xun Chu Yungang He Li Jin Yangfan Liu Yayun Shen Weiwei Sun Haifeng Wang Yi Wang Ying Wang Xiaoyan Xiong Liang Xu Mary M Y Waye Stephen K W Tsui Hong Xue J Tze-Fei Wong Luana M Galver Jian-Bing Fan Kevin Gunderson Sarah S Murray Arnold R Oliphant Mark S Chee Alexandre Montpetit Fanny Chagnon Vincent Ferretti Martin Leboeuf Jean-François Olivier Michael S Phillips Stéphanie Roumy Clémentine Sallée Andrei Verner Thomas J Hudson Pui-Yan Kwok Dongmei Cai Daniel C Koboldt Raymond D Miller Ludmila Pawlikowska Patricia Taillon-Miller Ming Xiao Lap-Chee Tsui William Mak You Qiang Song Paul K H Tam Yusuke Nakamura Takahisa Kawaguchi Takuya Kitamoto Takashi Morizono Atsushi Nagashima Yozo Ohnishi Akihiro Sekine Toshihiro Tanaka Tatsuhiko Tsunoda Panos Deloukas Christine P Bird Marcos Delgado Emmanouil T Dermitzakis Rhian Gwilliam Sarah Hunt Jonathan Morrison Don Powell Barbara E Stranger Pamela Whittaker David R Bentley Mark J Daly Paul I W de Bakker Jeff Barrett Yves R Chretien Julian Maller Steve McCarroll Nick Patterson Itsik Pe'er Alkes Price Shaun Purcell Daniel J Richter Pardis Sabeti Richa Saxena Stephen F Schaffner Pak C Sham Patrick Varilly David Altshuler Lincoln D Stein Lalitha Krishnan Albert Vernon Smith Marcela K Tello-Ruiz Gudmundur A Thorisson Aravinda Chakravarti Peter E Chen David J Cutler Carl S Kashuk Shin Lin Gonçalo R Abecasis Weihua Guan Yun Li Heather M Munro Zhaohui Steve Qin Daryl J Thomas Gilean McVean Adam Auton Leonardo Bottolo Niall Cardin Susana Eyheramendy Colin Freeman Jonathan Marchini Simon Myers Chris Spencer Matthew Stephens Peter Donnelly Lon R Cardon Geraldine Clarke David M Evans Andrew P Morris Bruce S Weir Tatsuhiko Tsunoda Todd A Johnson James C Mullikin Stephen T Sherry Michael Feolo Andrew Skol Houcan Zhang Changqing Zeng Hui Zhao Ichiro Matsuda Yoshimitsu Fukushima Darryl R Macer Eiko Suda Charles N Rotimi Clement A Adebamowo Ike Ajayi Toyin Aniagwu Patricia A Marshall Chibuzor Nkwodimmah Charmaine D M Royal Mark F Leppert Missy Dixon Andy Peiffer Renzong Qiu Alastair Kent Kazuto Kato Norio Niikawa Isaac F Adewole Bartha M Knoppers Morris W Foster Ellen Wright Clayton Jessica Watkin Richard A Gibbs John W Belmont Donna Muzny Lynne Nazareth Erica Sodergren George M Weinstock David A Wheeler Imtaz Yakub Stacey B Gabriel Robert C Onofrio Daniel J Richter Liuda Ziaugra Bruce W Birren Mark J Daly David Altshuler Richard K Wilson Lucinda L Fulton Jane Rogers John Burton Nigel P Carter Christopher M Clee Mark Griffiths Matthew C Jones Kirsten McLay Robert W Plumb Mark T Ross Sarah K Sims David L Willey Zhu Chen Hua Han Le Kang Martin Godbout John C Wallenburg Paul L'Archevêque Guy Bellemare Koji Saeki Hongguang Wang Daochang An Hongbo Fu Qing Li Zhen Wang Renwu Wang Arthur L Holden Lisa D Brooks Jean E McEwen Mark S Guyer Vivian Ota Wang Jane L Peterson Michael Shi Jack Spiegel Lawrence M Sung Lynn F Zacharia Francis S Collins Karen Kennedy Ruth Jamieson John Stewart

Nature 2007 Oct;449(7164):913-8

Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA.

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https://www.genome.gov/Pages/Newsroom/CurrentNewsReleases/Le
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http://www.nature.com/doifinder/10.1038/nature06250
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http://dx.doi.org/10.1038/nature06250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687721PMC
October 2007

The role of the N terminus and transmembrane domain of TRPM8 in channel localization and tetramerization.

J Biol Chem 2007 Dec 1;282(50):36474-80. Epub 2007 Oct 1.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://labs.mcb.harvard.edu/Gaudet/papers/trpm8_2007.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M707205200
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http://dx.doi.org/10.1074/jbc.M707205200DOI Listing
December 2007

The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity.

Neuron 2007 Jun;54(6):905-18

Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.neuron.2007.05.027DOI Listing
June 2007

The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity.

Neuron 2007 Jun;54(6):905-18

Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.neuron.2007.05.027DOI Listing
June 2007

Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter.

Mol Cell 2006 Oct;24(1):51-62

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.molcel.2006.07.034DOI Listing
October 2006

Structure of the N-terminal ankyrin repeat domain of the TRPV2 ion channel.

J Biol Chem 2006 Sep 29;281(35):25006-10. Epub 2006 Jun 29.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1074/jbc.C600153200DOI Listing
September 2006

Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I.

Immunol Cell Biol 2005 Oct;83(5):475-82

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1111/j.1440-1711.2005.01354.xDOI Listing
October 2005

Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I.

Immunol Cell Biol 2005 Oct;83(5):475-82

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1111/j.1440-1711.2005.01354.xDOI Listing
October 2005

Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin.

J Biol Chem 2002 Nov 4;277(46):44566-75. Epub 2002 Sep 4.

Laboratory for Nutrition & Vision Research, JMUSDA-HNRCA at Tufts University and Tufts Center for Vision Research, Boston, Massachusetts 02111, USA.

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http://dx.doi.org/10.1074/jbc.M205308200DOI Listing
November 2002