Publications by authors named "Rachel Lennon"

57Publications

A Point-of-Care Immunosensor Based on a Quartz Crystal Microbalance with Graphene Biointerface for Antibody Assay.

ACS Sens 2020 11 25;5(11):3520-3532. Epub 2020 Oct 25.

Department of Materials and National Graphene Institute, Faculty of Science and Engineering, The University of Manchester, Oxford Road, Manchester M13 9PL, U.K.

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November 2020

Bilateral native nephrectomies for severe hypertension in children with stage 5 chronic kidney disease leads to improved BP control following transplantation.

Pediatr Nephrol 2020 12 3;35(12):2373-2376. Epub 2020 Sep 3.

Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Oxford Road, Manchester, M13 9WL, UK.

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December 2020

Complexities of the glomerular basement membrane.

Nat Rev Nephrol 2020 Aug 24. Epub 2020 Aug 24.

Wellcome Centre for Cell-Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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August 2020

Clinical trial recommendations for potential Alport syndrome therapies.

Kidney Int 2020 06 6;97(6):1109-1116. Epub 2020 Apr 6.

Department of Nephrology and Hypertension, The Cleveland Clinic, Cleveland, Ohio, USA.

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June 2020

Genetic Disorders of the Glomerular Filtration Barrier.

Clin J Am Soc Nephrol 2020 Dec 23;15(12):1818-1828. Epub 2020 Mar 23.

Division of Cell-Matrix Biology and Regenerative Medicine, Wellcome Centre for Cell-Matrix Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom

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December 2020

Basement membrane ligands initiate distinct signalling networks to direct cell shape.

Matrix Biol 2020 08 6;90:61-78. Epub 2020 Mar 6.

Wellcome Centre for Cell-Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

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August 2020

Pre-emptive rituximab and plasma exchange does not prevent disease recurrence following living donor renal transplantation in high-risk idiopathic SRNS.

Pediatr Nephrol 2020 06 2;35(6):1081-1084. Epub 2020 Mar 2.

Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Oxford Road, Manchester, M13 9WL, UK.

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June 2020

A role for OCRL in glomerular function and disease.

Pediatr Nephrol 2020 04 6;35(4):641-648. Epub 2019 Dec 6.

Wellcome Centre for Cell-Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, M13 9PT, UK.

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April 2020

From podocyte biology to novel cures for glomerular disease.

Kidney Int 2019 10 31;96(4):850-861. Epub 2019 May 31.

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

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October 2019

The importance of clinician, patient and researcher collaborations in Alport syndrome.

Pediatr Nephrol 2020 05 1;35(5):733-742. Epub 2019 May 1.

Wellcome Centre for Cell-Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK.

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May 2020

The myriad possibility of kidney organoids.

Curr Opin Nephrol Hypertens 2019 05;28(3):211-218

Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester.

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May 2019

Engineered basement membranes: from in vivo considerations to cell-based assays.

Integr Biol (Camb) 2018 11;10(11):680-695

Sorbonne Université, Laboratoire d'Electronique et d'Electromagnétisme, L2E, F-75005 Paris, France.

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November 2018

Basement Membrane Defects in Genetic Kidney Diseases.

Front Pediatr 2018 29;6:11. Epub 2018 Jan 29.

Faculty of Biology Medicine and Health, Wellcome Trust Centre for Cell-Matrix Research, Division of Cell Matrix Biology, School of Biological Sciences, University of Manchester, Manchester, United Kingdom.

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January 2018

Generation of Functioning Nephrons by Implanting Human Pluripotent Stem Cell-Derived Kidney Progenitors.

Stem Cell Reports 2018 03 8;10(3):766-779. Epub 2018 Feb 8.

Division of Cell Matrix Biology and Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

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March 2018

Should We Increase GFR with Bardoxolone in Alport Syndrome?

J Am Soc Nephrol 2018 02 25;29(2):357-359. Epub 2018 Jan 25.

Wellcome Trust Centre for Cell-Matrix Research, Department of Paediatric Nephrology, School of Biological Sciences, University of Manchester, Manchester, England; and.

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February 2018

Vinculin is required to maintain glomerular barrier integrity.

Kidney Int 2018 03 12;93(3):643-655. Epub 2017 Dec 12.

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. Electronic address:

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March 2018

Genetic testing in steroid-resistant nephrotic syndrome: why, who, when and how?

Pediatr Nephrol 2019 02 27;34(2):195-210. Epub 2017 Nov 27.

Division of Cell Matrix Biology, Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK.

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February 2019

An inducible mouse model of podocin-mutation-related nephrotic syndrome.

PLoS One 2017 19;12(10):e0186574. Epub 2017 Oct 19.

Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany.

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November 2017

PLAR binds to the annexin A2-S100A10 complex in human podocytes.

Sci Rep 2017 07 31;7(1):6876. Epub 2017 Jul 31.

Division of Cardiovascular Science, University of Manchester, Manchester, UK.

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July 2017

Glucocorticoid therapy regulates podocyte motility by inhibition of Rac1.

Sci Rep 2017 07 27;7(1):6725. Epub 2017 Jul 27.

Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, England.

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July 2017

Be on alert for pediatric AKI.

Kidney Int 2017 08;92(2):286-288

Wellcome Trust Centre for Cell-Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, England, UK; Royal Manchester Children's Hospital, Central Manchester University Hospitals, NHS Foundation Trust, Manchester Academic Health Science Centre Manchester M13 9PL, England, UK.

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August 2017

The Effects of Extensive Glomerular Filtration of Thin Graphene Oxide Sheets on Kidney Physiology.

ACS Nano 2016 12 12;10(12):10753-10767. Epub 2016 Dec 12.

Department of Pediatric Nephrology, Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust (CMFT), Manchester Academic Health Science Centre , Manchester M13 9NT, United Kingdom.

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December 2016

Proteomic definitions of basement membrane composition in health and disease.

Matrix Biol 2017 01 20;57-58:12-28. Epub 2016 Aug 20.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, UK; Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK; Department of Paediatric Nephrology, Central Manchester University Hospitals NHS Foundation Trust (CMFT), Manchester Academic Health Science Centre (MAHSC), Manchester, UK. Electronic address:

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January 2017

Recent developments in the detection and management of acute kidney injury.

Arch Dis Child 2017 Jan 5;102(1):91-96. Epub 2016 Aug 5.

Department of Paediatric Nephrology, Central Manchester University Hospitals NHS Foundation Trust (CMFT), Manchester Academic Health Science Centre (MAHSC), Manchester, UK.

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January 2017

Alport Syndrome in Women and Girls.

Clin J Am Soc Nephrol 2016 09 10;11(9):1713-20. Epub 2016 Jun 10.

Department of Genetics, Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom.

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September 2016

Glomerular cell crosstalk.

Curr Opin Nephrol Hypertens 2016 May;25(3):187-93

aWellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences bInstitute of Human Development, Faculty of Human Sciences, University of Manchester cDepartment of Paediatric Nephrology, Central Manchester University Hospitals NHS Foundation Trust (CMFT), Manchester, UK dDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

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May 2016

Applying Proteomics to Investigate Extracellular Matrix in Health and Disease.

Curr Top Membr 2015 7;76:171-96. Epub 2015 Jul 7.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, UK; Institute of Human Development, Faculty of Human Sciences, University of Manchester, Manchester, UK; Department of Paediatric Nephrology, Central Manchester University Hospitals NHS Foundation Trust (CMFT), Manchester Academic Health Science Centre (MAHSC), Manchester, UK.

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September 2016

The non-immunosuppressive management of childhood nephrotic syndrome.

Pediatr Nephrol 2016 09 10;31(9):1383-402. Epub 2015 Nov 10.

Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Oxford Road, Manchester, M13 9WL, UK.

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September 2016

Pinpointing clinical diagnosis through whole exome sequencing to direct patient care: a case of Senior-Loken syndrome.

Lancet 2015 May;385(9980):1916

Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK. Electronic address:

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May 2015

Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization.

J Am Soc Nephrol 2015 Dec 20;26(12):3021-34. Epub 2015 Apr 20.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom; Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom;

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December 2015

Towards a biomarker panel for the assessment of AKI in children receiving intensive care.

Pediatr Nephrol 2015 Oct 15;30(10):1861-71. Epub 2015 Apr 15.

Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust (CMFT), Manchester Academic Health Science Centre, Manchester, UK.

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October 2015

Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease.

Pediatr Nephrol 2015 Sep 5;30(9):1459-65. Epub 2015 Mar 5.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Michael Smith Building, M13 9PT, Manchester, UK,

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September 2015

The importance of podocyte adhesion for a healthy glomerulus.

Front Endocrinol (Lausanne) 2014 14;5:160. Epub 2014 Oct 14.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester , Manchester , UK.

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October 2014

Identification of a major epitope recognized by PLA2R autoantibodies in primary membranous nephropathy.

J Am Soc Nephrol 2015 Feb 6;26(2):302-13. Epub 2014 Oct 6.

Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; and Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom.

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February 2015

Glomerular cell cross-talk influences composition and assembly of extracellular matrix.

J Am Soc Nephrol 2014 May 16;25(5):953-66. Epub 2014 Jan 16.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences and Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom;

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May 2014

Epithelial-mesenchymal status influences how cells deposit fibrillin microfibrils.

J Cell Sci 2014 Jan 4;127(Pt 1):158-71. Epub 2013 Nov 4.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.

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January 2014

Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.

J Immunol 2013 Mar 30;190(5):2049-57. Epub 2013 Jan 30.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom.

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March 2013

Establishment of conditionally immortalized human glomerular mesangial cells in culture, with unique migratory properties.

Am J Physiol Renal Physiol 2011 Nov 8;301(5):F1131-8. Epub 2011 Jun 8.

Children's Renal Unit and Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom.

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November 2011

Insulin signaling to the glomerular podocyte is critical for normal kidney function.

Cell Metab 2010 Oct;12(4):329-340

Academic Renal Unit, School of Clinical Sciences, University of Bristol, Bristol BS8 1TH, UK; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario M5G 1X5, Canada. Electronic address:

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October 2010

Intravenous methylprednisolone in idiopathic childhood nephrotic syndrome.

Pediatr Nephrol 2010 May 27;25(5):899-903. Epub 2010 Jan 27.

Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Manchester, UK.

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May 2010

Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy.

Nephrol Dial Transplant 2009 Nov 25;24(11):3288-96. Epub 2009 Jun 25.

Academic and Children's, Renal Unit, Paul O'Gorman Lifeline Centre, University of Bristol, Southmead Hospital, Bristol BS10, UK.

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November 2009

Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes.

J Am Soc Nephrol 2008 Nov 27;19(11):2140-9. Epub 2008 Aug 27.

Academic and Children's Renal Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom BS10 5NB.

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November 2008

The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cells.

Am J Physiol Renal Physiol 2008 Oct 6;295(4):F959-70. Epub 2008 Aug 6.

Academic and Children's Renal Unit, University of Bristol, Lifeline Bldg., Southmead Hospital, Bristol, BS10 5NB, United Kingdom.

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October 2008