Rachel F Tyndale

Rachel F Tyndale

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Rachel F Tyndale

Publications by authors named "Rachel F Tyndale"

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Neural basis of smoking-induced relief of craving and negative affect: Contribution of nicotine.

Addict Biol 2019 Sep 11;24(5):1087-1095. Epub 2018 Oct 11.

Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California.

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http://doi.wiley.com/10.1111/adb.12679
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http://dx.doi.org/10.1111/adb.12679DOI Listing
September 2019

Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults.

Br J Clin Pharmacol 2019 May 12;85(5):960-969. Epub 2019 Mar 12.

Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Kansas City, MO, USA.

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http://dx.doi.org/10.1111/bcp.13884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475679PMC
May 2019

Black Light Smokers: How Nicotine Intake and Carcinogen Exposure Differ Across Various Biobehavioral Factors.

J Natl Med Assoc 2019 May 10. Epub 2019 May 10.

Department of Preventive Medicine and Public Health, University of Kansas School of Medicine, Kansas City, KS, USA.

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http://dx.doi.org/10.1016/j.jnma.2019.04.004DOI Listing
May 2019

Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia.

Addict Biol 2019 Mar 21;24(2):228-238. Epub 2017 Dec 21.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) and Department of Pharmacology and Toxicology, University of Toronto, Canada.

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http://dx.doi.org/10.1111/adb.12590DOI Listing
March 2019

Effects of Nicotine Metabolic Rate on Withdrawal Symptoms and Response to Cigarette Smoking After Abstinence.

Clin Pharmacol Ther 2019 Mar 25;105(3):641-651. Epub 2018 Oct 25.

Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1002/cpt.1238DOI Listing
March 2019

Does the nicotine metabolite ratio moderate smoking cessation treatment outcomes in real-world settings? A prospective study.

Addiction 2019 Feb 30;114(2):304-314. Epub 2018 Oct 30.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) and Departments of Psychiatry and Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1111/add.14450
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http://dx.doi.org/10.1111/add.14450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492100PMC
February 2019

Impact of menthol on oral nicotine consumption in female and male Sprague Dawley rats.

Nicotine Tob Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmacology, Faculty of Medicine, Uludag University, Bursa, Turkey.

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http://dx.doi.org/10.1093/ntr/ntz019DOI Listing
February 2019

Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity.

Addict Biol 2019 Feb 27. Epub 2019 Feb 27.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, M5S 1A8, Canada.

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http://dx.doi.org/10.1111/adb.12741DOI Listing
February 2019

Factors that Explain Differences in Abstinence between Black and White Smokers: A Prospective Intervention Study.

J Natl Cancer Inst 2019 Jan 18. Epub 2019 Jan 18.

Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI.

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http://dx.doi.org/10.1093/jnci/djz001DOI Listing
January 2019

The association between self-reported varenicline adherence and varenicline blood levels in a sample of cancer patients receiving treatment for tobacco dependence.

Addict Behav Rep 2018 Dec 4;8:46-50. Epub 2018 Jul 4.

Department of Psychiatry and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S23528532183009
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http://dx.doi.org/10.1016/j.abrep.2018.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037908PMC
December 2018

Changes in Nicotine Metabolite Ratio among Daily Smokers receiving Treatment for Alcohol Use Disorder.

Nicotine Tob Res 2018 Dec 17. Epub 2018 Dec 17.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto Ontario Canada.

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http://dx.doi.org/10.1093/ntr/nty265DOI Listing
December 2018

Cigarette consumption and biomarkers of nicotine exposure during pregnancy and postpartum.

Addiction 2018 Nov 23;113(11):2087-2096. Epub 2018 Jul 23.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/add.14367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175668PMC
November 2018

Functional Connectivity of the Raphe Nuclei: Link to Tobacco Withdrawal in Smokers.

Int J Neuropsychopharmacol 2018 09;21(9):800-808

Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1093/ijnp/pyy054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119292PMC
September 2018

Predicting smoking abstinence with biological and self-report measures of adherence to varenicline: Impact on pharmacogenetic trial outcomes.

Drug Alcohol Depend 2018 09 26;190:72-81. Epub 2018 Jun 26.

Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada; Addictions Division, Centre for Addiction and Mental Health and Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, 100 Stokes Street BGB 3288, Toronto, ON, M6J 1H4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.drugalcdep.2018.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085881PMC
September 2018

A Comparison of Direct and Indirect Analytical Approaches to Measuring Total Nicotine Equivalents in Urine.

Cancer Epidemiol Biomarkers Prev 2018 08 31;27(8):882-891. Epub 2018 May 31.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072604PMC
August 2018

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.

Authors:
Xuemei Ji Yohan Bossé Maria Teresa Landi Jiang Gui Xiangjun Xiao David Qian Philippe Joubert Maxime Lamontagne Yafang Li Ivan Gorlov Mariella de Biasi Younghun Han Olga Gorlova Rayjean J Hung Xifeng Wu James McKay Xuchen Zong Robert Carreras-Torres David C Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert Chu Chen M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier A Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer Doherty Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske Judith Manz Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard Houlston John McLaughlin Victoria Stevens David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song María Soler Artigas Martin D Tobin Louise V Wain Fangyi Gu Jinyoung Byun Ahsan Kamal Dakai Zhu Rachel F Tyndale Wei-Qi Wei Stephen Chanock Paul Brennan Christopher I Amos

Nat Commun 2018 08 13;9(1):3221. Epub 2018 Aug 13.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.

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http://dx.doi.org/10.1038/s41467-018-05074-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089967PMC
August 2018

Pregnancy-Induced Increases in the Nicotine Metabolite Ratio: Examining Changes During Antepartum and Postpartum.

Nicotine Tob Res 2018 Aug 24. Epub 2018 Aug 24.

University of Vermont, Center on Tobacco Regulatory Science, Burlington, Vermont.

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http://dx.doi.org/10.1093/ntr/nty172DOI Listing
August 2018

Association of Reduced Nicotine Content Cigarettes With Smoking Behaviors and Biomarkers of Exposure Among Slow and Fast Nicotine Metabolizers: A Nonrandomized Clinical Trial.

JAMA Netw Open 2018 Aug 24;1(4). Epub 2018 Aug 24.

Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jamanetworkopen.2018.1346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322845PMC
August 2018

Effects of varenicline on cognitive function in non-smokers with schizophrenia.

Schizophr Res 2018 Jul 11;197:562-563. Epub 2017 Mar 11.

Institute of Medical Sciences (IMS), University of Toronto, Toronto, Ontario, Canada; Addictions Division, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.schres.2017.03.023DOI Listing
July 2018

Influence of Nicotine Metabolism Ratio on [11C]-(+)-PHNO PET Binding in Tobacco Smokers.

Int J Neuropsychopharmacol 2018 06;21(6):503-512

Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada.

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http://dx.doi.org/10.1093/ijnp/pyx119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007643PMC
June 2018

Opioids: The Painful Public Health Reality.

Clin Pharmacol Ther 2018 06;103(6):924-935

Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

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https://ascpt.onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.10
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https://ascpt.onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.10
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http://doi.wiley.com/10.1002/cpt.1074
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http://dx.doi.org/10.1002/cpt.1074DOI Listing
June 2018

Beyond Quitting: Any Additional Impact of Mailing Free Nicotine Patches to Current Smokers?

Nicotine Tob Res 2018 04;20(5):654-655

School of Public Health and Health Systems, University of Waterloo, Waterloo, Canada.

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http://dx.doi.org/10.1093/ntr/ntx106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892854PMC
April 2018

CYP-mediated drug metabolism in the brain impacts drug response.

Pharmacol Ther 2018 04 10;184:189-200. Epub 2017 Oct 10.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), University of Toronto, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2017.10.008DOI Listing
April 2018

Improvement of the association between self-reported pill count and varenicline levels following exclusion of participants with misreported pill count: A commentary on Peng et al. (2017).

Addict Behav 2018 04 2;79:14-16. Epub 2017 Dec 2.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.addbeh.2017.11.032DOI Listing
April 2018

Relationships Between Smoking Behaviors and Cotinine Levels Among Two American Indian Populations With Distinct Smoking Patterns.

Nicotine Tob Res 2018 03;20(4):466-473

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/ntr/ntx114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896446PMC
March 2018

Longitudinal Influence of Pregnancy on Nicotine Metabolic Pathways.

J Pharmacol Exp Ther 2018 02 20;364(2):238-245. Epub 2017 Nov 20.

Departments of Pharmacology and Toxicology (T.T., R.F.T.) and Psychiatry (R.F.T.), University of Toronto, Toronto, Ontario, Canada; University of Vermont Center on Tobacco Regulatory Science, Burlington, Vermont (C.A.A., S.H.H., S.T.H.); Departments of Psychiatry (C.A.A., S.H.H., S.T.H.) and Psychological Science (S.H.H., S.T.H.), University of Vermont, Burlington, Vermont; and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (R.F.T.)

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http://dx.doi.org/10.1124/jpet.117.245126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774213PMC
February 2018

Preparing the Way: Exploiting Genomic Medicine to Stop Smoking.

Trends Mol Med 2018 02 4;24(2):187-196. Epub 2018 Jan 4.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) and Departments of Psychiatry, Pharmacology and Toxicology, University of Toronto, Toronto, M5S 1A8, Ontario, Canada.

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http://dx.doi.org/10.1016/j.molmed.2017.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812803PMC
February 2018

Sex differences in tobacco withdrawal and responses to smoking reduced-nicotine cigarettes in young smokers.

Psychopharmacology (Berl) 2018 01 11;235(1):193-202. Epub 2017 Oct 11.

Department of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA, 90025, USA.

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http://dx.doi.org/10.1007/s00213-017-4755-xDOI Listing
January 2018

Measures and predictors of varenicline adherence in the treatment of nicotine dependence.

Addict Behav 2017 12 12;75:122-129. Epub 2017 Jul 12.

Department of Psychiatry, Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.addbeh.2017.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581992PMC
December 2017

Inducing rat brain CYP2D with nicotine increases the rate of codeine tolerance; predicting the rate of tolerance from acute analgesic response.

Biochem Pharmacol 2017 12 21;145:158-168. Epub 2017 Aug 21.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) and Departments of Psychiatry, Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.08.015DOI Listing
December 2017

Variation in CYP2A6 Activity and Personalized Medicine.

J Pers Med 2017 Dec 1;7(4). Epub 2017 Dec 1.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON M5T 1R8, Canada.

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http://dx.doi.org/10.3390/jpm7040018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748630PMC
December 2017

Characterising the nicotine metabolite ratio and its association with treatment choice: A cross sectional analysis of Stop Smoking Services in England.

Sci Rep 2017 12 14;7(1):17613. Epub 2017 Dec 14.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) and Departments of Psychiatry, Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41598-017-17994-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730579PMC
December 2017

Does coffee consumption impact on heaviness of smoking?

Addiction 2017 Oct 12;112(10):1842-1853. Epub 2017 Jul 12.

MRC Integrative Epidemiology Unit, (IEU) at the University of Bristol, UK.

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http://dx.doi.org/10.1111/add.13888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600104PMC
October 2017

Brain CYP2B induction can decrease nicotine levels in the brain.

Addict Biol 2017 Sep 27;22(5):1257-1266. Epub 2016 May 27.

Departments of Pharmacology and Toxicology and Psychiatry, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/adb.12411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124551PMC
September 2017

Rat brain CYP2D enzymatic metabolism alters acute and chronic haloperidol side-effects by different mechanisms.

Prog Neuropsychopharmacol Biol Psychiatry 2017 08 26;78:140-148. Epub 2017 Apr 26.

Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Canada; Department of Pharmacology and Toxicology, University of Toronto, Canada; Department of Psychiatry, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2017.04.030DOI Listing
August 2017

Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects.

Neuropsychopharmacology 2017 Jul 24;42(8):1610-1618. Epub 2017 Jan 24.

Department of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/npp.2017.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518898PMC
July 2017

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

Authors:
James D McKay Rayjean J Hung Younghun Han Xuchen Zong Robert Carreras-Torres David C Christiani Neil E Caporaso Mattias Johansson Xiangjun Xiao Yafang Li Jinyoung Byun Alison Dunning Karen A Pooley David C Qian Xuemei Ji Geoffrey Liu Maria N Timofeeva Stig E Bojesen Xifeng Wu Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier Alberto Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher A Haiman Lynne R Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Henricus F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer A Doherty Matt P Barnett Chu Chen Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske H-Erich Wichmann Judith Manz Thomas R Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances A Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard S Houlston John McLaughlin Victoria L Stevens Philippe Joubert Maxime Lamontagne David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song Linda Kachuri María Soler Artigas Martin D Tobin Louise V Wain Thorunn Rafnar Thorgeir E Thorgeirsson Gunnar W Reginsson Kari Stefansson Dana B Hancock Laura J Bierut Margaret R Spitz Nathan C Gaddis Sharon M Lutz Fangyi Gu Eric O Johnson Ahsan Kamal Claudio Pikielny Dakai Zhu Sara Lindströem Xia Jiang Rachel F Tyndale Georgia Chenevix-Trench Jonathan Beesley Yohan Bossé Stephen Chanock Paul Brennan Maria Teresa Landi Christopher I Amos

Nat Genet 2017 Jul 12;49(7):1126-1132. Epub 2017 Jun 12.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

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http://dx.doi.org/10.1038/ng.3892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510465PMC
July 2017

Sleep Disturbance During Smoking Cessation: Withdrawal or Side Effect of Treatment?

J Smok Cessat 2017 Jun 12;12(2):63-70. Epub 2016 Apr 12.

Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA, 19104.

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http://dx.doi.org/10.1017/jsc.2016.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443250PMC
June 2017

Variation in CYP2A6 and nicotine metabolism among two American Indian tribal groups differing in smoking patterns and risk for tobacco-related cancer.

Pharmacogenet Genomics 2017 05;27(5):169-178

aCentre for Addiction and Mental Health (CAMH), Campbell Family Mental Health Research Institute Departments of bPharmacology and Toxicology cPsychiatry, University of Toronto, Toronto, Ontario, Canada dBlack Hills Center for American Indian Health, Rapid City, South Dakota eElson S. Floyd College of Medicine, Initiative for Research and Education to Advance Community Health (IREACH), Washington State University, Seattle, Washington fThe Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, District of Columbia gMedStar Health Research Institute, Hyattsville, Maryland, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382092PMC
May 2017

CYP2A6 Genetic Variation Alters Striatal-Cingulate Circuits, Network Hubs, and Executive Processing in Smokers.

Biol Psychiatry 2017 04 28;81(7):554-563. Epub 2016 Sep 28.

Neuroimaging Research Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2016.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346346PMC
April 2017

The discriminative stimulus effects of i.v. nicotine in rhesus monkeys: Pharmacokinetics and apparent pA analysis with dihydro-β-erythroidine.

Neuropharmacology 2017 04 8;116:9-17. Epub 2016 Dec 8.

Department of Pharmacology, The University of Texas Health Science Center, San Antonio, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385163PMC
April 2017

Effect of UGT2B10, UGT2B17, FMO3, and OCT2 genetic variation on nicotine and cotinine pharmacokinetics and smoking in African Americans.

Pharmacogenet Genomics 2017 04;27(4):143-154

Departments of aPharmacology and Toxicology bPsychiatry, University of Toronto cDepartment of Molecular Brain Science, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada dDepartments of Medicine and Biopharmaceutical Sciences, Division of Clinical Pharmacology and Experimental Therapeutics, Medical Services eCenter for Tobacco Control Research and Education, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346034PMC
April 2017

Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.

J Clin Pharmacol 2017 02 23;57(2):230-234. Epub 2016 Aug 23.

Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1002/jcph.797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233579PMC
February 2017

CYP2D6 and CYP2A6 biotransform dietary tyrosol into hydroxytyrosol.

Food Chem 2017 Feb 7;217:716-725. Epub 2016 Sep 7.

Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Dr. Aiguader 88, Barcelona 08003, Spain; Department of Experimental and Health Sciences, Universitat Pompeu Fabra (CEXS-UPF), Dr. Aiguader 80, Barcelona 08003, Spain; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.foodchem.2016.09.026DOI Listing
February 2017

Pharmacogenetic Optimization of Smoking Cessation Treatment.

Trends Pharmacol Sci 2017 01 3;38(1):55-66. Epub 2016 Oct 3.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ONT, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ONT, Canada; Department of Psychiatry, University of Toronto, Toronto, ONT, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2016.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195866PMC
January 2017

Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors.

J Pharmacol Exp Ther 2017 Jan 4;360(1):129-139. Epub 2016 Nov 4.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada (J-A.T., R.F.T.); Department of Pharmacology and Toxicology (J-A.T., R.F.T.) and Department of Psychiatry (R.F.T.), University of Toronto, Toronto, Ontario, Canada; Department of Pharmaceutics (B.P., K.G.C, K.E.T.) and Center for Exposures, Diseases, Genomics, and Environment (P.S.), University of Washington, Seattle, Washington; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.C., E.G.S.)

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http://dx.doi.org/10.1124/jpet.116.237594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193072PMC
January 2017

Fatty Acid Amide Hydrolase Binding in Brain of Cannabis Users: Imaging With the Novel Radiotracer [C]CURB.

Biol Psychiatry 2016 11 25;80(9):691-701. Epub 2016 Apr 25.

Human Brain Lab, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050070PMC
http://dx.doi.org/10.1016/j.biopsych.2016.04.012DOI Listing
November 2016

CYP2A6 genotyping methods and strategies using real-time and end point PCR platforms.

Pharmacogenomics 2016 15;17(2):147-62. Epub 2015 Dec 15.

Campbell Family Mental Health Research Institute, Centre for Addiction & Mental Health (CAMH), Departments of Pharmacology & Toxicology & Psychiatry, University of Toronto, 1 King's College Circle, Toronto, M5S 1A8 ON, Canada.

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http://dx.doi.org/10.2217/pgs.15.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712027PMC
September 2016

Racial differences in the relationship between rate of nicotine metabolism and nicotine intake from cigarette smoking.

Pharmacol Biochem Behav 2016 09 11;148:1-7. Epub 2016 May 11.

Center for Tobacco Control Research and Education, University of California San Francisco, San Francisco, CA, USA; Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California San Francisco, San Francisco, CA, USA; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972680PMC
September 2016

Impact of self-reported lifetime depression or anxiety on effectiveness of mass distribution of nicotine patches.

Tob Control 2016 09 19;26(5):526-533. Epub 2016 Aug 19.

Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/tobaccocontrol-2016-052994DOI Listing
September 2016

Brain Responses to Smoking Cues Differ Based on Nicotine Metabolism Rate.

Biol Psychiatry 2016 08 26;80(3):190-7. Epub 2015 Nov 26.

Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2015.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625335PMC
August 2016

Disposition kinetics and metabolism of nicotine and cotinine in African American smokers: impact of CYP2A6 genetic variation and enzymatic activity.

Pharmacogenet Genomics 2016 07;26(7):340-50

aDepartment of Medicine and Biopharmaceutical Sciences, Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service bCenter for Tobacco Control Research and Education, University of California, San Francisco, California, USA cCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health dDepartments of Pharmacology & Toxicology and Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/FPC.0000000000000222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892970PMC
July 2016

Does cannabis use moderate smoking cessation outcomes in treatment-seeking tobacco smokers? Analysis from a large multi-center trial.

Am J Addict 2016 06 17;25(4):291-6. Epub 2016 May 17.

The Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/ajad.12382DOI Listing
June 2016

Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice.

PLoS One 2015 10;10(9):e0137070. Epub 2015 Sep 10.

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137070PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565647PMC
May 2016

Varenicline-Induced Elevation of Dopamine in Smokers: A Preliminary [(11)C]-(+)-PHNO PET Study.

Neuropsychopharmacology 2016 May 7;41(6):1513-20. Epub 2015 Oct 7.

Translational Addiction Research Laboratory, CAMH, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/npp.2015.305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832011PMC
May 2016

The Nicotine Metabolite Ratio is Associated With Early Smoking Abstinence Even After Controlling for Factors That Influence the Nicotine Metabolite Ratio.

Nicotine Tob Res 2016 Apr 11;18(4):491-5. Epub 2015 Jun 11.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada

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http://dx.doi.org/10.1093/ntr/ntv125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220835PMC
April 2016

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism.

PLoS Genet 2015 25;11(9):e1005498. Epub 2015 Sep 25.

Department of Public Health, University of Helsinki, Helsinki, Finland; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1371/journal.pgen.1005498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583245PMC
April 2016

Perceptions of pharmacogenetic research to guide tobacco cessation by patients, providers and leaders in a tribal healthcare setting.

Pharmacogenomics 2016 Mar 12;17(4):405-15. Epub 2016 Feb 12.

Research Department, Southcentral Foundation, 4105 Tudor Centre Drive, Anchorage, AK 99508, USA.

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http://dx.doi.org/10.2217/pgs.15.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558512PMC
March 2016

Effect of Mailing Nicotine Patches on Tobacco Cessation Among Adult Smokers: A Randomized Clinical Trial.

JAMA Intern Med 2016 Feb;176(2):184-90

School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada.

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http://dx.doi.org/10.1001/jamainternmed.2015.7792DOI Listing
February 2016

Variation in CYP2A6 and tobacco dependence throughout adolescence and in young adult smokers.

Drug Alcohol Depend 2016 Jan 21;158:139-46. Epub 2015 Nov 21.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), University of Toronto, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.drugalcdep.2015.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698159PMC
January 2016

Nicotine Dependence, Nicotine Metabolism, and the Extent of Compensation in Response to Reduced Nicotine Content Cigarettes.

Nicotine Tob Res 2015 Sep 2;17(9):1167-72. Epub 2015 Jan 2.

Center for Tobacco Control Research and Education, School of Medicine, University of California, San Francisco, CA; Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, Departments of Medicine, Bioengineering and Therapeutic Sciences and the Center for Tobacco Control Research and Education, University of California, San Francisco, CA

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http://dx.doi.org/10.1093/ntr/ntu337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542742PMC
September 2015

Pharmacogenetics of nicotine and associated smoking behaviors.

Curr Top Behav Neurosci 2015 ;23:37-86

Departments of Pharmacology and Toxicology and Psychiatry, University of Toronto, Toronto, ON, Canada.

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http://link.springer.com/content/pdf/10.1007%2F978-3-319-136
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http://link.springer.com/10.1007/978-3-319-13665-3_3
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http://dx.doi.org/10.1007/978-3-319-13665-3_3DOI Listing
September 2015

"Target-Site" Drug Metabolism and Transport.

Drug Metab Dispos 2015 Aug 18;43(8):1156-68. Epub 2015 May 18.

Amgen Pharmacokinetics and Drug Metabolism, Seattle, Washington (R.S.F., D.A.R.); Departments of Pharmacology and Toxicology and Psychiatry, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada (R.F.T., K.L.P.G.); Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia (D.H.S.); School of Pharmacy, Temple University, Philadelphia, Pennsylvania (S.N.); and College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (S.S.).

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http://dx.doi.org/10.1124/dmd.115.064576DOI Listing
August 2015

Nicotine metabolite ratio (3-hydroxycotinine/cotinine) in plasma and urine by different analytical methods and laboratories: implications for clinical implementation.

Cancer Epidemiol Biomarkers Prev 2015 Aug 26;24(8):1239-46. Epub 2015 May 26.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Schizophrenia Division, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-1381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526326PMC
August 2015

The fatty acid amide hydrolase C385A variant affects brain binding of the positron emission tomography tracer [11C]CURB.

J Cereb Blood Flow Metab 2015 Aug 3;35(8):1237-40. Epub 2015 Jun 3.

1] Human Brain Lab, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [2] Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [3] Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [4] Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://journals.sagepub.com/doi/10.1038/jcbfm.2015.119
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http://dx.doi.org/10.1038/jcbfm.2015.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527995PMC
August 2015

Effect of Brain CYP2B Inhibition on Brain Nicotine Levels and Nicotine Self-Administration.

Neuropsychopharmacology 2015 Jul 5;40(8):1910-8. Epub 2015 Feb 5.

1] Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada [2] Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada [3] Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/npp.2015.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839514PMC
July 2015

Nicotine Increases Codeine Analgesia Through the Induction of Brain CYP2D and Central Activation of Codeine to Morphine.

Neuropsychopharmacology 2015 Jun 29;40(7):1804-12. Epub 2015 Jan 29.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) and Departments of Psychiatry, Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/npp.2015.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916647PMC
June 2015

Genetic and phenotypic variation in UGT2B17, a testosterone-metabolizing enzyme, is associated with BMI in males.

Pharmacogenet Genomics 2015 May;25(5):263-9

aDepartment of Pharmacology and Toxicology bDepartment of Psychiatry, Center for Addiction and Mental Health, Campbell Family Mental Health Research Institute, University of Toronto, Toronto, Ontario, Canada cDepartment of Preventive Medicine and Public Health, School of Medicine, University of Kansas, Kansas City, Kansas dDepartment of Medicine and Center for Health Equity, University of Minnesota Medical School eDepartment of Psychiatry, University of Minnesota, Minneapolis, Minnesota fAlaska Native Medical Center, Cardiology Research and Program Development, Anchorage, Alaska gDepartment of Medicine and Bioengineering and Therapeutic Sciences, Division of Clinical Pharmacology and Experimental Therapeutics, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382380PMC
May 2015

Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial.

Lancet Respir Med 2015 Feb 12;3(2):131-138. Epub 2015 Jan 12.

Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/S2213-2600(14)70294-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480925PMC
February 2015

UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers.

Cancer Epidemiol Biomarkers Prev 2015 Jan 2;24(1):94-104. Epub 2014 Oct 2.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada. Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-0804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294984PMC
January 2015

CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers--findings from two independent populations.

Carcinogenesis 2015 Jan 21;36(1):99-103. Epub 2014 Nov 21.

Department of Pharmacology and Toxicology, The University of Toronto, Toronto, Ontario M5S 1A8, Canada, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1R8, Canada, Department of Psychiatry, The University of Toronto, Toronto, Ontario M5T 1R8, Canada,

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http://dx.doi.org/10.1093/carcin/bgu235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291053PMC
January 2015

Rational design of novel CYP2A6 inhibitors.

Bioorg Med Chem 2014 Dec 13;22(23):6655-6664. Epub 2014 Oct 13.

School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, POB 1627, 70211 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.10.001DOI Listing
December 2014

Effect of food training and training dose on nicotine self-administration in rats.

Behav Brain Res 2014 Nov 4;274:10-8. Epub 2014 Aug 4.

Departments of Pharmacology and Toxicology & Psychiatry, Toronto, Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2014.07.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179974PMC
November 2014

Gene variants in CYP2C19 are associated with altered in vivo bupropion pharmacokinetics but not bupropion-assisted smoking cessation outcomes.

Drug Metab Dispos 2014 Nov 3;42(11):1971-7. Epub 2014 Sep 3.

Departments of Pharmacology and Toxicology (A.Z.X.Z., Q.Z., R.F.T.) and Department of Psychiatry (R.F.T.), University of Toronto, Ontario, Canada; Department of Preventive Medicine and Public Health, University of Kansas School of Medicine, Kansas City, Kansas (L.S.C.); Department of Medicine and Center for Health Equity, University of Minnesota Medical School, Minneapolis, Minnesota (J.S.A.); Division of Clinical Pharmacology and Experimental Therapeutics, Departments of Medicine and Bioengineering & Therapeutic Sciences, University of California, San Francisco, California (N.L.B.); and Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, Ontario, Canada (R.F.T.)

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http://dx.doi.org/10.1124/dmd.114.060285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201132PMC
November 2014