Publications by authors named "Rachel F Tyndale"

100Publications

Centrally administered CYP2D inhibitors increase oral tramadol analgesia in rats.

Brain Res Bull 2020 Sep 11. Epub 2020 Sep 11.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brainresbull.2020.09.001DOI Listing
September 2020

OpenVape: an Open-Source E-Cigarette Vapour Exposure Device for Rodents.

eNeuro 2020 Aug 28. Epub 2020 Aug 28.

Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Ontario, Canada

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http://dx.doi.org/10.1523/ENEURO.0279-20.2020DOI Listing
August 2020

Genetics of smoking behavior in American Indians.

Cancer Epidemiol Biomarkers Prev 2020 Aug 27. Epub 2020 Aug 27.

Institute for Clinical and Translational Research, Baylor College of Medicine.

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http://dx.doi.org/10.1158/1055-9965.EPI-20-0026DOI Listing
August 2020

Addressing the instability issue of dopamine during microdialysis: the determination of dopamine, serotonin, methamphetamine and its metabolites in rat brain.

J Chromatogr A 2020 Sep 13;1627:461403. Epub 2020 Jul 13.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2020.461403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484461PMC
September 2020

Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice.

Mol Neurobiol 2020 Aug 6. Epub 2020 Aug 6.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/s12035-020-02050-wDOI Listing
August 2020

Acute effects of a very low nicotine content cigarette on laboratory smoking lapse: Impacts of nicotine metabolism and nicotine dependence.

Addict Biol 2020 Jun 23:e12930. Epub 2020 Jun 23.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/adb.12930DOI Listing
June 2020

Imaging Brain Fatty Acid Amide Hydrolase in Untreated Patients With Psychosis.

Biol Psychiatry 2020 Mar 12. Epub 2020 Mar 12.

Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2020.03.003DOI Listing
March 2020

Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study.

Nicotine Tob Res 2020 Apr 18. Epub 2020 Apr 18.

Center for Interdisciplinary Research on Nicotine Addiction, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1093/ntr/ntaa066DOI Listing
April 2020

Evaluation of nicotine patch adherence measurement using self-report and saliva cotinine among abstainers in a smoking cessation trial.

Drug Alcohol Depend 2020 May 20;210:107967. Epub 2020 Mar 20.

Department of Psychiatry and Norris Cancer Center, 1441 Eastlake Avenue, Health Sciences Campus, University of Southern California, Los Angeles, CA, 90033, USA.

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http://dx.doi.org/10.1016/j.drugalcdep.2020.107967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190433PMC
May 2020

Human CYP2D6 Is Functional in Brain In Vivo: Evidence from Humanized CYP2D6 Transgenic Mice.

Mol Neurobiol 2020 Jun 18;57(6):2509-2520. Epub 2020 Mar 18.

Department of Pharmacology and Toxicology, University of Toronto, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/s12035-020-01896-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383223PMC
June 2020

Fatty acid amide hydrolase is lower in young cannabis users.

Addict Biol 2020 Jan 20:e12872. Epub 2020 Jan 20.

Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/adb.12872DOI Listing
January 2020

Data on the endogenous conversion of tyrosol into hydroxytyrosol in humans.

Data Brief 2019 Dec 12;27:104787. Epub 2019 Nov 12.

Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Dr. Aiguader 88, 08003, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.dib.2019.104787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880089PMC
December 2019

Effects of Nicotine Metabolic Rate on Cigarette Reinforcement.

Nicotine Tob Res 2020 Jul;22(8):1419-1423

Program in Clinical Pharmacology, Division of Cardiology, Department of Medicine, University of California San Fransisco, San Francisco, CA.

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http://dx.doi.org/10.1093/ntr/ntz210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364822PMC
July 2020

Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities.

Clin Pharmacol Ther 2020 01 6;107(1):57-61. Epub 2019 Nov 6.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cpt.1664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077926PMC
January 2020

Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: Effects on activity and drug responses.

Br J Pharmacol 2020 Feb 6;177(3):701-712. Epub 2020 Jan 6.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Department of Pharmacology & Toxicology, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/bph.14884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012948PMC
February 2020

C57BL/6 Substrain Differences in Pharmacological Effects after Acute and Repeated Nicotine Administration.

Brain Sci 2019 Sep 21;9(10). Epub 2019 Sep 21.

Department of Pharmacology and Toxicology, and Translational Research Initiative for Pain and Neuropathy, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.3390/brainsci9100244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827359PMC
September 2019

Relationship between skin melanin index and nicotine pharmacokinetics in African American smokers.

Drug Alcohol Depend 2019 11 30;204:107474. Epub 2019 Aug 30.

Clinical Pharmacology Research Program, Division of Cardiology, Zuckerberg San Francisco General, Department of Medicine, University of California, San Francisco, CA 94143-1220, USA; Center for Tobacco Control Research and Education, University of California, San Francisco, CA 94143-1390, USA.

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http://dx.doi.org/10.1016/j.drugalcdep.2019.04.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272190PMC
November 2019

A Physiological Marriage Made in Heaven: Treating and Measuring the Brain Through Stimulation.

Clin Pharmacol Ther 2019 10;106(4):691-695

Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cpt.1576DOI Listing
October 2019

Impact of early nausea on varenicline adherence and smoking cessation.

Addiction 2020 01 5;115(1):134-144. Epub 2019 Nov 5.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/add.14810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933078PMC
January 2020

Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans. A randomized, controlled trial.

Free Radic Biol Med 2019 11 31;143:471-481. Epub 2019 Aug 31.

Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Dr. Aiguader 88, 08003, Barcelona, Spain; Department of Experimental and Health Sciences, Universitat Pompeu Fabra (CEXS-UPF), Dr. Aiguader 80, 08003, Barcelona, Spain; CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN, CB06/03/028), Monforte de Lemos 3-5, 28029, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.08.032DOI Listing
November 2019

Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity.

Addict Biol 2020 01 27;25(1):e12741. Epub 2019 Feb 27.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, M5S 1A8, Canada.

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http://dx.doi.org/10.1111/adb.12741DOI Listing
January 2020

Impact of Menthol on Oral Nicotine Consumption in Female and Male Sprague Dawley Rats.

Nicotine Tob Res 2020 02;22(2):196-203

Department of Pharmacology, Faculty of Medicine, Uludag University, Bursa, Turkey.

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http://dx.doi.org/10.1093/ntr/ntz019DOI Listing
February 2020

Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults.

Br J Clin Pharmacol 2019 05 12;85(5):960-969. Epub 2019 Mar 12.

Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Kansas City, MO, USA.

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http://dx.doi.org/10.1111/bcp.13884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475679PMC
May 2019

Association of Reduced Nicotine Content Cigarettes With Smoking Behaviors and Biomarkers of Exposure Among Slow and Fast Nicotine Metabolizers: A Nonrandomized Clinical Trial.

JAMA Netw Open 2018 08 24;1(4):e181346. Epub 2018 Aug 24.

Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jamanetworkopen.2018.1346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322845PMC
August 2018

Changes in Nicotine Metabolite Ratio Among Daily Smokers Receiving Treatment for Alcohol Use Disorder.

Nicotine Tob Res 2020 02;22(2):256-263

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/ntr/nty265DOI Listing
February 2020

Neural basis of smoking-induced relief of craving and negative affect: Contribution of nicotine.

Addict Biol 2019 09 11;24(5):1087-1095. Epub 2018 Oct 11.

Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California.

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http://doi.wiley.com/10.1111/adb.12679
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http://dx.doi.org/10.1111/adb.12679DOI Listing
September 2019

Does the nicotine metabolite ratio moderate smoking cessation treatment outcomes in real-world settings? A prospective study.

Addiction 2019 02 30;114(2):304-314. Epub 2018 Oct 30.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) and Departments of Psychiatry and Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1111/add.14450
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http://dx.doi.org/10.1111/add.14450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492100PMC
February 2019

Effects of Nicotine Metabolic Rate on Withdrawal Symptoms and Response to Cigarette Smoking After Abstinence.

Clin Pharmacol Ther 2019 03 25;105(3):641-651. Epub 2018 Oct 25.

Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1002/cpt.1238DOI Listing
March 2019

Pregnancy-Induced Increases in the Nicotine Metabolite Ratio: Examining Changes During Antepartum and Postpartum.

Nicotine Tob Res 2019 11;21(12):1706-1710

Tobacco Center on Regulatory Science, Vermont Center on Behavior and Health, Larner College of Medicine, University of Vermont, Burlington, VT.

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http://dx.doi.org/10.1093/ntr/nty172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861834PMC
November 2019

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.

Authors:
Xuemei Ji Yohan Bossé Maria Teresa Landi Jiang Gui Xiangjun Xiao David Qian Philippe Joubert Maxime Lamontagne Yafang Li Ivan Gorlov Mariella de Biasi Younghun Han Olga Gorlova Rayjean J Hung Xifeng Wu James McKay Xuchen Zong Robert Carreras-Torres David C Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert Chu Chen M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier A Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer Doherty Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske Judith Manz Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard Houlston John McLaughlin Victoria Stevens David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song María Soler Artigas Martin D Tobin Louise V Wain Fangyi Gu Jinyoung Byun Ahsan Kamal Dakai Zhu Rachel F Tyndale Wei-Qi Wei Stephen Chanock Paul Brennan Christopher I Amos

Nat Commun 2018 08 13;9(1):3221. Epub 2018 Aug 13.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.

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http://dx.doi.org/10.1038/s41467-018-05074-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089967PMC
August 2018

The association between self-reported varenicline adherence and varenicline blood levels in a sample of cancer patients receiving treatment for tobacco dependence.

Addict Behav Rep 2018 Dec 4;8:46-50. Epub 2018 Jul 4.

Department of Psychiatry and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S23528532183009
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http://dx.doi.org/10.1016/j.abrep.2018.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037908PMC
December 2018

Predicting smoking abstinence with biological and self-report measures of adherence to varenicline: Impact on pharmacogenetic trial outcomes.

Drug Alcohol Depend 2018 09 26;190:72-81. Epub 2018 Jun 26.

Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada; Addictions Division, Centre for Addiction and Mental Health and Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, 100 Stokes Street BGB 3288, Toronto, ON, M6J 1H4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.drugalcdep.2018.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085881PMC
September 2018

Functional Connectivity of the Raphe Nuclei: Link to Tobacco Withdrawal in Smokers.

Int J Neuropsychopharmacol 2018 09;21(9):800-808

Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1093/ijnp/pyy054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119292PMC
September 2018

Cigarette consumption and biomarkers of nicotine exposure during pregnancy and postpartum.

Addiction 2018 11 23;113(11):2087-2096. Epub 2018 Jul 23.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/add.14367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175668PMC
November 2018

Opioids: The Painful Public Health Reality.

Clin Pharmacol Ther 2018 06;103(6):924-935

Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

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https://ascpt.onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.10
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https://ascpt.onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.10
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http://doi.wiley.com/10.1002/cpt.1074
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http://dx.doi.org/10.1002/cpt.1074DOI Listing
June 2018

A Comparison of Direct and Indirect Analytical Approaches to Measuring Total Nicotine Equivalents in Urine.

Cancer Epidemiol Biomarkers Prev 2018 08 31;27(8):882-891. Epub 2018 May 31.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072604PMC
August 2018

Influence of Nicotine Metabolism Ratio on [11C]-(+)-PHNO PET Binding in Tobacco Smokers.

Int J Neuropsychopharmacol 2018 06;21(6):503-512

Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada.

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http://dx.doi.org/10.1093/ijnp/pyx119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007643PMC
June 2018

Preparing the Way: Exploiting Genomic Medicine to Stop Smoking.

Trends Mol Med 2018 02 4;24(2):187-196. Epub 2018 Jan 4.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) and Departments of Psychiatry, Pharmacology and Toxicology, University of Toronto, Toronto, M5S 1A8, Ontario, Canada.

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http://dx.doi.org/10.1016/j.molmed.2017.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812803PMC
February 2018

Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia.

Addict Biol 2019 03 21;24(2):228-238. Epub 2017 Dec 21.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) and Department of Pharmacology and Toxicology, University of Toronto, Canada.

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http://dx.doi.org/10.1111/adb.12590DOI Listing
March 2019

Characterising the nicotine metabolite ratio and its association with treatment choice: A cross sectional analysis of Stop Smoking Services in England.

Sci Rep 2017 12 14;7(1):17613. Epub 2017 Dec 14.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) and Departments of Psychiatry, Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41598-017-17994-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730579PMC
December 2017

Improvement of the association between self-reported pill count and varenicline levels following exclusion of participants with misreported pill count: A commentary on Peng et al. (2017).

Addict Behav 2018 04 2;79:14-16. Epub 2017 Dec 2.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.addbeh.2017.11.032DOI Listing
April 2018

Variation in CYP2A6 Activity and Personalized Medicine.

J Pers Med 2017 Dec 1;7(4). Epub 2017 Dec 1.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON M5T 1R8, Canada.

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http://dx.doi.org/10.3390/jpm7040018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748630PMC
December 2017

Longitudinal Influence of Pregnancy on Nicotine Metabolic Pathways.

J Pharmacol Exp Ther 2018 02 20;364(2):238-245. Epub 2017 Nov 20.

Departments of Pharmacology and Toxicology (T.T., R.F.T.) and Psychiatry (R.F.T.), University of Toronto, Toronto, Ontario, Canada; University of Vermont Center on Tobacco Regulatory Science, Burlington, Vermont (C.A.A., S.H.H., S.T.H.); Departments of Psychiatry (C.A.A., S.H.H., S.T.H.) and Psychological Science (S.H.H., S.T.H.), University of Vermont, Burlington, Vermont; and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (R.F.T.)

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http://dx.doi.org/10.1124/jpet.117.245126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774213PMC
February 2018

CYP-mediated drug metabolism in the brain impacts drug response.

Pharmacol Ther 2018 04 10;184:189-200. Epub 2017 Oct 10.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), University of Toronto, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2017.10.008DOI Listing
April 2018

Sex differences in tobacco withdrawal and responses to smoking reduced-nicotine cigarettes in young smokers.

Psychopharmacology (Berl) 2018 01 11;235(1):193-202. Epub 2017 Oct 11.

Department of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA, 90025, USA.

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http://dx.doi.org/10.1007/s00213-017-4755-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726112PMC
January 2018

Inducing rat brain CYP2D with nicotine increases the rate of codeine tolerance; predicting the rate of tolerance from acute analgesic response.

Biochem Pharmacol 2017 12 21;145:158-168. Epub 2017 Aug 21.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) and Departments of Psychiatry, Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.08.015DOI Listing
December 2017

Measures and predictors of varenicline adherence in the treatment of nicotine dependence.

Addict Behav 2017 12 12;75:122-129. Epub 2017 Jul 12.

Department of Psychiatry, Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.addbeh.2017.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581992PMC
December 2017

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

Authors:
James D McKay Rayjean J Hung Younghun Han Xuchen Zong Robert Carreras-Torres David C Christiani Neil E Caporaso Mattias Johansson Xiangjun Xiao Yafang Li Jinyoung Byun Alison Dunning Karen A Pooley David C Qian Xuemei Ji Geoffrey Liu Maria N Timofeeva Stig E Bojesen Xifeng Wu Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier Alberto Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher A Haiman Lynne R Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Henricus F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer A Doherty Matt P Barnett Chu Chen Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske H-Erich Wichmann Judith Manz Thomas R Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances A Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard S Houlston John McLaughlin Victoria L Stevens Philippe Joubert Maxime Lamontagne David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song Linda Kachuri María Soler Artigas Martin D Tobin Louise V Wain Thorunn Rafnar Thorgeir E Thorgeirsson Gunnar W Reginsson Kari Stefansson Dana B Hancock Laura J Bierut Margaret R Spitz Nathan C Gaddis Sharon M Lutz Fangyi Gu Eric O Johnson Ahsan Kamal Claudio Pikielny Dakai Zhu Sara Lindströem Xia Jiang Rachel F Tyndale Georgia Chenevix-Trench Jonathan Beesley Yohan Bossé Stephen Chanock Paul Brennan Maria Teresa Landi Christopher I Amos

Nat Genet 2017 Jul 12;49(7):1126-1132. Epub 2017 Jun 12.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

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http://dx.doi.org/10.1038/ng.3892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510465PMC
July 2017

Does coffee consumption impact on heaviness of smoking?

Addiction 2017 Oct 12;112(10):1842-1853. Epub 2017 Jul 12.

MRC Integrative Epidemiology Unit, (IEU) at the University of Bristol, UK.

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http://dx.doi.org/10.1111/add.13888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600104PMC
October 2017

Sleep Disturbance During Smoking Cessation: Withdrawal or Side Effect of Treatment?

J Smok Cessat 2017 Jun 12;12(2):63-70. Epub 2016 Apr 12.

Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA, 19104.

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http://dx.doi.org/10.1017/jsc.2016.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443250PMC
June 2017

Relationships Between Smoking Behaviors and Cotinine Levels Among Two American Indian Populations With Distinct Smoking Patterns.

Nicotine Tob Res 2018 03;20(4):466-473

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/ntr/ntx114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896446PMC
March 2018

Beyond Quitting: Any Additional Impact of Mailing Free Nicotine Patches to Current Smokers?

Nicotine Tob Res 2018 04;20(5):654-655

School of Public Health and Health Systems, University of Waterloo, Waterloo, Canada.

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http://dx.doi.org/10.1093/ntr/ntx106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892854PMC
April 2018

Rat brain CYP2D enzymatic metabolism alters acute and chronic haloperidol side-effects by different mechanisms.

Prog Neuropsychopharmacol Biol Psychiatry 2017 08 26;78:140-148. Epub 2017 Apr 26.

Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Canada; Department of Pharmacology and Toxicology, University of Toronto, Canada; Department of Psychiatry, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2017.04.030DOI Listing
August 2017

Effects of varenicline on cognitive function in non-smokers with schizophrenia.

Schizophr Res 2018 07 11;197:562-563. Epub 2017 Mar 11.

Institute of Medical Sciences (IMS), University of Toronto, Toronto, Ontario, Canada; Addictions Division, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.schres.2017.03.023DOI Listing
July 2018

Variation in CYP2A6 and nicotine metabolism among two American Indian tribal groups differing in smoking patterns and risk for tobacco-related cancer.

Pharmacogenet Genomics 2017 05;27(5):169-178

aCentre for Addiction and Mental Health (CAMH), Campbell Family Mental Health Research Institute Departments of bPharmacology and Toxicology cPsychiatry, University of Toronto, Toronto, Ontario, Canada dBlack Hills Center for American Indian Health, Rapid City, South Dakota eElson S. Floyd College of Medicine, Initiative for Research and Education to Advance Community Health (IREACH), Washington State University, Seattle, Washington fThe Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, District of Columbia gMedStar Health Research Institute, Hyattsville, Maryland, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382092PMC
May 2017

Effect of UGT2B10, UGT2B17, FMO3, and OCT2 genetic variation on nicotine and cotinine pharmacokinetics and smoking in African Americans.

Pharmacogenet Genomics 2017 04;27(4):143-154

Departments of aPharmacology and Toxicology bPsychiatry, University of Toronto cDepartment of Molecular Brain Science, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada dDepartments of Medicine and Biopharmaceutical Sciences, Division of Clinical Pharmacology and Experimental Therapeutics, Medical Services eCenter for Tobacco Control Research and Education, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346034PMC
April 2017

Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects.

Neuropsychopharmacology 2017 Jul 24;42(8):1610-1618. Epub 2017 Jan 24.

Department of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/npp.2017.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518898PMC
July 2017

The discriminative stimulus effects of i.v. nicotine in rhesus monkeys: Pharmacokinetics and apparent pA analysis with dihydro-β-erythroidine.

Neuropharmacology 2017 04 8;116:9-17. Epub 2016 Dec 8.

Department of Pharmacology, The University of Texas Health Science Center, San Antonio, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385163PMC
April 2017

CYP2A6 Genetic Variation Alters Striatal-Cingulate Circuits, Network Hubs, and Executive Processing in Smokers.

Biol Psychiatry 2017 04 28;81(7):554-563. Epub 2016 Sep 28.

Neuroimaging Research Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2016.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346346PMC
April 2017

Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors.

J Pharmacol Exp Ther 2017 Jan 4;360(1):129-139. Epub 2016 Nov 4.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada (J-A.T., R.F.T.); Department of Pharmacology and Toxicology (J-A.T., R.F.T.) and Department of Psychiatry (R.F.T.), University of Toronto, Toronto, Ontario, Canada; Department of Pharmaceutics (B.P., K.G.C, K.E.T.) and Center for Exposures, Diseases, Genomics, and Environment (P.S.), University of Washington, Seattle, Washington; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.C., E.G.S.)

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http://dx.doi.org/10.1124/jpet.116.237594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193072PMC
January 2017

Pharmacogenetic Optimization of Smoking Cessation Treatment.

Trends Pharmacol Sci 2017 01 3;38(1):55-66. Epub 2016 Oct 3.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ONT, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ONT, Canada; Department of Psychiatry, University of Toronto, Toronto, ONT, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2016.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195866PMC
January 2017

CYP2D6 and CYP2A6 biotransform dietary tyrosol into hydroxytyrosol.

Food Chem 2017 Feb 7;217:716-725. Epub 2016 Sep 7.

Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Dr. Aiguader 88, Barcelona 08003, Spain; Department of Experimental and Health Sciences, Universitat Pompeu Fabra (CEXS-UPF), Dr. Aiguader 80, Barcelona 08003, Spain; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.foodchem.2016.09.026DOI Listing
February 2017

Impact of self-reported lifetime depression or anxiety on effectiveness of mass distribution of nicotine patches.

Tob Control 2016 09 19;26(5):526-533. Epub 2016 Aug 19.

Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/tobaccocontrol-2016-052994DOI Listing
September 2016

Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.

J Clin Pharmacol 2017 02 23;57(2):230-234. Epub 2016 Aug 23.

Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1002/jcph.797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233579PMC
February 2017

Fatty Acid Amide Hydrolase Binding in Brain of Cannabis Users: Imaging With the Novel Radiotracer [C]CURB.

Biol Psychiatry 2016 11 25;80(9):691-701. Epub 2016 Apr 25.

Human Brain Lab, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050070PMC
http://dx.doi.org/10.1016/j.biopsych.2016.04.012DOI Listing
November 2016

Brain CYP2B induction can decrease nicotine levels in the brain.

Addict Biol 2017 Sep 27;22(5):1257-1266. Epub 2016 May 27.

Departments of Pharmacology and Toxicology and Psychiatry, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/adb.12411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124551PMC
September 2017

Does cannabis use moderate smoking cessation outcomes in treatment-seeking tobacco smokers? Analysis from a large multi-center trial.

Am J Addict 2016 06 17;25(4):291-6. Epub 2016 May 17.

The Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/ajad.12382DOI Listing
June 2016

Racial differences in the relationship between rate of nicotine metabolism and nicotine intake from cigarette smoking.

Pharmacol Biochem Behav 2016 09 11;148:1-7. Epub 2016 May 11.

Center for Tobacco Control Research and Education, University of California San Francisco, San Francisco, CA, USA; Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California San Francisco, San Francisco, CA, USA; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972680PMC
September 2016

Disposition kinetics and metabolism of nicotine and cotinine in African American smokers: impact of CYP2A6 genetic variation and enzymatic activity.

Pharmacogenet Genomics 2016 07;26(7):340-50

aDepartment of Medicine and Biopharmaceutical Sciences, Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service bCenter for Tobacco Control Research and Education, University of California, San Francisco, California, USA cCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health dDepartments of Pharmacology & Toxicology and Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/FPC.0000000000000222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892970PMC
July 2016

Perceptions of pharmacogenetic research to guide tobacco cessation by patients, providers and leaders in a tribal healthcare setting.

Pharmacogenomics 2016 Mar 12;17(4):405-15. Epub 2016 Feb 12.

Research Department, Southcentral Foundation, 4105 Tudor Centre Drive, Anchorage, AK 99508, USA.

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http://dx.doi.org/10.2217/pgs.15.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558512PMC
March 2016