Publications by authors named "Rachael Natrajan"

100Publications

Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes.

Authors:
Matthew Clarke Alan Mackay Britta Ismer Jessica C Pickles Ruth G Tatevossian Scott Newman Tejus A Bale Iris Stoler Elisa Izquierdo Sara Temelso Diana M Carvalho Valeria Molinari Anna Burford Louise Howell Alex Virasami Amy R Fairchild Aimee Avery Jane Chalker Mark Kristiansen Kelly Haupfear James D Dalton Wilda Orisme Ji Wen Michael Hubank Kathreena M Kurian Catherine Rowe Mellissa Maybury Stephen Crosier Jeffrey Knipstein Ulrich Schüller Uwe Kordes David E Kram Matija Snuderl Leslie Bridges Andrew J Martin Lawrence J Doey Safa Al-Sarraj Christopher Chandler Bassel Zebian Claire Cairns Rachael Natrajan Jessica K R Boult Simon P Robinson Martin Sill Ira J Dunkel Stephen W Gilheeney Marc K Rosenblum Debbie Hughes Paula Z Proszek Tobey J Macdonald Matthias Preusser Christine Haberler Irene Slavc Roger Packer Ho-Keung Ng Shani Caspi Mara Popović Barbara Faganel Kotnik Matthew D Wood Lissa Baird Monika Ashok Davare David A Solomon Thale Kristin Olsen Petter Brandal Michael Farrell Jane B Cryan Michael Capra Michael Karremann Jens Schittenhelm Martin U Schuhmann Martin Ebinger Winand N M Dinjens Kornelius Kerl Simone Hettmer Torsten Pietsch Felipe Andreiuolo Pablo Hernáiz Driever Andrey Korshunov Lotte Hiddingh Barbara C Worst Dominik Sturm Marc Zuckermann Olaf Witt Tabitha Bloom Clare Mitchell Evelina Miele Giovanna Stefania Colafati Francesca Diomedi-Camassei Simon Bailey Andrew S Moore Timothy E G Hassall Stephen P Lowis Maria Tsoli Mark J Cowley David S Ziegler Matthias A Karajannis Kristian Aquilina Darren R Hargrave Fernando Carceller Lynley V Marshall Andreas von Deimling Christof M Kramm Stefan M Pfister Felix Sahm Suzanne J Baker Angela Mastronuzzi Andrea Carai Maria Vinci David Capper Sergey Popov David W Ellison Thomas S Jacques David T W Jones Chris Jones

Cancer Discov 2020 Jul 1;10(7):942-963. Epub 2020 Apr 1.

Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-19-1030DOI Listing
July 2020

Translational genomics of ovarian clear cell carcinoma.

Semin Cancer Biol 2020 04 4;61:121-131. Epub 2019 Nov 4.

The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK; Division of Molecular Pathology, The Institute of Cancer Research, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2019.10.025DOI Listing
April 2020

Longitudinal analysis of a secondary BRCA2 mutation using digital droplet PCR.

J Pathol Clin Res 2020 01 20;6(1):3-11. Epub 2019 Nov 20.

The CRUK Gene Function Laboratory and Breast Cancer Now Research Centre, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1002/cjp2.146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966703PMC
January 2020

Splicing dysregulation as a driver of breast cancer.

Endocr Relat Cancer 2018 09 30;25(9):R467-R478. Epub 2018 May 30.

The Breast Cancer Now Toby Robins Research CentreThe Institute of Cancer Research, London, UK

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http://dx.doi.org/10.1530/ERC-18-0068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055305PMC
September 2018

SWATH mass spectrometry as a tool for quantitative profiling of the matrisome.

J Proteomics 2018 10 1;189:11-22. Epub 2018 Mar 1.

Division of Molecular Pathology, The Institute of Cancer Research, London, SW3 6JB, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2018.02.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215756PMC
October 2018

Driver Oncogenes but Not as We Know Them: Targetable Fusion Genes in Breast Cancer.

Cancer Discov 2018 03;8(3):272-275

The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-18-0091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372062PMC
March 2018

Identification and Validation of Driver Kinases from Next-Generation Sequencing Data.

Methods Mol Biol 2017 ;1636:179-195

Division of Breast Cancer, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK.

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http://dx.doi.org/10.1007/978-1-4939-7154-1_12DOI Listing
April 2018

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures.

J Vis Exp 2016 12 26(118). Epub 2016 Dec 26.

The Breast Cancer Now Toby Robins Research Centre, Division of Breast Cancer, The Institute of Cancer Research; Division of Molecular Pathology, The Institute of Cancer Research;

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http://dx.doi.org/10.3791/54738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226468PMC
December 2016

Comparative proteomic assessment of matrisome enrichment methodologies.

Biochem J 2016 Nov 2;473(21):3979-3995. Epub 2016 Sep 2.

Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, U.K.

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http://dx.doi.org/10.1042/BCJ20160686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095915PMC
November 2016

Risk Stratification and Intrinsic Subtype Classification of Breast Cancer: a Multi-Parameter Test to Rule Them All?

J Natl Cancer Inst 2016 09 29;108(9). Epub 2016 Apr 29.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA

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http://dx.doi.org/10.1093/jnci/djw118DOI Listing
September 2016

Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology-Genomic Integration Analysis.

PLoS Med 2016 Feb 16;13(2):e1001961. Epub 2016 Feb 16.

Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.1001961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755617PMC
February 2016

An ecological measure of immune-cancer colocalization as a prognostic factor for breast cancer.

Breast Cancer Res 2015 Sep 22;17(1):131. Epub 2015 Sep 22.

Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1186/s13058-015-0638-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579663PMC
September 2015

Breast cancer heterogeneity: parallel evolution or conscious uncoupling?

J Pathol 2015 Sep 28;237(1):1-3. Epub 2015 May 28.

Breakthrough Breast Cancer Research Centre and Department of Molecular Pathology, Institute of Cancer Research, London, UK.

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http://doi.wiley.com/10.1002/path.4557
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http://dx.doi.org/10.1002/path.4557DOI Listing
September 2015

Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms.

Mol Oncol 2015 Aug 20;9(7):1274-86. Epub 2015 Mar 20.

Department of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands; Division of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528812PMC
August 2015

SF3B1 mutations constitute a novel therapeutic target in breast cancer.

J Pathol 2015 Mar 22;235(4):571-80. Epub 2014 Dec 22.

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1002/path.4483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643177PMC
March 2015

Metaplastic breast carcinomas display genomic and transcriptomic heterogeneity [corrected]. .

Mod Pathol 2015 Mar 21;28(3):340-51. Epub 2014 Nov 21.

1] Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA [2] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/modpathol.2014.142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523239PMC
March 2015

Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity.

Cancer Res 2014 Jan 15;74(1):287-97. Epub 2013 Nov 15.

Authors' Affiliations: The CRUK Gene Function Laboratory, Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-2541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886090PMC
January 2014

Genomic profiling of histological special types of breast cancer.

Breast Cancer Res Treat 2013 Nov 27;142(2):257-69. Epub 2013 Oct 27.

Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10549-013-2740-6DOI Listing
November 2013

From integrative genomics to therapeutic targets.

Cancer Res 2013 Jun 5;73(12):3483-8. Epub 2013 Jun 5.

Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-4717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736308PMC
June 2013

Non-existence of caveolin-1 gene mutations in human breast cancer.

Breast Cancer Res Treat 2012 Jan 11;131(1):307-10. Epub 2011 Sep 11.

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1007/s10549-011-1761-2DOI Listing
January 2012

Molecular profiling reveals frequent gain of MYCN and anaplasia-specific loss of 4q and 14q in Wilms tumor.

Genes Chromosomes Cancer 2011 Dec 31;50(12):982-95. Epub 2011 Aug 31.

Molecular Haematology and Cancer Biology Unit, University College London, Institute of Child Health, London, UK.

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http://dx.doi.org/10.1002/gcc.20907DOI Listing
December 2011

High-throughput detection of fusion genes in cancer using the Sequenom MassARRAY platform.

Lab Invest 2011 Oct 1;91(10):1491-501. Epub 2011 Aug 1.

Molecular Pathology Team, The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/labinvest.2011.110DOI Listing
October 2011

Functional characterization of EMSY gene amplification in human cancers.

J Pathol 2011 Sep 7;225(1):29-42. Epub 2011 Jul 7.

Molecular Pathology Team, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1002/path.2944DOI Listing
September 2011

Next-generation sequencing applied to molecular diagnostics.

Expert Rev Mol Diagn 2011 May;11(4):425-44

Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK.

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http://www.tandfonline.com/doi/full/10.1586/erm.11.18
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http://dx.doi.org/10.1586/erm.11.18DOI Listing
May 2011

Microarray-based class discovery for molecular classification of breast cancer: analysis of interobserver agreement.

J Natl Cancer Inst 2011 Apr 18;103(8):662-73. Epub 2011 Mar 18.

The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Rd, London SW3 6JB, UK.

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http://dx.doi.org/10.1093/jnci/djr071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079850PMC
April 2011

Genomic analysis reveals the molecular heterogeneity of ovarian clear cell carcinomas.

Clin Cancer Res 2011 Mar;17(6):1521-34

Department of Gynaecologic Oncology, Royal Marsden Hospital NHS Foundation Trust, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Royal Marsden Hospital, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1688DOI Listing
March 2011

β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation.

Mod Pathol 2011 Feb 12;24(2):209-31. Epub 2010 Nov 12.

Molecular Pathology Laboratory, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/modpathol.2010.205DOI Listing
February 2011

Down-regulation of the miRNA master regulators Drosha and Dicer is associated with specific subgroups of breast cancer.

Eur J Cancer 2011 Jan 9;47(1):138-50. Epub 2010 Sep 9.

Molecular Pathology Laboratory, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S095980491000788
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http://dx.doi.org/10.1016/j.ejca.2010.08.007DOI Listing
January 2011

BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.

Cell Stem Cell 2010 Sep;7(3):403-17

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1016/j.stem.2010.07.010DOI Listing
September 2010

DNA amplifications in breast cancer: genotypic-phenotypic correlations.

Future Oncol 2010 Jun;6(6):967-84

The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London SW36JB, UK.

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http://dx.doi.org/10.2217/fon.10.56DOI Listing
June 2010

Genomic and immunohistochemical analysis of adenosquamous carcinoma of the breast.

Mod Pathol 2010 Jul 7;23(7):951-60. Epub 2010 May 7.

The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/modpathol201082
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http://dx.doi.org/10.1038/modpathol.2010.82DOI Listing
July 2010

Breast cancer molecular profiling with single sample predictors: a retrospective analysis.

Lancet Oncol 2010 Apr 22;11(4):339-49. Epub 2010 Feb 22.

Cancer Research UK, London Research Institute, London, UK.

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http://dx.doi.org/10.1016/S1470-2045(10)70008-5DOI Listing
April 2010

CD44 is overexpressed in basal-like breast cancers but is not a driver of 11p13 amplification.

Breast Cancer Res Treat 2010 Feb 7;120(1):95-109. Epub 2009 Apr 7.

Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK.

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http://dx.doi.org/10.1007/s10549-009-0380-7DOI Listing
February 2010

Resistance to therapy caused by intragenic deletion in BRCA2.

Nature 2008 Feb 10;451(7182):1111-5. Epub 2008 Feb 10.

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1038/nature06548DOI Listing
February 2008

Multifaceted dysregulation of the epidermal growth factor receptor pathway in clear cell sarcoma of the kidney.

Clin Cancer Res 2007 Aug 23;13(15 Pt 1):4360-4. Epub 2007 Jul 23.

Paediatric Oncology, Institute of Cancer Research/Royal Marsden NHS Trust, Sutton, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-0398DOI Listing
August 2007

Chromogenic and fluorescent in situ hybridization in breast cancer.

Hum Pathol 2007 Aug;38(8):1105-22

Molecular Pathology Laboratory, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, SW3 6JB London, UK.

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http://dx.doi.org/10.1016/j.humpath.2007.04.011DOI Listing
August 2007

Getting it right: designing microarray (and not 'microawry') comparative genomic hybridization studies for cancer research.

Lab Invest 2007 Aug 11;87(8):737-54. Epub 2007 Jun 11.

Molecular Pathology Team, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/labinvest.3700593DOI Listing
August 2007

Delineation of a 1Mb breakpoint region at 1p13 in Wilms tumors by fine-tiling oligonucleotide array CGH.

Genes Chromosomes Cancer 2007 Jun;46(6):607-15

Paediatric Oncology, Institute of Cancer Research/Royal Marsden NHS Trust, Sutton, UK.

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http://dx.doi.org/10.1002/gcc.20446DOI Listing
June 2007

Amplification and overexpression of CACNA1E correlates with relapse in favorable histology Wilms' tumors.

Clin Cancer Res 2006 Dec;12(24):7284-93

Paediatric Oncology, Institute of Cancer Research/Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1567DOI Listing
December 2006