Publications by authors named "Rabia Ghafoor"

10 Publications

  • Page 1 of 1

Comparison of efficacy of Tranexamic Acid Mesotherapy versus 0.9% normal Saline for Melasma; A split face study in a Tertiary Care Hospital of Karachi.

Pak J Med Sci 2020 Jul-Aug;36(5):930-934

Dr. Sidra Khan, MBBS, FCPS II Trainee., Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

Objectives: To compare the efficacy of tranexamic acid mesotherapy versus 0.9% normal saline for melasma by split-face study.

Methods: It was a non-randomized clinical trial performed at the Dermatology ward of JPMC from September 2018 to June 2019 after getting approval from the Ethical Committee. A total of sixty patients were recruited in the study, who had symmetrical melasma on their faces. Both halves of the face were treated by Injection Tranexamic Acid (TA) with a dose of 4mg/ml and Normal Saline (NS) two weekly for twelve weeks. Hemi Modified Melasma Area and Severity Scoring (H-mMASI) was calculated at the start and end of the study. Analyses were done by SPSS version 23. P < 0.05 was taken as significant.

Results: Mean of H-mMASI score was compared on both sides at the end of study, which showed significant reduction in mean score from 3.19 ±2.57 to 1.52 ± 1.2 (P < 0.05) on A side as compared to decline in scores on NS side from 3.46 ± 2.7 to 3.45 ± 2.6 (P > 0.05). Erythema, swelling, and burning were documented as temporary side effects on both sides.

Conclusion: Tranexamic Acid (TA) mesotherapy can be considered as the most cost-effective, safe and directly observed therapy for melasma which showed significant improvement when old prior therapies have failed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.12669/pjms.36.5.2379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372652PMC
July 2020

Efficacy of Low Dose Naltrexone in Psoriasis.

J Coll Physicians Surg Pak 2020 Jun;30(6):579-583

Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

Objective: To determine the efficacy of low dose naltrexone in the patients of psoriasis.

Study Design: Non-randomised clinical trial.

Place And Duration Of Study: Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi from January to July 2019.

Methodology: All patients of mild, moderate, and severe psoriasis with age above 13 years without any comorbids were included in this study. Patients were started on tablet naltrexone 6mg daily after assessing PASI, BSA and DLQI scores and were called every month for follow-up. After three months of treatment, these scores were assessed again. SPSS 23 was used to analyse the data.

Results: Out of 71 patients, 37 (52%) were males and 34 (48%) were females with age ranging from 13 to 60 years with mean age of 37.85 ±12.211 years. The mean duration of disease was 5.27 ±3.084 years. Before treatment 1 (1.4%), 20 (28.2%), 24 (33.8%), 26 (36.6%) patients had mild, moderate, severe and very severe psoriasis according to PASI score. After treatment, 14 (19.7 %), 23 (32.4%), 23 (32.4%), 11 (15.5%) patients had mild, moderate, severe and very severe psoriasis. The mean PASI, BSA and DLQI were 18.47 ±8.157, 11.97 ±3.873 and 22.63 ±5.235 before treatment, respectively. The mean PASI, BSA and DLQI were 13.51 ±8.017, 8.07 ±3.650 and 16.31 ±7.056 after treatment, respectively.

Conclusion: Low dose naltrexone is an effective therapy for psoriasis as in other chronic dermatological diseases. It is a cost-effective therapy with few tolerable side-effects. It requires further studies for long-term response. Key Words: Naltrexone, Psoriasis, PASI, DLQI, BSA.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.29271/jcpsp.2020.06.579DOI Listing
June 2020

Efficacy of Saline Injection Therapy for Atrophic Acne Scars.

J Coll Physicians Surg Pak 2020 04;30(4):359-363

Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

Objective: To determine the efficacy of saline injection in post-acne atrophic scars on face.

Study Design: Non-randomized clinical trial.

Place And Duration Of Study: Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi, from January to July 2019.

Methodology: All patients with mild, moderate and severe post-acne atrophic scars, above the age of 15 years without any co-morbid conditions were included in the study. Intra-dermal isotonic saline solution was administered under local anesthesia, into the scars weekly for 12 weeks. The results were assessed subjectively and objectively by photographs, Sharquie scoring system and Dermatology Life Quality Index (DLQI) at baseline and at the end of treatment. SPSS 23 was used for analyzing data.

Results: Out of 49 patients, 41 (83.7%) were females and 8 (16.3%) were males. The mean age was 24.69 ±4.35 years. According to Sharquie scoring system of grading scars at baseline, 3 (6.1%), 34 (69.4%) and 12 (24.5%) patients had mild, moderate and severe scarring respectively while at the end of treatment, 35 (71.4%), 12 (24.5%) and 2 (4.1%) patients had mild, moderate and severe scarring respectively (p=0.001). Regarding degree of satisfaction of patients, 6 (12.2%), 27 (55.1%), 12 (24.5%) and 4(8.2%) patients were mildly, moderately, greatly and completely satisfied respectively. The mean DLQI was 12.14 ±3.29 and 5.86 ±2.26 at baseline and at the end of treatment respectively (p=0.001).

Conclusion: The response of saline injection was significant in all types of post-acne atrophic scars as assessed with Sharquie score and DLQI, but more significant in mild and moderate scars, without any significant side effects. Key Words: Acne, scars, saline solution.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.29271/jcpsp.2020.04.359DOI Listing
April 2020

Safety and efficacy of miltefosine in cutaneous leishmaniasis: An open label, non-comparative study from Balochistan.

Pak J Med Sci 2019 Mar-Apr;35(2):495-499

Dr. Rabia Ghafoor, FCPS(Derm), SCE(UK), Assistant Professor of Dermatology, Jinnah Post Graduate of Medical Sciences, Karachi, Pakistan.

Background & Objective: Cutaneous Leishmaniasis (CL) is endemic in Baluchistan and treated traditionally with Meglumine antimoniate. Miltefosine appears appealing therapy in cutaneous Leishmaniasis. Our objective was to evaluate safety and efficacy of Miltifossine in treatment of cutaneous Leishmaniasis.

Methods: This experimental study was conducted from 10 September 2017 to 10 May 2018 at Combined Military Hospital Quetta. Total of 42 patients were recruited by purposive sampling technique. Lesional skin smears were stained with giemsa for Leishmania amastigotes under magnification (100 x).Complete blood count, serum urea, creatinine, bilirubin, aspartate aminotransferases (AST), alanine aminotransferase (ALT) were done at the beginning of treatment and then weekly, thereafter. Cap Miltefosine 50 mg (2.5mg/kg) were given as directly observed therapy .Daily observation during treatment phase was done for clinical side effects of therapy. Clinical response was documented at two weeks then at eight weeks. Photographs were taken before and after the therapy. Data was analyzed by SPSS 16.

Results: Complete clinical response was observed in 39 (92.9%) patients and partial clinical response in 1(2.4%) patient. Two patients were lost to follow up at eight weeks. No significant derangements in laboratory profile were noted before and after treatment. Mean duration of treatment was 23.47+SD 4.44 days. Sixteen patients (38.1%) took Miltefosine for 28 days, 12 (28.6%) for 21 days and 9 (25%) for 25 days.

Conclusion: Miltefosine is safe and cost effective treatment for cutaneous Leishmaniasis. It is effective in CL cases not susceptible to antimony compounds.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.12669/pjms.35.2.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500830PMC
May 2019

A Young Boy with Persistent Nodules and Hoarseness: A Rare Presentation of Nodular Secondary Syphilis.

J Coll Physicians Surg Pak 2018 Mar;28(3):S37-S38

Department of Dermatology, Bahria University Medical And Dental College (BUMDC) and PNS Shifa, Karachi.

Syphilis is a venereal disease caused by treponema pallidum, historically known as "great mimicker" because of its variable presentations. Secondary syphilis usually presents with maculopapular or papulosquamous rash. Rare manifestations include papulonodular, annular and lichenoid lesions. Nodules are usually found in benign tertiary syphilis. We present a case of a young boy who presented with five months' history of nodular skin lesions and hoarseness of voice. Venereal disease research laboratory (VDRL) was initially negative owing to prozone phenomenon. However, histopathology was confirmatory and he responded to benzathine penicillin. We present this case because of rare clinical presentation with persistent nodular lesions, unusual age group, and negative initial VDRL test.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.29271/jcpsp.2018.03.S37DOI Listing
March 2018

Vitamin D Deficiency in Alopecia Areata.

J Coll Physicians Surg Pak 2017 Apr;27(4):200-202

Department of Dermatology, PNS Shifa, Karachi.

Objective: To compare the mean Vitamin D level in patients with alopecia areata (AA) with age and gender controlled matched healthy controls.

Study Design: Case-control study.

Place And Duration Of Study: Dermatology OPD, JPMC, from October 2014 to March 2015.

Methodology: All the patients diagnosed of alopecia areata by a trained dermatologist were selected. Controls were age and gender matched healthy volunteers. Venous blood was drawn and sent to hospital laboratory for 25 (OH) vitamin D by enzyme immunoassay method on chemical analyser. Data was recorded on SPSS version 16. Mann-Whitney test was applied to compare vitamin D levels of cases and controls. P-value <0.05 was taken as significant.

Results: There are 30 cases of AA, and 30 age and gender matched controls. The mean age of our study group was 23.77 ±8.86 ng/dL in patients and 24.03 ±8.62 ng/dL in the control group. Fifteen (50%) patients presented between 3-12 months of onset of AA. Median (IQR) vitamin D level of cases was 13.5 (18.6) ng/dL and healthy controls was 22.5 (16.25) (p=0.001).

Conclusion: Serum Vitamin D levels were significantly lower in patients with alopecia areata compared to healthy controls.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/2589DOI Listing
April 2017

Successful Treatment of Haemoglobinopathy Associated Chronic Leg Ulcer with Platelet Rich Plasma.

J Coll Physicians Surg Pak 2016 Jun;26(6):545-6

Department of Dermatology, PNS Shifa Hospital, Karachi.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/2363DOI Listing
June 2016

Intralesional Triamcinolone Acetonide Versus Topical Betamethasone Valearate in the Management of Localized Alopecia Areata.

J Coll Physicians Surg Pak 2015 Dec;25(12):860-2

Department of Dermatology, Jinnah Postgraduate Medical Center (JPMC), Karachi.

Objective: To compare the efficacy of intralesional triamcinolone and topical betamethasone in the management of localized alopecia areata.

Study Design: A randomized trial.

Place And Duration Of Study: Dermatology OPD, PNS Shifa Hospital, Karachi, from January to June 2013.

Methodology: Patients aged 18 - 50 years with localized alopecia areata were included in the study. Exclusion criteria were more than three patches and those on already steroid or immunosuppressive therapy. Patients were randomly allocated in two treatment groups: Group A received intralesional triamcinolone acetonide (10 mg/ml) and Group B received topical betamethasone valearate cream 0.1% twice daily. Final outcome was ascertained as re-growth of hair on 12th week of follow-up and labelled as efficacy. The data was entered and analyzed using SPSS version 11. Relevant descriptive statistics were calculated. Chi-square test was used to compare efficacy of hair re-growth in both groups. P-value < 0.05 was considered significant.

Results: A total of 226 patients were enrolled, 113 in each group. The mean age was 34.36 ± 8.7 years. One hundred and sixty-four (72.6%) were males and 62 (27.4%) were females with male to female ratio of 2.6:1. Hair re-growth was seen in 84 (74.3%) of the intralesional steroid group and in 53 (46.9%) of the topical betamethasone group (p < 0.001), which was a significant difference.

Conclusion: Intralesional triamcinolone had a better efficacy in the treatment of localized alopecia areata as compared to topical betamethasone valearate.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/12.2015/JCPSP.860862DOI Listing
December 2015

Dyslipidemia and Psoriasis: A Case Control Study.

J Coll Physicians Surg Pak 2015 May;25(5):324-7

Department of Dermatology, PNS Shifa, Karachi.

Objective: To compare the mean values of lipid profile in psoriatic patients and healthy controls.

Study Design: Case control study.

Place And Duration Of Study: Department of Dermatology, PNS Shifa, Karachi, from November 2012 to April 2013.

Methodology: Patients with psoriasis fulfilling the inclusion and exclusion criteria were selected from Dermatology Outpatient Department (OPD) of PNS Shifa, Karachi. After fasting for 14 hours, 5 ml of venous blood was drawn in sterile syringe and submitted to the Hospital Laboratory for lipid profile, by enzymatic method on Hitachi (Roshe(®)) using reagents by the same firm. The mean values lipid profile in psoriatic patients versus healthy controls were recorded and compared.

Results: Atotal of 256 patients (128 in each group) were enrolled. Mean lipid profile in both groups revealed cholesterol (mg/dl) value of 203.43 ±1 1.43 in cases and 173.64 ± 13.65 in controls. Triglyceride (mg/dl) was 178.87 ± 43.60 and in cases 144.23 ± 34.01 in controls, HDL-C (mg/dl) was 37.81 ± 10.78 in cases and 41.41 ± 9.72 in controls while LDL-C (mg/dl) was 139.52 ± 13.71 in cases and 109.44 ± 13.80 in controls. Each parameters had p-value < 0.05 which was significant.

Conclusion: Dyslipidemia was found in a high percentage of psoriatic patients than healthy controls. Psoriatic patients require thorough lipid and cardiovascular examinations as they should be considered as individuals with increased risk of cardiovascular diseases.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/05.2015/JCPSP.324327DOI Listing
May 2015

Kindler's syndrome: a report of five cases in a family.

J Coll Physicians Surg Pak 2014 Oct;24(10):763-5

Department of Dermatology, PNS Shifa, Karachi.

Kindler's Syndrome (KS) is a rare genodermatosis with autosomal recessive mode of inheritance. The disease results from homozygous mutations on both alleles of the FERMT-1 gene (also known as KIND-1 gene) that encodes the protein Kindlin-1 (kindlerin). Clinical features include a constellation of early infantile skin blistering and mild photosensitivity, which improves with age, and progressive poikiloderma with widespread cutaneous atrophy. The differential diagnosis of Kindler syndrome include other congenital poikilodermatous and photosensitive conditions including Bloom syndrome, Cockayne syndrome, dyskeratosis congenita, epidermolysis bullosa, Rothmund-Thomson syndrome and xeroderma pigmentosum. We herein, report the presence of the Kindler's syndrome in 5 out of 7 children of consanguineous parents. To authors' knowledge, this is the first report of Kindler's syndrome involving 5 members of a family.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2014/JCPSP.763765DOI Listing
October 2014