Publications by authors named "Rabea Hinkel"

70Publications

AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury.

J Am Coll Cardiol 2020 Apr;75(15):1788-1800

DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany; Institut für Pharmakologie und Toxikologie, Technische Universität München, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2020.02.041DOI Listing
April 2020

Statins Make a Difference in Acute Myocardial Infarction: A Revival.

J Am Coll Cardiol 2020 Mar;75(12):1403-1405

Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technical University Munich, and DZHK (German Center for Cardiovascular Research), Munich Heart Alliance, Munich, Germany; Institute for Cardiovascular Prevention (IPEK), LMU Munich, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2020.02.008DOI Listing
March 2020

Stem Cells in Cardiovascular Medicine: Historical Overview and Future Prospects.

Cells 2019 11 27;8(12). Epub 2019 Nov 27.

Department of Laboratory Animal Science, Leibnitz-Institut für Primatenforschung, Deutsches Primatenzentrum GmbH, Kellnerweg 4, 37077 Göttingen, Germany.

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http://dx.doi.org/10.3390/cells8121530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952821PMC
November 2019

Dynamic Quantitative Iodine Myocardial Perfusion Imaging with Dual-Layer CT using a Porcine Model.

Sci Rep 2019 11 5;9(1):16046. Epub 2019 Nov 5.

Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, 81675, München, Germany.

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http://dx.doi.org/10.1038/s41598-019-52458-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831609PMC
November 2019

Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair.

J Am Coll Cardiol 2019 06;73(23):2990-3002

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität Munich, Munich, Germany; Deutsches Zentrum für Herz-Kreislaufforschung (DZHK), partner site Munich Heart Alliance, Munich, Germany; Department of Physiology and Pharmacology (FyFa) and Department of Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2019.03.503DOI Listing
June 2019

Thymosin β4-mediated protective effects in the heart.

Expert Opin Biol Ther 2018 07;18(sup1):121-129

a Internal Medicine I , Klinikum rechts der Isar der TU München , Munich , Germany.

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http://dx.doi.org/10.1080/14712598.2018.1490409DOI Listing
July 2018

Induced pluripotent stem cell derived cardiac models: effects of Thymosin β4.

Expert Opin Biol Ther 2018 07;18(sup1):111-120

a I. Medizinische Klinik & Poliklinik, Klinikum rechts der Isar , Technical University of Munich , Munich , Germany.

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http://dx.doi.org/10.1080/14712598.2018.1473370DOI Listing
July 2018

Tβ4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs.

Mol Ther 2018 07 19;26(7):1706-1714. Epub 2018 Jun 19.

Klinik und Poliklinik Innere Medizin I, Klinikum rechts der Isar - Technical University of Munich, 81675 Munich, Germany; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität (LMU), 80336 Munich, Germany; DZHK (German Centre for Cardiovascular Research) - partner site Munich Heart Alliance, 81675 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037200PMC
July 2018

Translational Aspects of Adeno-Associated Virus-Mediated Cardiac Gene Therapy.

Hum Gene Ther 2018 12 24;29(12):1341-1351. Epub 2018 Jul 24.

1 I. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technical University of Munich , Munich, Germany.

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http://dx.doi.org/10.1089/hum.2017.229DOI Listing
December 2018

Individualized Biventricular Epicardial Augmentation Technology in a Drug-Induced Porcine Failing Heart Model.

ASAIO J 2018 Jul/Aug;64(4):480-488

Institut für Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Universitätsklinikum Ulm, Ulm, Germany.

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http://dx.doi.org/10.1097/MAT.0000000000000686DOI Listing
March 2019

Steerable Induction of the Thymosin β4/MRTF-A Pathway via AAV-Based Overexpression Induces Therapeutic Neovascularization.

Hum Gene Ther 2017 Oct 3. Epub 2017 Oct 3.

1 Medizinische Klinik und Poliklinik I , Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.1089/hum.2017.013DOI Listing
October 2017

Thymosin 4 Improves Differentiation and Vascularization of EHTs.

Stem Cells Int 2017 16;2017:6848271. Epub 2017 Jan 16.

I. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.

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http://dx.doi.org/10.1155/2017/6848271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278226PMC
January 2017

Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium.

J Am Coll Cardiol 2017 Jan;69(2):131-143

I. Medizinische Klinik und Poliklinik, University Clinic Rechts der Isar, Technical University of Munich, Munich, Germany; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany; Walter-Brendel-Centre for Experimental Medicine, Ludwig Maximilian University of Munich, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.10.058DOI Listing
January 2017

Selective Pressure-Regulated Retroinfusion for Gene Therapy Application in Ischemic Heart Disease.

Methods Mol Biol 2017 ;1521:249-260

Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, TU Munich, Ismaningerstr. 22, 81675, Munich, Germany.

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http://dx.doi.org/10.1007/978-1-4939-6588-5_18DOI Listing
January 2018

Pim1 Overexpressing ckit Cardiac Stem Cells in Cardiac Regeneration: Preconditioning as Next-Generation Stem Cell Therapy?

Authors:
Rabea Hinkel

J Am Coll Cardiol 2016 12;68(22):2465-2466

I. Medizinische Klinik und Poliklinik, University Clinic Rechts der Isar, TUM (Technical University Munich) Institute for Cardiovascular Prevention, KUM (Klinikum der Universität München) Munich, Germany; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.09.924DOI Listing
December 2016

Endothelial RAGE exacerbates acute postischaemic cardiac inflammation.

Thromb Haemost 2016 08 2;116(2):300-8. Epub 2016 Jun 2.

Christian Kupatt, 1. Medizinische Klinik und Poliklinik, Klinikum Rechts der Isar, TUM Munich, Ismaninger Strasse 22, 81675 Munich, Germany, Tel.: +49 89 4140 9086, E-mail:

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http://dx.doi.org/10.1160/TH15-11-0898DOI Listing
August 2016

Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5.

Sci Transl Med 2015 Dec;7(317):317ra196

Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, 80336 Munich, Germany. German Centre for Cardiovascular Research, partner site Munich Heart Alliance, 80336 Munich, Germany. Department of Pathology, Academic Medical Center, 1105 Amsterdam, Netherlands.

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http://dx.doi.org/10.1126/scitranslmed.aad5330DOI Listing
December 2015

C-terminal variable AGES domain of Thymosin β4: the molecule's primary contribution in support of post-ischemic cardiac function and repair.

J Mol Cell Cardiol 2015 Oct 5;87:113-25. Epub 2015 Aug 5.

Department of Cardiovascular and Thoracic Surgery University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; University of Pecs, Faculty of Medicine, Szentagothai Research Centre, Pecs 7624, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.07.004DOI Listing
October 2015

Heme Oxygenase-1 Gene Therapy Provides Cardioprotection Via Control of Post-Ischemic Inflammation: An Experimental Study in a Pre-Clinical Pig Model.

J Am Coll Cardiol 2015 Jul;66(2):154-65

Medizinische Klinik I, Klinikum Grosshadern, Ludwig Maximilian University, Munich, Germany; Medizinische Klinik I, Klinikum Rechts der Isar, Technical University of Munich, and German Center for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany; Walter-Brendel-Centre for Experimental Medicine, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2015.04.064DOI Listing
July 2015

Thymosin-β4-mediated therapeutic neovascularization: role of the PI3K/AKT pathway.

Expert Opin Biol Ther 2015 4;15 Suppl 1:S175-85. Epub 2015 Feb 4.

Deutsches Herzzentrum München, Technische Universität , Munich , Germany.

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http://dx.doi.org/10.1517/14712598.2015.1011122DOI Listing
March 2016

Thymosin β4 attenuates microcirculatory and hemodynamic destabilization in sepsis.

Expert Opin Biol Ther 2015 21;15 Suppl 1:S203-10. Epub 2015 Jan 21.

Klinikum der Universität München, Medizinische Klinik und Poliklinik I , Marchioninistr. 15, 81377 Munich , Germany +49 89 44007 3075 ; +49 89 44007 6075 ;

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http://dx.doi.org/10.1517/14712598.2015.1006193DOI Listing
March 2016

Annexin A1 counteracts chemokine-induced arterial myeloid cell recruitment.

Circ Res 2015 Feb 17;116(5):827-35. Epub 2014 Dec 17.

From the Institute for Cardiovascular Prevention (IPEK), LMU Munich, Munich, Germany (M.D., R.d.J., J.R.V., G.L., J.G., C.W., Y.D., O.S.); Department of Pathology, Academic Medical Center (AMC), Amsterdam University, Amsterdam, The Netherlands (M.D., O.S.); Department of Anaesthesiology, University Münster, Münster, Germany (J.R., A.Z.); Max Planck Institute, Münster, Germany (J.R., A.Z.); Laboratory of Molecular Immunoregulation, NCI, Frederick, MD (J.M.W.); European Vascular Center Aachen-Maastricht, University Hospital RWTH Aachen, Aachen, Germany (J.G.); Medizinische Klinik und Poliklinik I, Klinikum Großhadern, LMU Munich, Munich, Germany (R.H., C.K.); and DZHK, Partner Site Munich Heart Alliance, Munich, Germany (R.H., C.K., C.W., O.S.).

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http://circres.ahajournals.org/content/early/2014/12/17/CIRC
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http://circres.ahajournals.org/cgi/doi/10.1161/CIRCRESAHA.11
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http://dx.doi.org/10.1161/CIRCRESAHA.116.305825DOI Listing
February 2015

Adeno-associated viral vector 2.9 thymosin ß4 application attenuates rejection after heart transplantation: results of a preclinical study in the pig.

Transplantation 2014 Oct;98(8):835-43

1 Herzchirurgischen Klinik und Poliklinik, Klinikum Großhadern, LMU, Munich, Germany. 2 DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. 3 Institut für Chirurgische Forschung am Walter-Brendel-Zentrum für Experimentelle Medizin, LMU, Munich, Germany. 4 Pathologisches Institut, Ludwig-Maximilians-Universität München. 5 Klinik für Anästhesiologie, Klinikum Großhadern, LMU, Munich, Germany. 6 Medizinische Klinik Und Poliklinik I, Klinikum Großhadern, LMU, Munich, Germany. 7 Address correspondence to: Rabea Hinkel, D.V.M., Medizinische Klinik und Poliklinik I, Klinikum Großhadern, LMU, Marchioninistr. 15, 81377 München.

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http://dx.doi.org/10.1097/TP.0000000000000327DOI Listing
October 2014

Targeting microRNAs for cardiovascular therapeutics in coronary artery disease.

Curr Opin Cardiol 2014 Nov;29(6):586-94

aMedizinische Klinik und Poliklinik I, Klinikum Großhadern, LMU bDZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.

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http://dx.doi.org/10.1097/HCO.0000000000000107DOI Listing
November 2014

MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.

Nat Commun 2014 Jun 9;5:3970. Epub 2014 Jun 9.

1] Medizinische Klinik und Poliklinik I, Klinikum Grosshadern, 81377 Munich, Germany [2] DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, 80802 München, Germany [3] Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians University, 81377 München, Germany.

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http://dx.doi.org/10.1038/ncomms4970DOI Listing
June 2014

VEGF-B: a more balanced approach toward cardiac neovascularization?

EMBO Mol Med 2014 03 12;6(3):297-8. Epub 2014 Feb 12.

Medizinische Klinik I Klinikum Großhadern, Munich, Germany.

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http://dx.doi.org/10.1002/emmm.201303730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958304PMC
March 2014

In vivo monitoring of sorafenib therapy effects on experimental prostate carcinomas using dynamic contrast-enhanced MRI and macromolecular contrast media.

Cancer Imaging 2013 Dec 16;13(4):557-66. Epub 2013 Dec 16.

Department of Clinical Radiology, Laboratory for Experimental Radiology, University of Munich Hospitals - Campus Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistrasse 15, 81377 Munich, Germany; Department of Medical Imaging, University Health Network, University of Toronto, 585 University Avenue, Toronto ON M5G 2N2, Canada.

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http://dx.doi.org/10.1102/1470-7330.2013.0049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876822PMC
December 2013

Myocardial CT perfusion imaging in a large animal model: comparison of dynamic versus single-phase acquisitions.

JACC Cardiovasc Imaging 2013 Dec 23;6(12):1229-38. Epub 2013 Oct 23.

Department of Clinical Radiology, Ludwig-Maximilians-University, Munich, Germany; DZHK (German Center for Cardiovascular Research) and Munich Heart Alliance, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jcmg.2013.05.018DOI Listing
December 2013

Inhibition of microRNA-92a protects against ischemia/reperfusion injury in a large-animal model.

Circulation 2013 Sep 29;128(10):1066-75. Epub 2013 Jul 29.

Medizinische Klinik und Poliklinik I, Klinikum Großhadern, and German Center for Cardiovascular Research-Munich Heart Alliance, Marchioninistrasse 15, Munich, Germany.

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http://circ.ahajournals.org/content/early/2013/07/24/CIRCULA
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http://circ.ahajournals.org/content/128/10/1066.full.pdf
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http://circ.ahajournals.org/cgi/doi/10.1161/CIRCULATIONAHA.1
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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.001904DOI Listing
September 2013

SDF-1 fused to a fractalkine stalk and a GPI anchor enables functional neovascularization.

Stem Cells 2013 Sep;31(9):1795-805

Medizinische Klinik und Poliklinik I, Klinikum Großhadern, Ludwig-Maximilians-University and DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.

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http://dx.doi.org/10.1002/stem.1439DOI Listing
September 2013

Angiogenetic potential of Ad2/Hif-1α/VP16 after regional application in a preclinical pig model of chronic ischemia.

Curr Vasc Pharmacol 2013 Jan;11(1):29-37

Internal Medicine I, University Clinic Grosshadern, Marchioninistr. 15, D-81371 Munich, Germany.

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January 2013

Molecular and cellular mechanisms of thymosin β4-mediated cardioprotection.

Ann N Y Acad Sci 2012 Oct;1269:102-9

Medizinische Klinik und Poliklinik I, Klinikum Großhadern, Ludwig Maximilians University, Munich, Germany.

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http://doi.wiley.com/10.1111/j.1749-6632.2012.06693.x
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http://dx.doi.org/10.1111/j.1749-6632.2012.06693.xDOI Listing
October 2012

Adjuvant early and late cardioprotective therapy: access to the heart.

Cardiovasc Res 2012 May 7;94(2):226-36. Epub 2012 Feb 7.

Medizinische Klinik und Poliklinik I, Klinikum der LMU München, Marchioninistraße 15, Munich, Germany.

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http://dx.doi.org/10.1093/cvr/cvs075DOI Listing
May 2012

Perfusion MRI for monitoring the effect of sorafenib on experimental prostate carcinoma: a validation study.

AJR Am J Roentgenol 2012 Feb;198(2):384-91

Department of Clinical Radiology, Center for Experimental Radiology, University Hospitals Munich, Campus Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistrasse 15, 81377 Munich, Germany.

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http://dx.doi.org/10.2214/AJR.11.6951DOI Listing
February 2012

Gene therapy for ischemic heart disease.

Expert Opin Biol Ther 2011 Jun 25;11(6):723-37. Epub 2011 Mar 25.

University Clinic Grosshadern, Internal medicine I, 81377 Munich, Germany.

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http://dx.doi.org/10.1517/14712598.2011.570749DOI Listing
June 2011

Thymosin beta4: a key factor for protective effects of eEPCs in acute and chronic ischemia.

Ann N Y Acad Sci 2010 Apr;1194:105-11

Internal Medicine I, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05489.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601487PMC
April 2010

Optimization of delivery of adeno-associated virus mediated gene transfer to a transplanted heart in a rat model.

Exp Clin Transplant 2009 Sep;7(3):184-7

Department of Cardiac Surgery, Ludwig-Maximilians-University of Munich, Munich, Germany.

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September 2009

Endothelial nitric oxide synthase overexpression provides a functionally relevant angiogenic switch in hibernating pig myocardium.

J Am Coll Cardiol 2007 Apr 23;49(14):1575-84. Epub 2007 Mar 23.

Internal Medicine I, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Munich, Germany.

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http://dx.doi.org/10.1016/j.jacc.2006.11.047DOI Listing
April 2007

First clinical experience with the VSTENT: a device for direct left ventricle-to-coronary artery bypass.

Ann Thorac Surg 2005 Feb;79(2):573-9; discussion 579

Department of Cardiac Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University Munich, Munich, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S000349750401785
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http://dx.doi.org/10.1016/j.athoracsur.2004.08.036DOI Listing
February 2005