Raajit Rampal

Raajit Rampal

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Raajit Rampal

Publications by authors named "Raajit Rampal"

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Risk of disease progression in low-risk MDS is linked to distinct epigenetic subtypes.

Leukemia 2019 Nov 22;33(11):2753-2757. Epub 2019 Jul 22.

Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1038/s41375-019-0518-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842085PMC
November 2019

Cobimetinib-induced "dropped head syndrome" and subsequent disease management in an Erdheim-Chester patient.

Clin Case Rep 2019 Oct 10;7(10):1989-1993. Epub 2019 Sep 10.

Department of Leukemia Memorial Sloan Kettering Cancer Center New York New York.

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http://dx.doi.org/10.1002/ccr3.2297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787838PMC
October 2019

Thrombosis in the Philadelphia Chromosome-Negative Myeloproliferative Neoplasms.

Cancer Treat Res 2019 ;179:159-178

Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1007/978-3-030-20315-3_11DOI Listing
September 2019

Targeted therapies for myeloproliferative neoplasms.

Biomark Res 2019 16;7:15. Epub 2019 Jul 16.

1MDS and MPN Centre, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020 China.

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http://dx.doi.org/10.1186/s40364-019-0166-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636147PMC
July 2019

Leukemic Transformation of Myeloproliferative Neoplasms: Therapeutic and Genomic Considerations.

Curr Hematol Malig Rep 2018 12;13(6):588-595

Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 443, New York, NY, 10022, USA.

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http://dx.doi.org/10.1007/s11899-018-0491-5DOI Listing
December 2018

Genomic characterization of spleens in patients with myelofibrosis.

Haematologica 2018 10 10;103(10):e446-e449. Epub 2018 May 10.

Myeloproliferative Neoplasms Research Program, Department of Hematology and Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Rockefeller University, New York, NY, USA

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http://dx.doi.org/10.3324/haematol.2018.193763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165826PMC
October 2018

JAK/MAP kinase pathway activation and TP53 mutations in acute leukemia with megakaryocytic and erythroid differentiation.

Leukemia 2018 08 24;32(8):1842-1845. Epub 2018 Apr 24.

Hematopathology Diagnostic Service, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41375-018-0145-6DOI Listing
August 2018

Single-agent dabrafenib for -mutated histiocytosis.

Haematologica 2018 04 22;103(4):e177-e180. Epub 2018 Feb 22.

Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

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http://dx.doi.org/10.3324/haematol.2017.185298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865413PMC
April 2018

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.

Cancer Cell 2018 01 14;33(1):29-43.e7. Epub 2017 Dec 14.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760343PMC
January 2018

High prevalence of myeloid neoplasms in adults with non-Langerhans cell histiocytosis.

Blood 2017 08 5;130(8):1007-1013. Epub 2017 Jul 5.

Service de Médecine Interne 2, Institut E3M, Centre de Références des Maladies Auto-Immunes et Systémiques Rares, Centre de Référence des Histiocytoses, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Pierre et Marie Curie, Paris, France.

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http://dx.doi.org/10.1182/blood-2017-01-761718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570678PMC
August 2017

Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia.

Cell Stem Cell 2017 03 16;20(3):315-328.e7. Epub 2017 Feb 16.

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337161PMC
March 2017

The use of Erwinia asparaginase for adult patients with acute lymphoblastic leukemia after pegaspargase intolerance.

Leuk Res 2016 11 26;50:17-20. Epub 2016 Aug 26.

Leukemia Service, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2016.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507575PMC
November 2016

Telomere length and associations with somatic mutations and clinical outcomes in acute myeloid leukemia.

Leuk Res 2016 10 25;49:62-5. Epub 2016 Jul 25.

Leukemia Service, Department of Medicine, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, United States.

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http://dx.doi.org/10.1016/j.leukres.2016.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526052PMC
October 2016

Diffuse reduction of cerebral grey matter volumes in Erdheim-Chester disease.

Orphanet J Rare Dis 2016 08 2;11(1):109. Epub 2016 Aug 2.

Department of Radiology, Well Cornell Medical College, New York, USA.

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http://dx.doi.org/10.1186/s13023-016-0490-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971748PMC
August 2016

Bisphosphonates in Langerhans Cell Histiocytosis: An International Retrospective Case Series.

Mediterr J Hematol Infect Dis 2016 1;8(1):e2016033. Epub 2016 Jul 1.

Division of Hematology/Oncology and Bone Marrow Transplantation, Department of Pediatrics, The Hospital for Sick Children (SickKids), University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4084/MJHID.2016.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928520PMC
July 2016

Clinical response to ruxolitinib in CSF3R T618-mutated chronic neutrophilic leukemia.

Ann Hematol 2016 Jun 11;95(7):1197-200. Epub 2016 Apr 11.

Department of Pathology, Brady Memorial Laboratory, Yale School of Medicine, 310 Cedar Street, New Haven, CT, 06510, USA.

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http://dx.doi.org/10.1007/s00277-016-2664-4DOI Listing
June 2016

Wilms tumor 1 mutations in the pathogenesis of acute myeloid leukemia.

Haematologica 2016 06;101(6):672-9

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA

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http://dx.doi.org/10.3324/haematol.2015.141796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013955PMC
June 2016

Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F.

J Clin Oncol 2015 Nov 31;33(33):3953-60. Epub 2015 Aug 31.

Brady L. Stein, Northwestern Feinberg University School of Medicine, Chicago, IL; Stephen T. Oh and Camille Abboud, Washington University School of Medicine, St Louis, MO; Dmitriy Berenzon, Wake Forest University School of Medicine, Winston Salem, NC; Gabriela S. Hobbs, Massachusetts General Hospital, Boston, MA; Marina Kremyanskaya, John Mascarenhas, and Ronald Hoffman, Mount Sinai School of Medicine; Raajit K. Rampal, Memorial Sloan Kettering Cancer Center; Mark L. Heaney, Columbia University Medical Center; Ellen K. Ritchie, Cornell University School of Medicine, New York, NY; Kenneth Adler, Regional Cancer Care Associates, Morristown, NJ; Elias J. Jabbour, MD Anderson Cancer Center; Lawrence Rice, Cornell Houston Methodist Hospital, Houston, TX; Rami S. Komrokji, Moffitt Cancer Center, Tampa, FL; and Alison R. Moliterno, Johns Hopkins University School of Medicine, Baltimore, MD.

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http://jco.ascopubs.org/content/early/2015/08/31/JCO.2015.61
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.61.6474
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http://dx.doi.org/10.1200/JCO.2015.61.6474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979103PMC
November 2015

Fibrogenesis in Primary Myelofibrosis: Diagnostic, Clinical, and Therapeutic Implications.

Oncologist 2015 Oct 24;20(10):1154-60. Epub 2015 Aug 24.

Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland, Ohio USA; Department of Hematopathology, and Leukemia Department, The University of Texas MD Anderson Cancer Center, Houston, Texas USA; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1634/theoncologist.2015-0094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591957PMC
October 2015

Clinical and molecular genetic characterization of myelofibrosis.

Curr Opin Hematol 2015 Mar;22(2):177-83

aLeukemia Service, Massachusetts General Hospital, Boston, Massachusetts bLeukemia Service, Memorial Sloan-Kettering Cancer Center, New York, USA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MOH.0000000000000122DOI Listing
March 2015

Prospective blinded study of BRAFV600E mutation detection in cell-free DNA of patients with systemic histiocytic disorders.

Cancer Discov 2015 Jan 16;5(1):64-71. Epub 2014 Oct 16.

Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705028PMC
January 2015

Recurrent RAS and PIK3CA mutations in Erdheim-Chester disease.

Blood 2014 Nov 22;124(19):3016-9. Epub 2014 Aug 22.

Department of Internal Medicine & French Reference Center for Rare Auto-immune & Systemic Diseases, Hôpital Pitié-Salpêtrière Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France; Pierre and Marie Curie University, Paris, France;

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http://dx.doi.org/10.1182/blood-2014-04-570937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224196PMC
November 2014

JAK2 inhibitors do not affect stem cells present in the spleens of patients with myelofibrosis.

Blood 2014 Nov 5;124(19):2987-95. Epub 2014 Sep 5.

Division of Hematology/Oncology/Pathology, The Tisch Cancer Institute, Department of Medicine, Myeloproliferative Disorders Research Consortium, Icahn School of Medicine at Mount Sinai, New York, NY; and.

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http://dx.doi.org/10.1182/blood-2014-02-558015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224194PMC
November 2014

Development of extramedullary sites of leukaemia during ruxolitinib therapy for myelofibrosis.

Br J Haematol 2014 Oct 26;167(1):144-6. Epub 2014 May 26.

Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://doi.wiley.com/10.1111/bjh.12948
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http://dx.doi.org/10.1111/bjh.12948DOI Listing
October 2014

Integrating genomics into prognostic models for AML.

Semin Hematol 2014 Oct 12;51(4):298-305. Epub 2014 Aug 12.

Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY; Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1053/j.seminhematol.2014.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236107PMC
October 2014

Acute myeloid leukemia presenting with panhypopituitarism or diabetes insipidus: a case series with molecular genetic analysis and review of the literature.

Leuk Lymphoma 2014 Sep 24;55(9):2125-9. Epub 2014 Feb 24.

Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine and Northwestern Memorial Hospital , Chicago, IL , USA.

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http://dx.doi.org/10.3109/10428194.2013.869327DOI Listing
September 2014

A primer on genomic and epigenomic alterations in the myeloproliferative neoplasms.

Best Pract Res Clin Haematol 2014 Jun 19;27(2):83-93. Epub 2014 Jul 19.

Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 443, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.beha.2014.07.001DOI Listing
June 2014

Efficacy of intermittent combined RAF and MEK inhibition in a patient with concurrent BRAF- and NRAS-mutant malignancies.

Cancer Discov 2014 May 3;4(5):538-45. Epub 2014 Mar 3.

1Human Oncology and Pathogenesis Program, 2Leukemia Service, 3Gastrointestinal Oncology Service, 4Melanoma and Immunotherapeutics Service, Department of Medicine, 5Molecular Diagnostics Service, Department of Pathology, 6Department of Radiology, 7Center for Molecular Oncology, 8Ludwig Center for Cancer Immunotherapy, and 9Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center; and 10Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-13-1038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850735PMC
May 2014

Pathogenesis and management of acute myeloid leukemia that has evolved from a myeloproliferative neoplasm.

Curr Opin Hematol 2014 Mar;21(2):65-71

aLeukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center bTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000017DOI Listing
March 2014

Leveraging cancer genome information in hematologic malignancies.

J Clin Oncol 2013 05 15;31(15):1885-92. Epub 2013 Apr 15.

Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1200/JCO.2013.48.7447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795664PMC
May 2013

Translocation t(11;17) in de novo myelodysplastic syndrome not associated with acute myeloid or acute promyelocytic leukemia.

Acta Haematol 2013 7;129(1):48-54. Epub 2012 Nov 7.

Department of Medicine, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1159/000342493DOI Listing
February 2013

Progression of RAS-mutant leukemia during RAF inhibitor treatment.

N Engl J Med 2012 Dec 7;367(24):2316-21. Epub 2012 Nov 7.

Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1056/NEJMoa1208958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627494PMC
December 2012

Finding a needle in a haystack: whole genome sequencing and mutation discovery in murine models.

J Clin Invest 2011 Apr 23;121(4):1255-8. Epub 2011 Mar 23.

Human Oncology and Pathogenesis Program and Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1172/JCI57200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069796PMC
April 2011

Notch signaling in normal and disease States: possible therapies related to glycosylation.

Curr Mol Med 2007 Jun;7(4):427-45

Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, Stony Brook University, Stony Brook, New York, 11794-5215, USA.

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http://dx.doi.org/10.2174/156652407780831593DOI Listing
June 2007

Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats.

J Biol Chem 2005 Dec 12;280(51):42454-63. Epub 2005 Oct 12.

Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, Stony Brook University, Stony Brook, New York 11794-5215, USA.

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http://dx.doi.org/10.1074/jbc.M509552200DOI Listing
December 2005

Highly conserved O-fucose sites have distinct effects on Notch1 function.

J Biol Chem 2005 Sep 1;280(37):32133-40. Epub 2005 Jul 1.

Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, Stony Brook University, New York 11794-5215, USA.

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http://dx.doi.org/10.1074/jbc.M506104200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242041PMC
September 2005

CADASIL mutations impair Notch3 glycosylation by Fringe.

Hum Mol Genet 2005 Jun 27;14(12):1631-9. Epub 2005 Apr 27.

Neurology Department, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/hmg/ddi171DOI Listing
June 2005