Publications by authors named "R Wang"

27,647 Publications

ANKRD22 is a novel therapeutic target for gastric mucosal injury.

Biomed Pharmacother 2022 Jan 17;147:112649. Epub 2022 Jan 17.

Laboratory of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China. Electronic address:

Ankyrin repeat domain 22 (ANKRD22) is a nuclear-encoded mitochondrial membrane protein that is highly expressed in normal gastric mucosal epithelial cells and activated macrophages. As a regulator of mitochondrial Ca, ANKRD22 could help repair damaged gastric mucosa by promoting the mobilization of LGR5 gastric epithelial cells via the upregulation of Wnt/β-catenin pathway activity in a mouse model. Furthermore, the inhibition of ANKRD22 alleviated the macrophage activation-mediated inflammatory response by reducing the phosphorylation of nuclear factor of activated T cells (NFAT). ANKRD22 plays a significant role in the repair of gastric mucosal damage and may become an ideal novel target for the treatment of gastric mucosal injury. However, there is no systematic introduction to ANKRD22 targeting. Therefore, we wrote this review to elaborate the functional mechanism of ANKRD22 in gastric mucosal injury and to analyze its potential application value in clinical therapy.
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http://dx.doi.org/10.1016/j.biopha.2022.112649DOI Listing
January 2022

Pharmacological treatments for psychotic symptoms in dementia: A systematic review with pairwise and network meta-analysis.

Ageing Res Rev 2022 Jan 17;75:101568. Epub 2022 Jan 17.

Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

Psychotic symptoms of dementia are highly prevalent and lead to poor medical outcomes and substantial dysfunction. To date, which drug to use remains controversial without a summary of all direct or indirect comparisons of pharmacotherapy. Therefore, we conducted a systematic review with pairwise and network meta-analysis to examine efficacy and tolerability outcomes of pharmacological treatments in dementia patients. MEDLINE, Cochrane Library, EMBASE, and PubMed were searched systematically up to August 31, 2020. We included trials of cholinesterase inhibitors (ChEIs), memantine, antipsychotics, antidepressants, and mood stabilizers, with final approval from the U.S. Food and Drug Administration. We ranked the comparative effects of all drugs against placebo with surface under the cumulative ranking (SUCRA) probabilities. This analysis is based on 34 trials, which included 10,415 patients randomly assigned to 15 commonly used drug regimens. Donepezil (standardized mean difference [SMD] -0.30, 95% credible interval [CrI] -0.50 to -0.12; SUCRA, 0.85), memantine (SMD -0.20, 95%CrI -0.34 to -0.07; SUCRA, 0.68) and aripiprazole (SMD -0.17, 95% CrI -0.32 to -0.02; SUCRA, 0.62) showed greater benefit than placebo, and with relatively good tolerability in network meta-analyses. Risperidone was also found to be more efficacious than placebo (SMD -0.16, 95% CrI -0.28 to -0.05; SUCRA, 0.60), but with poor tolerability (odds ratios [OR] 1.50, 95% CrI 1.06-2.26). Donepezil, memantine, haloperidol, aripiprazole and risperidone were more efficacious than quetiapine (SMDs ranged from -0.36 to -0.22). Besides, donepezil, memantine and mirtazapine were more efficacious than sertraline (SMDs ranged from -0.47 to -0.36). Most of the results were rated as "low" to "very low". Several effective treatment choices for psychotic symptoms are available across drug classes. Donepezil, memantine and aripiprazole are probably the appropriate options to consider when a pharmacological treatment is indicated. Given the limitations of the meta-analytic approach and the low methodological quality of the majority of studies, our results should be cautiously interpreted.
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http://dx.doi.org/10.1016/j.arr.2022.101568DOI Listing
January 2022

Comments on "Chronic Pain: Associated with an Increased Risk of Dementia?"

Pain Physician 2022 Jan;25(1):E165-E166

Department of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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January 2022

Peroxydisulfate activation by LaNiO nanoparticles with different morphologies for the degradation of organic pollutants.

Water Sci Technol 2022 Jan;85(1):39-51

School of Water Conservancy and Environment, University of Jinan, Jinan 250022, China E-mail:

A series of LaNiO perovskite nanoparticles with different morphologies, such as spheres, rods and cubes, were prepared through co-precipitation and hydrothermal methods, and used as the catalysts for peroxydisulfate (PDS) activation. The physical and chemical characterization of LaNiO perovskites was performed, including X-ray diffraction (XRD), scanning electron microscopy (SEM), nitrogen isotherm absorption (BET), electrochemical impedance spectroscopy (EIS), and X-ray photoelectron spectroscopy (XPS). The LaNiO with different shapes showed different activities in Acid Orange 7 (AO7) degradation. Sphere-like LaNiO exhibited the highest catalytic activity, which is probably due to the largest specific surface area, higher proportion of reductive Ni and the higher electron transfer ability. The radical scavenging experiments and electron paramagnetic resonance (EPR) revealed the production of massive sulfate radicals (SO) and hydroxyl radicals (OH) during the oxidation. Finally, the possible mechanisms of PDS activation and AO7 degradation were proposed. The prepared LaNiO perovskites also showed excellent reusability and stability.
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http://dx.doi.org/10.2166/wst.2021.504DOI Listing
January 2022

Circulating Metabolome and White Matter Hyperintensities in Females and Males.

Circulation 2022 Jan 20. Epub 2022 Jan 20.

Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK.

White matter hyperintensities (WMH) are identified on T2-weighted magnetic resonance images of the human brain as areas of enhanced brightness; WMH are a major risk factor of stroke, dementia, and death. Currently, there are no large-scale studies testing associations between WMH and circulating metabolites. We studied up to 9,290 individuals (50.7% females, average age 61 years) from 15 populations of 8 community-based cohorts. WMH volume was quantified from T2-weighted or fluid-attenuated inversion-recovery images or as hypointensities on T1-weighted images. Circulating metabolomic measures were assessed with mass spectrometry and nuclear magnetic resonance spectroscopy. Associations between WMH and metabolomic measures were tested by fitting linear regression models in the pooled sample, and in sex-stratified and statin treatment-stratified subsamples. Our basic models were adjusted for age, sex, age*sex, and technical covariates, and our fully adjusted models were additionally adjusted for statin treatment, hypertension, type 2 diabetes, smoking, body mass index, and estimated glomerular filtration rate. Population-specific results were meta-analyzed using the fixed-effect inverse variance-weighted method. Associations with false discovery rate (FDR)-adjusted -values ()<0.05 were considered significant. In the meta-analysis of results from the basic models, we identified 30 metabolomic measures associated with WMH (<0.05), 7 of which remained significant in the fully adjusted models. The most significant association was with higher level of hydroxyphenylpyruvate in males (=1.40×10) and in both the pooled sample (=1.66×10) and statin-nontreated (=1.65×10) subsample. In males, HPP explained 3-14% of variance in WMH. In males and the pooled sample, WMH were also associated with lower levels of lysophosphatidylcholines and hydroxysphingomyelins, and a larger diameter of low-density lipoprotein particles, likely arising from higher triglyceride-to-total-lipids and lower cholesteryl ester-to-total-lipids ratios within these particles. In females, the only significant association was with higher level of glucuronate (=0.047). Circulating metabolomic measures, including multiple lipid measures (e.g., lysophosphatidylcholines, hydroxysphingomyelins, low-density lipoprotein size and composition) and non-lipid metabolites (e.g., hydroxyphenylpyruvate, glucuronate) associate with WMH in a general population of middle-aged and older adults. Some metabolomic measures show marked sex specificities and explain sizable proportion of WMH variance.
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http://dx.doi.org/10.1161/CIRCULATIONAHA.121.056892DOI Listing
January 2022
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