R Stephanie Huang

R Stephanie Huang

UNVERIFIED PROFILE

Are you R Stephanie Huang?   Register this Author

Register author
R Stephanie Huang

R Stephanie Huang

Publications by authors named "R Stephanie Huang"

Are you R Stephanie Huang?   Register this Author

73Publications

962Reads

22Profile Views

iMIRAGE: An R package to impute microRNA expression using protein-coding genes.

Bioinformatics 2019 Dec 20. Epub 2019 Dec 20.

Department of Experimental & Clinical Pharmacology, University of Minnesota Twin Cities, 516 Delaware St. S.E., Minneapolis, MN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btz939DOI Listing
December 2019

MicroRNA targeting energy metabolism in ovarian cancer: a potent contender for future therapeutics.

Ann Transl Med 2019 Dec;7(Suppl 8):S299

Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/atm.2019.11.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976402PMC
December 2019

Emerging role of long non-coding RNAs in cancer precision medicine.

Mol Cell Oncol 2020 10;7(1):1684130. Epub 2019 Nov 10.

Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/23723556.2019.1684130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961685PMC
November 2019

Discovering long noncoding RNA predictors of anticancer drug sensitivity beyond protein-coding genes.

Proc Natl Acad Sci U S A 2019 Oct 23;116(44):22020-22029. Epub 2019 Sep 23.

Department of Experimental and Clinical Pharmacology, University of Minnesota Minneapolis, MN 55455;

View Article

Download full-text PDF

Source
http://www.pnas.org/lookup/doi/10.1073/pnas.1909998116
Publisher Site
http://dx.doi.org/10.1073/pnas.1909998116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825320PMC
October 2019

Long non-coding RNA transcriptome of uncharacterized samples can be accurately imputed using protein-coding genes.

Brief Bioinform 2019 Jan 17. Epub 2019 Jan 17.

Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bib/bby129DOI Listing
January 2019

Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit.

Front Pharmacol 2018 4;9:1436. Epub 2018 Dec 4.

Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2018.01436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289166PMC
December 2018

More than fishing for a cure: The promises and pitfalls of high throughput cancer cell line screens.

Pharmacol Ther 2018 11 25;191:178-189. Epub 2018 Jun 25.

Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharmthera.2018.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001883PMC
November 2018

Lymphoblastoid Cell Lines as a Tool to Study Inter-Individual Differences in the Response to Glucose.

PLoS One 2016 10;11(8):e0160504. Epub 2016 Aug 10.

Departments of Medicine and Pharmacology Case Western Reserve University, Cleveland, Ohio, United States of America, and the Veterans Administration Medical Center Research Service 151, Cleveland, Ohio, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160504PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979894PMC
August 2017

Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas.

PLoS One 2016 13;11(12):e0168284. Epub 2016 Dec 13.

Department of Medicine, University of Chicago, Chicago, Illinois, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168284PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154569PMC
July 2017

Exploring the Link between the Germline and Somatic Genome in Cancer.

Cancer Discov 2017 04;7(4):354-355

Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-17-0192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404740PMC
April 2017

The Promise of Pharmacogenomics in Reducing Toxicity During Acute Lymphoblastic Leukemia Maintenance Treatment.

Genomics Proteomics Bioinformatics 2017 04 6;15(2):82-93. Epub 2017 Apr 6.

Department of Medicine, University of Chicago, Chicago, IL 60637, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gpb.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414888PMC
April 2017

Consistency in large pharmacogenomic studies.

Nature 2016 11;540(7631):E1-E2

Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature19838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290674PMC
November 2016

Cancer biomarker discovery is improved by accounting for variability in general levels of drug sensitivity in pre-clinical models.

Genome Biol 2016 Sep 21;17(1):190. Epub 2016 Sep 21.

Section of Hematology/Oncology, The University of Chicago, 900 E 57th Street, KCBD room 7148, Chicago, IL, 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13059-016-1050-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031330PMC
September 2016

pRRophetic: an R package for prediction of clinical chemotherapeutic response from tumor gene expression levels.

PLoS One 2014 17;9(9):e107468. Epub 2014 Sep 17.

Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107468PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167990PMC
December 2015

The impact of the Cancer Genome Atlas on lung cancer.

Transl Res 2015 Dec 10;166(6):568-85. Epub 2015 Aug 10.

Department of Medicine, The University of Chicago, Chicago, Ill. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trsl.2015.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656061PMC
December 2015

Identifying and validating a combined mRNA and microRNA signature in response to imatinib treatment in a chronic myeloid leukemia cell line.

PLoS One 2014 15;9(12):e115003. Epub 2014 Dec 15.

Department of Medicine, University of Chicago, Chicago, Illinois, United States of America; The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang, China.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115003PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266614PMC
November 2015

Predicting Response to Histone Deacetylase Inhibitors Using High-Throughput Genomics.

J Natl Cancer Inst 2015 Nov 21;107(11). Epub 2015 Aug 21.

Department of Medicine (PG, DL, FW, BL, SK, JW, MLM, RSH), Committee on Clinical Pharmacology and Pharmacogenomics (MLM, RSH), and the Comprehensive Cancer Center (MLM, RSH), University of Chicago, Chicago, IL; Oncology Clinical Research, Merck Research Laboratories, North Wales, PA (AL, MN, MC, JH).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnci/djv247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643634PMC
November 2015

MicroRNA biogenesis and cellular proliferation.

Transl Res 2015 Aug 7;166(2):145-51. Epub 2015 Feb 7.

Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, Ill. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trsl.2015.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509805PMC
August 2015

Pharmacogenomics of EGFR-targeted therapies in non-small cell lung cancer: EGFR and beyond.

Chin J Cancer 2015 Apr 8;34(4):149-60. Epub 2015 Apr 8.

Department of Medicine, University of Chicago, 900 E 57th street, KCBD room 7148, Chicago, IL, 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40880-015-0007-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593375PMC
April 2015

Circulating microRNAs as biomarkers for inflammatory diseases.

Microrna 2013 ;2(1):63-71

Department of Medicine, The University of Chicago, Chicago, IL, 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/2211536611302010007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092001PMC
March 2015

Integrative "omic" analysis for tamoxifen sensitivity through cell based models.

PLoS One 2014 3;9(4):e93420. Epub 2014 Apr 3.

Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093420PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974759PMC
January 2015

Pharmacogenomics of cisplatin sensitivity in non-small cell lung cancer.

Genomics Proteomics Bioinformatics 2014 Oct 28;12(5):198-209. Epub 2014 Oct 28.

Department of Medicine, University of Chicago, Chicago, IL 60637, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gpb.2014.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411417PMC
October 2014

Translating pharmacogenomics discoveries into the clinic: an implementation framework.

Genome Med 2013 18;5(10):94. Epub 2013 Oct 18.

Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/gm497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066637PMC
August 2014

The impact of microRNA expression on cellular proliferation.

Hum Genet 2014 Jul 8;133(7):931-8. Epub 2014 Mar 8.

Section of Hematology/Oncology, Department of Medicine, The University of Chicago, 900 E 57th Street, KCBD, Chicago, IL, 60637, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00439-014-1434-4
Publisher Site
http://dx.doi.org/10.1007/s00439-014-1434-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677487PMC
July 2014

Poly-omic prediction of complex traits: OmicKriging.

Genet Epidemiol 2014 Jul 2;38(5):402-15. Epub 2014 May 2.

Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gepi.21808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072756PMC
July 2014

SCAN: a systems biology approach to pharmacogenomic discovery.

Methods Mol Biol 2013 ;1015:213-24

Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-62703-435-7_14
Publisher Site
http://dx.doi.org/10.1007/978-1-62703-435-7_14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032625PMC
February 2014

[Next-generation sequencing for lung cancer].

Zhongguo Fei Ai Za Zhi 2014 Jan;17(1):C1-C12

Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3779/j.issn.1009-3419.2014.01.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128952PMC
January 2014

Meta-analyses of four eosinophil related gene variants in coronary heart disease.

J Thromb Thrombolysis 2013 Nov;36(4):394-401

Ningbo Medical Center, Lihuili Hospital, Ningbo University, Ningbo, 315041, Zhejiang, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11239-012-0862-zDOI Listing
November 2013

Next-generation sequencing for lung cancer.

Future Oncol 2013 Sep;9(9):1323-36

Department of Medicine, University of Chicago, Chicago, IL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/fon.13.102DOI Listing
September 2013

Pharmacogenomics discovery and implementation in genome-wide association studies era.

Wiley Interdiscip Rev Syst Biol Med 2013 Jan-Feb;5(1):1-9. Epub 2012 Nov 27.

Department of Anatomy, Harbin Medical University-Daqing, Daqing, Heilongjiang Province, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/wsbm.1199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527666PMC
June 2013

Pharmacogenetics and pharmacogenomics: a bridge to individualized cancer therapy.

Pharmacogenomics 2013 Feb;14(3):315-24

Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs.12.213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605891PMC
February 2013

Positive association between rs10918859 of the NOS1AP gene and coronary heart disease in male Han Chinese.

Genet Test Mol Biomarkers 2013 Jan 21;17(1):25-9. Epub 2012 Nov 21.

The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/gtmb.2012.0254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903165PMC
January 2013

Identification of novel germline polymorphisms governing capecitabine sensitivity.

Cancer 2012 Aug 3;118(16):4063-73. Epub 2012 Jan 3.

Section of Hematology-Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cncr.26737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413892PMC
August 2012

Genetic architecture of microRNA expression: implications for the transcriptome and complex traits.

Am J Hum Genet 2012 Jun 31;90(6):1046-63. Epub 2012 May 31.

Section of Genetic Medicine, Department of Medicine, University of Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajhg.2012.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370272PMC
June 2012

Population differences in microRNA expression and biological implications.

RNA Biol 2011 Jul-Aug;8(4):692-701. Epub 2011 Jul 1.

Section of Hematology-Oncology, University of Illinois at Chicago, Chicago, IL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/rna.8.4.16029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225983PMC
April 2012

Copy number polymorphisms and anticancer pharmacogenomics.

Genome Biol 2011 25;12(5):R46. Epub 2011 May 25.

Section of Genetic Medicine, Department of Medicine, University of Chicago, 900 East 57th Street, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/gb-2011-12-5-r46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219969PMC
February 2012

Population differences in the rate of proliferation of international HapMap cell lines.

Am J Hum Genet 2010 Dec 25;87(6):829-33. Epub 2010 Nov 25.

Department of Human Genetics, University of Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajhg.2010.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997375PMC
December 2010

Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci.

Proc Natl Acad Sci U S A 2010 May 4;107(20):9287-92. Epub 2010 May 4.

Sections of Genetic Medicine and Hematology/Oncology, Department of Medicine, Pharmacogenomics, University of Chicago, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1001827107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889115PMC
May 2010

Approaches to the discovery of pharmacogenomic markers in oncology: 2000-2010-2020.

Pharmacogenomics 2010 Apr;11(4):471-4

Department of Medicine, University of Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs.10.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864525PMC
April 2010

A pharmacogene database enhanced by the 1000 Genomes Project.

Pharmacogenet Genomics 2009 Oct;19(10):829-32

Department of Medicine, The University of Chicago, Illinois, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e3283317bacDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935084PMC
October 2009

Gene set enrichment analyses revealed differences in gene expression patterns between males and females.

In Silico Biol 2009 ;9(3):55-63

Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757739PMC
October 2009

Identification of genomic regions contributing to etoposide-induced cytotoxicity.

Hum Genet 2009 Mar 17;125(2):173-80. Epub 2008 Dec 17.

Department of Medicine, University of Chicago, 5841 S. Maryland Ave, Box MC2115, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00439-008-0607-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714550PMC
March 2009

Identification of common genetic variants that account for transcript isoform variation between human populations.

Hum Genet 2009 Feb 4;125(1):81-93. Epub 2008 Dec 4.

Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Box MC6091, 5841 S. Maryland Ave., Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00439-008-0601-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665168PMC
February 2009

Pharmacogenetics and pharmacogenomics of anticancer agents.

CA Cancer J Clin 2009 Jan-Feb;59(1):42-55

Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3322/caac.20002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109906PMC
February 2009

Population-specific GSTM1 copy number variation.

Hum Mol Genet 2009 Jan 23;18(2):366-72. Epub 2008 Oct 23.

Section of Hematology-Oncology, Department of Medicine, The University of Chicago, 5841 S. Maryland Ave., PB Box MC2115, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddn345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722188PMC
January 2009

Integrating Epigenomics into Pharmacogenomic Studies.

Pharmgenomics Pers Med 2008 Nov;2008(1):7-14

Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901114PMC
http://dx.doi.org/10.2147/pgpm.s4341DOI Listing
November 2008

Genetic variants associated with carboplatin-induced cytotoxicity in cell lines derived from Africans.

Mol Cancer Ther 2008 Sep 2;7(9):3038-46. Epub 2008 Sep 2.

Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Box MC2115, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-08-0248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743011PMC
September 2008

Genetic architecture of transcript-level variation in humans.

Am J Hum Genet 2008 May 24;82(5):1101-13. Epub 2008 Apr 24.

Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajhg.2008.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651622PMC
May 2008

Cell-based Models for Discovery of Pharmacogenomic Markers of Anticancer Agent Toxicity.

Trends Cancer Res 2008 ;4:1-13

Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076057PMC
January 2008

A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity.

Proc Natl Acad Sci U S A 2007 Jun 30;104(23):9758-63. Epub 2007 May 30.

Section of Hematology-Oncology, Biostatistics Consulting Laboratory, Department of Health Studies, University of Chicago, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.0703736104
Publisher Site
http://dx.doi.org/10.1073/pnas.0703736104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887589PMC
June 2007