Publications by authors named "R Savant"

15 Publications

Huntington's procedure revisited.

J Clin Orthop Trauma 2019 Nov-Dec;10(6):1128-1131. Epub 2019 Jun 13.

Department of Surgery NSCB Government Medical College, Jabalpur, MP, 482003, India.

Background: Management of gap nonunion of tibia is difficult for the surgeons, and time consuming for patients with unpredictable results. There are various methods to treat gap nonunion, but each one has its own limitations. We report the outcomes of ipsilateral fibular transposition (Huntington's procedure) for reconstruction of major tibial defects.

Methods: It is a retrospective study including 4 patients who underwent ipsilateral vascularized transposition of fibula for gap nonunion of tibia. Fibula was transferred to tibia as vascularized pedicle graft in one-staged procedure.

Results: Single stage fibular transposition was performed in four patients The transferred fibula united in all patients. Mean follow-up after fibular transposition was 1.2 years. Partial weight bearing started after an average of 5.25 months till hypertrophy of fibula is seen on radiographs than full weight bearing started. The mean time to healing was 7.5 months (range: 5-10 months). Tibialization of fibula occurred in all patients as evident on radiographs.

Conclusions: Huntington procedure is a simple and technically easy for large tibial defects. It does not require microsurgical skill and implants. The union of transferred fibula is faster than conventional graft as it is a vascularized graft. It is a rational choice for the treatment of large tibial defects in selected cases.
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June 2019

The effect of surgical management of endometrioma on the IVF/ICSI outcomes when compared with no treatment? A systematic review and meta-analysis.

Arch Gynecol Obstet 2018 Apr 17;297(4):1043-1057. Epub 2018 Jan 17.

Central Manchester Foundation Trust, Manchester, UK.

Objective: To assess the impact of surgical management of endometrioma on the outcome of assisted reproduction treatment (ART).

Design: A systematic review and meta-analysis.

Setting: Department of reproductive medicine at teaching university hospital, UK.

Patients: Subfertile women with endometrioma undergoing ART.

Interventions: Surgical removal of endometrioma or expectant management.

Main Outcome Measures: Clinical pregnancy rate, pregnancy rate, live birth rate, number of oocytes retrieved and number of embryos available and ovarian response to gonadotrophins.

Results: An extensive search of electronic databases for articles published from inception to September 2016 yielded 11 eligible studies for meta-analysis. Meta-analysis was conducted comparing surgery versus no treatment of endometrioma. There were no significant differences in pregnancy rate per cycle, clinical pregnancy rate and live birth rate between women who underwent surgery for endometrioma and those who did not.

Conclusion: Current evidence suggests that women with endometriosis-related infertility have similar cycle outcomes to other patients going through ART. It is pertinent for clinicians to assess the risks of surgical intervention on ovarian reserve prior to initiating therapy.
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April 2018

Determination of Stability from Multicomponent Pesticide Mixes.

J Agric Food Chem 2016 Aug 15;64(31):6108-24. Epub 2016 Mar 15.

Medallion Laboratories/General Mills Inc. , Spectra Building, Hiranandani Business Park, Powai, Mumbai 400076, India.

A study was conducted to evaluate the stability of 528 pesticides, metabolites, and contaminants prepared in large multicomponent mixes to enhance laboratory efficiency by allowing maximum use of the useful shelf life of the mixtures. Accelerated aging at 50 °C simulated 6 month, 1 year, and 2 year storage periods at -20 °C. Initial mixture composition was based on the instrument of analysis. After preliminary stability data had been obtained, mixtures were reformulated and re-evaluated. In all, 344 compounds showed satisfactory stability across all treatment groups, 100 compounds showed statistically significant changes between the control and the 6 month simulated storage period (27 with losses >20%), and the remainder showed borderline stability or were tested in one protocol. Stability behavior for organophosphates agreed with the proposed reaction mechanism responsible for acetylcholinesterase inhibition. A small number of compounds increased in response over time, suggesting the occurrence of degradation of precursor pesticides into these respective compounds.
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August 2016

Intrauterine instillation of lignocaine gel does not help in reducing pain after endometrial ablation.

Anaesth Intensive Care 2014 Jul;42(4):524-5

Wales, United Kingdom.

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July 2014

A fast, inexpensive, and safe method for residue analysis of meptyldinocap in different fruits by liquid chromatography/tandem mass spectrometry.

J AOAC Int 2010 Nov-Dec;93(6):1957-64

National Research Centre for Grapes, Manjri Farm, Pune, Maharashtra, India 412307.

An analytical method is reported for residue analysis of the fungicide meptyldinocap in different fruit matrixes that involves extraction with ethyl acetate, hydrolysis of the residues with ethanolamine, and determination by LC/MS/MS. The method involves extraction of 10 g sample with 10 mL ethyl acetate; evaporation of the ethyl acetate phase to dryness, and subsequent hydrolysis of the residues to 4,6-dinitro-2-(1-methylheptyl) phenol on reaction with 1% ethanolamine. The pH of this hydrolyzed product was neutralized with formic acid and analyzed by LC/MS/MS. The hydrolysis reaction followed pseudo-first-order kinetics, and the reaction product was spectroscopically confirmed as 2-(1-methylheptyl)-4,6-dinitrophenol. The method offered > 80% recoveries at an LOQ of 10 ng/g for grape and mango, 25 ng/g for pomegranate with intralaboratory Horwitz ratio < 0.5, and measurement uncertainties < 10% at LOQ levels. Considering first-order rate kinetics, activation energy, enthalpy of activation, and entropy of activation varied as solvent > mango > grape > pomegranate. Free energy of activation at 298 K was higher than at 280 K and was similar for solvent and three matrixes at both temperatures.
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March 2011