Publications by authors named "R K Gupta"

11,917 Publications

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Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2.

Commun Biol 2021 Apr 12;4(1):475. Epub 2021 Apr 12.

ModMab Therapeutics, Foster City, CA, USA.

COVID-19 is a respiratory illness caused by a novel coronavirus called SARS-CoV-2. The viral spike (S) protein engages the human angiotensin-converting enzyme 2 (ACE2) receptor to invade host cells with ~10-15-fold higher affinity compared to SARS-CoV S-protein, making it highly infectious. Here, we assessed if ACE2 polymorphisms can alter host susceptibility to SARS-CoV-2 by affecting this interaction. We analyzed over 290,000 samples representing >400 population groups from public genomic datasets and identified multiple ACE2 protein-altering variants. Using reported structural data, we identified natural ACE2 variants that could potentially affect virus-host interaction and thereby alter host susceptibility. These include variants S19P, I21V, E23K, K26R, T27A, N64K, T92I, Q102P and H378R that were predicted to increase susceptibility, while variants K31R, N33I, H34R, E35K, E37K, D38V, Y50F, N51S, M62V, K68E, F72V, Y83H, G326E, G352V, D355N, Q388L and D509Y were predicted to be protective variants that show decreased binding to S-protein. Using biochemical assays, we confirmed that K31R and E37K had decreased affinity, and K26R and T92I variants showed increased affinity for S-protein when compared to wildtype ACE2. Consistent with this, soluble ACE2 K26R and T92I were more effective in blocking entry of S-protein pseudotyped virus suggesting that ACE2 variants can modulate susceptibility to SARS-CoV-2.
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http://dx.doi.org/10.1038/s42003-021-02030-3DOI Listing
April 2021

Artificial intelligence to deep learning: machine intelligence approach for drug discovery.

Mol Divers 2021 Apr 12. Epub 2021 Apr 12.

Molecular Neuroscience and Functional Genomics Laboratory, Department of Biotechnology, Delhi Technological University (Formerly DCE), Shahbad Daulatpur, Bawana Road, Delhi, 110042, India.

Drug designing and development is an important area of research for pharmaceutical companies and chemical scientists. However, low efficacy, off-target delivery, time consumption, and high cost impose a hurdle and challenges that impact drug design and discovery. Further, complex and big data from genomics, proteomics, microarray data, and clinical trials also impose an obstacle in the drug discovery pipeline. Artificial intelligence and machine learning technology play a crucial role in drug discovery and development. In other words, artificial neural networks and deep learning algorithms have modernized the area. Machine learning and deep learning algorithms have been implemented in several drug discovery processes such as peptide synthesis, structure-based virtual screening, ligand-based virtual screening, toxicity prediction, drug monitoring and release, pharmacophore modeling, quantitative structure-activity relationship, drug repositioning, polypharmacology, and physiochemical activity. Evidence from the past strengthens the implementation of artificial intelligence and deep learning in this field. Moreover, novel data mining, curation, and management techniques provided critical support to recently developed modeling algorithms. In summary, artificial intelligence and deep learning advancements provide an excellent opportunity for rational drug design and discovery process, which will eventually impact mankind. The primary concern associated with drug design and development is time consumption and production cost. Further, inefficiency, inaccurate target delivery, and inappropriate dosage are other hurdles that inhibit the process of drug delivery and development. With advancements in technology, computer-aided drug design integrating artificial intelligence algorithms can eliminate the challenges and hurdles of traditional drug design and development. Artificial intelligence is referred to as superset comprising machine learning, whereas machine learning comprises supervised learning, unsupervised learning, and reinforcement learning. Further, deep learning, a subset of machine learning, has been extensively implemented in drug design and development. The artificial neural network, deep neural network, support vector machines, classification and regression, generative adversarial networks, symbolic learning, and meta-learning are examples of the algorithms applied to the drug design and discovery process. Artificial intelligence has been applied to different areas of drug design and development process, such as from peptide synthesis to molecule design, virtual screening to molecular docking, quantitative structure-activity relationship to drug repositioning, protein misfolding to protein-protein interactions, and molecular pathway identification to polypharmacology. Artificial intelligence principles have been applied to the classification of active and inactive, monitoring drug release, pre-clinical and clinical development, primary and secondary drug screening, biomarker development, pharmaceutical manufacturing, bioactivity identification and physiochemical properties, prediction of toxicity, and identification of mode of action.
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http://dx.doi.org/10.1007/s11030-021-10217-3DOI Listing
April 2021

Correlation between Prostate Imaging Reporting and Data System Version 2, Prostate-Specific Antigen Levels, and Local Staging in Biopsy-Proven Carcinoma Prostate: A Retrospective Study.

Int J Appl Basic Med Res 2021 Jan-Mar;11(1):32-35. Epub 2021 Jan 26.

Department of Pathology, Government Medical College, Jammu, Jammu and Kashmir, India.

Background: Multi-parametric magnetic resonance imaging (mp-MRI) is a promising tool in the diagnosis of clinically significant prostate cancer. Morphologic assessment using T2-weighted (T2W) images and functional assessment with diffusion-weighted imaging is the cornerstone for the diagnosis of prostate cancer on mp-MRI.

Aim/objectives: The aim of this study is to evaluate the role of mp-MRI based prostate imaging reporting and data system version 2 (PI-RADS v2) for the assessment of prostate cancer and its correlation with serum prostate specific antigen (S.PSA) levels, local (T) staging on MRI and histopathology.

Materials And Methods: The study was carried out from June 2019 to February 2020. All patients with raised S.PSA levels and abnormal digital rectal examination who underwent mp-MRI of the prostate were included. MRI findings were characterized on the basis of PI-RADS v2 grading. All the patients underwent biopsy and histopathology. The score was correlated with S.PSA levels and the local stage of disease on MRI. Statistical analysis was performed, and results interpreted.

Results: Carcinoma prostate was reported in 32/33 cases on biopsy. A significant correlation was observed between PI-RADS v2 score and S.PSA Levels and between PI-RADS v2 score and T stage of disease in our study. MRI was highly sensitive (93.75%) and specific (100%) in the diagnosis of prostate cancer in our study.

Conclusions: Significant correlation between lesion score on PI-RADS v2 with the local stage and S.PSA levels was seen, thus signifying the importance of mp-MRI in detecting clinically significant prostate cancer. Diffusion-weighted and T2W sequences were the primary diagnostic sequence for the prostate cancer with no additional role of dynamic contrast enhanced sequences.
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http://dx.doi.org/10.4103/ijabmr.IJABMR_115_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025949PMC
January 2021

Comparative study of hemodynamic effects of intrathecal bupivacaine with butorphanol in cardiac and non-cardiac patients.

J Anaesthesiol Clin Pharmacol 2020 Oct-Dec;36(4):511-517. Epub 2021 Jan 18.

Department of Anaesthesia, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India.

Background And Aims: The synergism between intrathecal opioids and low dose local anesthetics makes it possible to achieve reliable spinal anesthesia (SA) with minimal hypotension. The study objective was to compare the hemodynamic effects of reduced dose of 0.5% intrathecal bupivacaine (2mL) with 25 μg butorphanol in cardiac vs non-cardiac patients.

Material And Methods: We included sixty patients aged 30-80 years, undergoing infraumbilical surgeries in the study and compared thirty cardiac patients with mild to moderate reduction in left ventricular ejection fraction (LVEF) on 2D echocardiography (Group C) with 30 non-cardiac patients (Group NC) for similar types of surgery. Both the groups received 0.5% bupivacaine 2.0 ml with 25 μg butorphanol.

Results: The spinal block characteristics were similar in both groups ( > 0.05). The blood pressure of the patients in the two groups was comparable till 80 min > 0.05 after which Group NC had significant increase in blood pressure compared to Group C upto 95 min ( < 0.05). Similarly, heart rate was comparable until 90 min ( > 0.05) after which Group NC had significant increase in heart rate versus Group C upto 100 min ( < 0.05). Eight patients in group C and five patients in group NC showed hypotension. Bradycardia was seen in 4 patients in group C in comparison to only one patient in group NC.

Conclusion: We can safely consider spinal anesthesia with 10 mg bupivacaine and 25μg butorphanol in cardiac patients with mild to moderately reduced ejection fraction presenting for infraumbilical non-cardiac surgeries with the advantage of intraoperative hemodynamic stability and adequate postoperative analgesia.
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http://dx.doi.org/10.4103/joacp.JOACP_70_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022051PMC
January 2021

Evaluating the effectiveness of TENS for maternal satisfaction in laboring parturients - Comparison with epidural analgesia.

J Anaesthesiol Clin Pharmacol 2020 Oct-Dec;36(4):500-505. Epub 2021 Jan 18.

Department of Anaesthesia, SGRD Institute of Medical Sciences and Research, Amritsar, Punjab, India.

Background And Aims: Labor pain is one of the most severe pain that a woman experiences in her lifetime. Various methods are being used to relieve this pain and to achieve higher maternal satisfaction. One such technique is transcutaneous electrical nerve stimulation (TENS) that uses low-frequency electrotherapy. The aim of our study was to evaluate TENS by comparing it to an established labor analgesia technique, i.e., epidural analgesia in terms of maternal satisfaction.

Material And Methods: This prospective study was conducted on 60 parturients in active stage of labor. The choice of analgesia was made by the parturient after informed consent. In group A (n = 30) TENS was used, while in group B (n = 30) epidural ropivacaine 0.125% + 2 μg/ml fentanyl was given. Continuous monitoring of maternal vitals, visual analogue score, and fetal heart rate (FHR) was done. Maternal satisfaction was scored considering pain relief, ability to move and experience of labor at the end of delivery and outcome was labeled as favorable and unfavorable.

Results: TENS was found to be favorable in 90% of parturients as compared to 96.6% in epidural ( 0.301). The number of highly satisfied parturients was 4 (13.3%) in TENS group and 17 (56.6%) in the epidural group (= 0.000). Three patients in the epidural group had assisted delivery and two had cesarean section whereas all patients in TENS group delivered normally (= 0.065). No significant difference was found in the fetal outcome.

Conclusions: TENS is a good alternate choice for providing labor analgesia and may have a major role in future.
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http://dx.doi.org/10.4103/joacp.JOACP_286_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022049PMC
January 2021

Restless legs syndrome among subjects having chronic liver disease: A systematic review and meta-analysis.

Sleep Med Rev 2021 Mar 11;58:101463. Epub 2021 Mar 11.

Department of Neurology, John Hopkins University, Baltimore, MD, USA.

Sleep disturbances are commonly reported in patients with chronic liver disease (CLD). Changes in quality of sleep in patients with CLD could be related to multiple factors viz., elevated levels of tryptophan, histamine, and increased turnover of dopamine in caudate-putamen and cingulate cortex. Also, iron metabolism disturbances are reported in patients with CLD. These changes may result in restless legs syndrome (RLS) that worsens sleep-quality. There have been reports suggesting an increased prevalence of RLS among patients with CLD. Literature was searched in PubMed, EMBASE, and Google Scholar. A total of twenty-two relevant articles were found. Out of these, nine studies have assessed the prevalence of RLS among patients with chronic liver disease or cirrhosis in the clinical population. Population prevalence reported from various studies was used to calculate odds ratio. Having included studies using various methods for diagnosis (clinical as well as questionnaires) pooled odds-ratio for the RLS was 8.62. It remains unaffected by study-method, gender, age, and geographical-area. However, studies using clinical diagnosis for RLS had lower odds compared to questionnaire based diagnosis. Studies varied with regards to diagnostic methods, age, gender, etiology, and severity of liver dysfunction. The severity and etiology of CLD and biochemical correlate of CLD were not found to be associated with RLS. Possible pathophysiological mechanisms are discussed for the occurrence of RLS in this population. In conclusion, the prevalence of RLS is higher among patients with CLD, however, the correlates are unknown.
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http://dx.doi.org/10.1016/j.smrv.2021.101463DOI Listing
March 2021

Search for Dark Matter Produced in Association with a Dark Higgs Boson Decaying into W^{±}W^{∓} or ZZ in Fully Hadronic Final States from sqrt[s]=13  TeV pp Collisions Recorded with the ATLAS Detector.

Authors:
G Aad B Abbott D C Abbott A Abed Abud K Abeling D K Abhayasinghe S H Abidi O S AbouZeid N L Abraham H Abramowicz H Abreu Y Abulaiti B S Acharya B Achkar L Adam C Adam Bourdarios L Adamczyk L Adamek J Adelman A Adiguzel S Adorni T Adye A A Affolder Y Afik C Agapopoulou M N Agaras A Aggarwal C Agheorghiesei J A Aguilar-Saavedra A Ahmad F Ahmadov W S Ahmed X Ai G Aielli S Akatsuka M Akbiyik T P A Åkesson E Akilli A V Akimov K Al Khoury G L Alberghi J Albert M J Alconada Verzini S Alderweireldt M Aleksa I N Aleksandrov C Alexa T Alexopoulos A Alfonsi F Alfonsi M Alhroob B Ali S Ali M Aliev G Alimonti C Allaire B M M Allbrooke B W Allen P P Allport A Aloisio F Alonso C Alpigiani E Alunno Camelia M Alvarez Estevez M G Alviggi Y Amaral Coutinho A Ambler L Ambroz C Amelung D Amidei S P Amor Dos Santos S Amoroso C S Amrouche F An C Anastopoulos N Andari T Andeen J K Anders S Y Andrean A Andreazza V Andrei C R Anelli S Angelidakis A Angerami A V Anisenkov A Annovi C Antel M T Anthony E Antipov M Antonelli D J A Antrim F Anulli M Aoki J A Aparisi Pozo M A Aparo L Aperio Bella N Aranzabal V Araujo Ferraz R Araujo Pereira C Arcangeletti A T H Arce J-F Arguin S Argyropoulos J-H Arling A J Armbruster A Armstrong O Arnaez H Arnold Z P Arrubarrena Tame G Artoni H Asada K Asai S Asai T Asawatavonvanich N Asbah E M Asimakopoulou L Asquith J Assahsah K Assamagan R Astalos R J Atkin M Atkinson N B Atlay H Atmani P A Atmasiddha K Augsten V A Austrup G Avolio M K Ayoub G Azuelos D Babal H Bachacou K Bachas F Backman P Bagnaia M Bahmani H Bahrasemani A J Bailey V R Bailey J T Baines C Bakalis O K Baker P J Bakker E Bakos D Bakshi Gupta S Balaji R Balasubramanian E M Baldin P Balek F Balli W K Balunas J Balz E Banas M Bandieramonte A Bandyopadhyay Sw Banerjee L Barak W M Barbe E L Barberio D Barberis M Barbero G Barbour T Barillari M-S Barisits J Barkeloo T Barklow R Barnea B M Barnett R M Barnett Z Barnovska-Blenessy A Baroncelli G Barone A J Barr L Barranco Navarro F Barreiro J Barreiro Guimarães da Costa U Barron S Barsov F Bartels R Bartoldus G Bartolini A E Barton P Bartos A Basalaev A Basan A Bassalat M J Basso R L Bates S Batlamous J R Batley B Batool M Battaglia M Bauce F Bauer P Bauer H S Bawa A Bayirli J B Beacham T Beau P H Beauchemin F Becherer P Bechtle H C Beck H P Beck K Becker C Becot A Beddall A J Beddall V A Bednyakov M Bedognetti C P Bee T A Beermann M Begalli M Begel A Behera J K Behr F Beisiegel M Belfkir A S Bell G Bella L Bellagamba A Bellerive P Bellos K Beloborodov K Belotskiy N L Belyaev D Benchekroun N Benekos Y Benhammou D P Benjamin M Benoit J R Bensinger S Bentvelsen L Beresford M Beretta D Berge E Bergeaas Kuutmann N Berger B Bergmann L J Bergsten J Beringer S Berlendis G Bernardi C Bernius F U Bernlochner T Berry P Berta A Berthold I A Bertram O Bessidskaia Bylund N Besson S Bethke A Betti A J Bevan J Beyer S Bhatta D S Bhattacharya P Bhattarai V S Bhopatkar R Bi R M Bianchi O Biebel D Biedermann R Bielski K Bierwagen N V Biesuz M Biglietti T R V Billoud M Bindi A Bingul C Bini S Biondi C J Birch-Sykes M Birman T Bisanz J P Biswal D Biswas A Bitadze C Bittrich K Bjørke T Blazek I Bloch C Blocker A Blue U Blumenschein G J Bobbink V S Bobrovnikov S S Bocchetta D Bogavac A G Bogdanchikov C Bohm V Boisvert P Bokan T Bold A E Bolz M Bomben M Bona J S Bonilla M Boonekamp C D Booth A G Borbély H M Borecka-Bielska L S Borgna A Borisov G Borissov D Bortoletto D Boscherini M Bosman J D Bossio Sola K Bouaouda J Boudreau E V Bouhova-Thacker D Boumediene A Boveia J Boyd D Boye I R Boyko A J Bozson J Bracinik N Brahimi G Brandt O Brandt F Braren B Brau J E Brau W D Breaden Madden K Brendlinger R Brener L Brenner R Brenner S Bressler B Brickwedde D L Briglin D Britton D Britzger I Brock R Brock G Brooijmans W K Brooks E Brost P A Bruckman de Renstrom B Brüers D Bruncko A Bruni G Bruni M Bruschi N Bruscino L Bryngemark T Buanes Q Buat P Buchholz A G Buckley I A Budagov M K Bugge O Bulekov B A Bullard T J Burch S Burdin C D Burgard A M Burger B Burghgrave J T P Burr C D Burton J C Burzynski V Büscher E Buschmann P J Bussey J M Butler C M Buttar J M Butterworth P Butti W Buttinger C J Buxo Vazquez A Buzatu A R Buzykaev G Cabras S Cabrera Urbán D Caforio H Cai V M M Cairo O Cakir N Calace P Calafiura G Calderini P Calfayan G Callea L P Caloba A Caltabiano S Calvente Lopez D Calvet S Calvet T P Calvet M Calvetti R Camacho Toro S Camarda D Camarero Munoz P Camarri M T Camerlingo D Cameron C Camincher S Campana M Campanelli A Camplani V Canale A Canesse M Cano Bret J Cantero T Cao Y Cao M Capua R Cardarelli F Cardillo G Carducci I Carli T Carli G Carlino B T Carlson E M Carlson L Carminati R M D Carney S Caron E Carquin S Carrá G Carratta J W S Carter T M Carter M P Casado A F Casha E G Castiglia F L Castillo L Castillo Garcia V Castillo Gimenez N F Castro A Catinaccio J R Catmore A Cattai V Cavaliere V Cavasinni E Celebi F Celli K Cerny A S Cerqueira A Cerri L Cerrito F Cerutti A Cervelli S A Cetin Z Chadi D Chakraborty J Chan W S Chan W Y Chan J D Chapman B Chargeishvili D G Charlton T P Charman M Chatterjee C C Chau S Che S Chekanov S V Chekulaev G A Chelkov B Chen C Chen C H Chen H Chen H Chen J Chen J Chen J Chen S Chen S J Chen X Chen Y Chen Y-H Chen H C Cheng H J Cheng A Cheplakov E Cheremushkina R Cherkaoui El Moursli E Cheu K Cheung T J A Chevalérias L Chevalier V Chiarella G Chiarelli G Chiodini A S Chisholm A Chitan I Chiu Y H Chiu M V Chizhov K Choi A R Chomont Y Chou Y S Chow L D Christopher M C Chu X Chu J Chudoba J J Chwastowski L Chytka D Cieri K M Ciesla V Cindro I A Cioară A Ciocio F Cirotto Z H Citron M Citterio D A Ciubotaru B M Ciungu A Clark P J Clark S E Clawson C Clement Y Coadou M Cobal A Coccaro J Cochran R Coelho Lopes De Sa H Cohen A E C Coimbra B Cole A P Colijn J Collot P Conde Muiño S H Connell I A Connelly S Constantinescu F Conventi A M Cooper-Sarkar F Cormier K J R Cormier L D Corpe M Corradi E E Corrigan F Corriveau M J Costa F Costanza D Costanzo G Cowan J W Cowley J Crane K Cranmer R A Creager S Crépé-Renaudin F Crescioli M Cristinziani V Croft G Crosetti A Cueto T Cuhadar Donszelmann H Cui A R Cukierman W R Cunningham S Czekierda P Czodrowski M M Czurylo M J Da Cunha Sargedas De Sousa J V Da Fonseca Pinto C Da Via W Dabrowski F Dachs T Dado S Dahbi T Dai C Dallapiccola M Dam G D'amen V D'Amico J Damp J R Dandoy M F Daneri M Danninger V Dao G Darbo O Dartsi A Dattagupta T Daubney S D'Auria C David T Davidek D R Davis I Dawson K De R De Asmundis M De Beurs S De Castro N De Groot P de Jong H De la Torre A De Maria D De Pedis A De Salvo U De Sanctis M De Santis A De Santo J B De Vivie De Regie D V Dedovich A M Deiana J Del Peso Y Delabat Diaz D Delgove F Deliot C M Delitzsch M Della Pietra D Della Volpe A Dell'Acqua L Dell'Asta M Delmastro C Delporte P A Delsart S Demers M Demichev G Demontigny S P Denisov L D'Eramo D Derendarz J E Derkaoui F Derue P Dervan K Desch K Dette C Deutsch M R Devesa P O Deviveiros F A Di Bello A Di Ciaccio L Di Ciaccio W K Di Clemente C Di Donato A Di Girolamo G Di Gregorio A Di Luca B Di Micco R Di Nardo K F Di Petrillo R Di Sipio C Diaconu F A Dias T Dias Do Vale M A Diaz F G Diaz Capriles J Dickinson M Didenko E B Diehl J Dietrich S Díez Cornell C Diez Pardos A Dimitrievska W Ding J Dingfelder S J Dittmeier F Dittus F Djama T Djobava J I Djuvsland M A B Do Vale M Dobre D Dodsworth C Doglioni J Dolejsi Z Dolezal M Donadelli B Dong J Donini A D'onofrio M D'Onofrio J Dopke A Doria M T Dova A T Doyle E Drechsler E Dreyer T Dreyer A S Drobac D Du T A du Pree Y Duan F Dubinin M Dubovsky A Dubreuil E Duchovni G Duckeck O A Ducu D Duda A Dudarev A C Dudder E M Duffield M D'uffizi L Duflot M Dührssen C Dülsen M Dumancic A E Dumitriu M Dunford S Dungs A Duperrin H Duran Yildiz M Düren A Durglishvili D Duschinger B Dutta D Duvnjak G I Dyckes M Dyndal S Dysch B S Dziedzic M G Eggleston T Eifert G Eigen K Einsweiler T Ekelof H El Jarrari V Ellajosyula M Ellert F Ellinghaus A A Elliot N Ellis J Elmsheuser M Elsing D Emeliyanov A Emerman Y Enari M B Epland J Erdmann A Ereditato P A Erland M Errenst M Escalier C Escobar O Estrada Pastor E Etzion G E Evans H Evans M O Evans A Ezhilov F Fabbri L Fabbri V Fabiani G Facini R M Fakhrutdinov S Falciano P J Falke S Falke J Faltova Y Fang Y Fang G Fanourakis M Fanti M Faraj A Farbin A Farilla E M Farina T Farooque S M Farrington P Farthouat F Fassi P Fassnacht D Fassouliotis M Faucci Giannelli W J Fawcett L Fayard O L Fedin W Fedorko A Fehr M Feickert L Feligioni A Fell C Feng M Feng M J Fenton A B Fenyuk S W Ferguson J Ferrando A Ferrari P Ferrari R Ferrari D E Ferreira de Lima A Ferrer D Ferrere C Ferretti F Fiedler A Filipčič F Filthaut K D Finelli M C N Fiolhais L Fiorini F Fischer J Fischer W C Fisher T Fitschen I Fleck P Fleischmann T Flick B M Flierl L Flores L R Flores Castillo F M Follega N Fomin J H Foo G T Forcolin B C Forland A Formica F A Förster A C Forti E Fortin M G Foti D Fournier H Fox P Francavilla S Francescato M Franchini S Franchino D Francis L Franco L Franconi M Franklin G Frattari A N Fray P M Freeman B Freund W S Freund E M Freundlich D C Frizzell D Froidevaux J A Frost M Fujimoto C Fukunaga E Fullana Torregrosa T Fusayasu J Fuster A Gabrielli A Gabrielli S Gadatsch P Gadow G Gagliardi L G Gagnon G E Gallardo E J Gallas B J Gallop R Gamboa Goni K K Gan S Ganguly J Gao Y Gao Y S Gao F M Garay Walls C García J E García Navarro J A García Pascual C Garcia-Argos M Garcia-Sciveres R W Gardner N Garelli S Gargiulo C A Garner V Garonne S J Gasiorowski P Gaspar A Gaudiello G Gaudio P Gauzzi I L Gavrilenko A Gavrilyuk C Gay G Gaycken E N Gazis A A Geanta C M Gee C N P Gee J Geisen M Geisen C Gemme M H Genest C Geng S Gentile S George T Geralis L O Gerlach P Gessinger-Befurt G Gessner M Ghasemi Bostanabad M Ghneimat A Ghosh A Ghosh B Giacobbe S Giagu N Giangiacomi P Giannetti A Giannini G Giannini S M Gibson M Gignac D T Gil B J Gilbert D Gillberg G Gilles N E K Gillwald D M Gingrich M P Giordani P F Giraud G Giugliarelli D Giugni F Giuli S Gkaitatzis I Gkialas E L Gkougkousis P Gkountoumis L K Gladilin C Glasman J Glatzer P C F Glaysher A Glazov G R Gledhill I Gnesi M Goblirsch-Kolb D Godin S Goldfarb T Golling D Golubkov A Gomes R Goncalves Gama R Gonçalo G Gonella L Gonella A Gongadze F Gonnella J L Gonski S González de la Hoz S Gonzalez Fernandez R Gonzalez Lopez C Gonzalez Renteria R Gonzalez Suarez S Gonzalez-Sevilla G R Gonzalvo Rodriguez L Goossens N A Gorasia P A Gorbounov H A Gordon B Gorini E Gorini A Gorišek A T Goshaw M I Gostkin C A Gottardo M Gouighri A G Goussiou N Govender C Goy I Grabowska-Bold E C Graham J Gramling E Gramstad S Grancagnolo M Grandi V Gratchev P M Gravila F G Gravili C Gray H M Gray C Grefe K Gregersen I M Gregor P Grenier K Grevtsov C Grieco N A Grieser A A Grillo K Grimm S Grinstein J-F Grivaz S Groh E Gross J Grosse-Knetter Z J Grout C Grud A Grummer J C Grundy L Guan W Guan C Gubbels J Guenther A Guerguichon J G R Guerrero Rojas F Guescini D Guest R Gugel A Guida T Guillemin S Guindon J Guo W Guo Y Guo Z Guo R Gupta S Gurbuz G Gustavino M Guth P Gutierrez C Gutschow C Guyot C Gwenlan C B Gwilliam E S Haaland A Haas C Haber H K Hadavand A Hadef M Haleem J Haley J J Hall G Halladjian G D Hallewell K Hamano H Hamdaoui M Hamer G N Hamity K Han L Han L Han S Han Y F Han K Hanagaki M Hance D M Handl M D Hank R Hankache E Hansen J B Hansen J D Hansen M C Hansen P H Hansen E C Hanson K Hara T Harenberg S Harkusha P F Harrison N M Hartman N M Hartmann Y Hasegawa A Hasib S Hassani S Haug R Hauser M Havranek C M Hawkes R J Hawkings S Hayashida D Hayden C Hayes R L Hayes C P Hays J M Hays H S Hayward S J Haywood F He Y He M P Heath V Hedberg A L Heggelund N D Hehir C Heidegger K K Heidegger W D Heidorn J Heilman S Heim T Heim B Heinemann J G Heinlein J J Heinrich L Heinrich J Hejbal L Helary A Held S Hellesund C M Helling S Hellman C Helsens R C W Henderson L Henkelmann A M Henriques Correia H Herde Y Hernández Jiménez H Herr M G Herrmann T Herrmann G Herten R Hertenberger L Hervas G G Hesketh N P Hessey H Hibi S Higashino E Higón-Rodriguez K Hildebrand J C Hill K K Hill K H Hiller S J Hillier M Hils I Hinchliffe F Hinterkeuser M Hirose S Hirose D Hirschbuehl B Hiti O Hladik J Hobbs R Hobincu N Hod M C Hodgkinson A Hoecker D Hohn D Hohov T Holm T R Holmes M Holzbock L B A H Hommels T M Hong J C Honig A Hönle B H Hooberman W H Hopkins Y Horii P Horn L A Horyn S Hou A Hoummada J Howarth J Hoya M Hrabovsky J Hrivnac A Hrynevich T Hryn'ova P J Hsu S-C Hsu Q Hu S Hu Y F Hu D P Huang X Huang Y Huang Y Huang Z Hubacek F Hubaut M Huebner F Huegging T B Huffman M Huhtinen R Hulsken R F H Hunter N Huseynov J Huston J Huth R Hyneman S Hyrych G Iacobucci G Iakovidis I Ibragimov L Iconomidou-Fayard P Iengo R Ignazzi R Iguchi T Iizawa Y Ikegami M Ikeno N Ilic F Iltzsche H Imam G Introzzi M Iodice K Iordanidou V Ippolito M F Isacson M Ishino W Islam C Issever S Istin J M Iturbe Ponce R Iuppa A Ivina J M Izen V Izzo P Jacka P 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Phys Rev Lett 2021 Mar;126(12):121802

CERN, Geneva, Switzerland.

Several extensions of the Standard Model predict the production of dark matter particles at the LHC. An uncharted signature of dark matter particles produced in association with VV=W^{±}W^{∓} or ZZ pairs from a decay of a dark Higgs boson s is searched for using 139  fb^{-1} of pp collisions recorded by the ATLAS detector at a center-of-mass energy of 13 TeV. The s→V(qq[over ¯])V(qq[over ¯]) decays are reconstructed with a novel technique aimed at resolving the dense topology from boosted VV pairs using jets in the calorimeter and tracking information. Dark Higgs scenarios with m_{s}>160  GeV are excluded.
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http://dx.doi.org/10.1103/PhysRevLett.126.121802DOI Listing
March 2021

Longitudinal Flow Decorrelations in Xe+Xe Collisions at sqrt[s_{NN}]=5.44  TeV with the ATLAS Detector.

Authors:
G Aad B Abbott D C Abbott A Abed Abud K Abeling D K Abhayasinghe S H Abidi O S AbouZeid N L Abraham H Abramowicz H Abreu Y Abulaiti B S Acharya B Achkar S Adachi L Adam C Adam Bourdarios L Adamczyk L Adamek J Adelman M Adersberger A Adiguzel S Adorni T Adye A A Affolder Y Afik C Agapopoulou M N Agaras A Aggarwal C Agheorghiesei J A Aguilar-Saavedra F Ahmadov W S Ahmed X Ai G Aielli S Akatsuka T P A Åkesson E Akilli A V Akimov K Al Khoury G L Alberghi J Albert M J Alconada Verzini S Alderweireldt M Aleksa I N Aleksandrov C Alexa T Alexopoulos A Alfonsi F Alfonsi M Alhroob B Ali M Aliev G Alimonti C Allaire B M M Allbrooke B W Allen P P Allport A Aloisio F Alonso C Alpigiani A A Alshehri E Alunno Camelia M Alvarez Estevez M G Alviggi Y Amaral Coutinho A Ambler L Ambroz C Amelung D Amidei S P Amor Dos Santos S Amoroso C S Amrouche F An C Anastopoulos N Andari T Andeen C F Anders J K Anders S Y Andrean A Andreazza V Andrei C R Anelli S Angelidakis A Angerami A V Anisenkov A Annovi C Antel M T Anthony E Antipov M Antonelli D J A Antrim F Anulli M Aoki J A Aparisi Pozo M A Aparo L Aperio Bella J P Araque V Araujo Ferraz R Araujo Pereira C Arcangeletti A T H Arce F A Arduh J-F Arguin S Argyropoulos J-H Arling A J Armbruster A Armstrong O Arnaez H Arnold Z P Arrubarrena Tame G Artoni S Artz S Asai T Asawatavonvanich N Asbah E M Asimakopoulou L Asquith J Assahsah K Assamagan R Astalos R J Atkin M Atkinson N B Atlay H Atmani K Augsten G Avolio M K Ayoub G Azuelos H Bachacou K Bachas M Backes F Backman P Bagnaia M Bahmani H Bahrasemani A J Bailey V R Bailey J T Baines C Bakalis O K Baker P J Bakker D Bakshi Gupta S Balaji E M Baldin P Balek F Balli W K Balunas J Balz E Banas M Bandieramonte A Bandyopadhyay Sw Banerjee L Barak W M Barbe E L Barberio D Barberis M Barbero G Barbour T Barillari M-S Barisits J Barkeloo T Barklow R Barnea B M Barnett R M Barnett Z Barnovska-Blenessy A Baroncelli G Barone A J Barr L Barranco Navarro F Barreiro J Barreiro Guimarães da Costa S Barsov F Bartels R Bartoldus G Bartolini A E Barton P Bartos A Basalaev A Basan A Bassalat M J Basso R L Bates S Batlamous J R Batley B Batool M Battaglia M Bauce F Bauer K T Bauer H S Bawa J B Beacham T Beau P H Beauchemin F Becherer P Bechtle H C Beck H P Beck K Becker C Becot A Beddall A J Beddall V A Bednyakov M Bedognetti C P Bee T A Beermann M Begalli M Begel A Behera J K Behr F Beisiegel A S Bell G Bella L Bellagamba A Bellerive P Bellos K Beloborodov K Belotskiy N L Belyaev D Benchekroun N Benekos Y Benhammou D P Benjamin M Benoit J R Bensinger S Bentvelsen L Beresford M Beretta D Berge E Bergeaas Kuutmann N Berger B Bergmann L J Bergsten J Beringer S Berlendis G Bernardi C Bernius F U Bernlochner T Berry P Berta C Bertella I A Bertram O Bessidskaia Bylund N Besson A Bethani S Bethke A Betti A J Bevan J Beyer D S Bhattacharya P Bhattarai R Bi R M Bianchi O Biebel D Biedermann R Bielski K Bierwagen N V Biesuz M Biglietti T R V Billoud M Bindi A Bingul C Bini S Biondi M Birman T Bisanz J P Biswal D Biswas A Bitadze C Bittrich K Bjørke T Blazek I Bloch C Blocker A Blue U Blumenschein G J Bobbink V S Bobrovnikov S S Bocchetta A Bocci D Bogavac A G Bogdanchikov C Bohm V Boisvert P Bokan T Bold A E Bolz M Bomben M Bona J S Bonilla M Boonekamp C D Booth H M Borecka-Bielska L S Borgna A Borisov G Borissov J Bortfeldt D Bortoletto D Boscherini M Bosman J D Bossio Sola K Bouaouda J Boudreau E V Bouhova-Thacker D Boumediene S K Boutle A Boveia J Boyd D Boye I R Boyko A J Bozson J Bracinik N Brahimi G Brandt O Brandt F Braren B Brau J E Brau W D Breaden Madden K Brendlinger L Brenner R Brenner S Bressler B Brickwedde D L Briglin D Britton D Britzger I Brock R Brock G Brooijmans W K Brooks E Brost J H Broughton P A Bruckman de Renstrom D Bruncko A Bruni G Bruni L S Bruni S Bruno M Bruschi N Bruscino L Bryngemark T Buanes Q Buat P Buchholz A G Buckley I A Budagov M K Bugge F Bührer O Bulekov T J Burch S Burdin C D Burgard A M Burger B Burghgrave J T P Burr C D Burton J C Burzynski V Büscher E Buschmann P J Bussey J M Butler C M Buttar J M Butterworth P Butti W Buttinger C J Buxo Vazquez A Buzatu A R Buzykaev G Cabras S Cabrera Urbán D Caforio H Cai V M M Cairo O Cakir N Calace P Calafiura G Calderini P Calfayan G Callea L P Caloba A Caltabiano S Calvente Lopez D Calvet S Calvet T P Calvet M Calvetti R Camacho Toro S Camarda D Camarero Munoz P Camarri D Cameron C Camincher S Campana M Campanelli A Camplani A Campoverde V Canale A Canesse M Cano Bret J Cantero T Cao Y Cao M D M Capeans Garrido M Capua R Cardarelli F Cardillo G Carducci I Carli T Carli G Carlino B T Carlson E M Carlson L Carminati R M D Carney S Caron E Carquin S Carrá J W S Carter M P Casado A F Casha F L Castillo L Castillo Garcia V Castillo Gimenez N F Castro A Catinaccio J R Catmore A Cattai V Cavaliere E Cavallaro M Cavalli-Sforza V Cavasinni E Celebi L Cerda Alberich K Cerny A S Cerqueira A Cerri L Cerrito F Cerutti A Cervelli S A Cetin Z Chadi D Chakraborty J Chan W S Chan W Y Chan J D Chapman B Chargeishvili D G Charlton T P Charman C C Chau S Che S Chekanov S V Chekulaev G A Chelkov B Chen C Chen C H Chen H Chen J Chen J Chen J Chen S Chen S J Chen X Chen Y-H Chen H C Cheng H J Cheng A Cheplakov E Cheremushkina R Cherkaoui El Moursli E Cheu K Cheung T J A Chevalérias L Chevalier V Chiarella G Chiarelli G Chiodini A S Chisholm A Chitan I Chiu Y H Chiu M V Chizhov K Choi A R Chomont S Chouridou Y S Chow M C Chu X Chu J Chudoba J J Chwastowski L Chytka D Cieri K M Ciesla D Cinca V Cindro I A Cioară A Ciocio F Cirotto Z H Citron M Citterio D A Ciubotaru B M Ciungu A Clark M R Clark P J Clark C Clement Y Coadou M Cobal A Coccaro J Cochran R Coelho Lopes De Sa H Cohen A E C Coimbra B Cole A P Colijn J Collot P Conde Muiño S H Connell I A Connelly S Constantinescu F Conventi A M Cooper-Sarkar F Cormier K J R Cormier L D Corpe M Corradi E E Corrigan F Corriveau M J Costa F Costanza D Costanzo G Cowan J W Cowley J Crane K Cranmer S J Crawley R A Creager S Crépé-Renaudin F Crescioli M Cristinziani V Croft G Crosetti A Cueto T Cuhadar Donszelmann A R Cukierman W R Cunningham S Czekierda P Czodrowski M M Czurylo M J Da Cunha Sargedas De Sousa J V Da Fonseca Pinto C Da Via W Dabrowski F Dachs T Dado S Dahbi T Dai C Dallapiccola M Dam G D'amen V D'Amico J Damp J R Dandoy M F Daneri N S Dann M Danninger V Dao G Darbo O Dartsi A Dattagupta T Daubney S D'Auria C David T Davidek D R Davis I Dawson K De R De Asmundis M De Beurs S De Castro S De Cecco N De Groot P de Jong H De la Torre A De Maria D De Pedis A De Salvo U De Sanctis M De Santis A De Santo K De Vasconcelos Corga J B De Vivie De Regie C Debenedetti D V Dedovich A M Deiana J Del Peso Y Delabat Diaz D Delgove F Deliot C M Delitzsch M Della Pietra D Della Volpe A Dell'Acqua L Dell'Asta M Delmastro C Delporte P A Delsart D A DeMarco S Demers M Demichev G Demontigny S P Denisov L D'Eramo D Derendarz J E Derkaoui F Derue P Dervan K Desch C Deterre K Dette C Deutsch M R Devesa P O Deviveiros F A Di Bello A Di Ciaccio L Di Ciaccio W K Di Clemente C Di Donato A Di Girolamo G Di Gregorio B Di Micco R Di Nardo K F Di Petrillo R Di Sipio C Diaconu F A Dias T Dias Do Vale M A Diaz J Dickinson E B Diehl J Dietrich S Díez Cornell A Dimitrievska W Ding J Dingfelder F Dittus F Djama T Djobava J I Djuvsland M A B Do Vale M Dobre D Dodsworth C Doglioni J Dolejsi Z Dolezal M Donadelli B Dong J Donini A D'onofrio M D'Onofrio J Dopke A Doria M T Dova A T Doyle E Drechsler E Dreyer T Dreyer A S Drobac D Du Y Duan F Dubinin M Dubovsky A Dubreuil E Duchovni G Duckeck A Ducourthial O A Ducu D Duda A Dudarev A C Dudder E M Duffield L Duflot M Dührssen C Dülsen M Dumancic A E Dumitriu A K Duncan M Dunford A Duperrin H Duran Yildiz M Düren A Durglishvili D Duschinger B Dutta D Duvnjak G I Dyckes M Dyndal S Dysch B S Dziedzic K M Ecker M G Eggleston T Eifert G Eigen K Einsweiler T Ekelof H El Jarrari R El Kosseifi V Ellajosyula M Ellert F Ellinghaus A A Elliot N Ellis J Elmsheuser M Elsing D Emeliyanov A Emerman Y Enari M B Epland J Erdmann A Ereditato P A Erland M Errenst M Escalier C Escobar O Estrada Pastor E Etzion H Evans M O Evans A Ezhilov F Fabbri L Fabbri V Fabiani G Facini R M Faisca Rodrigues Pereira R M Fakhrutdinov S Falciano P J Falke S Falke J Faltova Y Fang Y Fang G Fanourakis M Fanti M Faraj A Farbin A Farilla E M Farina T Farooque S M Farrington P Farthouat F Fassi P Fassnacht D Fassouliotis M Faucci Giannelli W J Fawcett L Fayard O L Fedin W Fedorko A Fehr M Feickert L Feligioni A Fell C Feng M Feng M J Fenton A B Fenyuk S W Ferguson J Ferrando A Ferrante A Ferrari P Ferrari R Ferrari D E Ferreira de Lima A Ferrer D Ferrere C Ferretti F Fiedler A Filipčič F Filthaut K D Finelli M C N Fiolhais L Fiorini F Fischer W C Fisher I Fleck P Fleischmann T Flick B M Flierl L Flores L R Flores Castillo F M Follega N Fomin J H Foo G T Forcolin A Formica F A Förster A C Forti A G Foster M G Foti D Fournier H Fox P Francavilla S Francescato M Franchini S Franchino D Francis L Franconi M Franklin A N Fray P M Freeman B Freund W S Freund E M Freundlich D C Frizzell D Froidevaux J A Frost C Fukunaga E Fullana Torregrosa T Fusayasu J Fuster A Gabrielli A Gabrielli S Gadatsch P Gadow G Gagliardi L G Gagnon B Galhardo G E Gallardo E J Gallas B J Gallop G Galster R Gamboa Goni K K Gan S Ganguly J Gao Y Gao Y S Gao C García J E García Navarro J A García Pascual C Garcia-Argos M Garcia-Sciveres R W Gardner N Garelli S Gargiulo C A Garner V Garonne S J Gasiorowski P Gaspar A Gaudiello G Gaudio I L Gavrilenko A Gavrilyuk C Gay G Gaycken E N Gazis A A Geanta C M Gee C N P Gee J Geisen M Geisen C Gemme M H Genest C Geng S Gentile S George T Geralis L O Gerlach P Gessinger-Befurt G Gessner S Ghasemi M Ghasemi Bostanabad M Ghneimat A Ghosh A Ghosh B Giacobbe S Giagu N Giangiacomi P Giannetti A Giannini G Giannini S M Gibson M Gignac D Gillberg G Gilles D M Gingrich M P Giordani P F Giraud G Giugliarelli D Giugni F Giuli S Gkaitatzis I Gkialas E L Gkougkousis P Gkountoumis L K Gladilin C Glasman J Glatzer P C F Glaysher A Glazov G R Gledhill I Gnesi M Goblirsch-Kolb D Godin S Goldfarb T Golling D Golubkov A Gomes R Goncalves Gama R Gonçalo G Gonella L Gonella A Gongadze F Gonnella J L Gonski S González de la Hoz S Gonzalez Fernandez C Gonzalez Renteria S Gonzalez-Sevilla G R Gonzalvo Rodriguez L Goossens N A Gorasia P A Gorbounov H A Gordon B Gorini E Gorini A Gorišek A T Goshaw M I Gostkin C A Gottardo M Gouighri A G Goussiou N Govender C Goy E Gozani I Grabowska-Bold E C Graham J Gramling E Gramstad S Grancagnolo M Grandi V Gratchev P M Gravila F G Gravili C Gray H M Gray C Grefe K Gregersen I M Gregor P Grenier K Grevtsov C Grieco N A Grieser A A Grillo K Grimm S Grinstein J-F Grivaz S Groh E Gross J Grosse-Knetter Z J Grout C Grud A Grummer L Guan W Guan C Gubbels J Guenther A Guerguichon J G R Guerrero Rojas F Guescini D Guest R Gugel T Guillemin S Guindon U Gul J Guo W Guo Y Guo Z Guo R Gupta S Gurbuz G Gustavino M Guth P Gutierrez C Gutschow C Guyot C Gwenlan C B Gwilliam A Haas C Haber H K Hadavand A Hadef M Haleem J Haley G Halladjian G D Hallewell K Hamacher P Hamal K Hamano H Hamdaoui M Hamer G N Hamity K Han L Han S Han Y F Han K Hanagaki M Hance D M Handl B Haney R Hankache E Hansen J B Hansen J D Hansen M C Hansen P H Hansen E C Hanson K Hara T Harenberg S Harkusha P F Harrison N M Hartman N M Hartmann Y Hasegawa A Hasib S Hassani S Haug R Hauser L B Havener M Havranek C M Hawkes R J Hawkings D Hayden C Hayes R L Hayes C P Hays J M Hays H S Hayward S J Haywood F He M P Heath V Hedberg S Heer K K Heidegger W D Heidorn J Heilman S Heim T Heim B Heinemann J J Heinrich L Heinrich J Hejbal L Helary A Held S Hellesund C M Helling S Hellman C Helsens R C W Henderson Y Heng L Henkelmann A M Henriques Correia H Herde Y Hernández Jiménez H Herr M G Herrmann T Herrmann G Herten R Hertenberger L Hervas T C Herwig G G Hesketh N P Hessey H Hibi A Higashida S Higashino E Higón-Rodriguez K Hildebrand J C Hill K K Hill K H Hiller S J Hillier M Hils I Hinchliffe F Hinterkeuser M Hirose S Hirose D Hirschbuehl B Hiti O Hladik D R Hlaluku J Hobbs N Hod M C Hodgkinson A Hoecker D Hohn D Hohov T Holm T R Holmes M Holzbock L B A H Hommels S Honda T M Hong J C Honig A Hönle B H Hooberman W H Hopkins Y Horii P Horn L A Horyn S Hou A Hoummada J Howarth J Hoya M Hrabovsky J Hrdinka I Hristova J Hrivnac A Hrynevich T Hryn'ova P J Hsu S-C Hsu Q Hu S Hu Y F Hu D P Huang Y Huang Y Huang Z Hubacek F Hubaut M Huebner F Huegging T B Huffman M Huhtinen R F H Hunter P Huo N Huseynov J Huston J Huth R Hyneman S Hyrych G Iacobucci G Iakovidis I Ibragimov L Iconomidou-Fayard P Iengo R Ignazzi O Igonkina R Iguchi T Iizawa Y Ikegami M Ikeno D Iliadis N Ilic F Iltzsche G Introzzi M Iodice K Iordanidou V Ippolito M F Isacson M Ishino W Islam C Issever S Istin F Ito J M Iturbe Ponce R Iuppa A Ivina H Iwasaki J M Izen V Izzo P Jacka P Jackson R M Jacobs B P Jaeger V Jain G Jäkel K B Jakobi K Jakobs T Jakoubek J Jamieson K W Janas R Jansky M Janus P A Janus G Jarlskog A E Jaspan N Javadov T Javůrek M Javurkova F Jeanneau L Jeanty J Jejelava A Jelinskas P Jenni N Jeong S Jézéquel H Ji J Jia H Jiang Y Jiang Z Jiang S Jiggins F A Jimenez Morales J Jimenez Pena S Jin A Jinaru O Jinnouchi H Jivan P Johansson K A Johns C A Johnson R W L Jones S D Jones S Jones T J Jones J Jongmanns P M Jorge J Jovicevic X Ju J J Junggeburth A Juste Rozas A Kaczmarska M Kado H Kagan M Kagan A Kahn C Kahra T Kaji E Kajomovitz C W Kalderon A Kaluza A Kamenshchikov M Kaneda N J Kang S Kang Y Kano J Kanzaki L S Kaplan D Kar K Karava M J Kareem I Karkanias S N Karpov Z M Karpova V Kartvelishvili A N Karyukhin A Kastanas C Kato J Katzy K Kawade K Kawagoe T Kawaguchi T Kawamoto G Kawamura E F Kay V F Kazanin R Keeler R Kehoe J S Keller E Kellermann D Kelsey J J Kempster J Kendrick K E Kennedy O Kepka S Kersten B P Kerševan S Ketabchi Haghighat M Khader F Khalil-Zada M Khandoga A Khanov A G Kharlamov T Kharlamova E E Khoda A Khodinov T J Khoo E Khramov J Khubua S Kido M Kiehn C R Kilby E Kim Y K Kim N Kimura O M Kind B T King D Kirchmeier J Kirk A E Kiryunin T Kishimoto D P Kisliuk V Kitali O Kivernyk T Klapdor-Kleingrothaus M Klassen C Klein M H Klein M Klein U Klein K Kleinknecht P Klimek A Klimentov T Klingl T Klioutchnikova F F Klitzner P Kluit S Kluth E Kneringer E B F G Knoops A Knue D Kobayashi T Kobayashi M Kobel M Kocian T Kodama P Kodys D M Koeck P T Koenig T Koffas N M Köhler M Kolb I Koletsou T Komarek T Kondo K Köneke A X Y Kong A C König T Kono V Konstantinides N Konstantinidis B Konya R Kopeliansky S Koperny K Korcyl K Kordas G Koren A Korn I Korolkov E V Korolkova N Korotkova O Kortner S Kortner V V Kostyukhin A Kotsokechagia A Kotwal A Koulouris A Kourkoumeli-Charalampidi C Kourkoumelis E Kourlitis V Kouskoura A B Kowalewska R Kowalewski W Kozanecki A S Kozhin V A Kramarenko G Kramberger D Krasnopevtsev M W Krasny A Krasznahorkay D Krauss J A Kremer J Kretzschmar P Krieger F Krieter A Krishnan K Krizka K Kroeninger H Kroha J Kroll J Kroll K S Krowpman U Kruchonak H Krüger N Krumnack M C Kruse J A Krzysiak T Kubota O Kuchinskaia S Kuday D Kuechler J T Kuechler S Kuehn A Kugel T Kuhl V Kukhtin R Kukla Y Kulchitsky S Kuleshov Y P Kulinich M Kuna T Kunigo A Kupco T Kupfer O Kuprash H Kurashige L L Kurchaninov Y A Kurochkin A Kurova M G Kurth E S Kuwertz M Kuze A K Kvam J Kvita T Kwan L La Rotonda F La Ruffa C Lacasta F Lacava D P J Lack H Lacker D Lacour E Ladygin R Lafaye B Laforge T Lagouri S Lai I K Lakomiec S Lammers W Lampl C Lampoudis E Lançon U Landgraf M P J Landon M C Lanfermann V S Lang J C Lange R J Langenberg A J Lankford F Lanni K Lantzsch A Lanza A Lapertosa S Laplace J F Laporte T Lari F Lasagni Manghi M Lassnig T S Lau A Laudrain A Laurier M Lavorgna S D Lawlor M Lazzaroni B Le E Le Guirriec A Lebedev M LeBlanc T LeCompte F Ledroit-Guillon A C A Lee C A Lee G R Lee L Lee S C Lee S Lee B Lefebvre H P Lefebvre M Lefebvre C Leggett K Lehmann N Lehmann G Lehmann Miotto W A Leight A Leisos M A L Leite C E Leitgeb R Leitner D Lellouch K J C Leney T Lenz R Leone S Leone C Leonidopoulos A Leopold C Leroy R Les C G Lester M Levchenko J Levêque D Levin L J Levinson D J Lewis B Li B Li C-Q Li F Li H Li H Li J Li K Li L Li M Li Q Li Q Y Li S Li X Li Y Li Z Li Z Li Z Liang B Liberti A Liblong K Lie S Lim C Y Lin K Lin T H Lin R A Linck R E Lindley J H Lindon A L Lionti E Lipeles A Lipniacka T M Liss A Lister J D Little B Liu B X Liu H B Liu H Liu J B Liu J K K Liu K Liu M Liu P Liu Y Liu Y Liu Y L Liu Y W Liu M Livan A Lleres J Llorente Merino S L Lloyd C Y Lo E M Lobodzinska P Loch S Loffredo T Lohse K Lohwasser M Lokajicek J D Long R E Long L Longo K A Looper I Lopez Paz A Lopez Solis J Lorenz N Lorenzo Martinez A M Lory P J Lösel A Lösle X Lou X Lou A Lounis J Love P A Love J J Lozano Bahilo M Lu Y J Lu H J Lubatti C Luci A Lucotte C Luedtke F Luehring I Luise L Luminari B Lund-Jensen M S Lutz D Lynn H Lyons R Lysak E Lytken F Lyu V Lyubushkin T Lyubushkina H Ma L L Ma Y Ma G Maccarrone A Macchiolo C M Macdonald J Machado Miguens D Madaffari R Madar W F Mader M Madugoda Ralalage Don N Madysa J Maeda T Maeno M Maerker V Magerl N Magini J Magro D J Mahon C Maidantchik T Maier A Maio K Maj O Majersky S Majewski Y Makida N Makovec B Malaescu Pa Malecki V P Maleev F Malek U Mallik D Malon C Malone S Maltezos S Malyukov J Mamuzic G Mancini I Mandić L Manhaes de Andrade Filho I M Maniatis J Manjarres Ramos K H Mankinen A Mann A Manousos B Mansoulie I Manthos S Manzoni A Marantis G Marceca L Marchese G Marchiori M Marcisovsky L Marcoccia C Marcon C A Marin Tobon M Marjanovic Z Marshall M U F Martensson S Marti-Garcia C B Martin T A Martin V J Martin B Martin Dit Latour L Martinelli M Martinez V I Martinez Outschoorn S Martin-Haugh V S Martoiu A C Martyniuk A Marzin S R Maschek L Masetti T Mashimo R Mashinistov J Masik A L Maslennikov L Massa P Massarotti P Mastrandrea A Mastroberardino T Masubuchi D Matakias A Matic N Matsuzawa P Mättig J Maurer B Maček D A Maximov R Mazini I Maznas S M Mazza S P Mc Kee T G McCarthy W P McCormack E F McDonald J A Mcfayden G Mchedlidze M A McKay K D McLean S J McMahon P C McNamara C J McNicol R A McPherson J E Mdhluli Z A Meadows S Meehan T Megy S Mehlhase A Mehta T Meideck B Meirose D Melini B R Mellado Garcia J D Mellenthin M Melo F Meloni A Melzer S B Menary E D Mendes Gouveia L Meng X T Meng S Menke E Meoni S Mergelmeyer S A M Merkt C Merlassino P Mermod L Merola C Meroni G Merz O Meshkov J K R Meshreki A Messina J Metcalfe A S Mete C Meyer J-P Meyer H Meyer Zu Theenhausen F Miano M Michetti R P Middleton L Mijović G Mikenberg M Mikestikova M Mikuž H Mildner M Milesi A Milic C D Milke D W Miller A Milov D A Milstead R A Mina A A Minaenko M Miñano Moya I A Minashvili A I Mincer B Mindur M Mineev Y Minegishi L M Mir A Mirto K P Mistry T Mitani J Mitrevski V A Mitsou M Mittal O Miu A Miucci P S Miyagawa A Mizukami J U Mjörnmark T Mkrtchyan M Mlynarikova T Moa K Mochizuki P Mogg S Mohapatra R Moles-Valls M C Mondragon K Mönig J Monk E Monnier A Montalbano J Montejo Berlingen M Montella F Monticelli S Monzani N Morange D Moreno M Moreno Llácer C Moreno Martinez P Morettini M Morgenstern S Morgenstern D Mori M Morii M Morinaga V Morisbak A K Morley G Mornacchi A P Morris L Morvaj P Moschovakos B Moser M Mosidze T Moskalets H J Moss J Moss E J W Moyse S Muanza J Mueller R S P Mueller D Muenstermann G A Mullier D P Mungo J L Munoz Martinez F J Munoz Sanchez P Murin W J Murray A Murrone M Muškinja C Mwewa A G Myagkov A A Myers J Myers M Myska B P Nachman O Nackenhorst A Nag Nag K Nagai K Nagano Y Nagasaka J L Nagle E Nagy A M Nairz Y Nakahama K Nakamura T Nakamura H Nanjo F Napolitano R F Naranjo Garcia R Narayan I Naryshkin T Naumann G Navarro P Y Nechaeva F Nechansky T J Neep A Negri M Negrini C Nellist M E Nelson S Nemecek M Nessi M S Neubauer F Neuhaus M Neumann R Newhouse P R Newman C W Ng Y S Ng Y W Y Ng B Ngair H D N Nguyen T Nguyen Manh E Nibigira R B Nickerson R Nicolaidou D S Nielsen J Nielsen N Nikiforou V Nikolaenko I Nikolic-Audit K Nikolopoulos P Nilsson H R Nindhito Y Ninomiya A Nisati N Nishu R Nisius I Nitsche T Nitta T Nobe Y Noguchi I Nomidis M A Nomura M Nordberg T Novak O Novgorodova R Novotny L Nozka K Ntekas E Nurse F G Oakham H Oberlack J Ocariz A Ochi I Ochoa J P Ochoa-Ricoux K O'Connor S Oda S Odaka S Oerdek A Ogrodnik A Oh S H Oh C C Ohm H Oide M L Ojeda H Okawa Y Okazaki M W O'Keefe Y Okumura T Okuyama A Olariu L F Oleiro Seabra S A Olivares Pino D Oliveira Damazio J L Oliver M J R Olsson A Olszewski J Olszowska D C O'Neil A P O'neill A Onofre P U E Onyisi H Oppen M J Oreglia G E Orellana D Orestano N Orlando R S Orr V O'Shea R Ospanov G Otero Y Garzon H Otono P S Ott G J Ottino M Ouchrif J Ouellette F Ould-Saada A Ouraou Q Ouyang M Owen R E Owen V E Ozcan N Ozturk J Pacalt H A Pacey K Pachal A Pacheco Pages C Padilla Aranda S Pagan Griso M Paganini G Palacino S Palazzo S Palestini M Palka D Pallin P Palni I Panagoulias C E Pandini J G Panduro Vazquez P Pani G Panizzo L Paolozzi C Papadatos K Papageorgiou S Parajuli A Paramonov D Paredes Hernandez S R Paredes Saenz B Parida T H Park A J Parker M A Parker F Parodi E W Parrish J A Parsons U Parzefall L Pascual Dominguez V R Pascuzzi J M P Pasner F Pasquali E Pasqualucci S Passaggio F Pastore P Pasuwan S Pataraia J R Pater A Pathak J Patton T Pauly J Pearkes B Pearson M Pedersen L Pedraza Diaz R Pedro T Peiffer S V Peleganchuk O Penc H Peng B S Peralva M M Perego A P Pereira Peixoto L Pereira Sanchez D V Perepelitsa F Peri L Perini H Pernegger S Perrella A Perrevoort K Peters R F Y Peters B A Petersen T C Petersen E Petit A Petridis C Petridou F Petrucci M Pettee N E Pettersson K Petukhova A Peyaud R Pezoa L Pezzotti T Pham F H Phillips P W Phillips M W Phipps G Piacquadio E Pianori A Picazio R H Pickles R Piegaia D Pietreanu J E Pilcher A D Pilkington M Pinamonti J L Pinfold C Pitman Donaldson M Pitt L Pizzimento M-A Pleier V Pleskot E Plotnikova P Podberezko R Poettgen R Poggi L Poggioli I Pogrebnyak D Pohl I Pokharel G Polesello A Poley A Policicchio R Polifka A Polini C S Pollard V Polychronakos D Ponomarenko L Pontecorvo S Popa G A Popeneciu L Portales D M Portillo Quintero S Pospisil K Potamianos I N Potrap C J Potter H Potti T Poulsen J Poveda T D Powell G Pownall M E Pozo Astigarraga P Pralavorio S Prell D Price M Primavera S Prince M L Proffitt N Proklova K Prokofiev F Prokoshin S Protopopescu J Proudfoot M Przybycien D Pudzha A Puri P Puzo J Qian Y Qin A Quadt M Queitsch-Maitland A Qureshi M Racko F Ragusa G Rahal J A Raine S Rajagopalan A Ramirez Morales K Ran T Rashid S Raspopov D M Rauch F Rauscher S Rave B Ravina I Ravinovich J H Rawling M Raymond A L Read N P Readioff M Reale D M Rebuzzi G Redlinger K Reeves L Rehnisch J Reichert D Reikher A Reiss A Rej C Rembser A Renardi M Renda M Rescigno S Resconi E D Resseguie S Rettie B Reynolds E Reynolds O L Rezanova P Reznicek E Ricci R Richter S Richter E Richter-Was O Ricken M Ridel P Rieck O Rifki M Rijssenbeek A Rimoldi M Rimoldi L Rinaldi G Ripellino I Riu J C Rivera Vergara F Rizatdinova E Rizvi C Rizzi R T Roberts S H Robertson M Robin D Robinson C M Robles Gajardo M Robles Manzano A Robson A Rocchi E Rocco C Roda S Rodriguez Bosca A Rodriguez Perez D Rodriguez Rodriguez A M Rodríguez Vera S Roe O Røhne R Röhrig R A Rojas B Roland C P A Roland J Roloff A Romaniouk M Romano N Rompotis M Ronzani L Roos S Rosati G Rosin B J Rosser E Rossi E Rossi E Rossi L P Rossi L Rossini R Rosten M Rotaru B Rottler D Rousseau G Rovelli A Roy D Roy A Rozanov Y Rozen X Ruan F Rühr A Ruiz-Martinez A Rummler Z Rurikova N A Rusakovich H L Russell L Rustige J P Rutherfoord E M Rüttinger M Rybar G Rybkin E B Rye A Ryzhov J A Sabater Iglesias P Sabatini S Sacerdoti H F-W Sadrozinski R Sadykov F Safai Tehrani B Safarzadeh Samani M Safdari P Saha S Saha M Sahinsoy A Sahu M Saimpert M Saito T Saito H Sakamoto D Salamani G Salamanna J E Salazar Loyola A Salnikov J Salt A Salvador Salas D Salvatore F Salvatore A Salvucci A Salzburger J Samarati D Sammel D Sampsonidis D Sampsonidou J Sánchez A Sanchez Pineda H Sandaker C O Sander I G Sanderswood M Sandhoff C Sandoval D P C Sankey M Sannino Y Sano A Sansoni C Santoni H Santos S N Santpur A Santra A Sapronov J G Saraiva O Sasaki K Sato F Sauerburger E Sauvan P Savard R Sawada C Sawyer L Sawyer C Sbarra A Sbrizzi T Scanlon J Schaarschmidt P Schacht B M Schachtner D Schaefer L Schaefer J Schaeffer S Schaepe U Schäfer A C Schaffer D Schaile R D Schamberger N Scharmberg V A Schegelsky D Scheirich F Schenck M Schernau C Schiavi L K Schildgen Z M Schillaci E J Schioppa M Schioppa K E Schleicher S Schlenker K R Schmidt-Sommerfeld K Schmieden C Schmitt S Schmitt S Schmitz J C Schmoeckel L Schoeffel A Schoening P G Scholer E Schopf M Schott J F P Schouwenberg J Schovancova S Schramm F Schroeder A Schulte H-C Schultz-Coulon M Schumacher B A Schumm Ph Schune A Schwartzman T A Schwarz Ph Schwemling R Schwienhorst A Sciandra G Sciolla M Scodeggio M Scornajenghi F Scuri F Scutti L M Scyboz C D Sebastiani P Seema S C Seidel A Seiden B D Seidlitz T Seiss C Seitz J M Seixas G Sekhniaidze S J Sekula N Semprini-Cesari S Sen C Serfon L Serin L Serkin M Sessa H Severini S Sevova F Sforza A Sfyrla E Shabalina J D Shahinian N W Shaikh D Shaked Renous L Y Shan M Shapiro A Sharma A S Sharma P B Shatalov K Shaw S M Shaw M Shehade Y Shen A D Sherman P Sherwood L Shi S Shimizu C O Shimmin Y Shimogama M Shimojima I P J Shipsey S Shirabe M Shiyakova J Shlomi A Shmeleva M J Shochet J Shojaii D R Shope S Shrestha E M Shrif E Shulga P Sicho A M Sickles P E Sidebo E Sideras Haddad O Sidiropoulou A Sidoti F Siegert Dj Sijacki M Silva M V Silva Oliveira S B Silverstein S Simion R Simoniello C J Simpson-Allsop S Simsek P Sinervo V Sinetckii S Singh M Sioli I Siral S Yu Sivoklokov J Sjölin E Skorda P Skubic M Slawinska K Sliwa R Slovak V Smakhtin B H Smart J Smiesko N Smirnov S Yu Smirnov Y Smirnov L N Smirnova O Smirnova J W Smith M Smizanska K Smolek A Smykiewicz A A Snesarev H L Snoek I M Snyder S Snyder R Sobie A Soffer A Søgaard F Sohns C A Solans Sanchez E Yu Soldatov U Soldevila A A Solodkov A Soloshenko O V Solovyanov V Solovyev P Sommer H Son W Song W Y Song A Sopczak A L Sopio F Sopkova C L Sotiropoulou S Sottocornola R Soualah A M Soukharev D South S Spagnolo M Spalla M Spangenberg F Spanò D Sperlich T M Spieker G Spigo M Spina D P Spiteri M Spousta A Stabile B L Stamas R Stamen M Stamenkovic E Stanecka B Stanislaus M M Stanitzki M Stankaityte B Stapf E A Starchenko G H Stark J Stark P Staroba P Starovoitov S Stärz R Staszewski G Stavropoulos M Stegler P Steinberg A L Steinhebel B Stelzer H J Stelzer O Stelzer-Chilton H Stenzel T J Stevenson G A Stewart M C Stockton G Stoicea M Stolarski S Stonjek A Straessner J Strandberg S Strandberg M Strauss P Strizenec R Ströhmer D M Strom R Stroynowski A Strubig S A Stucci B Stugu J Stupak N A Styles D Su W Su S Suchek V V Sulin M J Sullivan D M S Sultan S Sultansoy T Sumida S Sun X Sun K Suruliz C J E Suster M R Sutton S Suzuki M Svatos M Swiatlowski S P Swift T Swirski A Sydorenko I Sykora M Sykora T Sykora D Ta K Tackmann J Taenzer A Taffard R Tafirout R Takashima K Takeda T Takeshita E P Takeva Y Takubo M Talby A A Talyshev N M Tamir J Tanaka R Tanaka S Tapia Araya S Tapprogge A Tarek Abouelfadl Mohamed S Tarem K Tariq G Tarna G F Tartarelli P Tas M Tasevsky T Tashiro E Tassi A Tavares Delgado Y Tayalati A J Taylor G N Taylor W Taylor H Teagle A S Tee R Teixeira De Lima P Teixeira-Dias H Ten Kate J J Teoh S Terada K Terashi J Terron S Terzo M Testa R J Teuscher S J Thais N Themistokleous T Theveneaux-Pelzer F Thiele D W Thomas J O Thomas J P Thomas P D Thompson L A Thomsen E Thomson E J Thorpe R E Ticse Torres V O Tikhomirov Yu A Tikhonov S Timoshenko P Tipton S Tisserant K Todome S Todorova-Nova S Todt J Tojo S Tokár K Tokushuku E Tolley K G Tomiwa M Tomoto L Tompkins P Tornambe E Torrence H Torres E Torró Pastor C Tosciri J Toth D R Tovey A Traeet C J Treado T Trefzger F Tresoldi A Tricoli I M Trigger S Trincaz-Duvoid D A Trischuk W Trischuk B Trocmé A Trofymov C Troncon F Trovato L Truong M Trzebinski A Trzupek F Tsai J C-L Tseng P V Tsiareshka A Tsirigotis V Tsiskaridze E G Tskhadadze M Tsopoulou I I Tsukerman V Tsulaia S Tsuno D Tsybychev Y Tu A Tudorache V Tudorache T T Tulbure A N Tuna S Turchikhin D Turgeman I Turk Cakir R J Turner R Turra P M Tuts S Tzamarias E Tzovara G Ucchielli K Uchida F Ukegawa G Unal A Undrus G Unel F C Ungaro Y Unno K Uno J Urban P Urquijo G Usai Z Uysal V Vacek B Vachon K O H Vadla A Vaidya C Valderanis E Valdes Santurio M Valente S Valentinetti A Valero L Valéry R A Vallance A Vallier J A Valls Ferrer T R Van Daalen P Van Gemmeren I Van Vulpen M Vanadia W Vandelli M Vandenbroucke E R Vandewall A Vaniachine D Vannicola R Vari E W Varnes C Varni T Varol D Varouchas K E Varvell M E Vasile G A Vasquez F Vazeille D Vazquez Furelos T Vazquez Schroeder J Veatch V Vecchio M J Veen L M Veloce F Veloso S Veneziano A Ventura N Venturi A Verbytskyi V Vercesi M Verducci C M Vergel Infante C Vergis W Verkerke A T Vermeulen J C Vermeulen C Vernieri M C Vetterli N Viaux Maira T Vickey O E Vickey Boeriu G H A Viehhauser L Vigani M Villa M Villaplana Perez E Vilucchi M G Vincter G S Virdee A Vishwakarma C Vittori I Vivarelli M Vogel P Vokac S E von Buddenbrock E Von Toerne V Vorobel K Vorobev M Vos J H Vossebeld M Vozak N Vranjes M Vranjes Milosavljevic V Vrba M Vreeswijk R Vuillermet I Vukotic S Wada P Wagner W Wagner J Wagner-Kuhr S Wahdan H Wahlberg R Wakasa V M Walbrecht J Walder R Walker S D Walker W Walkowiak V Wallangen A M Wang A Z Wang C Wang F Wang H Wang H Wang J Wang J Wang P Wang Q Wang R-J Wang R Wang R Wang S M Wang W T Wang W Wang W X Wang Y Wang Z Wang C Wanotayaroj A Warburton C P Ward D R Wardrope N Warrack A Washbrook A T Watson M F Watson G Watts B M Waugh A F Webb C Weber M S Weber S A Weber S M Weber A R Weidberg J Weingarten M Weirich C Weiser P S Wells T Wenaus T Wengler S Wenig N Wermes M D Werner M Wessels T D Weston K Whalen N L Whallon A M Wharton A S White A White M J White D Whiteson B W Whitmore W Wiedenmann C Wiel M Wielers N Wieseotte C Wiglesworth L A M Wiik-Fuchs H G Wilkens L J Wilkins H H Williams S Williams C Willis S Willocq I Wingerter-Seez E Winkels F Winklmeier B T Winter M Wittgen M Wobisch A Wolf T M H Wolf R Wolff R Wölker J Wollrath M W Wolter H Wolters V W S Wong N L Woods S D Worm B K Wosiek K W Woźniak K Wraight S L Wu X Wu Y Wu T R Wyatt B M Wynne S Xella Z Xi L Xia X Xiao I Xiotidis D Xu H Xu H Xu L Xu T Xu W Xu Z Xu Z Xu B Yabsley S Yacoob K Yajima D P Yallup N Yamaguchi Y Yamaguchi A Yamamoto M Yamatani T Yamazaki Y Yamazaki J Yan Z Yan H J Yang H T Yang S Yang T Yang X Yang Y Yang Z Yang W-M Yao Y C Yap Y Yasu E Yatsenko H Ye J Ye S Ye I Yeletskikh M R Yexley E Yigitbasi K Yorita K Yoshihara C J S Young C Young J Yu R Yuan X Yue M Zaazoua B Zabinski G Zacharis E Zaffaroni J Zahreddine A M Zaitsev T Zakareishvili N Zakharchuk S Zambito D Zanzi D R Zaripovas S V Zeißner C Zeitnitz G Zemaityte J C Zeng O Zenin T Ženiš D Zerwas M Zgubič B Zhang D F Zhang G Zhang H Zhang J Zhang K Zhang L Zhang L Zhang M Zhang R Zhang S Zhang X Zhang X Zhang Y Zhang Z Zhang Z Zhang P Zhao Z Zhao A Zhemchugov Z Zheng D Zhong B Zhou C Zhou H Zhou M S Zhou M Zhou N Zhou Y Zhou C G Zhu C Zhu H L Zhu H Zhu J Zhu Y Zhu X Zhuang K Zhukov V Zhulanov D Zieminska N I Zimine S Zimmermann Z Zinonos M Ziolkowski L Živković G Zobernig A Zoccoli K Zoch T G Zorbas R Zou L Zwalinski

Phys Rev Lett 2021 Mar;126(12):122301

CERN, Geneva, Switzerland.

The first measurement of longitudinal decorrelations of harmonic flow amplitudes v_{n} for n=2-4 in Xe+Xe collisions at sqrt[s_{NN}]=5.44  TeV is obtained using 3  μb^{-1} of data with the ATLAS detector at the LHC. The decorrelation signal for v_{3} and v_{4} is found to be nearly independent of collision centrality and transverse momentum (p_{T}) requirements on final-state particles, but for v_{2} a strong centrality and p_{T} dependence is seen. When compared with the results from Pb+Pb collisions at sqrt[s_{NN}]=5.02  TeV, the longitudinal decorrelation signal in midcentral Xe+Xe collisions is found to be larger for v_{2}, but smaller for v_{3}. Current hydrodynamic models reproduce the ratios of the v_{n} measured in Xe+Xe collisions to those in Pb+Pb collisions but fail to describe the magnitudes and trends of the ratios of longitudinal flow decorrelations between Xe+Xe and Pb+Pb. The results on the system-size dependence provide new insights and an important lever arm to separate effects of the longitudinal structure of the initial state from other early and late time effects in heavy-ion collisions.
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March 2021

A Preliminary Study on the Evaluation of In-vitro Inhibition Potential of Antimicrobial Efficacy of Raw and Commercial Honey on Escherichia coli: An Emerging Periodontal Pathogen.

Mymensingh Med J 2021 Apr;30(2):547-554

Professor Dr Ira Gupta, Professor, Department of Periodontology, Rama Dental College, Hospital & Research Centre (RDC, H&RC), Kanpur (UP)- 208024, India; E-mail:

Periodontitis, a multiple pathogen disease has the latest addition to the family i.e. Escherichia coli as a potential and emerging periodontal pathogen owing to its lipopolysaccharide more potent than Porphyromonas gingivalis, which makes it an emerging threat in periodontal disease. The role of antimicrobial agents in the management of periodontal diseases is of utmost importance. However, in the present scenario, antibiotic resistance is a public health concern now and there are very few options left for treatment. So, honey, a pioneer in traditional medicine was tried in the treatment against Escherichia coli to evaluate and compare the "in-vitro" antibacterial activity and efficacy of raw and commercial honey at different concentrations in comparison to tetracycline as a control on patient-isolated Escherichia coli and the American Type Culture Collection (ATCC) Escherichia coli 25922 strain from 5th Aug 2018 to 15th Feb 2019 at the Department of Microbiology, Rama Medical College, Kanpur (UP), India. In the in-vitro study different concentrations (100%, 75%, 50% and 25% v/v) of raw and commercial honey were studied and sensitivity tests were used to evaluate their antibacterial effect on patient-isolated Escherichia coli and the ATCC Escherichia coli 25922 strain. Minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) were also determined for raw honey, and commercial honey in comparison to tetracycline. In case of raw honey, zone of inhibition was seen at 100%, 75% and 50% concentration, with maximum inhibition being 27±1.154mm and 23±0.666mm for patient-isolated Escherichia coli and ATCC Escherichia coli 25922 strain respectively at 100% concentration, whereas, the commercial honey was effective only at 100% and 75% concentration, with maximum inhibition zone of 13±1.054mm and 17±0.942mm at 100% concentration on patient-isolated Escherichia coli and ATCC Escherichia coli 25922 strain respectively. However, no effect was observed at 25% concentration for both raw and commercial honey. The MIC and MBC of raw and commercial honey were determined by the broth dilution method, where raw honey exhibited both MIC and MBC at 512 mg/ml whereas, and commercial honey exhibited MIC at 512mg/ml and MBC at 1024 mg/ml respectively. While comparing the zone of inhibition of raw and commercial honey, it was observed that the raw honey showed almost equivalent potency and efficacy as compared to a positive control tetracycline (2.5%). There was statistically significant difference (p≤0.01) in zone of inhibition of raw and commercial honey at 100% concentration on patient-isolated Escherichia coli and ATCC Escherichia coli 25922 strain. Antimicrobial activity of raw honey at 100% concentration was equivalent to that of tetracycline and was significantly better than commercial honey.
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April 2021

Bis(μ-thiolato)-dicopper Containing Fully Spin Delocalized Mixed Valence Copper-Sulfur Clusters and Their Electronic Structural Properties with Relevance to the Cu Site.

Inorg Chem 2021 Apr 8. Epub 2021 Apr 8.

Department of Chemistry, National Institute of Technology Durgapur, Mahatma Gandhi Avenue, Durgapur 713 209, India.

With aromatic and aliphatic thiol-S donor Schiff base ligands, the copper-sulfur clusters, [(L1)CuCu](ClO)·DMF·0.5CHOH () and [(L2)CuCu(μ-S)(μ-O)](ClO)·4HO, respectively, have been reported ( 2017, 53, 3334); HL1/HL2 are 2-(((3-methylthiophen-2-yl)methylene)amino)benzene/ethanethiol). Complex comprises a wheel shaped CuS framework, made up of interlinked Cu{μ-S(R)} units. To understand the properties with relevance to the Cu site and to check whether self-assembly generates similar type clusters to , three complexes, [(L3)CuCu](ClO)·(CH)O·2.5HO (), [(L3)CuCu](ClO)·1.25(CH)O·1.25CHOH·2HO (), and [(L3)CuCu](ClO)·2(CH)O·HO () have been synthesized with supporting ligands HL3 (HL3 = 2-((furan-2-ylmethylene)amino)benzenethiol when X = -H; X = -Cl or -CF to thiol-S are HL3 and HL3 ligands, respectively). The X-ray structures of and feature a similar CuS architecture to . The spectroscopic properties and the X-ray structures revealed that - are fully spin delocalized mixed valence (MV) of type clusters. The structural parameters of the NCu{μ-S(R)} units of and closely resemble those of the MV binuclear Cu site. With the aid of UV-vis-NIR, EPR, and spectroelectrochemical studies, the electronic properties of these complexes have been described in comparison with the MV model complexes and Cu site.
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April 2021

Neuroform Atlas Stent for Treatment of Middle Cerebral Artery Aneurysms: 1-Year Outcomes From Neuroform Atlas Stent Pivotal Trial.

Neurosurgery 2021 Apr 7. Epub 2021 Apr 7.

Neuroscience Department, Bon Secours Mercy Health St. Vincent Medical Center, Toledo, Ohio, USA.

Background: Heterogeneous effect of endovascular aneurysm therapy has been observed across different anatomic locations. There is a paucity of data for stent-assisted coiling of middle cerebral artery (MCA) aneurysms.

Objective: To present the results of the MCA aneurysm group from the Neuroform Atlas (Stryker Neurovascular) investigational device exemption (IDE) trial.

Methods: The Atlas IDE trial is a prospective, multicenter, single-arm, open-label study of wide-neck aneurysms (neck ≥ 4 mm or dome-to-neck ratio < 2) in the anterior circulation treated with the Neuroform Atlas Stent and approved coils. Follow-up was obtained immediately postprocedure and 2, 6, and 12 mo postoperatively. We herein describe safety and efficacy outcomes, and functional independence of the subjects with aneurysms from all segments of MCA.

Results: A total of 35 patients were included (27 MCA bifurcation, 5 M1, 3 M2). The mean aneurysm size was 6.0 ± 1.8 mm, and the mean neck was 4.4 ± 1.2 mm. Technical procedural success was achieved in all patients. A total of 26 patients had follow-up digital subtraction angiography available at 12 mo, with 80.8% (21/26) having complete aneurysm occlusion. Twelve-month safety data were collected for 91.4% (32/35), 8.5% (3/35) had primary safety endpoint, all 3 major ischemic strokes. Mortality occurred in 2 patients beyond 30 d unrelated to procedure (1 gallbladder cancer and 1 fentanyl intoxication). At 1 yr, modified Rankin Score was 0 to 2 in 84.4% (27/32), 3 in 9.4%, and 3 patients were missing. Approximately 5.7% (2/35) of patients were retreated at 12 mo.

Conclusion: Stent-assisted coiling with the Neuroform Atlas Stent is a viable alternative to clipping for selected MCA aneurysms. Complete aneurysm occlusion rates have improved compared to historical data. Proper case selection can lead to acceptable endovascular results.
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http://dx.doi.org/10.1093/neuros/nyab090DOI Listing
April 2021

Are the concerns destroying mental health of college students?: A qualitative analysis portraying experiences amidst COVID-19 ambiguities.

Anal Soc Issues Public Policy 2021 Feb 1. Epub 2021 Feb 1.

Department of Management Studies J.C. Bose University of Science and Technology, YMCA Faridabad Haryana India.

Coronavirus presenting an unforeseeable chain of events has exaggerated misery for students in India as they attracted the most detrimental experiences associated with lockdown restrictions leading to a shutdown of colleges as a preventive measure. The research endeavors to furnish a review of the overall hardships and psychological state of mind of college students and improvement in the implementation of policy decisions. Researchers conceptualize the newly discovered phenomenon by adopting grounded theory. Data from 256 newspaper articles, online articles and magazines have been gathered and converted into 256 separate files. To broaden the justification of research, social media analysis employing tweets, Facebook posts and Whatsapp messages are considered adding to the contributory prospects of the study. Compiled data is then refined through data mining technique. Triangulation approach amalgamating content analysis and thematic analysis has been deployed, thereby exploring the qualitative aspect of data gathering. Reviews from 31 students through telephonic conversation and 8 academic experts extended more accuracy to the research process. Findings administered academic disruptions with career concern, emotional suffering, financial concern, online learning, overseas injustice and psychological effects as the final themes representing various concerns experienced by college students. Hence, this work concludes with some constructive suggestions to deteriorate the amplified concerns.
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http://dx.doi.org/10.1111/asap.12232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013217PMC
February 2021

Minimal Hepatic Encephalopathy in Patients with Alcohol Related and Non-alcoholic Steatohepatitis Related Cirrhosis by Psychometric Hepatic Cephalopathy Score and Critical Flicker Frequency.

Acta Med Indones 2021 Jan;53(1):24-30

Department of Gastroenterology and Hepatology, Asian Institute of Gastroenterology, Hyderabad 500082, India.

Background: alcohol may have additional neurotoxic ill-effects in patients with alcohol related cirrhosis apart from hepatic encephalopathy. We aimed to evaluate minimal hepatic encephalopathy (MHE) with Psychometric Hepatic Encephalopathy (PHES) score and Critical Flicker Frequency (CFF) in alcohol (ALD) and non-alcoholic steatohepatitis related (NASH) related cirrhosis.

Methods: 398 patients were screened between March 2016 and December 2018; of which 71 patients were included in ALD group and 69 in NASH group. All included patients underwent psychometric tests which included number connection test A and B (NCT-A and NCT-B), serial dot test (SDT), digit symbol test (DST), line tracing test (LTT) and CFF. MHE was diagnosed when their PHES was <-4.

Results: the prevalence of MHE was significantly higher in ALD group compared to NASH (69.01% vs 40.58%; P=0.007). The performance of individual psychometric tests was significantly poorer in ALD (P<0.05). Overall sensitivity and specificity of CFF was 76.62% (95%CI 65.59 - 85.52) and 46.03% (95%CI 33.39 - 59.06) respectively. Mean CFF was significantly lower in ALD than NASH (37.07 (SD 2.37) vs 39.05 (SD 2.40), P=0.001); also in presence of MHE (36.95 (SD 2.04) vs 37.96 (SD 1.87), P=0.033) and absence of MHE (37.34 (SD 3.01) vs 39.79 (SD 2.46), P=0.001).

Conclusion: MHE is significantly more common in patients with ALD cirrhosis than NASH counterparts. Overall CFF values are less in alcohol related cirrhosis than NASH related cirrhosis, even in presence or absence of MHE. We recommend additional caution in managing MHE in ALD cirrhosis.
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January 2021

International Pediatric Perfusion Practice: 2016 Survey Results.

J Extra Corpor Technol 2021 Mar;53(1):7-26

The Heart Center Nationwide Children's Hospital, Columbus, Ohio; Cincinnati Children's Hospital and Medical Center, Cincinnati, Ohio; Norton Children's Hospital, University of Louisville Physicians, Louisville, Kentucky; All India Institute of Medical Sciences, New Delhi, India; A. N. Bakulev National Medical Research Center of Cardiovascular Surgery, Moscow, Russia; Heart Institute, University of São Paulo, Medical School, São Paulo, Brazil; and Cardiothoracic Surgery, Tenwek Mission Hospital, Bomet, Kenya.

New cardiopulmonary bypass device techniques emerge and are reported in the scientific literature. The extent to which they are actually adopted into clinical practice is not well known. Since 1989, we have periodically surveyed pediatric cardiac centers to ascertain practice patterns. In December 2016, a 186-question perfusion survey was distributed to pediatric cardiac surgery centers all over the world using a Web-based survey tool. Responses were received from 93 North American (NA) centers (the United States and Canada) and 67 non-NA (NNA) centers, representing 19,645 cumulative annual procedures in NA and 27,776 in NNA centers on patients <18 years. Wide variation in practice was evident across geographic regions. However, the most common pediatric circuit consisted of a hard-shell (open) venous reservoir, an arterial roller pump, and a hollow-fiber membrane oxygenator with a separate or integrated arterial filter. Compared with our previous surveys, there was increased utilization of all types of safety devices. The use of an electronic perfusion record was reported by 50% of NA centers and 31% of NNA centers. There was wide regional variation in cardioplegia delivery systems and cardioplegia solutions. Seventy-nine percent of the centers reported the use of some form of modified ultrafiltration. The survey demonstrated that there remains variation in perfusion practice for pediatric patients. Future surveys will be useful to evaluate the adoption of emerging perfusion practice guidelines.
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http://dx.doi.org/10.1182/ject-2000033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995632PMC
March 2021

Discharge readiness after minor gynaecological surgeries comparing dexmedetomidine and ketamine premedication in bispectral index (BIS) guided propofol-based anaesthesia.

Indian J Anaesth 2021 Mar 20;65(Suppl 1):S34-S40. Epub 2021 Mar 20.

Department of Surgery, Life Kare Hospital, Amritsar, Punjab, India.

Background And Aims: Dexmedetomidine and ketamine are commonly used pre-medicants to propofol. Previous literature shows a delay in recovery with their use without any clarity on discharge. This study was planned to find out whether adding these premedicants to Bispectral index (BIS) guided propofol anaesthesia led to delayed discharge in minor gynaecological surgeries.

Methods: Totally, 120 adult females belonging to American Society of Anesthesiologists (ASA) physical status I and II undergoing minor gynaecological surgeries under general anaesthesia were randomly allocated to receive 1 μg/kg dexmedetomidine (Group D), 0.5 mg/kg ketamine (Group K) and normal saline (Group P) as premedication. Propofol 1% was used for induction and maintenance of anaesthesia keeping BIS between 55 and 70. After the procedure, patients were assessed primarily for discharge readiness using Modified Post Anaesthesia Discharge Scoring System (MPADSS).The secondary outcomes were Modified Aldrete Score (MAS), total dose of propofol used and haemodynamics.

Results: The percentage of patients ready for discharge were 22.5%, 30% and 15%at 1 hour in group D, K and P, respectively (p = 0.275). Median MAS was 5, 4 and 6 respectively for group D, K and P immediately post-surgery (p = 0.000). The mean dose of propofol used was 69.75 ± 12.56 mg in group D and 135.25 ± 9.2 mg in group (p = 0.001). There were significant haemodynamic variations in group D (16.4% fall in heart rate at 5 minutes and 24.18% fall in mean arterial pressure at 15 minutes).

Conclusion: Premedication with dexmedetomidine and ketamine in propofol anaesthesia does not delay discharge. However, stable haemodynamics and good analgesia with ketamine make it a better option.
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http://dx.doi.org/10.4103/ija.IJA_998_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993037PMC
March 2021

Effects of ventilation mode type on intra-abdominal pressure and intra-operative blood loss in patients undergoing lumbar spine surgery: A randomised clinical study.

Indian J Anaesth 2021 Mar 20;65(Suppl 1):S12-S19. Epub 2021 Mar 20.

Department of Anaesthesia, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Background And Aims: The aim of the study was to evaluate the effect of mode of mechanical ventilation; pressure-controlled ventilation (PCV) vs. volume-controlled ventilation (VCV) on airway pressures, intra-abdominal pressure (IAP) and intra-operative surgical bleeding in patients undergoing lumbar spine surgery.

Methods: This was a prospective, randomised study that included 50 American Society of Anesthesiologists class I and II patients undergoing lumbar spine surgery who were mechanically ventilated using PCV or VCV mode. The respiratory parameters (peak and plateau pressures) and IAP were measured after anaesthesia induction in supine position, 10 min after the patients were changed from supine to prone position, at the end of the surgery in prone position, and after the patients were changed from prone to supine position. The amount of intraoperative surgical bleeding was measured by objective and subjective methods.

Results: The primary outcome was the amount of intraoperative surgical bleeding. It was significantly less in the PCV group than in the VCV group (137 ± 24.37 mL vs. 311 ± 66.98 mL) ( = 0.000). Similarly, on comparing other parameters like peak inspiratory pressures, plateaupressures and IAP, the patients in PCV group had significantly lower parameters than those in VCV group ( < 0.05). No harmful events were recorded.

Conclusion: In patie,nts undergoing lumbar spine surgery, use of PCV mode decreased intraoperative surgical bleeding, which may be related to lower intraoperative respiratory pressures and IAP.
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http://dx.doi.org/10.4103/ija.IJA_706_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993040PMC
March 2021

Naloxone prescriptions following emergency department encounters for opioid use disorder, overdose, or withdrawal.

Am J Emerg Med 2021 Mar 24;47:154-157. Epub 2021 Mar 24.

Leonard Davis Institute of Health Economics, University of Pennsylvania, United States; Department of General Internal Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.

Objective: To determine the rate at which commercially-insured patients fill prescriptions for naloxone after an opioid-related ED encounter as well as patient characteristics associated with obtaining naloxone.

Methods: This is a retrospective cohort study of adult patients discharged from the ED following treatment for an opioid-related condition from 2016 to 2018 using a commercial insurance claims database (Optum Clinformatics® Data Mart). The primary outcome was a pharmacy claim for naloxone in the 30 days following the ED encounter. A multivariable logistic regression model examined the association of patient characteristics with filled naloxone prescriptions, and predictive margins were used to report adjusted probabilities with 95% confidence intervals.

Results: 21,700 patients had opioid-related ED encounters during the study period, of which 1743 (8.0%) had encounters for heroin overdose, 8825 (40.7%) for overdose due to other opioids, 5400 (24.9%) for withdrawal, and 5732 (26.4%) for other opioid use disorder conditions. 230 patients (1.1%) filled a prescription for naloxone within 30 days. Patients with heroin overdose (2.6%; 95%CI 1.7 to 3.4), recent prescriptions for opioid analgesics (1.4%; 95%CI 1.1 to 1.7), recent prescriptions for buprenorphine (1.9%; 95%CI 1.0 to 2.9), and naloxone prescriptions in the prior year (3.3%; 95%CI 1.8 to 4.8) were more likely to obtain naloxone. The rate was significantly higher in 2018 [1.9% (95%CI 1.5 to 2.2)] as compared to 0.4% (95%CI 0.3 to 0.6) in 2016.

Conclusions: Few patients use insurance to obtain naloxone by prescription following opioid-related ED encounters. Clinical and policy interventions should expand distribution of this life-saving medication in the ED.
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http://dx.doi.org/10.1016/j.ajem.2021.03.056DOI Listing
March 2021

Performance of Repaired Concrete under Cyclic Flexural Loading.

Materials (Basel) 2021 Mar 11;14(6). Epub 2021 Mar 11.

Department of Civil Engineering, University of Victoria, 3800 Finnerty Road, Victoria, BC V8W 2Y2, Canada.

There is limited research reported on the effect of cyclic loading on cement-based repair materials as conducting such tests is time consuming. To overcome this issue, this study utilized a novel loading regime consisting of cycle groups with increasing stress amplitude to accelerate the test process. The Palmgren-Minder rule was used to estimate the fatigue life of repaired specimens. Specimens repaired with Mix M (cementitious repair mortar), which was estimated to have the highest 2-million-cycle fatigue endurance limit (77.4%), showed the longest fatigue life (95,991 cycles) during the cyclic loading test, the highest slant, and splitting bond strength among all repair mixes. The estimated two-million cycle fatigue endurance limit of Mix S (70.8%) was very similar to that was reported in literature (71%) using the traditional loading method. This study confirms the usefulness of Palmgren-Minder rule on estimating the fatigue life of repaired specimens. Additionally, the use of the novel loading regime showed the benefit of shortening the test process while producing results similar to those from using traditional loading methods. To improve the prediction accuracy, future research is required to modify the failure criteria to accommodate specimens that may not fail even when the average flexural strength is met.
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http://dx.doi.org/10.3390/ma14061363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999455PMC
March 2021

Unilateral benign yellow dot maculopathy.

Am J Ophthalmol Case Rep 2021 Jun 11;22:101068. Epub 2021 Mar 11.

Department of Ophthalmology and Visual Sciences, Dalhousie University, 1276 South Park Street, Room 2035D, 2 West Victoria Building, Halifax, Nova Scotia, B3H 2Y9, Canada.

Purpose: To describe a unique case of unilateral benign yellow dot maculopathy.

Observations: A 25-year-man was evaluated after incidental finding of yellow dots in the right macula. The findings of examination and multimodal imaging were in keeping with a diagnosis of benign yellow dot maculopathy.

Conclusions And Importance: Benign yellow dot maculopathy is a recently described entity with either a sporadic or dominant inheritance pattern. This is the first known report of the characteristic findings of this phenotype presenting unilaterally.
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http://dx.doi.org/10.1016/j.ajoc.2021.101068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995479PMC
June 2021

ST6GalNAc-I promotes lung cancer metastasis by altering MUC5AC sialylation.

Mol Oncol 2021 Mar 31. Epub 2021 Mar 31.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.

Lung cancer (LC) is the leading cause of cancer-related mortality. However, the molecular mechanisms associated with the development of metastasis is poorly understood. Understanding the biology of LC metastasis is critical to unveil the molecular mechanisms for designing targeted therapies. We developed two genetically engineered LC mouse models- Kras ;Trp53 ;Ad-Cre (KPA) and Kras ; Ad-Cre (KA). Survival analysis showed significantly (P=0.0049) shorter survival in KPA tumor-bearing mice as compared to KA, suggesting the aggressiveness of the model. Our transcriptomic data showed high expression of St6galnac-I in KPA compared to KA tumors. ST6GalNAc-I is an O-glycosyltransferase, which catalyzes the addition of sialic acid (SA) to the initiating GalNAc residues forming sialyl Tn (STn) on glycoproteins, such as mucins. Ectopic expression of species-specific p53 mutants in the syngeneic mouse and human LC cells led to increased cell migration and high expression of ST6GalNAc-I, STn, and MUC5AC. Immunoprecipitation of MUC5AC in the ectopically expressing p53 cells exhibited higher affinity towards STn. In addition, ST6GalNAc-I knockout (KO) cells also showed decreased migration, possibly due to reduced glycosylation of MUC5AC as observed by low STn on the glycoprotein. Interestingly, ST6GalNAc-I KO cells injected mice developed less liver metastasis (P=0.01) compared to controls, while co-localization of MUC5AC and STn was observed in the liver metastatic tissues of control mice. Collectively, our findings support the hypothesis that mutant p53 mediates ST6GalNAc-I expression, leading to the sialyation of MUC5AC, and thus contribute to LC liver metastasis.
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http://dx.doi.org/10.1002/1878-0261.12956DOI Listing
March 2021

The Role of UBI in Mitigating the Effects of Psychosocial Stressors: A Review and Proposal.

Psychol Rep 2021 Mar 31:332941211005115. Epub 2021 Mar 31.

School of International Development, University of East Anglia, UK.

Psychosocial stressors and social disadvantages contribute to inequalities in opportunities and outcomes. In the current paper, we use an epidemiological perspective and highlight the role stress plays on individuals by reviewing the outcomes of major stressors such as poverty and unemployment. We further analyzed the psychological and physical cost of these stressors and their long-term impact. We examined the role of universal basic income and closely looked at income experiments that were implemented in the past, in terms of their effectiveness in enhancing the community as well as individual outcomes and propose the UBI as a tool for alleviating the impact of these stressors. At a time when a major pandemic (e.g., COVID-19) threatens economic stability and health globally, we believe the UBI is relevant now, more than ever.
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http://dx.doi.org/10.1177/00332941211005115DOI Listing
March 2021

Modern Principles in the Acute Surgical Management of Open Distal Tibial Fractures.

J Am Acad Orthop Surg 2021 Mar 31. Epub 2021 Mar 31.

From the Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD (Shafiq), the Department of Orthopaedic Surgery, New York University School of Medicine, New York, NY (Hacquebord), and the Department of Orthopaedic Surgery, University of California, School of Medicine, Los Angeles, CA (Wright and Gupta).

Over the past two decades, management of open distal tibial fractures has evolved such that a staged approach, with external fixation and débridement during the index procedure, followed by definitive fixation and wound closure at a later date, is often considered the standard of care. Although definitive treatment of these complex injuries is often done by a multidisciplinary team of surgeons well versed in periarticular fracture repair and soft-tissue coverage in the distal extremity, the on-call orthopaedic surgeon doing the index procedure must understand the principles and rationale of the staged treatment algorithm to avoid compromising definitive treatment options and ensure the best possible patient outcome. The mechanism of injury, neurovascular status, size and location of soft-tissue injury, fracture pattern, and concomitant injuries in the polytraumatized patient should direct the treatment plan and anticipated outcomes. This review focuses on evaluation and management of these complex injuries with an emphasis on early aggressive débridement, principles of initial fracture fixation, and modern options for soft-tissue coverage, including local and free tissue transfer.
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http://dx.doi.org/10.5435/JAAOS-D-20-00502DOI Listing
March 2021

In-vitro evaluation of microleakage of bioceramic root-end filling materials: A spectrophotometric study.

J Oral Biol Craniofac Res 2021 Apr-Jun;11(2):330-333. Epub 2021 Mar 10.

NMC Medical Centre, Dubai, United Arab Emirates.

Aim: To evaluate the microleakage of newer bioceramic root-end filling materials.

Material And Method: Sixty freshly extracted human single-rooted mandibular premolar teeth were selected for the study. Teeth with fractured root, cracks, anddilacerations were rejected. All teeth were cleaned with ultrasonic scalers. Standard access opening was done and root canal treatment was performed with rotary files followed by obturation. After storing in saline for a week apical 3 ​mm of the root was resected at 900 angles to the long axis of the root. Retro cavity preparation was done with ultrasonic tips. The teeth were divided into four groups of 15 specimens each. Group I - Biodentin, GroupII-Bioaggregate, Group III - MTA Plus, and Group IV - MTA. After the restoration of retro cavities of all the teeth as per manufacture instructions, two coats of nail varnish were applied to leave apical 3 ​mm. All teeth were stored in 2% methylene blue for 72 ​h followed by emersion in 65% nitric acid for the next 72 ​h for Dye extraction. The obtained supernatant solution was then centrifuged and optical density or absorbance was measured with a UV spectrophotometer.

Result: Microleakage was found to be increasing in this order: Biodentin ​< ​Bioaggregate ​< ​MTA Plus ​< ​MTA. No significant difference was found in the microleakage of Biodentin compared to that of Bioaggregate(p ​> ​0.01).

Conclusion: All materials exhibit some amount of microleakage. Biodentin shows the least microleakage among all the bioceramic material groups. Hence, Biodentin and bioaggregate are better material of choice for the retrograde filling to prevent microleakage.
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http://dx.doi.org/10.1016/j.jobcr.2021.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994504PMC
March 2021

History, evolution and classification of CRISPR-Cas associated systems.

Prog Mol Biol Transl Sci 2021 9;179:11-76. Epub 2021 Feb 9.

Daulat Ram College, University of Delhi, New Delhi, Delhi, India. Electronic address:

This chapter provides a detailed description of the history of CRISPR-Cas and its evolution into one of the most efficient genome-editing strategies. The chapter begins by providing information on early findings that were critical in deciphering the role of CRISPR-Cas associated systems in prokaryotes. It then describes how CRISPR-Cas had been evolved into an efficient genome-editing strategy. In the subsequent section, latest developments in the genome-editing approaches based on CRISPR-Cas are discussed. The chapter ends with the recent classification and possible evolution of CRISPR-Cas systems.
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http://dx.doi.org/10.1016/bs.pmbts.2020.12.012DOI Listing
February 2021