Publications by authors named "R F Wang"

24,984 Publications

Association Between Serum Irisin and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis.

Horm Metab Res 2021 May 7;53(5):293-300. Epub 2021 May 7.

Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, China.

Irisin, an emerging adipokine, has been involved in the pathogenesis of type 2 diabetes mellitus (T2DM). However, previous studies evaluating the association between irisin and diabetic nephropathy (DN) showed inconsistent results. We performed a meta-analysis to evaluate the above association. Matched case-control studies evaluating the difference of serum irisin between T2DM patients with and without DN were identified via systematic search of PubMed, Embase, Cochranes' Library, China National Knowledge Infrastructure, and WanFang databases from inception to December 5, 2020. A random-effects model or a fixed-effects model was used to pool the results according to the heterogeneity. Overall, thirteen matched case-control studies including 1735 T2DM patients were included. Results of meta-analysis showed that compared to T2DM patients with normoalbuminuria, those with microalbuminuria [10 studies, standard mean difference (SMD): 1.12, 95% confidence interval (CI): 0.48-1.77, p<0.001; I=94%] and macroalbuminuria (10 studies, SMD: 1.86, 95% CI: 0.93-2.79, p<0.001; I=97%) had significantly lower serum irisin. Besides, the serum level of irisin was significantly lower in T2DM patients with macroalbuminuria than those with microalbuminuria (10 studies, SMD: 0.91, 95% CI: 0.44-1.38, p<0.001; I=90%). In addition, patients with estimated glomerular infiltration rate (eGFR)<60 ml/min 1.73 m had lower serum irisin compared to those with eGFR≥60 ml/min 1.73 m (4 studies, SMD: 0.89, 95% CI: 0.32-1.46, p=0.002; I=91%). In conclusion, serum irisin may be associated with albuminuria and reduced eGFR in T2DM patients.
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http://dx.doi.org/10.1055/a-1475-4444DOI Listing
May 2021

Fabrication of Chinese Traditional Medicines incorporated collagen biomaterials for human bone marrow mesenchymal stem cells.

Biomed Pharmacother 2021 May 5;139:111659. Epub 2021 May 5.

Department of Marine Bio-Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China. Electronic address:

Chinese Traditional Medicines (CTMs) are very popular for therapeutic applications to cure several chronic diseases. Many researchers are trying to discover the potential application and actual mechanism of CTMs in order to scientifically prove their effects for commercial use. One of the main functions of CTMs is to aid stem cell regeneration. Since, this study was focused to fabricate CTMs incorporated fish collagen film, which has good biocompatibility in mammalian cell growth and thus investigated the effect on human Mesenchymal stem cells (hMSCs) proliferation and differentiation. In this study, three types of CTMs such as Genistein, Icariin, and Naringin were used for film fabrication. Mechanical properties of collagen films were improved by the addition of CTMs, especially in Collagen-Naringin films. Solubility and In-vitro biodegradation of collagen films were enhanced by the hydrophobicity and chemical interaction of CTMs with collagen. The proliferation rate was accelerated in hMSCs cultured on CTMs incorporated collagen films in a dose- and time-dependent manner. Proliferation biomarkers such as Ki-67 and BrdU levels were higher in hMSCs cultured on CTMs incorporated collagen films. The proliferative and differentiation effect of CTMs was further confirmed by higher gene expression of Collagen I, Runx2, c-Fos, SMAD3 and TGF-β1 in hMSCs. Overall, this study provides a new insight on novel biomaterial fabrication using CTMs and fish collagen for making a compatible platform for in-vitro stem cell culture.
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http://dx.doi.org/10.1016/j.biopha.2021.111659DOI Listing
May 2021

Neural Graph Matching Network: Learning Lawler's Quadratic Assignment Problem with Extension to Hypergraph and Multiple-graph Matching.

IEEE Trans Pattern Anal Mach Intell 2021 May 7;PP. Epub 2021 May 7.

Graph matching involves combinatorial optimization based on edge-to-edge affinity matrix, which can be generally formulated as Lawlers Quadratic Assignment Problem (QAP). This paper presents a QAP network directly learning with the affinity matrix (equivalently the association graph) whereby the matching problem is translated into a vertex classification task. The association graph is learned by an embedding network for vertex classification, followed by Sinkhorn normalization and a cross-entropy loss for end-to-end learning. We further improve the embedding model on association graph by introducing Sinkhorn based matching-aware constraint, as well as dummy nodes to deal with unequal sizes of graphs. To our best knowledge, this is the first network to directly learn with the general Lawlers QAP. In contrast, recent deep matching methods focus on the learning of node/edge features in two graphs respectively. We also show how to extend our network to hypergraph matching, and matching of multiple graphs. Experimental results on both synthetic graphs and real-world images show its effectiveness. For pure QAP tasks on synthetic data and QAPLIB benchmark, our method can perform competitively and even surpass state-of-the-art graph matching and QAP solvers with notable less time cost. We provide a project homepage at http://thinklab.sjtu.edu.cn/project/NGM/index.html.
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http://dx.doi.org/10.1109/TPAMI.2021.3078053DOI Listing
May 2021

Angular Analysis of the B^{+}→K^{*+}μ^{+}μ^{-} Decay.

Phys Rev Lett 2021 Apr;126(16):161802

Laboratoire Leprince-ringuet (llr), Palaiseau, France.

We present an angular analysis of the B^{+}→K^{*+}(→K_{S}^{0}π^{+})μ^{+}μ^{-} decay using 9  fb^{-1} of pp collision data collected with the LHCb experiment. For the first time, the full set of CP-averaged angular observables is measured in intervals of the dimuon invariant mass squared. Local deviations from standard model predictions are observed, similar to those in previous LHCb analyses of the isospin-partner B^{0}→K^{*0}μ^{+}μ^{-} decay. The global tension is dependent on which effective couplings are considered and on the choice of theory nuisance parameters.
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http://dx.doi.org/10.1103/PhysRevLett.126.161802DOI Listing
April 2021

Probing the Symmetry Energy with the Spectral Pion Ratio.

Phys Rev Lett 2021 Apr;126(16):162701

Many neutron star properties, such as the proton fraction, reflect the symmetry energy contributions to the equation of state that dominate when neutron and proton densities differ strongly. To constrain these contributions at suprasaturation densities, we measure the spectra of charged pions produced by colliding rare isotope tin (Sn) beams with isotopically enriched Sn targets. Using ratios of the charged pion spectra measured at high transverse momenta, we deduce the slope of the symmetry energy to be 42
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http://dx.doi.org/10.1103/PhysRevLett.126.162701DOI Listing
April 2021