Publications by authors named "R Duane Cespedes"

84 Publications

Clinical Significance of an Alloantibody against the Kell Blood Group Glycoprotein.

Transfus Med Hemother 2017 Jan 2;44(1):53-57. Epub 2016 Nov 2.

IDICER-CONICET, Rosario, Argentina; Laboratorio de Inmunohematología - Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.

Background: Kell null (K) individuals can produce anti-Ku, an antibody against many epitopes in the Kell glycoprotein, after transfusion and/or pregnancy. Since sensitized K patients are rare, little is known about anti-Ku clinical relevance and in particular about its association to hemolytic disease of the fetus and newborn.

Case Report: This work describes a case of neonatal hyperbilirubinemia due to immune-mediated erythrocyte destruction by an alloantibody directed against the Kell glycoprotein. Serologic and molecular approaches identified an anti-Ku alloantibody in maternal serum. A homozygous IVS3 + 1g>a point mutation ( allele) was found to be responsible for the lack of Kell antigen expression in the mother's red blood cell and subsequent alloimmunization after a previous pregnancy. Even though in most cases Kell antibodies are clinically severe and may cause suppression of erythropoiesis, in our case the newborn had a moderate anemia and hyperbilirubinemia that was successfully treated with phototherapy without requiring exchange transfusion. Serological and molecular studies performed in the proband's family members allowed us to provide them with proper counseling regarding alloimmunization after transfusion and/or pregnancy.

Conclusions: This case enlarges the understanding of the clinical significance of alloantibodies against Kell blood group antigens.
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http://dx.doi.org/10.1159/000448381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318919PMC
January 2017

Cow, sheep and llama manure at psychrophilic anaerobic co-digestion with low cost tubular digesters in cold climate and high altitude.

Bioresour Technol 2015 Apr 22;181:238-46. Epub 2015 Jan 22.

Centre Internacional de Mètodes Numèrics en Enginyeria (CIMNE), Building Energy and Environment Group, Edifici GAIA (TR14), C/Rambla Sant Nebridi 22, 08222 Terrassa, Barcelona, Spain.

The aim of this research is to evaluate the co-digestion of cow and llama manure combined with sheep manure, in psychrophilic conditions and real field low cost tubular digesters adapted to cold climate. Four digesters were monitored in cold climate conditions; one fed with cow manure, a second one with llama manure, the third one with co-digestion of cow-sheep manure and the fourth one was fed with llama-sheep manure. The slurry had a mean temperature of 16.6 °C, the organic load rate was 0.44 kgvs m(-3) d(-1) and the hydraulic retention time was 80 days. After one hundred days biogas production was stable, as was the methane content and the pH of the effluent. The co-digestion of cow-sheep manure results in a biogas production increase of 100% compared to the mono-digestion of cow manure, while co-digestion of llama-sheep manure results in a decrease of 50% in biogas production with respect to mono-digestion of llama manure.
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http://dx.doi.org/10.1016/j.biortech.2015.01.063DOI Listing
April 2015

Improvement through low cost biofilm carrier in anaerobic tubular digestion in cold climate regions.

Bioresour Technol 2014 Sep 9;167:87-93. Epub 2014 Jun 9.

Centre Internacional de Mètodes Numèrics en Enginyeria (CIMNE), Building Energy and Environment Group, Edifici GAIA (TR14), C/Rambla Sant Nebridi 22, 08222 Terrassa, Barcelona, Spain(1).

The aim of this research is to evaluate the increase of biogas production with low cost tubular digesters in cold climates using PET rings inside the reactor. Two similar digesters have been operated and monitored in cold weather conditions and have been fed with cow manure. Digester 1 was filled with PET - rings as a biofilm carrier, Digester 2 was kept as a reference. Through the PET - rings the functional surface could be increased by a factor 4.2. The results show that 44% more biogas per Kg SV has been produced with the biofilm carrier in use (0.33 m(3)/kg SV) (reference digester -0.23 m(3)/kg SV), at an organic load rate of 0.26 kg SV/m(3)/d. The thermal performance shows that with an adaptation of the low cost tubular digester the slurry temperature can be raised up to 16.6°C (average) by surrounding temperature of 6.1°C (average) without using any active heating system.
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http://dx.doi.org/10.1016/j.biortech.2014.05.115DOI Listing
September 2014

Editorial comment.

Authors:
R Duane Cespedes

Urology 2014 May;83(5):1188-9

Comprehensive Continence and Pelvic Health Center, Shore Medical Group, University of Maryland Medical System, Easton, MD.

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http://dx.doi.org/10.1016/j.urology.2013.12.062DOI Listing
May 2014

Editorial comment.

Authors:
R Duane Cespedes

Urology 2013 Jul 21;82(1):41-2. Epub 2013 May 21.

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http://dx.doi.org/10.1016/j.urology.2012.10.088DOI Listing
July 2013